Background: Breast cancer is the
leading malignancy in women, but it is relatively rare in men, accounting for
1% of all breast cancers. In Morocco, its incidence is 0.8/ 100,000 in men.
This condition epidemiology, therapeutic and prognostic remains unknown given
the scarcity of reported series. The objective of this work is to identify the
epidemiological, clinical, pathological and therapeutic of this cancer in men. Results:
Six patients were diagnosed with breast cancer with a ratio of 6/1277 cases. The mean age
of patients was 63.3 ± 9.7 ans;
the most common histological type was invasive ductal carcinoma (83.3%). The
grade 2 SBR has a majority (66.7%), while that of SBR 3 is less represented
(33.3%). A positive estrogen receptor (66.7% of cases) and progesterone (50.0%
of cases) was noted. The HER2 receptor is overexpressed in 25% of cases. The
treatment was essentially surgical (83.3%). Additional treatment included
adjuvant chemotherapy (50.0%), radiotherapy (50.0%) and hormonal therapy
(16.7%) was administered. Discussion/Conclusion: Breast cancer in men is rare
and appears to have a very close clinical, histological characteristics and
prognosis to those of elderly women. The diagnosis is usually late and tumors
are treated in advanced stages. An improved prognosis requires better awareness
for early detection.
Cite this paper
Khalil, A. I. , Mestaghanmi, H. , Qachach, F. , Saile, R. , Bendahhou, K. and Benider, A. (2016). Breast Cancer in Men: Characteristics Epidemiological, Clinicopathological and Therapeutic. Open Access Library Journal, 3, e3166. doi: http://dx.doi.org/10.4236/oalib.1103166.
Giordano, S.H., Cohen, D.S., Buzdar, A.U., Perkins, G. and Hortobagyi, G.N. (2004) Breast Carcinoma in Men:
A Population Based Study. Cancer, 101, 51-57. http://dx.doi.org/10.1002/cncr.20312
Benchellal, Z., Wagner, A., Harchaoui, Y., Huten, N. and Body G. (2002) Cancer du sein chez l’homme : A propos
de 19 cas. Annales de Chirurgie, 127, 619-623. http://dx.doi.org/10.1016/S0003-3944(02)00816-7
Wilsher, P.C., Leach, I.H. and Ellis, I.O. (1997) A Comparison Outcome of Male
Breast Cancer with Female Breast Cancer. The
American Journal of Surgery, 173, 185-188. http://dx.doi.org/10.1016/S0002-9610(97)89592-X
Jaiyesimi,
A., Buzdar, A.U., Sahin, A.A. and Ross, M.A. (1992) Carcinoma of the Male
Breast. Annals of Internal Medicine, 117, 771-777. http://dx.doi.org/10.7326/0003-4819-117-9-771
Harlan, L.C., Zujewski, J.A., Goodman, M.T.,
Goodman, M.T. and Stevens,
J.L. (2010 Breast Cancer in Men in the United States: A Population-Based Study
of Diagnosis, Treatment, and Survival. Cancer,
116, 3558-3568. http://dx.doi.org/10.1002/cncr.25153
Ndom, P., Um, G.,
Bell, E.M., Eloundou, A., Houssain, N.M. and Huo,
D. (2012) Ameta- Analysis
of Male Breast Cancer in Africa. Breast,
21, 237-241. http://dx.doi.org/10.1016/j.breast.2012.01.004
El Hajjam, M., Khaiz,
D., Benider, A., Lakhloufi, A., Abi, F., Kahlain, A., et al. (1995) Cancer
du sein chez l’homme. à propos de 50 observations. Journal
de Chirurgie, 132, 131- 136.
Korde, L.A., Zujewski,
J.A., Kamin, L., Giodano, S., Domchek, S. anderson, W.F., Bartlet, J.M., Gelmon,
K., Nahleh, Z., Bergh, J., Cutuli,
B., Pruneri,
G., McCaskil-Stevens, W., Gralow, J., Hortobagyi, G. and Cardoso,
F. (2010) Multidisciplinary Meeting on Male Breast Cancer: Summary and Research
Recommendations. Journal of Clinical
Oncology, 28, 2114-2122. http://dx.doi.org/10.1200/JCO.2009.25.5729
Cutuli, B.F., Lacroze, M., Dilhuydy,
J.M., Florentz, P., Velten, M., Allavena, C., De Lafontan, B., Resbeut, M., Campana,
F., Graic, Y., et al. (1992) Breast Cancer in Men: Incidence
and Types of Associated Previous Synchronous and Metachronous Cancers. Bull Cancer, 79, 689-696.
Lenfant-Pejovic,
M.H., Mlika-Cabanne, N., Bouchardy, C. and Auquier,
A. (1990) Risk Factors for Male Breast Cancer: A Franco-Swiss Case-Control Study. International Journal of Cancer, 45, 661-665. http://dx.doi.org/10.1002/ijc.2910450415
Casagrande, J.T., Hanisch,
R., Pike, M.C., Ross, R.K., Brown, J.B. and Henderson B.E. (1988) A Case-Control
Study of Male Breast Cancer. Cancer Research, 48, 1326-1330.
Satram-Hoang, S., Ziogas, A. and Anton-Culver, H. (2007) Risk of Second Primary Cancer
in Men with Breast Cancer. Breast Cancer
Research, 9, R10. http://dx.doi.org/10.1186/bcr1643
Hines, S.L., Tan, W.W.,
Yasrebi, M., DePeri, E.R. and Perez,
E.A. (2007) The Role of Mammography in Male Patients with Breast Symptoms. Mayo Clinic Proceedings, 82, 297- 300. http://dx.doi.org/10.1016/S0025-6196(11)61025-2
Giordano, S.H., Valero,
V., Buzdar, A.U. and Hortobagyi,
G.N. (2002) Efficacy of Anastrozole in Male Breast Cancer. American Journal of Clinical Oncology, 25, 235-237. http://dx.doi.org/10.1097/00000421-200206000-00006
Oger, A.-S., Boukerrou, M., Cutuli, B., Campion, L., Rousseau, E., Bussières, E., Raro, P. and Classe, J.-M. (2015)
Le cancer du sein chez l’homme: approche épidémiologique, diagnostique, et thérapeutique:
étude multicentrique rétrospective à propos de 95 cas. Gynécologie
Obstétrique & Fertilité, 43, 290-296. http://dx.doi.org/10.1016/j.gyobfe.2015.02.010
Cloyd, J.M., Hernandez-Boussard,
T. and Wapnir, I.L.
(2013) Outcomes of Partial Mastect- omy in Male Breast Cancer Patients:
Analysus of SEER, 1983-2009. Annals of
Surgical Oncology, 20, 1545-1550. http://dx.doi.org/10.1245/s10434-013-2918-5
Cutuli, B., Lacroze, M., Dilhuydy,
J.M., Velten, M., De Lafontan, B., Marchal, C., et al. (1995) Male Breast Cancer: Results of the Treatments and Prognostic Factors
in 397 Cases. European Journal of Cancer,
31A, 1960-1964. http://dx.doi.org/10.1016/0959-8049(95)00366-5
Tunon de Lara, C., Goudy,
G., MacGrogan, G., Durand, M., Dilhuydy, J.-M., Avril, A.,
Stoeckle, E., Bussieres, J.-E., Debled, M., de Mascarel, I. and Mauriac,
L. (2008) Male Breast Cancer: A Review of 52 Cases Collected at the Institute Bergonie’ (Bordeaux,
France) from 1980 to 2004. Gynécologie Obstétrique & Fertilité, 36, 386-394. http://dx.doi.org/10.1016/j.gyobfe.2008.02.020
Stalsberg, H., Thomas, D.B., Rosenblatt, K.A., Jimenez, L.M., McTiernan, A., Stemhagen, A., et al. (1993) Histologic Types and
Hormone Receptors in Breast Cancer in Men: A Population-Based Study in 282 United
States Men. Cancer Causes Control, 4, 143-151. http://dx.doi.org/10.1007/BF00053155
Ribeiro, G. and Swindell, R. (1992) Adjuvant Tamoxifen for Male Breast
Cancer (MBC). British Journal of Cancer,
65, 252-254. http://dx.doi.org/10.1038/bjc.1992.50
