The present study focused on synthesizing a series of novel derivatives
of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl)
acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The
structure of the synthesized compounds has been elucidated on the basis of
elemental analyses and spectroscopic methods (IR, 1H-NMR, 13C-NMR
and MS). The in vitro cytotoxic activity of the synthesized derivatives
was evaluated against two human cell lines: prostate cancer (PC-3) and colon
cancer (HCT-116).
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