Background: Haemostaticab normalities were associated with hyper
thyrodism patients. This study aimed to assess the D-dimer levels which
indicate the hypercoagulable state in Sudanese patients with hyper thyrodism. Material
and Methods: A descriptive analytical case study was conducted in faculty of
medical laboratory science, Alneelain University, Khartoum, Sudan. A total of
80 participants were selected for this study, 40 of them were patient known
diagnosed by hyperthyroidism as a test group; 20 (50%) were female and 20 (50%)
were male; their mean age 36.3 years. Other 40 participants were normal healthy
individual as control group. The plasma D-dimer level was measured by using
semi-automated coagulometer (MISPA-i2Reagent-SWITZERLAND). Data were analyzed
by using statistical package for social sciences (SPSS) Version 20. Results: In
this study, the plasma D-dimer level has statistically significantly higher in
hyperthyroidism patient compared to normal healthy control group (mean ± SD 0.5008
± 0.239 vs. 0.5 ± 0.618 mg/dl with P value 0.00), respectively. Conclusions:
The present study revealed that the D-dimer levels were statistically
significant higher in hyper thyroid patients.
Cite this paper
Mohmed, H. A. and Mohammed, N. E. A. (2016). Measurement of D-Dimer Levels in Hyperthyroidism Patients. Open Access Library Journal, 3, e2772. doi: http://dx.doi.org/10.4236/oalib.1102772.
Suzuki, T., Distante, A.
and Eagle, K. (2010) Biomarker-Assisted Diagnosis of Acute Aortic
Dissection: How Far We Have Come and What to Expect. Current Opinion in
Cardiology, 25, 541-545. http://dx.doi.org/10.1097/HCO.0b013e32833e6e13
Wells, P.S.,
Anderson, D.R.,
Rodger, M.,
Forgie, M.,
Kearon, C.,
Dreyer, J.,
Kovacs, G.,
Mitchell, M.,
Lewandowski, B. and Kovacs, M.J.
(2003) Evaluation
of D-Dimer in the Diagnosis of Suspected Deep-Vein Thrombosis. The New England Journal of Medicine, 349, 1227-1235. http://dx.doi.org/10.1056/NEJMoa023153
Ogbera, A.O. and Kuku, S.F. (2011)
Epidemiology of Thyroid Diseases in Africa. Indian
Journal of Endocrinology and Metabolism, 15, S82-S88. http://dx.doi.org/10.4103/2230-8210.83331
Bahn, R.S., et al. (2011) Hyperthyroidism and Other Causes of Thyrotoxicosis:
Management Guidelines of the American Thyroid Association and American
Association of Clinical Endocrinologists.Thyroid, 21, 593-646. http://dx.doi.org/10.1089/thy.2010.0417
Devereaux, D. and Tewelde, S.Z. (2014) Hyperthyroidism and Thyrotoxicosis. Emergency
Medicine Clinics of North America, 32, 277-292. http://dx.doi.org/10.1016/j.emc.2013.12.001
Frost, L., Vestergaard, P.
and Mosekilde, L. (2004) Hyperthyroidism and Risk of Atrial Fibrillation or
Flutter: A Population-Based Study. Archives
of Internal Medicine, 164,
1675-1678. http://dx.doi.org/10.1001/archinte.164.15.1675
Squizzato, A.,
Romualdi, E.,
Buller, H.R., et al. (2007) Clinical Review: Thyroid Dysfunction and Effects
on Coagulation and Fibrinolysis: A Systematic Review. The Journal of Clinical Endocrinology &
Metabolism, 92, 2415-2420. http://dx.doi.org/10.1210/jc.2007-0199
Vescovi, P.P., Favaloro, E.J.,
Lippi, G., et al. (2011) The Spectrum of Coagulation Abnormalities in
Thyroid Disorders. Seminars
in Thrombosis and Hemostasis,
37, 7-10. http://dx.doi.org/10.1055/s-0030-1270065
Chadarevian, R.,
Bruckert, E.,
Leenhardt, L., et al. (2001) Components of the Fibrin Lytic System Are Differently
Altered In Moderate and Severe Hypothyroidism. The Journal of Clinical Endocrinology & Metabolism, 86, 732-737. http://dx.doi.org/10.1210/jcem.86.2.7221
Debeij, J.,
Suzanne, C.C.,
van Zaane, B., et al. (2010) The Effect of Changes in Thyroxine and Thyroid
Stimulating Hormone Levels on the Coagulation System. Journal of Thrombosis and Haemostasis, 8, 2823-2826. http://dx.doi.org/10.1111/j.1538-7836.2010.04054.x
Erem, C.,
Ersoz, H.O.,
Karti, S.S., et al. (2002) Blood Coagulation and Fibrinolysis in Patients with
Hyperthyroidism. Journal of
Endocrinological Investigation, 25, 345-350. http://dx.doi.org/10.1007/bf03344016
Burggraaf, J.,
Lalezari, S., Emeis, J.J., et al. (2001) Endothelial Function in Patients with Hyperthyroidism
before and after Treatment with Propranolol and Thiamazol. Thyroid, 11, 153-160. http://dx.doi.org/10.1089/105072501300042820
Yango, J.,
Alexopoulou, O.,
Eeckhoudt, S., et al. (2011) Evaluation of the Respective Influence of
Thyroid Hormones and TSH on Blood Coagulation Parameters after Total
Thyroidectomy. European Journal of Endocrinology, 164, 599- 603. http://dx.doi.org/10.1530/EJE-10-0837
