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DNA to DNA Transcription Might Exist in Eukaryotic Cells

DOI: 10.4236/oalib.1102665, PP. 1-4

Subject Areas: Molecular Biology, Genetics, Cell Biology

Keywords: Plasmodium falciparum, Chloroquine, Genome, CAGFs, Noncoding DNA, Junk DNA, DNA to DNA Transcription, Single-Stranded DNA (ssDNA), ssDNA Transcript

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Abstract

Till now, in biological sciences, the term, transcription, mainly refers to DNA to RNA transcription. But our recently published experimental findings obtained from Plasmodium falciparum strongly suggest the existence of DNA to DNA transcription in the genome of eukaryotic cells, which could shed some light on the functions of certain noncoding DNA in the human and other eukaryotic genomes.

Cite this paper

Li, G. (2016). DNA to DNA Transcription Might Exist in Eukaryotic Cells. Open Access Library Journal, 3, e2665. doi: http://dx.doi.org/10.4236/oalib.1102665.

References

[1]  Ohno, S. (1972) So Much ‘‘Junk’’ DNA in Our Genome. In: Smith, H.H., Ed., Evolution of Genetic Systems, Gordon and Breach, New York, 366-370.
[2]  ENCODE Project Consortium (2012) An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature, 489, 57-74.
http://dx.doi.org/10.1038/nature11247
[3]  Palazzo, A.F. and Gregory, T.R. (2014) The Case for Junk DNA. PLoS Genet, 10, e1004351.
http://dx.doi.org/10.1371/journal.pgen.1004351
[4]  Rands, C.M., Meader, S., Ponting, C.P. and Lunte, G. (2014) 8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage. PLoS Genet, 10, e1004525.
http://dx.doi.org/10.1371/journal.pgen.1004525
[5]  Li, G.D. (2016) Certain Amplified Genomic-DNA Fragments (AGFs) May Be Involved in Cell Cycle Progression and Chloroquine Is Found to Induce the Production of Cell-Cycle-Associated AGFs (CAGFs) in Plasmodium falciparum. Open Access Library Journal, 3, e2447.
http://dx.doi.org/10.4236/oalib.1102447
[6]  Li, G.D. (2016) “Natural Site-Directed Mutagenesis” Might Exist in Eukaryotic Cells. Open Access Library Journal, 3, e2595.
http://dx.doi.org/10.4236/oalib.1102595
[7]  Galhardo, R.S., Hastings, P.J. and Rosenberg, S.M. (2007) Mutation as a Stress Response and the Regulation of Evolvability. Critical Reviews in Biochemistry and Molecular Biology, 42, 399-435.
http://dx.doi.org/10.1080/10409230701648502
[8]  Hanania, N., Schaool, D., Poncy, C., Tapiero, H. and Harel, J. (1977) Isolation of Single Stranded Transcription Sites from Human Nuclear DNA. Cell Biology International Reports, 1, 309-315.
[9]  Leibovitch, S.A. and Harel, J. (1978) Active DNA Transcription Sites Released from the Genome of Normal Embryonic Chicken Cells. Nucleic Acids Research, 5, 777-787.
http://dx.doi.org/10.1093/nar/5.3.777
[10]  Hanania, N., Shaool, D. and Harel, J. (1982) Isolation of a Mouse DNA Fraction Which Encodes More Informational Than Non Informational RNA Sequences. Molecular Biology Reports, 8, 91-96.
http://dx.doi.org/10.1007/BF00778510
[11]  Alwine, J.C., Kemp, D.J. and Stark, G.R. (1977). Method for Detection of Specific RNAs in Agarose Gels by Transfer to Diazobenzyloxymethyl-Paper and Hybridization with DNA Probes. Proceedings of the National Academy of Sciences of the United States of America, 74, 5350-5354.
http://dx.doi.org/10.1073/pnas.74.12.5350
[12]  Kevil, C.G., Walsh, L., Laroux, F.S., Kalogeris, T., Grisham, M.B. and Alexander, J.S. (1997) An Improved, Rapid Northern Protocol. Biochemical and Biophysical Research Communications, 238, 277-279.
[13]  Cmarko, D. and Koberna, K. (2007) Electron Microscopy in Situ Hybridization: Tracking of DNA and RNA Sequences at High Resolution. In: Methods in Molecular BiologyTM, 369, 213-228.
http://dx.doi.org/10.1007/978-1-59745-294-6_11
[14]  Gardner, M.J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R.W., et al. (2002) Genome Sequence of the Human Malaria Parasite Plasmodium falciparum. Nature, 419, 498-511.
http://dx.doi.org/10.1038/nature01097

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