Objective: To study the expression of Transient receptor potential p8 (Trp-p8)
in prostate tissues of prostate-specific antigen (PSA) in “grey district” with different
PSA density of transition zone (PSADTZ) interval and explore the role of Trp-p8
and PSADTZ determinated in the early diagnosis on prostate cancer. Methods: Immunohistochemical
and RT-PCR were applied to determinate Trp- p8 in the prostate cancer and benign
prostatic hyperplasia group with different PSADTZ interval, which were both 30 specimens.
The difference of expression level was judged and analyzed. Results: The expression
of Trp-p8 was weak or negative in the benign prostatic hyperplasia group, while
it appeared to be far more abundant in prostate cancer group and was higher in PSADTZ
group, the difference was of statistical significance. Conclusions: The expression
of Trp-p8 in prostate tissues of PSA in grey district was different. The expression
in prostate cancer was higher than that in benign prostatic hyperplasia group.
Cite this paper
Zhang, X. , Zhang, Y. , Wu, P. , Liu, S. and Zhou, J. (2016). The Role of Trp-p8 Combined with PSADTZ Determinated in the Early Diagnosis of Prostate Cancer. Open Access Library Journal, 3, e2626. doi: http://dx.doi.org/10.4236/oalib.1102626.
Moon, D.G., Cheon, J., Kim, J.J.,Yoon, D.K. and Koh, S.K. (1999) Prostate-Specific
Antigen Adjusted for the Transition Zone Volume versus Free-to-Total Prostate-Specific
Antigen Ratio in Predicting Prostate Cancer. International Journal of Urology, 6, 455-462. http://dx.doi.org/10.1046/j.1442-2042.1999.00089.x
Yang, X.R., Lin, M.J., McIntosh, L.S. and Sham, J.S.K. (2006) Functional Expression of Transient Receptor Potential
Melastatin- and Vanilloid-Related Channels in Pulmonary Arterial and Aortic Smooth Muscle. American
Journal of Physiology—Lung Cellular
and Molecular Physiology, 290, L1267-L1276. http://dx.doi.org/10.1152/ajplung.00515.2005
Kalish, J., Coone, W.H. and Graham Jr., S.D. (1994) Serum PSA Adjusted for Volume of Transition
Zone (PSAT) Is
More Accurate than PSA Adjusted for Total Gland Volume (PSAD) in Detecting Adenocarcinoma of the Prostate. Urology, 43, 601-606. http://dx.doi.org/10.1016/0090-4295(94)90170-8
Tanaka, N., Fujimoto, K., Chihara, Y., et al. (2007) Prostatic
Volume and Volume-Adjusted Prostate-Specific Antigen as Predictive Parameters
for Prostate Cancer Patients with Intermediate PSA Levels. Prostate
Cancer and Prostatic Diseases, 10, 274-278. http://dx.doi.org/10.1038/sj.pcan.4500957
Ji, G.Y., Pan, Y.Z., Wang, W.H., et al. (2007) The Role of
PSA Density in Transitional Zone in the Early Diagnosis of Prostate Cancer PSA in
Grey District. China Laboratory Diagnostics, 11, 1353-1355.
Zhang, X.S., Zhang, Y., Xu, J.X., et al. (2012) Expression of Trp-p8 in Prostate Cancer Tissues of PSA in Grey District. Chinese Journal of Surgery of Integrated Traditional
and Western Medicine, 18, 241-244.
