Site-directed mutagenesis refers to a man-made molecular biology method that
is used to make genetic alterations in the DNA sequence of a gene of interest. But
based on our recently published experimental findings, we propose that “natural
site-directed mutagenesis” might exist in eukaryotic cells, which is triggered by
harmful agents and co-directed by special transcription hotspots and mutation-contained
intranuclear primers.
Cite this paper
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