This work was about Andrographis peniculata (Burm. F). Ab initio,the LD50 test showed
non-toxicity at the highest administered dose of 5000 mg/kg in rats. Male
albino Wistar rats were treated with daily single doses of ethanol extracts
(100/200/500 mg/kg) of Andrographis peniculata (A.p.) for 14 days with intermittent administration, i.p.,
of CCl4 every four days. Liver and kidney TBARS concentrations showed lower values with increased
doses of extract administration. In both cases, “CCl4A.p. 500 mg/kg” values compared to “CCl4Silymarin” group, while “CCl4A.p. 100 mg/kg”showed no significant difference
from “CCl4 only” group. The “NC” (normal control) however, presented
the least concentration of 66.17 ± 2.74 and 38.04 ± 4.34 nmol/mg protein, respectively. Total and Indirect bilirubin concentrations indicated decreased values with increasing doses, such
that respectively, the lowest values of 1.18 ± 0.47 and 0.98 ± 0.31 mg/dl in the “CCl4A.p. 500 mg/kg” group were observed.
There was no significant difference among all the various groups except the
“NC” which showed the least value. Urea and creatinine levels were
significantly higher (p ≤ 0.05) in the “CCl4 only” group than
all others. Liver function parameters, viz., AST and ALT indicated significantly
higher values in the “CCl4 only” group, compared to all others (p ≤ 0.05). Values obtained for “CCl4A.p. (500 mg/kg)” were comparable to the
“NC” and “CCl4Silymarin”groups.
Cite this paper
Adejo, G. O. , Gnimintakpa, J. M. , Olowoniyi, O. D. and Matthew, P. O. (2016). Andrographis peniculata: Capabilities against Free Radicals, Lipid Peroxidation, Hepatotoxicity, and Nephrotoxicity. Open Access Library Journal, 3, e2541. doi: http://dx.doi.org/10.4236/oalib.1102541.
Dekkers, J.C.,
van Doornen, L.J.P. and Kemper, H.C.G.
(1996) The
Role of Antioxidant Vitamins and Enzymes in the Prevention of Exercise-Induced
Muscle Damage. Sports Medicine,21, 213-238. http://dx.doi.org/10.2165/00007256-199621030-00005
Valko, M., Rhodes, C.J., Moncol, J.,
Izakovic, M. and Mazur, M. (2006) Free
Radical Metals and Antioxidants in Oxidative Stress-Induced Cancer. Chemico-Biological Interactions, 160, 1-40. http://dx.doi.org/10.1016/j.cbi.2005.12.009
Rajagopal,
S., Kumar, R.A.,
Deevi, D.S.,
Satyanarayana, C. and Rajagopal, R. (2003) Andrographolide, a Potential Cancer Therapeutic
Agent Isolated from Andrographispaniculata.Journal of Experimental
Therapeutics & Oncology, 3, 147-158. http://dx.doi.org/10.1046/j.1359-4117.2003.01090.x
Kumar,
R.A., Sridevi, K., Kumar, N.V., Nanduri, S. and Rajagopal, S.
(2004) Anticancer
and Immunostimulatory Compounds from Andrographispaniculata. Journal of Ethnopharmacology, 92, 291-295. http://dx.doi.org/10.1016/j.jep.2004.03.004
Calabrese, C., Berman, S.H., Babish, J.G., Ma, X.F., Shinto, L., Dorr, M., Wells, K., Wenner, C.A., et al.
(2000) A Phase
I Trial of Andrographolide in HIV Positive Patients and Normal Volunteers. Phytotherapy
Research, 14,
333- 338. http://dx.doi.org/10.1002/1099-1573(200008)14:5
<333::AID-PTR584>3.0.CO;2-D
Pratibha, S., Srivastava, M.M. and Khemani, L.D. (2009) Renoprotective Effects of Andrographispaniculata (Burm. f.) Nees in Rats. UpsalaJournal of Medical Sciences, 114,
136-139. http://dx.doi.org/10.1080/03009730903174321
Bruck, R.R.,
Hershkoviz, O.,
Lider, H.,
Aeed, L.,
Zaidel, Z.,
Matas, J.B.
and Halpern, Z.
(1996) Inhibition
of Experimentally-Induced Liver Cirrhosis in Rats by a Nonpeptidic Mimetic of
the Extracellular Matrix-Associated Arg-Gly- Asp Epitope. Journal
of Hepatology, 24, 731-738. http://dx.doi.org/10.1016/S0168-8278(96)80270-4
Noori, S., Nayab, R., Madiha, Q. and Tabassum, M. (2009) Reduction of Carbon Tetrachloride-Induced Rat
Liver Injury by Coffee and Green Tea. Pakistan
Journal of Nutrition, 8, 452-458. http://dx.doi.org/10.3923/pjn.2009.452.458
Ozbek, E. (2012) Induction of Oxidative Stress in Kidney. Hindawi
Publishing Corporation. International
Journal of Nephrology, 2012, Article ID: 465897. http://dx.doi.org/10.1155/2012/465897
Hinds, T.S., Wesk, W.L.
and Knight, E.M. (1997) Carotenoids and Retinoids: A Review of Research,
Clinical and Public Health Applicationsz. The
Journal of Clinical Pharmacology, 37, 551-558. http://dx.doi.org/10.1002/j.1552-4604.1997.tb04336.x
We, Y.T.,
Liu, D.W.,
Ding, L.Y.,
Li, Q. and Xiao, Y.H.
(2004) Therapeutic
Effects and Molecular Mechanical of Antifibrosis Herbs and Selection on Rats with
Hepatic Fibrosis. World Journal of Gastroenterology, 10, 703-706. http://dx.doi.org/10.3748/wjg.v10.i5.703
Adejo, G.O.,
Atawodi, S.E.,
Ameh, D.A. and
Ibrahim, S.
(2014) Anti-Peroxidative, Protective and Ameliorative Properties of
Methanol Extract of All Parts of Morinda
Lucida Benth in CCl4-Induced Liver Injury. Natural Products Chemistry & Research, S1, 003.
Mishra, B.B., Gautam, S. and Sharma, A. (2006) Microbial Decontamination of Tea (Camellia sinensis) by Gamma Radiation. Journal of Food Science, 71,
M151-M156. http://dx.doi.org/10.1111/j.1750-3841.2006.00057.x
Gyamfi, M.A.,
Yonamine, M. and
Aniya, Y.
(1999) Free-Radical Scavenging Action of Medicinal Herbs from Ghana: Thonningiasanguinea on Experimentally-Induced Liver Injuries. General Pharmacology, 32,
661-667. http://dx.doi.org/10.1016/S0306-3623(98)00238-9
Usoh, I.F.,
Akpan, E.J.,
Etim, E.O. and
Farombi, E.O.
(2005) Antioxidant Actions of Dried Flower Extracts of Hibiscussabdariffa L. On
Sodium Arsenite-Induced
Oxidative Stress in Rats. Pakistan
Journal of Nutrition, 4, 135-141. http://dx.doi.org/10.3923/pjn.2005.135.141
Ohkawa, H.,
Ohishi, N. and
Yagi, K.
(1979) Assay for Lipid Peroxides in Animal Tissue by Thiobarbituric Acid Re- action. Analytical Biochemistry, 2,
351-358. http://dx.doi.org/10.1016/0003-2697(79)90738-3
Adejo, G.O., Agbali, F.A. and Otokpa, O.S.
(2015) Antioxidant, Total Lycopene, Ascorbic Acid and Microbial Load Estimation
in Powdered Tomato Varieties Sold in Dutsin-Ma Market. Open Access Library Journal, 2,
e1768. http://dx.doi.org/10.4236/oalib.1101768
Tsukamoto, H., Matsuoka, M. and French, S.W. (1990) Experimental Models of Hepatic Fibrosis:
A Review. Seminars in Liver Disease, 10, 56-65. http://dx.doi.org/10.1055/s-2008-1040457
Deshwal, N., Sharma, A.K. and Sharma, P. (2011) Review on Hepatoprotective Plants. International Journal of Pharmaceutical
Sciences Review and Research, 7, 15-26.
Seakins, A.
and Robinson, D.S.
(1963) The Effect of the Admin-Istration of Carbon Tetrachloride on the Formation
of Plasma Lipoproteins in the Rats. Biochemical
Journal, 86, 401-407. http://dx.doi.org/10.1042/bj0860401