Analysis of Serum Biochemical Indexes for the Diagnosis of Coronary Heart Disease in Suspected Patients

Background: The serum biochemical indexes are classic detection in clinical practice. Methods: In this study, for avoiding the risks of serious complications, high-cost in diagnosis of suspected coronary heart disease (CHD), the common biochemical indexes were detected from 68 eligible patients with suspected CHD. Treadmill exercises test (TET)-electrocardiogram (ECG) was measured during TET, and invasive examination of coronary angiography (CAG, golden standard for CHD diagnosis) was also performed. Results: For CAG, 48 patients were positive and 20 were negative; while for TET 38 were positive, 14 were inconclusive, and 16 were negative, respectively. Among these biochemical indexes, the HbA1c (%) level in CAG positive patients was much higher than that in CAG negative patients (P = 0.019). Furthermore, according to receiver operating characteristic (ROC) curve, HbA1c showed effective diagnosis for CHD and its best cutoff value was 5.85% and 29 of the patients were HbA1c positive and 30 were negative. Conclusions: It was found that HbA1c combined with TET obviously enhanced the sensitivity of examinations. All the patients who were negative in both HbA1c and TET tests turned out to be 90% CAG negative, which meant that the combination might stand invasive examination of CAG for CHD diagnosis. Further studies in multi-center investigation will be expected to validate the findings.