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Activities of Lactate Dehydrogenase, Methemoglobin, Carboxyhemoglobin and Sulfhemoglobin Concentrations in the Blood of Albino Rats Exposed to Cashew Seed Fume

DOI: 10.4236/oalib.1102284, PP. 1-6

Subject Areas: Toxicology

Keywords: Cashew Seed Fume, Methemoglobin, Sulfhemoglobin, Carboxyhemoglobin, Albino Wistar Rats

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Abstract

Smoke produced in cashew processing factories during roasting of the seed contains toxic chemicals which have adverse health effects on workers exposed to it. This study investigated the effect of cashew seed fume on lactate dehydrogenase (LDH) activity, methemoglobin (Hi), carboxyhemoglobin (HbCO) and sulfhemoglobin (SHb) in the blood of rats exposed to cashew seed fumes (CSF), via the dynamic exposure system. Eighteen (18) male albino rats were used; they were divided into three groups of six animals each as: control, rats exposed for two (2) hours and rats exposed four (4) hours for five days. The results showed that serum level of LDH in rats exposed to CSF was significantly (P < 0.05) increased compared with the control rats. The %SHb and %HbCO in the blood of rats exposed to CSF were significantly (P < 0.05) increased compared with the control rats. However there were no significant (P > 0.05) differences in the % methemoglobin level of rats in all groups. This study revealed that exposure to CSF may have adverse effects on the lungs and may also result in system poisoning. This should be a cause of concern for industrial regulatory bodies who should regulate the safety of cashew factory workers.

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Tope, M. T. , Adedotun, I. D. , Dorcas, A. T. , Bode, O. M. , Otaru, O. W. and Esther, A. T. (2016). Activities of Lactate Dehydrogenase, Methemoglobin, Carboxyhemoglobin and Sulfhemoglobin Concentrations in the Blood of Albino Rats Exposed to Cashew Seed Fume. Open Access Library Journal, 3, e2284. doi: http://dx.doi.org/10.4236/oalib.1102284.

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