全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

The Effect of Gold Nanoparticle on Absorbed Dose by IMRT in Esophagus Phantom

DOI: 10.4236/oalib.1101919, PP. 1-10

Subject Areas: Biophysics

Keywords: IMRT, Dosimetry, Gold Nanoparticle, Esophagus Phantom

Full-Text   Cite this paper   Add to My Lib

Abstract

This study aimed to evaluate the use of dosimeters MAGICA gel impregnated with nanoparticles of gold to increase the dose of faulty tissue in the chest phantom in the esophagus and other organs to determine the dose and dose distribution in the tissue with an IMRT treatment. In this study, based on previous studies, the optimal concentration of 0.1 mM gold nanoparticles has been considered. Also, better localization and avoid radiation received dose by other organizations around the IMRT machine used for radiation. For comparison and understanding of dose distribution and dose rate increase factor (DEF), gel dosimeters were acquired by MRI. The results showed that by adding gold nanoparticles with a diameter of 50 nm and optimum concentration is 0.1 mM, the dose and energy 500 cGy and 6 MV with IMRT respectively, the factors increasing the dose (DEF) is about 9.74%. It’s remarkable, this research is that Esophagus phantom to containing gold nanoparticles to other tissues (lung and spinal cord) and also the Phantom of the esophagus in the absence of gold nanoparticles, has received the highest dose and compared with the non-nano R2 Increased. It is also a good match between the results of dosimetry gel and results of treatment.

Cite this paper

Shiraazi, Z. , Mahdavi, S. , Mahdavi, M. and Abolfazli, M. K. (2015). The Effect of Gold Nanoparticle on Absorbed Dose by IMRT in Esophagus Phantom. Open Access Library Journal, 2, e1919. doi: http://dx.doi.org/10.4236/oalib.1101919.

References

[1]  Letsinger, R.L., Mirkin, C.A., Elghanian, R., Mucic, R.C. and Storhoff, J.J. (1999) Chemistry of Oligonucleotide-Gold Nanoparticle Conjugates. Phosphorus, Sulfur and Silicon and the Related Elements, 144, 359-362.
http://dx.doi.org/10.1080/10426509908546255
[2]  Maeda, H., Seymour, L.W. and Miyamoto, Y. (1992) Conjugates of Anticancsr Agents and Polymers-Advantages of Macromolecular Therapeutics in Vivo. Bioconjugate Chemistry, 3, 351-362.
http://dx.doi.org/10.1021/bc00017a001
[3]  Qi, X.R., Maitani, Y., Nagai, T. and Wei, S.L. (1997) Comparative Pharmacokinetics and Antitumor Efficacy of Doxorubicin Encapsulated in Soybean-Derived Sterols and Poly (Ethylene Glycol) Liposomes in Mice. International Jour- nal of Pharmaceutics, 146, 31-39.
http://dx.doi.org/10.1016/S0378-5173(96)04753-9
[4]  Connor, E.E., Mwamuka, J., Gole, A., Murphy, C.J. and Wyatt, M.D. (2005) Gold Nanoparticles Are Taken up by Human Cells but Do Not Cause Cytotoxicity. Small, 1, 325-327.
http://dx.doi.org/10.1002/smll.200400093
[5]  Fong, P.M., Kiel, D.Z., Does, M.D. and Core, J.C. (2001) Polymer Gels for Magnetic Resonance Imaging of Radiation Dose Distributions at Normal Room Atmosphere. Physics in Medicine and Biology, 46, 3105-3113.
http://dx.doi.org/10.1088/0031-9155/46/12/303
[6]  Khadem Abolfazli, M., Mahdavi, M., Mahdavi, S.R.M. and Ataei, Gh. (2013) Dose Enhancement Effect of Gold Nanoparticles on MAGICA Polymer Gel in Mega Voltage Radiation Therapy. International Journal of Radiation Research, 11, 55-61.
[7]  Mahdavi, M., Khadem Abolfazli, M., Mahdavi, S.R.M. and Ataei, Gh. (2013) Effect of Gold Nanoparticle on Percentage Depth Dose Enhancement on Megavoltage Energy in MAGICA Polymer Gel Dosimeter. Journal of Biomedical Physics and Engineering, 3, 37-44.
[8]  Atae, Gh., Mahdavi, S.R., Mohammadi Nokhandani, A., Taheri Otaghsara, M. and Khadem Abolfazli, M. (2015) Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter. International Journal of Biomedical Science and Engineering, 3, 1-4.
http://dx.doi.org/10.11648/j.ijbse.20150301.11

Full-Text


comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133

WeChat 1538708413