The in vitro anthelmintic evaluation of the
crude extracts and solvent partitions on Pheretima posthumaand Ascarissuum (eggs and L2 stage) respectively showed significant results at the same
concentration (10, 20, 40 and 80 mg/ml). This study
provides a clear evidence for usage of Mucuna pruriens and Canarium schweinfurthii asan anthelmintic. The most
potent ovicidal partition of C. schweinfurthii (Engl) leaves and bark and leaves
of M. pruriens (DC) is hexane (100.00 ± 0.33), chloroform (98.20 ± 0.12) and chloroform (98.70 ± 0.88)
partitioned crude respectively at 80 mg/ml while the most potent larvicidal partition is hexane (0.06%), chloroform
(0.1%) and chloroform (0.2%). The active compounds are predominantly in
the non-polar solvent which supports the tegumental diffusing activity of the
compounds.
Cite this paper
Okoli, B. J. , Ayo, R. G. , Habila, J. D. , Japhet, S. L. and Ndukwe, G. I. (2015). In Vitro Anthelmintic Activity of Mucuna pruriens (DC) and Canarium schweinfurthii (Engl) on Ascaris suum. Open Access Library Journal, 2, e1102. doi: http://dx.doi.org/10.4236/oalib.1101102.
Bundy, D.A. (1994)
Immunoepidemiology of Intestinal Helminthic Infection I: The Global Burden of Intestinal
Nematode Disease. The Royal Society of Tropical
Medicine and Hygiene, 8, 259-261. http://dx.doi.org/10.1016/0035-9203(94)90069-8
Farkas,
R., Gyurcso, A. and Borzsonyi, L. (2003) Fly Larvicidal Activity in the Faeces of Cattle and Pigs
Treated with Endectocide Products. Medical
and Veterinary Entomology, 17, 301-306. http://dx.doi.org/10.1046/j.1365-2915.2003.00443.x
Spratt, D.M. (1997) Endoparasite Control Strategies: Implications for Biodiversity of Native
Fauna. International Journal for Parasitology, 27,
173-180. http://dx.doi.org/10.1016/S0020-7519(96)00147-6
Sondhi, S.M.,
Shahu, R. and Archana, M. (1994) Anti-Amoebic
and Anthelmintic Evaluation of Heterocyclic Compounds Containing Nitrogen and/or
Sulphur. Indian Drugs,31, 317-320.
Weeks, A., Daly, D.C. and
Simpson, B.B. (2005) The Phylogenetic History and Biogeography of the Frankincense
and Myrrh Family (Burseraceae) Based on Nuclear
and Chloroplast Sequence Data. Molecular
Phylogenetics and Evolution, 35, 85-101. http://dx.doi.org/10.1016/j.ympev.2004.12.021
Jabbar, A., Zaman, M.A., Iqbal, Z., Yassen, M. and Shamim, A. (2007) Anthelmintic Activity of Chemopodium album (L.) and Caesalpinia crista (L.) against Trichostrongylid Nematodes of Sheep. Journal of Ethnopharmacology, 114, 86-91. http://dx.doi.org/10.1016/j.jep.2007.07.027
Marie-Magdeleine,
C., Hoste, H., Mahieu, M., Varo, H. and Archimede, H. (2009) In Vitro Effects
of Cucurbitamoschata Seed Extracts on Haemonchuscontortus. Veterinary Parasitology, 161, 99-105. http://dx.doi.org/10.1016/j.vetpar.2008.12.008
McGaw, L.J., Rabe, T., Sparg, S.G., Jager, A.K., Eloff, J.N. and van Staden, J. (2000) An Investigation on the Biological Activity of Combretum Species. Journal of Ethnopharmacology, 75, 45-50.
Bizimenyera, E.S., Githiori, J.B., Eloff, J.N. and Swan, G.E. (2006)In Vitro Activity of Peltophorumafricanum Sond. (Fabaceae)
Extracts on the Egg Hatching and Larval Development of the Parasitic Nematode
Trichostrongylus Colubriformis. Veterinary
Parasitology, 142, 336-343.
Hoste, H., Jackson, F.,
Athanasiadou, S., Thamsborg, S.M. and Hoskin, S.O. (2006) The Effects of Tannin-Rich Plants on Parasitic Nematodes
in Ruminants. Review. Trends in Parasitology, 22, 253-261.