全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

The Psychosocial Research of the Members in a Large Von Hippel-Lindau Family in China

DOI: 10.4236/oalib.1101079, PP. 1-10

Subject Areas: Psychiatry & Psychology, Oncology

Keywords: Von Hippel-Lindau (VHL) Syndrome, SAS, SDS, SCL-90-R, Depression, Anxiety

Full-Text   Cite this paper   Add to My Lib

Abstract

Von Hippel-Lindau (VHL) disease is a rare, autosomal inherited tumor disorder caused by mutations or deletions of the VHL gene. Most of the previous research focused on the clinical features and molecular mechanisms of the disease, few concerned about the psychosocial impact on the patients and their family. We encountered a VHL family in the clinical work and attempted to assess the possible psychological effects of the disease on the members of the family. Three questionnaires including Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) and Revised Symptom Checklist (SCL-90-R) were used in the research. A total of 61 members participated in the investigation. The SAS and SDS tests showed that 13 members were affected by anxiety which was associated with age, and 19 members suffered from depression which was correlated with gender, marital status, age, being patients, occupation, education and close relative of the VHL patients. The SCL-90 results showed that the “total scores”, “interpersonal sensitivity”, “depression”, “anxiety” and “panic” scored higher in our study than Chinese average level. Meanwhile, the SCL-90 data revealed that: 1) age was associated with anxiety disorder; 2) marital status was related to higher prevalence of hostility; 3) Being VHL patients was related to bigoted symptoms; and 4) closer relationship with the VHL patients was associated with depressive and hostility symptoms in the family. The study revealed that susceptibility to psychiatric symptoms was correlated with certain sociodemographic and clinical characteristics. Depression and anxiety were the most prevalent psychiatric symptoms in the VHL family. This was the first study focusing on the psychological consequences of the VHL disease. An understanding of these factors would be helpful in providing appropriate mental health services to the VHL family.

Cite this paper

Zhang, J. , Chang, H. , Wu, Q. , Yan, R. , Tai, M. , Xu, X. and Liu, C. (2015). The Psychosocial Research of the Members in a Large Von Hippel-Lindau Family in China. Open Access Library Journal, 2, e1079. doi: http://dx.doi.org/10.4236/oalib.1101079.

References

[1]  Lonser, R.R., Glenn, G.M., Walther, M., Chew, E.Y., Libutti, S.K., Linehan, W.M. and Oldfield, E.H. (2003) Von Hippel-Lindau Disease. The Lancet, 361, 2059-2067.
http://dx.doi.org/10.1016/S0140-6736(03)13643-4
[2]  Latif, F., Tory, K., Gnarra, J., Yao, M., Duh, F.M., Orcutt, M.L., Stackhouse, T., Kuzmin, I., Modi, W., Geil, L., et al. (1993) Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene. Science, 260, 1317-1320.
http://dx.doi.org/10.1126/science.8493574
[3]  Zbar, B., Kishida, T., Chen, F., Schmidt, L., Maher, E.R., Richards, F.M., Crossey, P.A., Webster, A.R., Affara, N.A., Ferguson-Smith, M.A., Brauch, H., Glavac, D., Neumann, H.P., Tisherman, S., Mulvihill, J.J., Gross, D.J., Shuin, T., Whaley, J., Seizinger, B., Kley, N., Olschwang, S., Boisson, C., Richard, S., Lips, C.H., Lerman, M., et al. (1996) Germline Mutations in the Von Hippel-Lindau Disease (VHL) Gene in Families from North America, Europe, and Japan. Human Mutation, 8, 348-357.
http://dx.doi.org/10.1002/(SICI)1098-1004(1996)8:4<348::AID-HUMU8>3.0.CO;2-3
[4]  Pirl, W.F. (2004) Evidence Report on the Occurrence, Assessment, and Treatment of Depression in Cancer Patients. JNCI Monographs, 32, 32-39.
http://dx.doi.org/10.1093/jncimonographs/lgh026
[5]  Zabora, J., BrintzenhofeSzoc, K., Curbow, B., Hooker, C. and Piantadosi, S. (2001) The Prevalence of Psychological Distress by Cancer Site. Psychooncology, 10, 19-28.
http://dx.doi.org/10.1002/1099-1611(200101/02)10:1<19::AID-PON501>3.0.CO;2-6
[6]  Lloyd-Williams, M. (2000) Difficulties in Diagnosing and Treating Depression in the Terminally Ill Cancer Patient. Postgraduate Medical Journal, 76, 555-558.
http://dx.doi.org/10.1136/pmj.76.899.555
[7]  Lynch, M.E. (1995) The Assessment and Prevalence of Affective Disorders in Advanced Cancer. Journal of Palliative Care, 11, 10-18.
[8]  Mystakidou, K., Tsilika, E., Parpa, E., Katsouda, E., Galanos, A. and Vlahos, L. (2005) Assessment of Anxiety and Depression in Advanced Cancer Patients and Their Relationship with Quality of Life. Quality of Life Research, 14, 1825-1833.
http://dx.doi.org/10.1007/s11136-005-4324-3
[9]  Costantini, M., Musso, M., Viterbori, P., Bonci, F., Del Mastro, L., Garrone, O., Venturini, M. and Morasso, G. (1999) Detecting Psychological Distress in Cancer Patients: Validity of the Italian Version of the Hospital Anxiety and Depression Scale. Supportive Care in Cancer, 7, 121-127.
http://dx.doi.org/10.1007/s005200050241
[10]  Hudson, P. (2004) Positive Aspects and Challenges Associated with Caring for a Dying Relative at Home. International Journal of Palliative Nursing, 10, 58-65.
http://dx.doi.org/10.12968/ijpn.2004.10.2.12454
[11]  Yates, P. and Stetz, K. (2000) Families’ Awareness of and Response to Dying. Clin J OncolNurs, 4, 46.
[12]  Tuncay, T. and Isikhan, V. (2010) Psychological Symptoms, Illness-Related Concerns and Characteristics of Relatives of Turkish Patients with Cancer. Asian Pacific Journal of Cancer Prevention, 11, 1659-1667.
[13]  Grbich, C., Parker, D. and Maddocks, I. (2001) The Emotions and Coping Strategies of Caregivers of Family Members with a Terminal Cancer. Journal of Palliative Care, 17, 30-36.
[14]  McGrath, P. (2001) Caregivers’ Insights on the Dying Trajectory in Hematology Oncology. Cancer Nursing, 24, 413- 421.
http://dx.doi.org/10.1097/00002820-200110000-00014
[15]  Milberg, A. and Strang, P. (2004) Exploring Comprehensibility and Manageability in Palliative Home Care: An Interview Study of Dying Cancer Patients’ Informal Carers. Psycho-Oncology, 13, 605-618.
http://dx.doi.org/10.1002/pon.774
[16]  Oguz, N.Y., Miles, S.H., Buken, N. and Civaner, M. (2003) End-of-Life Care in Turkey. Cambridge Quarterly of Healthcare Ethics, 12, 279-284.
http://dx.doi.org/10.1017/S0963180103123109
[17]  Gao, J. (2013) Correlation between Anxiety-Depression Status and Cytokines in Diarrhea-Predominant Irritable Bowel Syndrome. Experimental and Therapeutic Medicine, 6, 93-96.
[18]  Kong, L., Cai, Y., Mei, G., Gu, R., Zhang, X., Qin, Y., Cai, Y., Li, Y., Zhou, H., Zhang, M. and Yang, T. (2013) Psychological Status and Diabetes-Related Distress of Chinese Type 1 Diabetes Patients in Jiangsu Province, China. Journal of Biomedical Research, 27, 380-385.
http://dx.doi.org/10.7555/JBR.27.20120112
[19]  Tang, Y.R., Yang, W.W., Liang, M.L., Xu, X.Y., Wang, M.F. and Lin, L. (2012) Age-Related Symptom and Life Quality Changes in Women with Irritable Bowel Syndrome. World Journal of Gastroenterology, 18, 7175-7183.
[20]  Derogatis, L. and Cleary, P. (1977) Factorial Invariance across Gender for the Primary Symptom Dimensions of the SCL-90. British Journal of Social and Clinical Psychology, 16, 347-356.
http://dx.doi.org/10.1111/j.2044-8260.1977.tb00241.x
[21]  Schmitz, N., Kruse, J. and Tress, W. (2000) Application of Stratum-Specific Likelihood Ratios in Mental Health Screening. Social Psychiatry and Psychiatric Epidemiology, 35, 375-379.
http://dx.doi.org/10.1007/s001270050253
[22]  Jacobson, N.S. and Truax, P. (1991) Clinical Significance: A Statistical Approach to Defining Meaningful Change in Psychotherapy Research. Journal of Consulting and Clinical Psychology, 59, 12-19.
http://dx.doi.org/10.1037/0022-006X.59.1.12
[23]  Jin, H., Wu, W. and Zhang, M. (1986) The Preliminary Analysis for Evaluation Results of SCL-90 in China Normal. Chin J Nervous Ment Dis, 12, 260-263. (In Chinese)
[24]  Jadoon, N.A., Munir, W., Shahzad, M.A. and Choudhry, Z.S. (2010) Assessment of Depression and Anxiety in Adult Cancer Outpatients: A Cross-Sectional Study. BMC Cancer, 10, 594.
http://dx.doi.org/10.1186/1471-2407-10-594
[25]  Hirschfeld, R. (2001) The Comorbidity of Major Depression and Anxiety Disorders: Recognition and Management in Primary Care. Primary Care Companion to the Journal of Clinical Psychiatry, 3, 244-254.
http://dx.doi.org/10.4088/PCC.v03n0609
[26]  O’Mahony, S., Goulet, J., Kornblith, A., Abbatiello, G., Clarke, B., Kless-Siegel, S., Breitbart, W. and Payne, R. (2005) Desire for Hastened Death, Cancer Pain and Depression: Report of a Longitudinal Observational Study. Journal of Pain and Symptom Management, 29, 446-457.
http://dx.doi.org/10.1016/j.jpainsymman.2004.08.010
[27]  Bui, Q.U., Ostir, G.V., Kuo, Y.F., Freeman, J. and Goodwin, J.S. (2005) Relationship of Depression to Patient Satisfaction: Findings from the Barriers to Breast Cancer Study. Breast Cancer Research and Treatment, 89, 23-28.
http://dx.doi.org/10.1007/s10549-004-1005-9
[28]  Pitceathly, C. and Maguire, P. (2003) The Psychological Impact of Cancer on Patients’ Partners and Other Key Relatives: A Review. European Journal of Cancer, 39, 1517-1524.
http://dx.doi.org/10.1016/S0959-8049(03)00309-5
[29]  Kim, Y. and Given, B.A. (2008) Quality of Life of Family Caregivers of Cancer Survivors—Across the Trajectory of the Illness. Cancer, 112, 2556-2568.
http://dx.doi.org/10.1002/cncr.23449
[30]  Janda, M., Steginga, S., Dunn, J., Langbecker, D., Walker, D. and Eakin, E. (2008) Unmet Supportive Care Needs and Interest in Services among Patients with a Brain Tumour and Their Carers. Patient Education and Counseling, 71, 251-258.
http://dx.doi.org/10.1016/j.pec.2008.01.020
[31]  Iconomou, G., Viha, A., Kalofonos, H.P. and Kardamakis, D. (2001) Impact of Cancer on Primary Caregivers of Patients Receiving Radiation Therapy. Acta Oncologica, 40, 766-771.
http://dx.doi.org/10.1080/02841860152619205

Full-Text


comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133

WeChat 1538708413