Addiction is characterized by loss of control over
substance use, often operationally defined as continued use of substances
despite knowledge of adverse consequences. The exact cause of addiction is not
known, but it’s hypothesized that both environmental and genetic factors play a
crucial role in the predisposition of this disease. When an individual abruptly
stops using a drug or an addictive substance, withdrawal symptoms often take
place, which include vomiting, nausea, loss of appetite and depression. Not
much is known about the neurobiology of addiction and treatment remains a huge challenge. Current research aims at identifying
the neurological circuit of addiction as well as the key neurotransmitters and
biological markers involved in this disease. In this paper, I will first begin
by giving you an overview of the major substances that cause addiction as well
as the most common addictive behavior patterns. Second, I will discuss the
major findings that have been done using animal models of addiction, and
describe in more details the role that brain imaging technology plays in improving
our understanding of drug abuse. Finally, a closer look will be taken at the
behavioral and pharmacological approaches frequently employed to treat
addiction.
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