The epithelial-to-mesenchymal transition (EMT) is a process where epithelial cells
with polarity and tight junction change into mesenchymal cells without polarity
and intercellular adhesion to obtain an ability of invasion and metastasis. Interest in the EMT theory has grown exponentially in the last several
years and it has become one of the hottest subjects in cancer research.
However, there is no convincing evidence of EMT in human tumor and numerous
paradoxes do exist about EMT theory from molecular
researches to clinical observations. Thus, the so-called EMT in carcinoma
metastasis is probably a pseudo concept at present.
Garber, K. (2008) Epithelial-to-Mesenchymal Transition Is Important to Metastasis, but Questions Remain. Journal of the National Cancer Institute, 100, 232-233,239. http://dx.doi.org/10.1093/jnci/djn032
Christiansen, J.J. and Raja-sekaran, A.K. (2006) Reassessing Epithelial to Mesenchymal Transition as a Prerequisite for Carcinoma Invasion and Metastasis. Cancer Research, 66, 8319-8326. http://dx.doi.org/10.1158/0008-5472.CAN-06-0410
Tarin, D., Thompson, E.W. and Newgreen, D.F. (2005) The Fallacy of Epithelial Mesenchymal Transition in Neoplasia. Cancer Research, 65, 5996-6000. http://dx.doi.org/10.1158/0008-5472.CAN-05-0699
Lou, Y., Preobrazhenska, O., auf dem Keller, U., Sutcliffe, M., Barclay, L., McDonald, P.C., Roskelley, C., Overall, C.M. and Dedhar, S. (2008) Epithelial-Mesenchymal Transition (EMT) Is Not Sufficient for Spontaneous Murine Breast Cancer Metastasis. Developmental Dynamics, 237, 2755-2768. http://dx.doi.org/10.1002/dvdy.21658
Gilles, C. and Thompson, E.W. (1996) The Epithelial to Mes-enchymal Transition and Metastatic Progression in Carcinoma. The Breast Journal, 2, 83-96. http://dx.doi.org/10.1111/j.1524-4741.1996.tb00076.x
Economopoulou, P., Hanby, A. and Odell, E.W. (2000) Expression of E-Cadherin, Cellular Differentiation and Polarity in Epithelial Salivary Neoplasms. Oral Oncology, 36, 515-518. http://dx.doi.org/10.1016/S1368-8375(00)00043-9
Gabbert, H.E., Mueller, W., Schneiders, A., Meier, S., Moll, R., Birchmeier, W. and Hommel, G. (1996) Prognostic Value of E-Cadherin Expression in 413 Gastric Carcinomas. International Journal of Cancer, 69, 184-189. http://dx.doi.org/10.1002/(SICI)1097-0215(19960621)69:3<184::AID-IJC6>3.0.CO;2-W
Christiansen, J.J., Ra-jasekaran, S.A., Inge, L., Cheng, L., Anilkumar, G., Bander, N.H. and Rajasekaran, A.K. (2005) N-Glycosylation and Microtubule Integrity Are Involved in Apical Targeting of Prostate-Specific Membrane Antigen: Implications for Immunotherapy. Molecular Cancer Therapeutics, 4, 704-714. http://dx.doi.org/10.1158/1535-7163.MCT-04-0171
Ng, W.K. (2002) Fine-Needle Aspiration Cytology Findings of an Uncommon Micropapillary Variant of Pure Mucinous Carcinoma of the Breast: Review of Patients over an 8-Year Period. Cancer, 96, 280-288. http://dx.doi.org/10.1002/cncr.10747
Thompson, E.W., Newgreen, D.F. and Tarin, D. (2005) Carcinoma Invasion and Metastasis: A Role for Epithelial- Mesenchymal Transition? Cancer Research, 65, 991-995. http://dx.doi.org/10.1158/0008-5472.CAN-05-0616
Erickson, C.A., Tosney, K.W. and Weston, J.A. (1980) Analysis of Migratory Behavior of Neural Crest and Fibroblastic Cells in Embryonic Tissues. Developmental Biology, 77, 142-156. http://dx.doi.org/10.1016/0012-1606(80)90462-5
Kalluri, R. and Neilson, E.G. (2003) Epithelial-Mesenchymal Transition and Its Implications for Fibrosis. The Journal of Clinical Investigation, 112, 1776-1784. http://dx.doi.org/10.1172/JCI200320530
Tan, D.S., Potts, H.W., Leong, A.C., Gillett, C.E., Skilton, D., Harris, W.H., Liebmann, R.D. and Hanby, A.M. (1999) The Biological and Prognostic Significance of Cell Polarity and E-Cadherin in Grade I Infiltrating Ductal Carcinoma of the Breast. The Journal of Pathology, 189, 20-27. http://dx.doi.org/10.1002/(SICI)1096-9896(199909)189:1<20::AID-PATH394>3.0.CO;2-2
Parker, C., Rampaul, R.S., Pinder, S.E., Bell, J.A., Wencyk, P.M., Blamey, R.W., Nicholson, R.I. and Robertson, J.F. (2001) E-Cadherin as a Prognostic Indicator in Primary Breast Cancer. British Journal of Cancer, 85, 1958-1963. http://dx.doi.org/10.1054/bjoc.2001.2178
