Determination of Zoledronic Acid and Four Common Anions in Zoledronic Acid Injection by Gradient Ion Chromatography with a Self-Regeneration Suppressor
A simple method to determine zoledronic acid and
impurities in drug by ion chromatography with conductivity detection was
developed. Target analytes have been sufficiently separated from each other on
an Ionpac AS19 by using potassium hydroxide as eluent with a self-regeneration
suppressor. This novel proposed method enables direct analysis of zoledronic
acid in injection sample and provides good resolution. This novel method also exhibits
satisfactory precision (less than 1.68%) and accuracy (90.0% - 110.0%), good
linearity (r2 = 0.9993 - 0.9999) and sufficient
sensitivity (0.007 - 0.030 μg/mL). It can
be easily and conveniently adopted for the routine quality control analysis.
Cite this paper
Chen, M. and Ye, M. (2014). Determination of Zoledronic Acid and Four Common Anions in Zoledronic Acid Injection by Gradient Ion Chromatography with a Self-Regeneration Suppressor. Open Access Library Journal, 1, e827. doi: http://dx.doi.org/10.4236/oalib.1100827.
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