Objective:
Homogenous pathogenesis of preeclampsia has been challenged. We examined the
clinical characteristics of preeclamptic patients with discordant fetal growth
which is one of the controversial issues in preeclampsia. Methods: Clinical
index values including central hemodynamics of third-trimester preeclamptic
patients with distinct fetal birth weights (group A: birth weight ≥ 50th
percentile; n = 23 and group B: birth weight < 50th percentile; n = 14) were
compared. Results: Pregnant women of group A were characteristically obese and
edematous, but no fetal complications were observed. Patients of group B were
younger, onset of preeclampsia was earlier, proteinuria was more severe, and
fetal compromise was frequent. A marked difference between the two groups was
noticed in central hemodynamics as the mean of CO (cardiac output) was 8.5 and
5.6 l/min in group A and B, respectively (p < 0.001). CO of less than 7.45
l/min was found to be associated with fetal birth weight below 50th percentile
(OR = 15.6; 95% CI: 3.2 and 45.8, p = 0.001). Conclusions: Augmented CO in
pregnancy may ensure efficient placental blood supply, but it may cause
hypertension with subsequent moderate proteinuria. This condition, however,
seems to be different from the “classical” preeclampsia.
Cite this paper
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