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Role of Trace Elements Alzheimer’s Disease

DOI: 10.4236/oalib.1100714, PP. 1-30

Subject Areas: Public Health, Clinical Medicine

Keywords: Alzheimer’s Disease, Trace Elements, Flame Atomic Absorption, Multiple and Partial Correlation Coefficients and Regression Equations

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Abstract

Atomic absorption analysis involves measuring the absorption of light by vaporized ground state atoms and relating the absorption to concentration. The incident beam of light is attenuated by atomic vapour absorption according to Beer’s Law. The estimation of trace elements shows a colorful presentation of different metals. It has been seen and found that the levels of zinc, calcium, magnesium, aluminum are lower in Alzheimer’s disease samples in comparison to healthy controls. The elements such as copper, iron, potassium and sodium were found higher than controls. A statistical analysis has been applied and measured regression with correlation coefficients including multiple correlation coefficients between different trace elements like Na, K, Ca, Mg, Zn, Cu, Fe and Al in normal samples. A trend has been found in coefficient of correlation such aswith positive correlation and  with negative correlation. Coefficient of partial correlation is also calculated and found that a trend has been set up between trace elements and given here as  with positive correlation and with negative correlation. Multiple correlation coefficient in normal healthy person has been estimated and found that a trend, which is given here as. Multiple correlation coefficient in AD samples has been estimated and found that a trend, which is given here as .

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Kumar, S. , Mittal, R. , Chaudhary, S. and Jain, D. C. (2014). Role of Trace Elements Alzheimer’s Disease. Open Access Library Journal, 1, e714. doi: http://dx.doi.org/10.4236/oalib.1100714.

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