Comparative Study between Metformin and Laparoscopic Ovarian Drilling for Ovulation Induction, Achievement of Pregnancy and Live Birth in Asian Women with Polycystic Ovarian Syndrome: A Prospective Trial
Objective: To compare the efficacy of
metformin and laparoscopic ovarian drilling to be used in anovulatory patients
with polycystic ovarian syndrome (PCOS) for ovulation induction and pregnancy
achievement. Materials and Methods: Setting and Design: A prospective clinical
trial conducted in the outpatient department of Gynaecology and Obstetrics of
BIRDEM hospital from August 2008 to August 2013. Patient(s): Three hundred and eight
newly diagnosed patients with PCOS based on ESHRE/ASRM criteria. These patients
were assigned to two groups: Group 1 (152 patients) received 500 mg of
metformin three times a day; Group 2 (156 patients) received laparoscopic
ovarian drilling. Main Outcome Measure(s): Rate of ovulation, pregnancy rate
(PR), and live birth. Ovulation was monitored by serum progesterone,
transvaginal sonography up to six cycles or till pregnancy occurred upto six
months. Result(s): The ovulation rate was 68.4% in the metformin group, 59% in
the laparoscopy treatment group. The pregnancy rate was (20.1% and 16.6%) and
live birth rate was (18.4% and 15.4%) in metformin and laparoscopy treatment
groups, respectively. The rate of spontaneous first trimester loss was three
and two in metformin and laparoscopy group respectively. There were no ectopic
pregnancies in metformin group and two in laparoscopy group. There was no
second trimester pregnancy loss in metformin group, three in laparoscopy group.
There were no multiple pregnancies in metformin group, two in laparoscopy
group.
Cite this paper
Jahan, S. , Habib, S. H. , Khan, M. S. H. , Jahan, A. , Nayer, R. and Sharmin, F. (2014). Comparative Study between Metformin and Laparoscopic Ovarian Drilling for Ovulation Induction, Achievement of Pregnancy and Live Birth in Asian Women with Polycystic Ovarian Syndrome: A Prospective Trial. Open Access Library Journal, 1, e645. doi: http://dx.doi.org/10.4236/oalib.1100645.
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