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Models of experimental epilepsy
G?nül Bambal,Duygu ?ak?l,Fatih Ekici
Journal of Clinical and Experimental Investigations , 2011,
Abstract: Epilepsy is the most common serious neurological conditionin the world, with an estimated prevalence of 1% ofthe population. A large number of experimental modelsof seizure and epilepsy have been developed. These experimentalmodels are elicited by chemical convulsants,electrical stimulation, genetic models, structural lesions,physical stimuli (cold, pressure, hyperthermia, electrical)in animals. Well-characterized animal models may allowthe understanding of the basic mechanisms underlyingepileptogenesis (it refers to the alteration of a normalneuronal network into a hyperexcitable network in whichrecurrent, spontaneous seizures occur). Moreover, thesemodels might also prove useful in identifying novel therapeuticapproaches to treatment of epilepsy. J Clin ExpInvest 2011; 2(1): 118-123
Thallium poisoning: Clinical observations through two outbreaks in Basrah
Khalil I. Al-Hamdi,Ahmed A. Al-Mohammadi
Journal of Clinical and Experimental Investigations , 2011,
Abstract: Objectives: Thallium is one of the most suitable agentsfor criminal poisoning of human as it is tasteless andodorless. The aim of this study was to report clinical featuresof thallium poisoning in two outbreaks.Materials and methods: This case descriptive study wasconducted in Basrah Teaching Hospital from January2009 to February 2010, where a total of 32 patients withthallium poisoning were enrolled. At the first outbreak,poisoning occurred due to ingestion of cake, while thesecond outbreak was due to accidental ingestion of ratpoisons. A detailed history was taken and complete clinicalexamination was performed. Thallium in urine wasmeasured using the colorimetric method and was foundas positive in all patients.Results: Thirty two patients were evaluated. The firstoutbreak included 17 patients (mean age 24 years), andthe second outbreak included 15 patients (mean age15years). Among both outbreaks the dermatological findingswere mainly hair loss in diffuse and patchy patternaffected the scalp and limbs. Also dusky ecchymotic reddermatitis like rash was observed on the face, especiallyperioral region and dorsum of hands and legs. Neurologicmanifestations, mainly of peripheral neuropathy,were seen in 50% patients of the second group. Patientserroneously had received zinc-sulphate before correctdiagnosis. Thirty patients were improved and two died.Conclusion: Outbreak of thallium poisoning may be resultof accidental ingestion or criminal purposes. It givescharacteristic cutaneous, neurological and psychologicalfeatures that can lead to the definite diagnosis. J Clin ExpInvest 2010; 2 (1): 11-15
The opinions of nurses regarding the orientation training
Gül P?nar,Aysun Do?an,Yeter K?rlang??,?i?dem ?zdemir
Journal of Clinical and Experimental Investigations , 2010,
Abstract: Objectives: The aim of this study was to investigate the opinions of nurses regarding the orientation training.Materials and methods: This research is a descriptive type of study. Since it is planned that all the nurses (N=250) in Baskent University Ankara Hospital will be in the scope of the research, sampling was not performed. The number of nurses who are reached and agreed to join the research is 203. Hence, 80% of them are reached. The researchers prepared a questionnaire containing 30 questions after examining the literature. The questionnaire was carried out between April 15 and May 15 2008 to participants.Results: The mean age is 23±5.29 years and 97% of the nurses are female, 50.2% of them are male from Health College. Of all, 55.2% of them have worked less than 3 years. A total of 91.1% of the nurses stated that orientation training must be carried out and 80.3% of them who attended to orientation training think that the training is adequate.Conclusion: The nurses stated that the materials were adequate and organized while evaluating the orientation training which they attended, moreover they emphasized that the training should be given periodically rather than by classical method. J Clin Exp Invest 2010; 1(3): 199-205
Emergent gynecological operations: A report of 105 cases
Mehmet S?dd?k Evsen,Hatice Ender Soydin?
Journal of Clinical and Experimental Investigations , 2010,
Abstract: Objectives: To evaluate the clinical characteristics of patients that hospitalized with acute abdominopelvic pain (AAP) and underwent emergent gynecological operations in obstetrics and gynecology clinics.Methods: This retrospective study was performed at Dicle University Hospital, Department of Obstetrics and Gynecology, from June 2006 to May 2009. The data were collected from hospital records and patients charts. The age, gravidy, parity, last menstrual period, physical examination findings, initial complaints, operation diagnosis, preoperative and postoperative hematocrit values, the type of the operation that performed and the amount of blood products transfusions were investigated.Results: During the study period, a total of 105 patients were operated due to characteristic clinical sign and symptoms of acute abdomen. The initial complaints were abdominopelvic pain in 62 patients (59.0%) and abdomino-pelvic pain with vaginal bleeding in 43 patients (41.0%). Of all cases; 60 (57.1%) women had ruptured ectopic pregnancy, 29 (27.6%) had corpus hemorrhagic cyst rupture. Only 68 (64.76%) of the cases were subjected to laparotomy under emergency conditions, while 37 (35.2%) of them were subjected to laparoscopy. Fifty five (52.4%) women needed blood products transfusion.Conclusion: The initial evaluation of abdominopelvic pain related to gynecologic causes should include taking a careful history, performing abdominopelvic examination, pregnancy test, laboratory studies and color Doppler ultrasound. Although the patients can be followed conservatively, they may need an emergent surgery for life saving. J Clin Exp Invest 2010; 1(1): 12-15
Henoch-Sch nlein purpura in childhood: Review of 214 patients
Ayd?n Ece,?lyas Yolba?,Hasan Bal?k,Halil Kocamaz
Journal of Clinical and Experimental Investigations , 2012,
Abstract: Objectives: Due to involvement of various systems andclinical variety of in Henoch-Sch nlein purpura (HSP), inthis study, it was aimed to investigate clinical and laboratoryfeatures of children with HSP.Materials and methods: Hospital records of 214 childrenwith HSP followed up between 2000 and 2007 at DicleUniversity Hospital Pediatrics Clinics were retrospectivelyevaluated. Diagnosis was made based on the HSP criteriaof American College of Rheumatology. Age, gender,clinical findings, laboratory variables, applied treatments,and outcome were recorded.Results: Totally 214 HSP patients (121 male, 93 female)with the mean age of 9.0 ± 3.2 years (range, 2-16) wereincluded. There was a history of upper respiratory tractinfection in 136 children (63.6%). There was abdominalpain in 62.1% of patients, vomiting in 22.1%, and occultblood in stool or melena in 25.4%. Three patients underwentoperation due to intusception. Joint involvementwas seen in 117 (54.7%) and craniofacial edema in 73(34.3%) of patients. Renal involvement as hematuria wasseen in 63 (29.4%) children, proteinuria in 57 (26.6%),leukocyturia (9.8%), and nephritic/nephritic proteinuria infive patients. Increased IgA and C3 levels were found in35 (16.0%) and 41 (19.3%), respectively; and decreasedC3 in 23 (10.7%). Benzathine penicillin and penicillin Vwere used in 114 (53.5%) of children, non-steroidal antiinflammatorydrugs in 128 (59.8%) and parenteral/oralcorticosteroids in 86 (40.2%). Immonusuppressives weregiven to 5 patients with nephrotic proteinuria following renalbiopsy.Conclusions: Gastrointestinal and renal involvement inchildren with HSP, rarely lead to major complications. JClin Exp Invest 2012; 3(1): 91-95
Acute glomerulonephritis in children: A seven-year experience in a tertiary health center
Ali Güne?,Ayd?n Ece,Servet Yel,?lyas Yolba?
Journal of Clinical and Experimental Investigations , 2012,
Abstract: Objectives: The aim of this study was to examine clinicaland laboratory characteristics of children with AGN in atertiary university hospital.Materials and methods: Hospital records of childrenwhich hospitalized with AGN diagnosis in Pediatric NephrologyUnit, between 2004 and 2011, were retrospectivelyreviewed. Patients were divided into threesubgroups as age <5 years, 5-10 years and >10 years.Characteristics at hospital admission including, bloodpressure, diuresis state, serum urea, creatinine and electrolytelevels, complement factors C3 and C4, completeblood count and urine analysis results were recorded.Data about primary infection, treatments, disease courseand outcome were recorded and analyzed.Results: Totally 220 children (157 male, 71.2%; 63 female,28.8%) were included. Probable etiological infectionswere tonsillopharyngitis in 133 (60.5%), pyodermain 12 (5.5%), other infections in 27 (12.2%) children. In48 (21.8) children with AGN, no primary infection weredetected. Edema was found in 81.4% of patients, hypertensionin 73.6%, and pulmonary stasis in 22.6%. Low C3levels were found in 89.1%, azotemia in 45.9%, hematuriain 95.4%, nephritic proteinuria in 80.5%, and leukocyturiain 37.6% of patients. Diuresis was enabled withinone week in 82%. Additional vasodilators were given to45 (20.5%) patients, and hemodialysis was performedto three. Except for frequency of low C3 (p=0.018) andanemia (p=0.006), no significant differences were foundin clinical and laboratory findings between age groups(p>0.05).Conclusions: No difference was found in clinical andlaboratory features of AGN based on age groups, excludinglow C3 and anemia frequency. J Clin Exp Invest 2012;3 (3): 357-362Key words: Acute glomerulonephritis, childhood, clinicalfindings, laboratory findings, age grops
Formation and clinical importance of postoperative peritoneal adhesions
Murat Ba?bu?,Zülfü Ar?kano?lu
Journal of Clinical and Experimental Investigations , 2010,
Abstract: Abdominal adhesions following abdominopelvic surgical interventions are well-known causes of increased morbidity and mortality at early and late postoperative period. It is suggested that intraabdominal adhesions are thought to be developed secondary to peritoneal or bowel serosal surface trauma, foreign body reaction and ischemia. In present study, development and clinical importance of postoperative peritoneal adhesions are discussed together with literature knowledge.
Stapled hemorrhoidopexy: Clinical results of 65 cases
Ahmet Pergel,Ahmet Fikret Yücel,?brahim Ayd?n,Dursun Ali ?ahin
Journal of Clinical and Experimental Investigations , 2012,
Abstract: Objectives: To present results of our patients underwentstapled hemorrhoidopexy due to hemorrhoidal diseaseand discuss in accompaniment with the literature.Material and methods: The patients, who diagnosed by3rd-4th degree hemorrhoidal disease and underwent hemorrhoidopexywith Longo method between January, 2009and April, 2011, were included. All data were prospectivelycollected and retrospectively examined. The patientswere evaluated in terms of demographic properties, complaintson admission, and postoperative complications.Results: Forty-three (66%) of 65 patients were male,22 (34%) were female. The mean age was 38±11.9(range:23-76) years. The most frequent complaints werebleeding, swelling, itching, pain, constipation respectively.Third degree hemorrhoid was present in fifty-eight (89%)patients, 4th degree hemorrhoid was in 7 (11%) patients.The mean operation duration was 37.6±8.1(range:24-55)minutes, the mean hospitalization duration was 27±7.8(range:20-76) hours. One or more complication developedin total 17 (26%) patients. As complication, bleedingwas determined in 13 (20%) patients, pain was in 6 (9%),urinary retention was in 2 (3%), tenesmus was in 3 (5%),external hemorrhoidal thrombosis was in 1 (2%), and recurrencewas in 4 (6%).Conclusions: The patients can return their daily activitiesearly with stapled hemorrhoidopexy because of less painand quick recovery period. We consider that appropriatepatient selection and proper application of the techniqueare important in the success of this method. Particularly in3rd degree hemorrhoidal disease, Longo’s technique canbe suggested as an alternative to classical methods. JClin Exp Invest 2012; 3 (3): 340-344Key words: Hemorrhoidal disease, stapled hemorrhoidopexy,Longo’s procedure
Clinical characteristics of sarcoidosis patients diagnosed in a university hospital
?zlem Abakay,Abdurrahman Abakay,Abdullah ?etin Tanr?kulu,Fatih Metero?lu
Journal of Clinical and Experimental Investigations , 2012,
Abstract: Objectives: The clinical characteristics and treatment resultsof patients diagnosed with sarcoidosis was investigatedin Dicle University Medical Faculty Hospital.Materials and methods: A total of 39 patients were includeddiagnosed with sarcoidosis between 01 January2008 and31 December 2011.Demographic data, laboratoryfindings, spirometric test data, diagnostic methodsand treatment regimens for the study were recorded form.According to pulmonary function test results of patients,61.5% were normal pattern, 30.8% were restrictive patternand 7.7% were obstructive pattern.Results: Of the 39 patients 15.4% male, 84.6% werefemale. The mean age was 39.5±13.1 years for males,females 44.8±14.0 years. All patients of was 17.9%stage 1, 66.7% stage 2, 10.3% stage 3 and 5.1% stage4. 61.5% were symptomatic, 38.5% were asymptomatic.Methods of diagnosis of the patients examined, 25.6% ofpatients bronchoscopic biopsy procedures, 74.4% of patientssurgical biopsy procedures. Of the 56.4% patientshad received corticosteroid treatment, 5.1% patients hadreceived corticosteroid + methotrexate treatment, 38.5%were followed up without the pharmacological treatment.Pharmacological treatment in the group complete at thetime of the study 20.5% concluded the treatment of theperson. Patients who treatment ending 8.4 months hadused pharmacological treatment.Conclusions: Interstitial lung diseases which are prevalentamong patients with sarcoidosis diagnosed by examiningthe clinical features, differential diagnosis and treatmentmay be possible detection of potential problems. JClin Exp Invest 2012; 3 (3): 363-367Key words: Sarcoidosis diagnosis, treatment
Clinical evaluation of World Health Organization criteria proposed for the diagnosis of tuberculosis in children
Erhan Bayram,Demet Can,Suna Asilsoy,Meral Torun Bayram
Journal of Clinical and Experimental Investigations , 2012,
Abstract: Objectives: Because of the difficulty in confirming childhoodtuberculosis, the World Health Organization developeda scale based on clinical parameters. In our studythe utility of this scale was evaluated.Materials and methods: Patients whom were admittedto the Dr. Beh et Uz Children Hospital due to the complaintsof chronic cough, weight loss and/or close householdcontact with adult tuberculosis were included. Patientswere evaluated in according to the history, physicalexamination and/or chest radiography, PPD and theresults of the cultures obtained from fasting gastric juice/sputum and implanted on Bactec and Lowenstein-Jensenculture medium.Results: Totally, 108 patients were included in this study.According to World Health Organization criteria, 24 cases(22.2%) were classified as suspicious, 80 cases (74.1%)as probable and 4 of them (3.7%) as definite tuberculosis.Lymphodenopathy and atelectasis in chest radiographyand in addition lymphodenopathy, bronchiectasis andcalcification in thorax computed tomography were morefrequently seen in the PPD positive group compared withthe PPD negative group (p=0.012, p=0.02). Anti-tuberculosistreatment were not given for twenty four patientswho were included in suspicious group and tuberculosiswere not seen in any of these patients during their sixmonth follow up period. During the six months follow-upof the probable and definite tuberculosis groups, clinicalfindings improved in all of the patients who were treated.Conclusion: World Health Organization diagnosis criteriawere considered to be useful for the diagnosis of tuberculosisin children. J Clin Exp Invest 2012; 3(2): 255-259
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