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Search Results: 1 - 10 of 442 matches for " puneet chhabra "
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Methotrexate induced lung injury in a patient with primary CNS lymphoma : A case report
puneet chhabra,arjun dutt law,dr vikas suri,dr pankaj malhotra
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate . Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.
Uniform Convergence and Dynamical Behavior of a Discrete Dynamical System  [PDF]
Puneet Sharma
Journal of Applied Mathematics and Physics (JAMP) , 2015, DOI: 10.4236/jamp.2015.37093

In this paper we study the dynamical behavior of a system \"\" ?approximated uniformly by a sequence \"\" ?of chaotic maps. We give examples to show that properties like sensitivity and denseness of periodic points need not be preserved under uniform convergence. We derive conditions under which some of the dynamical properties of the maps \"\"

When a Glue Sniffer Turns Weak  [PDF]
Poh Juliana, Puneet Seth
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.37A135

Toluene inhalation can result in electrolyte and acid-base derangements and should be considered in the differential diagnosis of young patients with unexplained hypokalaemia and normal anion gap metabolic acidosis. This case serves to illustrate the abnormalities and heighten awareness among emergency physicians who may not have laboratory results on hand when evaluating causes of limb weakness.

When Computers Can Kill—Two Unusual Cases of “E-Thrombosis”  [PDF]
Nausheen Doctor, Puneet Seth
International Journal of Clinical Medicine (IJCM) , 2018, DOI: 10.4236/ijcm.2018.94029
Abstract: Deep vein thrombosis (DVT) is a common and potentially fatal vascular event when it leads to pulmonary embolism. Occurring as part of the broader phenomenon of Venous Thromboembolism (VTE), DVT classically arises when Virchow’s triad of hypercoagulability, changes in blood flow (e.g. stasis) and endothelial dysfunction, is fulfilled. Although such immobilisation is most often seen in bedbound patients and travellers on long distance flights, there is increasing evidence that prolonged periods of work or leisure related to using computers while seated at work desks, is an independent risk factor. In this report, we present two cases of “e-thrombosis” from prolonged sitting while using a computer.
Exhaled Breath Condensates as a Source for Biomarkers for Characterization of Inflammatory Lung Diseases  [PDF]
Puneet Bajaj, Faoud T. Ishmael
Journal of Analytical Sciences, Methods and Instrumentation (JASMI) , 2013, DOI: 10.4236/jasmi.2013.31004

Inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease are common and difficult to diagnose and characterize. This is due in large part to difficulty in obtaining samples directly from the inflamed lung. The collection of lung secretions by traditional methods including bronchoalveolar lavage and induced sputum collection are limited by their invasive nature. Exhaled breath condensate (EBC) is a simple and non-invasive technique of collecting fluid samples, which are representative of airway lining fluid. Advances in collection methods and evolving molecular techniques have led to development of more sensitive assays for existing biomarkers and identification of new biomarkers, which can be potentially useful in monitoring lung inflammation. In this review, we present the current understanding of various biomarkers including small molecules (H2O2, pH and nitric oxide related biomarkers), lipid mediators (8-isprostane, leukotrienes and prostaglandins), small proteins (cytokines and chemokines) and nucleic acids (DNA and microRNAs). We also discuss the differential profile of biomarkers in recognizing different patterns of lung inflammation. As the sensitivity of methods of EBC improves, this biofluid will play an increasing role in diagnosis and monitoring of lung diseases.

Connecting care competencies and culture during disasters
Chhabra Vivek
Journal of Emergencies, Trauma and Shock , 2009,
Abstract: Connecting care Competencies and Culture are core fundamentals in responding to disasters. Thick coordination between professionals, communities and agencies in different geographical areas is crucial to the happening of appropriate preparedness and thus efficient response and mitigation of a disaster. In the next few articles, we present diverse examples related to the preparedness and recovery process to adverse disasters across the globe
Breathing exercises and postural drainage for asthma, emphysema and bronchitis
Chhabra S
Lung India , 2005,
Application of Human Pluripotent Stem Cells in T Cell Based Cancer Immunotherapy
Arvind Chhabra
Insciences Journal , 2011,
Abstract: Human pluripotent stem cells represent a unique reservoir that could be utilized for generating cells of a given lineage. Cancer immunotherapy field could benefit from this, since one of the key limitations in developing an effective immune based cancer therapy is the lack of sufficient high avidity anti-tumor T cells in a great majority of cancer patients. The main reason for this is the fact that most human tumor antigens are “self-antigens” and most self reactive high avidity T cells are deleted during development to avoid autoimmunity. This manuscript reviews recent advances towards differentiating human pluripotent stem (hPS) cells into different immune effector cells, and potential strategies to utilize hPS cells in T cell based cancer immunotherapy approaches. We will also discuss the advantages and concerns associated with their clinical applications.
Agreement and differences between venous and arterial gas analysis
Chhabra Sunil
Annals of Thoracic Medicine , 2011,
Using arm span to derive height: Impact of three estimates of height on interpretation of spirometry
Chhabra S
Annals of Thoracic Medicine , 2008,
Abstract: Background: When standing height required to calculate forced vital capacity (FVC) cannot be measured, it can be derived from arm span using different methods. Objectives: To compare three different estimates of height derived from arm span and investigate their impact on interpretation of spirometric data. Methods: In a cross-sectional study, 517 subjects aged 7 to 76 years, with various respiratory diseases underwent spirometry. Three estimates of height were obtained from arm span: (a) by direct substitution (Ht AS ); (b) estimated height (Ht est ), obtained from the mean arm span:standing height ratio; and (c) predicted height (Ht pred ), obtained from arm span by linear regression analysis. Predicted values of forced vital capacity (FVC) obtained from these estimates were compared with those obtained from actual standing height (Ht act ), followed by Bland Altman analysis of agreement in the patterns of ventilatory impairment. Results: The arm span was 5%-6% greater than the height. The difference increased with increasing height. Ht AS and the FVC predicted from it were significantly greater than the other measures of height and the related predicted FVCs respectively. Compared to Ht act , Ht AS gave a misclassification rate of 23.7% in taller subjects (Ht act > 150 cm) and 14.2% in shorter subjects in the patterns of ventilatory impairment. Misclassification rates were 6%-8% with Ht est and Ht pred . Agreement analysis showed that FVCs predicted from Ht pred had the best agreement with the FVC predicted from Ht act . Conclusions: Among several methods of estimating height from the arm span, prediction by regression is most appropriate as it gives least errors in interpretation of spirometric data
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