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Search Results: 1 - 10 of 13415 matches for " polycistic ovary syndrome "
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Hirsutismo: Un problema estético en Adolescentes
Pe?a Irún,álvaro; González Santamaría,Ana; Cavadas López,Ana; García Espinosa,Rafael;
Revista Clínica de Medicina de Familia , 2012, DOI: 10.4321/S1699-695X2012000100014
Abstract: hirsutism has a prevalence of 8% in women of reproductive age, with significant esthetic repercussions in some cases. history and physical examination are of vital importance in the diagnostic work-up of these patients. our challenge, in addition to identifying those cases with serious underlying disease, is to provide the most effective treatment possible to prevent psychological problems.
EFECTOS DE LA METFORMINA EN EL SINDROME DE OVARIO POLIQUISTICO ASOCIADO A INSULINO RESISTENCIA
Caro,Claudio; Fuhrer,Juan; Sáez,Rodrigo; Rubio,Víctor; Moreno,Luis; Cumsille,Miguel;
Revista chilena de obstetricia y ginecología , 2002, DOI: 10.4067/S0717-75262002000100007
Abstract: we present the clinical experience with the use of metformyn (1.7 g per day) for four months in eleven patients with pco associated with insulin resistance. we determinate the clinical effects, biochemical and hormonal changes during four month of therapy. five of the patients, who wanted to get pregnant, continued receiving the drug for a year. we evaluated the clinical feelings menstrual history, hyrsutism and the levels of serum gonadotrophin, sex hormone-binding globulin (shbg) basal insulin and postcharge glucose, lipid profile and ovarian volume. seven of the eleven women (63.3%) start again the menstrual cycle. three patients became pregnant between the fifth and seventh month (60%), one of them have an abortion at eight-week. we didn't find changes in hirsutism, corporal mass and arterial pressure. the result was a significat disminution in plasmatic levels of basal insulin and post overcharge, of free testosterone and one increase of the shbg. no changes in gonadotrophins, dheas, lipid profile levels and the average ovarian volume were seen. the drug have a good tolerance and we consider it a good and useful alternative in patient with over, weight and with pco, menstrual changes and infertility, associated with hiperinsulinism and insulin resistance
Leptina en pacientes con síndrome de ovario poliquístico: Correlación directa con la resistencia insulínica
Calvar,C. E.; Intebi,A. D.; Bengolea,S. V.; Hermes,R.; Spinedi,E.;
Medicina (Buenos Aires) , 2003,
Abstract: up to now it is unclear whether there is a relationship between insulin resistance and circulating leptin levels (lep) in women with polycystic ovary syndrome (pcos). to assess the role of lep in pcos and to clarify the relationship between plasma lep levels and insulin resistance (ir) in pcos patients, we studied 49 women with pcos and 14 normal premenopausal women. all subjects were evaluated by a 2 hours, 75 g, oral glucose tolerance test. fasting plasma lep, insulin, glucose, insulin sensitivity indexes and lep:body mass index (bmi) were determined. results were analyzed by anova and the pearson's correlation test when appropriate. the results indicate that: 1) no differences were found in basal plasma lep levels (ng/ml) between normal (17.6 ± 4.9) and pcos (21.9 ± 2.8) women; 2) in pcos patients, a significant (p < 0.01) correlation between plasma lep levels and bmi and insulin sensitivity indexes were found; and 3) seventeen pcos patients were insulin resistant (ir) and showed higher basal plasma lep levels (32.8 ± 4.3, p < 0.01) and lep:bmi (0.95 ± 0.09, p < 0.05) than non insulin resistant (non ir) pcos subjects (16.2 ± 3.2 and 0.61 ± 0.08, respectively). our results suggest that pcos seems to be associated with normoleptinemia, however, if ir are analyzed separately from non ir pcos patients, there is a clear relationship between ir pcos and hyperleptinemia, regardless of the bmi. the present study strongly supports bi-directional relationship between fat and carbohydrate metabolisms under a very particular physiopathological condition (pcos).
Evaluación de la sensibilidad a la insulina en el síndrome de ovarios poliquísticos
García García,Yudit; Monteagudo Pe?a,Gilda; Padrón Durán,Rubén S.; González Suárez,Roberto;
Revista Cubana de Endocrinolog?-a , 2009,
Abstract: introduction: women with polycistic ovary syndrome have a increasing risk of insulin resistance, dyslipidemia, obesity, hypertension and type 2 diabetes mellitus; thus, with higher likelihood to develop cardiovascular disease. objective: to determine the frequency and features of insulin sensitivity disorders in a group of women with polycistic ovary syndrome. methods: twenty three women with this diagnosis were studied according to the androgen excess society (aes) criteria,underwent basal glycemia and insulinemia determinations and during frequently sampled intravenous glucose tolerance test). several insulin sensitivity and insulin resistance mathematic indexes were calculated. results: sixty-five percent of women had insulin resistance (homa-ir 3 3.22 rate). analysis of area under the curve of insulin during the test revealed that women with insulin resistance had higher insulinemia rates in baseline state and post-stimulation;in both groups concentrations were similar to the initial ones at the end of test. glycemia and insulinemia 0-10 areas and insulin area were higher in women with insulin resistance. all indexes including io/go, firi, isi, belfiore, bennet and quicki had a good correlation with homa-ir. conclusions: insulin resistance and hyperinsulinism frequency in women with policystic ovary syndrome was high and the fasting insulin resistance assessment may to predict the response during the glucose-intravenous stimulation.
EFECTOS DE LA METFORMINA EN EL SINDROME DE OVARIO POLIQUISTICO ASOCIADO A INSULINO RESISTENCIA
Claudio Caro,Juan Fuhrer,Rodrigo Sáez,Víctor Rubio
Revista Chilena de Obstetricia y Ginecología , 2002,
Abstract: Se presenta la experiencia clínica del uso de metformina (1,7 g día), por 4 meses, en 11 pacientes con (SOP) asociado a resistencia insulínica. Se determinaron los efectos clínicos, bioquímicos y hormonales luego de 4 meses de terapia. Cinco de las pacientes que deseaban embarazo, continuaron recibiendo la droga, hasta por un a o. Se evaluó durante el tratamiento los síntomas clínicos, historia menstrual, hirsutismo; y los niveles séricos de gonadotrofinas, andrógenos, globulina ligante sexual, insulina basal y postsobrecarga de glucosa, perfil lipídico y volumen ovárico. Siete de 11 mujeres (63,3%) restablecieron la ciclicidad menstrual. Tres pacientes lograron embarazo entre el 5o y 7o mes de tratamiento (60%) una de ellas presentó un aborto a las 8 semanas. No se observaron cambios en el hirsutismo índice de masa corporal y presión arterial. Hubo una disminución significativa de los niveles plasmáticos de insulina tanto basal como postsobrecarga; de la testosterona libre y un incremento de SHBG. No hubo cambios en los niveles de gonadotrofinas, dehidroepiandosterona sulfato (DHEAS) perfil lipídico ni del volumen ovárico promedio. La droga fue bien tolerada, y la consideramos como una alternativa útil en pacientes obesas con (SOP) con alteraciones menstruales y o infertilidad, asociada a hiperinsulinemia y resistencia insulínica We present the clinical experience with the use of metformyn (1.7 g per day) for four months in eleven patients with PCO associated with insulin resistance. We determinate the clinical effects, biochemical and hormonal changes during four month of therapy. Five of the patients, who wanted to get pregnant, continued receiving the drug for a year. We evaluated the clinical feelings menstrual history, hyrsutism and the levels of serum gonadotrophin, sex hormone-binding globulin (SHBG) basal insulin and postcharge glucose, lipid profile and ovarian volume. Seven of the eleven women (63.3%) start again the menstrual cycle. Three patients became pregnant between the fifth and seventh month (60%), one of them have an abortion at eight-week. We didn't find changes in hirsutism, corporal mass and arterial pressure. The result was a significat disminution in plasmatic levels of basal insulin and post overcharge, of free testosterone and one increase of the SHBG. No changes in gonadotrophins, DHEAS, lipid profile levels and the average ovarian volume were seen. The drug have a good tolerance and we consider it a good and useful alternative in patient with over, weight and with PCO, menstrual changes and infertility, associated with hiper
Leptina en pacientes con síndrome de ovario poliquístico: Correlación directa con la resistencia insulínica
C. E. Calvar,A. D. Intebi,S. V. Bengolea,R. Hermes
Medicina (Buenos Aires) , 2003,
Abstract: La presencia de resistencia insulínica (RI) es un hecho frecuentemente asociado al síndrome de ovario poliquístico (PCO), sin embargo aún no está clara la relación existente entre la RI y los niveles circulantes de leptina en estas pacientes. En este trabajo investigamos los niveles plasmáticos de leptina en pacientes con PCO y evaluamos su relación con la presencia de RI. Se seleccionaron 49 pacientes con PCO y 14 mujeres normales. A todas las pacientes se les realizó un test de tolerancia oral a la glucosa. Se dosó leptina (LEP), insulina y glucosa séricas durante las 2 hs del test y se determinaron los índices de sensibilidad insulínica y relación leptina: índice de masa corporal (LEP:BMI). 1) No observamos diferencias significativas en los niveles séricos de LEP (ng/ml) entre las pacientes PCO (21.9 ± 2.8) y los controles normales (17.6 ± 4.9). 2) En las pacientes con PCO, los niveles séricos de LEP y el índice LEP:BMI se correlacionaron en forma significativa con el BMI y los índices de sensibilidad insulínica (P<0.01). 3) Diecisiete pacientes con PCO que presentaron RI evidenciaron niveles significativamente mayores de leptina sérica (32.8 ± 4.3 vs. 16.2 ± 3.2, P<0.01) y LEP:BMI (0.95 ± 0.09 vs. 0.61 ± 0.08, P<0.05) que las pacientes sin RI. En conclusión, nuestros resultados evidencian que el síndrome PCO parecería cursar con normoleptinemia, sin embargo la presencia de RI podría estar relacionada con un aumento de la concentración de leptina sérica independientemente del BMI. Estos resultados avalan la existencia de una interrelación leptina - insulina en este grupo de pacientes. Up to now it is unclear whether there is a relationship between insulin resistance and circulating leptin levels (LEP) in women with polycystic ovary syndrome (PCOS). To assess the role of LEP in PCOS and to clarify the relationship between plasma LEP levels and insulin resistance (IR) in PCOS patients, we studied 49 women with PCOS and 14 normal premenopausal women. All subjects were evaluated by a 2 hours, 75 g, oral glucose tolerance test. Fasting plasma LEP, insulin, glucose, insulin sensitivity indexes and LEP:body mass index (BMI) were determined. Results were analyzed by ANOVA and the Pearson's correlation test when appropriate. The results indicate that: 1) no differences were found in basal plasma LEP levels (ng/ml) between normal (17.6 ± 4.9) and PCOS (21.9 ± 2.8) women; 2) in PCOS patients, a significant (P < 0.01) correlation between plasma LEP levels and BMI and insulin sensitivity indexes were found; and 3) seventeen PCOS patients were insulin resistant (I
Evaluación de la sensibilidad a la insulina en el síndrome de ovarios poliquísticos Evaluation of insulin-sensitivity in polycistic ovary syndrome
Yudit García García,Gilda Monteagudo Pe?a,Rubén S. Padrón Durán,Roberto González Suárez
Revista Cubana de Endocrinología , 2009,
Abstract: INTRODUCCIóN: las mujeres con síndrome de ovarios poliquísticos tienen un aumento del riesgo de padecer resistencia a la insulina, dislipidemia, obesidad, hipertensión arterial y diabetes mellitus tipo 2; por lo tanto, tienen mayor probabilidad de desarrollar enfermedad cardiovascular. OBJETIVO: determinar la frecuencia y características de los trastornos de la sensibilidad a la insulina en un grupo de mujeres con síndrome de ovarios poliquísticos. MéTODOS: se estudiaron 23 mujeres con este diagnóstico según los criterios de la Androgen Excess Society (AES), a las cuales se les realizaron determinaciones de glucemias e insulinemias basales y durante la prueba de tolerancia a la glucosa endovenosa de muestras múltiples. Se calcularon varios índices matemáticos de sensibilidad a la insulina e insulinorresistencia. RESULTADOS: 65 % de las mujeres tenían insulinorresistencia (índice HOMA-IR 3 3,22). El análisis del área bajo la curva de insulinemia durante la prueba evidenció que las mujeres con insulinorresistencia tenían insulinemias mayores en estado basal y posestimulación; en ambos grupos las concentraciones fueron similares a las iniciales al final de la prueba. El área glucémica e insulinémica 0-10 y el área total de la insulinemia fueron significativamente mayores en las mujeres con insulinorresistencia. Todos los índices I0/G0, FIRI, ISI, Belfiore, BENNET y QUICKI tuvieron buena correlación con el HOMA-IR. CONCLUSIONES: la frecuencia de insulinorresistencia e hiperinsulinismo en las mujeres con síndrome de ovarios poliquísticos estudiadas fue alta y las estimaciones de insulinorresistencia en estado de ayuno pueden predecir la respuesta durante la estimulación endovenosa con glucosa. INTRODUCTION: women with polycistic ovary syndrome have a increasing risk of insulin resistance, dyslipidemia, obesity, hypertension and type 2 diabetes mellitus; thus, with higher likelihood to develop cardiovascular disease. OBJECTIVE: to determine the frequency and features of insulin sensitivity disorders in a group of women with polycistic ovary syndrome. METHODS: twenty three women with this diagnosis were studied according to the Androgen Excess Society (AES) criteria,underwent basal glycemia and insulinemia determinations and during frequently sampled intravenous glucose tolerancetest). Several insulin sensitivity and insulin resistance mathematic indexes were calculated. RESULTS: sixty-five percent of women had insulin resistance (HOMA-IR 3 3.22 rate). Analysis of area under the curve of insulin during the test revealed that women with insulin resistance had h
Serum Adiponectin levels in Different Phenotypes of Polycystic Ovary Syndrome  [PDF]
Carolina Fux Otta, Paula Szafryk de Mereshian, Raquel Kaplan, Gabriel Santino Iraci, Silvia Ojeda, José Ochoa, Andrés Albrecht, Natalia Filipone, Marta Fiol de Cuneo
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2012, DOI: 10.4236/ojemd.2012.24019
Abstract: Objectives: to evaluate and compare serum adiponectin levels in different phenotypes of polycystic ovary syndrome (PCOS) and to investigate their correlation with endocrine and metabolic parameters. Material and methods: we studied 5 groups of patients: A (n = 20): H (hyperandrogenism) + O (oligoanovulation) + P (polycystic ovary) [classic phenotype]; B (n = 17): H + O [classic phenotype but normal ovaries]; C (n = 15): H + P [Ovulatory phenotype]; D (n = 17): O + P [Normoandrogenic phenotype]; and E (n = 16) control group. Body mass index, waist circumference, waist/hip ratio, blood pressure and hirsutism were evaluated. Serum concentrations of adiponectin, insulin, Creactive protein, SHBG, androgens and lipids were measured. Oral glucose tolerance test was performed. Results: there were no differences between the groups in terms of age and BMI. Total cholesterol, LDL-C and triglyceride levels were higher in phenotype A than in C (P < 0.05); HDL-C was slightly lower in phenotype D compared to E (P = 0.03). HOMA-IR, insulin and glucose/insulin ratio were significantly higher in phenotypes A and D vs C and E (P < 0.05). Serum adiponectin levels were lower in phenotype A (11.6 ± 8 ug/mL) than in the rest of the groups (B: 12.5 ± 8 ug/mL; C: 20.5 ± 8 ug/mL; D: 17.4 ± 4 ug/mL; E: 20 ± 6 ug/mL). This diference reached statistical significance when comparing group A with groups C and E (P < 0.05). Adiponectin levels were significant and negatively correlated with total testosterone, free androgen index, androstenedione, DHEAS, 17-hydroxyprogesterone, LH/FSH, insulin, HOMA-IR, Creactive protein, LDL-C, triglycerides, and waist/hip ratio. A positive correlation was found with glucose/insulin ratio and HDL-C (P < 0.05). Conclusions: adiponectin serum concentrations vary according to the phenotypic expression of PCOS. Our results suggest that adiponectin could be used as a biochemical marker to identify phenotypes at increased metabolic risk.
Influence of Thioctic Acid on the Hyperinsulinemia and Ovarian Volume in Female Patients with Polycystic Ovary Syndrome  [PDF]
L. A. Ivanova
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2015, DOI: 10.4236/ojemd.2015.54005
Abstract: 45 female patients with polycystic ovary syndrome took thioctic acid (Thioctacid-HR), 600 mg (n = 25) or high protein diet (n = 20). Fast insulin and glucose stimulus insulin were investigated before and after 3 months taken treatment. The use of thioctic acid, 600 mg is a new effective pathogenetics therapy of polycystic ovary syndrome on influence of hyperinsulinemia, HOMA-IR index and ovary volume in female patients with polycystic ovary syndrome.
The Effects of Plasma Homocysteine in PCOS Women: A Review  [PDF]
Pranita Maharjan, Peng Dan Hong
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.81005
Abstract: Homocysteine is an intermediate substance formed during the breakdown of the amino acid methionine and may undergo remethylation to methionine or trans-sulfuration to cystathionine or cysteine. The metabolism occurs via two pathways: remethylation to methionine, which requires folate and vitamin B12; and transsulfuration to cystathionine, which requires pyridoxal-5’-phosphate. The disturbances in the metabolic pathways lead to the accumulation of Hcy, either by insufficient transsulfuration (through CBS mutations or vitamin B6 deficiency) or by a blockage of remethylation. In the latter case, folate or vitamin B12 deficiency may be involved, as well as MTHFR. High levels of Hcy induce sustained injury of arterial endothelial cells, proliferation of arterial smooth muscle cells and enhance activity of key participants in vascular inflammation, atherogenesis, and vulnerability of the established atherosclerotic plaque. Hyperhomocysteinemia has become the topic of interest in recent years. It has been highly associated with increased risk for cardiovascular disorders, such as, atherosclerosis, thromboembolism and dyslipidemia. Women with PCOS show constellation of metabolic syndromes. Obesity, hyperandrogenemia and type 2 diabetes mellitus is the hallmark of PCOS which later becomes the risk factors for cardiovascular disease. Various studies had revealed the presence of increased Hcy level in PCOS women which may or may not be associated with other biochemical parameters. Intense treatment for PCOS can influence homocysteine levels.
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