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A administra??o de nandrolona n?o promove hipertrofia do músculo sóleo em ratos
Cunha, Tatiana S.;Tanno, Ana Paula;Marcondes, Fernanda K.;Perez, Sérgio E.A.;Selistre-Araújo, Heloisa S.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2006, DOI: 10.1590/S0004-27302006000300017
Abstract: anabolic androgenic steroids (aas) are compounds formed from testosterone or one of its derivatives, which are largely used by amateur e professional athletes to improve the athletic performance. however, the scientific information about the relation between the use of aas and muscle hypertrophy is controversial. the aim of this study was to evaluate the effects of testosterone and physical training on muscle hypertrophy. male wistar rats received i.m. injections of deca-durabolin? or vehicle during 6 weeks. trained rats were submitted to a resistance physical training, by jumping up and down in water carrying an overload. sedentary and trained animals were anesthetized and sacrificed. soleus muscle was removed for the quantification of total protein and dna concentration. in the end of the treatment, body weight of trained animals treated with vehicle or aas was lower than the body weight of respective sedentary. total protein concentration and the ratio muscle weight/body weight of all experimental groups were not altered. trained group treated with aas presented lower dna concentration than trained group treated with vehicle. the administration of nandrolone decanoate did not promote hypertrophy on soleus muscle, not even when the use of aas was associated to resistance physical training.
Effect of Nandrolone Decanoate on Serum Lipoprotein (a) and its isoforms in hemodialysis patients
Amir Ghorbanihaghjo, Hassan Argani, Mohammad Rohbaninoubar, Nadereh Rashtchizadeh
Lipids in Health and Disease , 2004, DOI: 10.1186/1476-511x-3-16
Abstract: It is well-recognized that in chronic hemodialysis patients the rate of mortality is higher than that of general population [1,2]. The cause of discrepancy is probably multifactorial, but malnutrition, anemia, hypoalbuminemia, reduced muscle mass and increased atherosclerosis are common in dialysis patients [1-3]. Therapies designed to improve the nutritional status, control of anemia and atherosclerosis of hemodialysis patients might therefore be expected to improve outcome [2,4]. Anabolic agents, such as human growth hormone (HuGH) can improve nitrogen balance, reduces urea generation and protein catabolic rate in long term hemodialysis patients. However HuGH is expensive, can exacerbate hyperglycemia and may have a limited potential role as a long-term treatment for anabolism [2].The anemia of renal failure responses, directly to treatment with erythropoietin [5]. Because of the relatively high cost of recombinant human erythropoietin, the use of Nandrolone Decanoate (ND) a non-17alpha-alkylated androgen has been suggested instead of the above mentioned hormone [2,6]. Many studies have shown that ND not only increased RBC production, but also prolonged RBC survival [7]. In spite that the drug is associated with high incidence of adverse effects including acne, virilization, abnormal liver function, discomfort from intramuscular injection [7], It can increase weight, triceps skinfold thickness, nitrogen balance and bone mineral density [2,7]. Moreover a reduction in the level of atherogenic lipoprotein (a) [Lp(a)] particles following ND administration to hemodialysis patients has been described [4].Lp(a) is an important independent risk factor for atherosclerotic cardiovascular disease in general population as well as in hemodialysis patients [8-10]. The lipoprotein contributes at least partially to the increased cardiovascular risk seen in patients with renal failure [11]. Therefore it is clinically important to reduce high serum Lp(a) by intervention [12-14].Lp(
Hipersensibilidad Tipo I asociada a la administración de nandrolona, boldenona y dexametasona en un equino pura sangre de carrera
Morales,Abelardo; Sánchez,Marta; García,Francisco; Coronado,Raúl; Latouche,Orihana; Rivero,Luís; Leal,Luís; López,Pedro; Rodríguez,Carlos;
Archivos Venezolanos de Farmacología y Terapéutica , 2010,
Abstract: the doping is the administration of illicit drugs or other agents in animal competition with the intention of altering its physical performance, whether positive or negative. the aim of this study was to report a case of type i hypersensitivity associated with illicit administration of nandrolone, boldenone and dexamethasone. reference is an equine (thoroughbreds), 5 years old with a history of collapse and sudden death after the administration of medication unknown. samples of blood and urine were recollected for toxicological by competitive elisa. tissue samples were collected by necropsy of lung, liver, kidney, stomach, spleen, heart and central nervous system for histopathological study, the samples were processed by conventional histological methods. the necropsy findings were severe phlebitis right jugular vein, with hematoma in the jugular furrow. severe edema of glottis, pulmonary congestion and hemorrhage. subendocardial petechial hemorrhage. spleen foci of coagulation necrosis. acute hydronephrosis and hematury. liver with accentuated lobular pattern. the rest of the bodies with obvious congestion and hemorrhage. the histological sections showed edema, congestion and severe pulmonary hemorrhage. marked subepicardial hemorrhage. edema and necrosis of splenic subcapsular follicular center. tubular hydropic degeneration, acute tubular necrosis. necrosis of renal cortex. toxicological studies allowed the detection of boldenone, nandrolone and dexamethasone generic in blood and urine samples. in conclusion we report a type i hypersensitivity syndrome associated with the administration nandrolone, boldenone and dexamethasone.
Rela??o entre a administra??o de esteróide anabólico androgênico, treinamento físico aeróbio e supercompensa??o do glicogênio
Cunha, Tatiana S;Tanno, Ana Paula;Moura, Maria José C.S.;Marcondes, Fernanda Klein;
Revista Brasileira de Medicina do Esporte , 2005, DOI: 10.1590/S1517-86922005000300007
Abstract: glycogen supercompensation is one of the adaptations induced by physical training. to potentiate this phenomenon, many athletes use supraphysiological doses of anabolic androgenic steroids (aas). the purpose of this study was to evaluate the effects of nandrolone and aerobic physical exercise in rats, on body weight, plasmatic triglycerides levels, blood glucose and glycogen content. male wistar rats were randomly divided into 4 groups: sedentary + vehicle (sv), trained + vehicle (tv), sedentary + aas (saas) and trained + aas (taas) (n = 7-14/group). they received i.m. injections of nandrolone or vehicle for 9 weeks, and during the same period trained rats were submitted to aerobic exercise. data were analyzed by two-way anova and tukey tests (p < 0.05). the groups saas, tv and taas presented lower body weight than the sv group (saas: 339 ± 10 = tv: 342 ± 14 = taas: 332 ± 6 < sv: 398 ± 9 g). physical training significantly reduced plasmatic concentration of triglycerides [(tv: 46 ± 4 = taas: 44 ± 3) < (sv: 104 ± 1 = saas: 101 ± 6 mg/dl)] and of hepatic glycogen [(tv: 3,38 ± 0,57 = taas: 2,62 ± 0,34) < (sv: 4,95 ± 0,11 = saas: 4,43 ± 0,23 mg/100 mg)] and increased the cardiac glycogen concentration [(tv: 0,38 ± 0,04 = taas: 0,42 ± 0,03) > (sv: 0,2 ± 0,02 = saas: 0,21 ± 0,02 mg/100 mg)]. blood glucose and soleus glycogen reserves remained unaltered. the use of supraphysiological doses of nandrolone did not potentiate any of the effects obtained in response to aerobic physical training.
Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats
Urtado CB, Pereira GB, Urtado MB, Carvalho EB, Leite GS, Donatto FF, Assump o CO, Leite RD, Silva CA, Sales MM, Tibana RA, Alves SCC, Prestes J
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy , 2011, DOI: http://dx.doi.org/10.2147/DMSO.S24362
Abstract: istance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats Original Research (2350) Total Article Views Authors: Urtado CB, Pereira GB, Urtado MB, Carvalho EB, Leite GS, Donatto FF, Assump o CO, Leite RD, Silva CA, Sales MM, Tibana RA, Alves SCC, Prestes J Published Date November 2011 Volume 2011:4 Pages 385 - 391 DOI: http://dx.doi.org/10.2147/DMSO.S24362 Christiano Bertoldo Urtado1,2, Guilherme Borges Pereira3, Marilia Bertoldo Urtado4, érica Blascovi de Carvalho2, Gerson dos Santos Leite1, Felipe Fedrizzi Donatto1, Claudio de Oliveira Assump o1, Richard Diego Leite3, Carlos Alberto da Silva1, Marcelo Magalh es de Sales5, Ramires Alsamir Tibana5, Silvia Cristina Crepaldi Alves1, Jonato Prestes5 1Health Sciences, Methodist University of Piracicaba, Piracicaba, SP, 2Center for Investigation in Pediatrics, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, 3Department of Physiological Sciences, Federal University of S o Carlos, S o Carlos, SP, 4Laboratory of Orofacial Pain, Division of Oral Physiology, Piracicaba Dental School, State University of Campinas, Campinas, SP, 5Graduation Program in Physical Education, Catholic University of Brasilia, Brasilia, DF, Brazil Abstract: The aim of the present study was to investigate the effects of anabolic-androgenic steroids and resistance training (RT) on insulin sensitivity in ovariectomized rats. Adult female Wistar rats were divided into ten experimental groups (n = 5 animals per group): (1) sedentary (Sed-Intact); (2) sedentary ovariectomized (Sed-Ovx); (3) sedentary nandrolone (Sed-Intact-ND); (4) sedentary ovariectomized plus nandrolone (Sed-Ovx-ND); (5) trained (TR-Intact); (6) trained nandrolone (TR-Intact-ND); (7) trained ovariectomized (TR-Ovx); (8) trained ovariectomized plus nandrolone; (9) trained sham; and (10) trained ovariectomized plus sham. Four sessions of RT were used, during which the animals climbed a 1.1 m vertical ladder with weights attached to their tails. The sessions were performed once every 3 days, with between four and nine climbs and with eight to twelve dynamic movements per climb. To test the sensitivity of insulin in the pancreas, glucose and insulin tolerance tests were performed. For insulin sensitivity, there was a statistically significant interaction for the TR-Ovx group, which presented higher sensitivity than the Sed-Intact, Sed-Ovx, and TR-Intact groups. Sed-Intact-ND and TR-Intact-ND groups exhibited higher values of insulin sensitivity than the Sed-Intact group. Except for the TR-Intact group, sensitivity was greater in trained groups than in the Sed-Intact group. There was higher insulin sensitivity in the TR-Intact-ND group than in the Sed-Intact and Sed-Intact-ND groups (P < 0.05). In conclusion, ovariectomy and short-term RT alone induced no change on insulin action. Administration of nandrolone decanoate improved insulin action, mainly when it was associate
Vascular adaptive responses to physical exercise and to stress are affected differently by nandrolone administration
Bruder-Nascimento, T.;Cordellini, S.;
Brazilian Journal of Medical and Biological Research , 2011, DOI: 10.1590/S0100-879X2011007500043
Abstract: androgenic anabolic steroid, physical exercise and stress induce cardiovascular adaptations including increased endothelial function. the present study investigated the effects of these conditions alone and in combination on the vascular responses of male wistar rats. exercise was started at 8 weeks of life (60-min swimming sessions 5 days per week for 8 weeks, while carrying a 5% body-weight load). one group received nandrolone (5 mg/kg, twice per week for 8 weeks, im). acute immobilization stress (2 h) was induced immediately before the experimental protocol. curves for noradrenaline were obtained for thoracic aorta, with and without endothelium from sedentary and trained rats, submitted or not to stress, treated or not with nandrolone. none of the procedures altered the vascular reactivity to noradrenaline in denuded aorta. in intact aorta, stress and exercise produced vascular adaptive responses characterized by endothelium-dependent hyporeactivity to noradrenaline. these conditions in combination did not potentiate the vascular adaptive response. exercise-induced vascular adaptive response was abolished by nandrolone. in contrast, the aortal reactivity to noradrenaline of sedentary rats and the vascular adaptive response to stress of sedentary and trained rats were not affected by nandrolone. maximum response for 7-10 rats/group (g): sedentary 3.8 ± 0.2 vs trained 3.0 ± 0.2*; sedentary/stress 2.7 ± 0.2 vs trained/stress 3.1 ± 0.1*; sedentary/nandrolone 3.6 ± 0.1 vs trained/nandrolone 3.8 ± 0.1; sedentary/stress/nandrolone 3.2 ± 0.1 vs trained/stress/nandrolone 2.5 ± 0.1*; *p < 0.05 compared to its respective control. stress and physical exercise determine similar vascular adaptive response involving distinct mechanisms as indicated by the observation that only the physical exercise-induced adaptive response was abolished by nandrolone.
Anabolic steroid- and exercise-induced cardiac stress protein (HSP72) in the rat
Lunz, W.;Oliveira, E.C.;Neves, M.T.D.;Fontes, E.P.B.;Dias, C.M.G.C.;Natali, A.J.;
Brazilian Journal of Medical and Biological Research , 2006, DOI: 10.1590/S0100-879X2006000700006
Abstract: the present study investigated the effects of exercise and anabolic-androgenic steroids on cardiac hsp72 expression. male wistar rats were divided into experimental groups: nandrolone exercise (ne, n = 6), control exercise (ce, n = 6), nandrolone sedentary (ns, n = 6), and control sedentary (cs, n = 6). animals in the ne and ns groups received a weekly intramuscular injection (6.5 mg/kg of body weight) of nandrolone decanoate, while those in the cs and ce groups received mineral oil as vehicle. animals in the ne and ce groups were submitted to a progressive running program on a treadmill, for 8 weeks. fragments of the left ventricle were collected at sacrifice and the relative immunoblot contents of hsp72 were determined. heart weight to body weight ratio was higher in exercised than in sedentary animals (p < 0.05, 4.65 ± 0.38 vs 4.20 ± 0.47 mg/g, respectively), independently of nandrolone, and in nandrolone-treated than untreated animals (p < 0.05, 4.68 ± 0.47 vs 4.18 ± 0.32 mg/g, respectively), independently of exercise. cardiac hsp72 accumulation was higher in exercised than in sedentary animals (p < 0.05, 677.16 ± 129.14 vs 246.24 ± 46.30 relative unit, respectively), independently of nandrolone, but not different between nandrolone-treated and untreated animals (p > 0.05, 560.88 ± 127.53 vs 362.52 ± 95.97 relative unit, respectively) independently of exercise. exercise-induced hsp72 expression was not affected by nandrolone. these levels of hsp72 expression in response to nandrolone administration suggest either a low intracellular stress or a possible less protection to the myocardium.
A a??o do decanoato de nandrolona (Deca-durabolin?) sobre parametros hematológicos e proteína total plasmática de ratos (Rattus rattus) com depress?o medular induzida após administra??o de sulfato de vincristina (Oncovin?)
Perez, Regina Raquel;Silva, Maria Adriana Machado Lobo e;Varzim, Fernanda Leme Silva Bastos;Oliveira, Sylvia Bonci de;Hucke, érica Engelberg Teixeira da Silva;
Ciência Rural , 2005, DOI: 10.1590/S0103-84782005000300015
Abstract: in veterinary practice it is common to submit animals to chemotherapy for neoplasia control and to observe bone marrow depression, with presence of anemia, leukopenia and thrombocytopenia as collateral effects. in these cases, two therapeutical protocols can be adopted: chemotherapy by suppression and/or use of bone marrow stimulants. nandrolone decanoate (deca-durabolin?) is a bone marrow stimulant used in veterinary medicine despite few studies were conducted in domestic animals. the objective of this study was to analyse nandrolone decanoate (nd-1,5mg/kg, intramuscular), as a bone marrow stimulant in rats (rattus rattus) with medular suppression induced by 4 and 8 mg/m2 (intraperitoneal) of vincristine (oncovin?). hemogram, platelets counting and total plasma protein determination were evaluated. these results showed that its effectiveness in bone marrow stimulation depends on the degree of depression and the dose of administration.
The Impact Of Nandrolone Decanovate On Lipid Profile In Chronic Hemodyalysis Patient
Mahdavi Mazdeh M,Moradiance V,Lesan Pezeshki M,Jahan Zad I
Tehran University Medical Journal , 2003,
Abstract: LP(a) level in uremic patients is high. It has recently considered that the effect of androgens on lipids vary widely. The aim of this study was to determine the effect of nandrolone decanoate on lipid profile in chronic hemodialysis patients."nMaterials and Methods: thirty six stable male patients over 40 years who were under maintenance hemodialysis were randomized to receive nandrolone decanoate , 100 mg weekly for six month, by intramuscular injection on nondialysis day (Group A, N=18) or B complex (Group B, N=18). Between September 2001 and 2002, male hemodialysis patients more than 40 years old without history of high prostatic specific antigen (PAS) or sensitization to drug were started on treatment with androgen therapy. The evolution in the liquid profile was prospectively assessed immediately before the first dose of nandrolone decanoate (basal values) and at 2, 4 and 6 month of therapy. The evolution of lipids after withdrawal of androgens at 2 month after the last dose was also studied. The patients underwent hemodialysis 3 to 4 hours three times a week. The dialysis schedule was not modified during the period of study."nResults: Mean decrease of LP(a) level in group A was significantly lower then group B in second month (p<0.05). Surprisingly HP level decreased also in second month. Other lipid parameters did not show significant changes."nConclusion: In this study we observed that nandrolone decanoate affects on LP(a) leveK but the changes of it did not correlate with those of hemoglobin or other lipid parameters< suggesting that the underlying mechanisms are unrelated. Our finding might be affected by low dose of the drug. Further studies with higher doses will be requied to clarify the beneficial or adverse effects of this type of therapy.
Stereological estimation of ovarian oocyte volume, surface area and number: application on mice treated with nandrolone decanoate
Saied Karbalay-Doust,Ali Noorafshan
Folia Histochemica et Cytobiologica , 2012, DOI: 10.5603/fhc.2012.0037
Abstract: Changes in the number and size of oocytes can lead to fertilization problems. The present study aimed to evaluate the number, volume, and surface area of oocytes in healthy as well as nandrolone decanoate-treated (ND) mice using stereological methods. Five control mice received vehicle, and five ND-treated mice received ND. Using the ‘isotropic Cavalieri’ design’, the ovary was sectioned. The volume of the ovary (cortex and medulla) was estimated. The oocytes’ volume and surface area were estimated using the invariator. The number of the oocytes was estimated using an optical disector. The volumes of the ovary, cortex, and medulla decreased ~50% in the ND-treated mice. The mean number (coefficient of variation) of preantral, antral, and atretic oocytes in the control ovary were 1,690 (0.29), 2,100 (0.52), and 3,900 (0.2), respectively, which decreased ~54%, ~87%, and ~91%, respectively in the ND-treated animals. The mean volume (coefficient of variation) of the preantral, antral, and atretic oocytes were 86,000 (0.27), 110,000 (0.48), and 27,000 (0.33) μm3, respectively. The mean surface area (coefficient of variation) of the three types of oocytes were 9,000 (0.24), 9,900 (0.28), and 4,700 (0.21) μm2, respectively. These parameters remained unchanged in the ND-treated mice. ND induces reduction in the number of oocytes, but not in the volume or the surface area.
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