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Search Results: 1 - 10 of 4901 matches for " marine fungi "
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The Distribution and Substrate Specificity of Extracellular Nuclease Activity in Marine Fungi  [PDF]
Larissa A. Balabanova, Michael V. Pivkin, Valery A. Rasskazov
Open Journal of Marine Science (OJMS) , 2012, DOI: 10.4236/ojms.2012.24022
Abstract: The distribution and specificity of extracellular nucleases produced by marine fungi belonging to eleven genera, namely: Alternaria, Aspergillus, Aureobasidium, Chaetomium, Fusarium, Gliomastix, Humicola, Penicillium, Scopulariopsis, Wardomyces, Periconia, have implied its important function in the organic phosphorus and nitrogen circle in the Ocean. The fungal nucleases of 64 isolates tested were more or less specific for single-stranded DNA with a high preferential specificity towards poly-U substrate with forming of 5’-phosphate mononucleotides. A couple of the nucleases were capable of RNA digesting. The highest level of extracellular nucleolytic ability was observed in Penicillium spp. isolates. The tight correlation found between extracellular nuclease activity and the rate of thymidine uptake by actively growing and sporulating marine fungus Penicillium melinii suggests that this nuclease is required for fulfilling the nucleotide pool of precursors of DNA biosynthesis during transformation of hyphae into the aerial mycelium and conidia in stressful environmental conditions.
Assessment of Secondary Metabolites from Marine-Derived Fungi as Antioxidant  [PDF]
Nihad Abdel-Monem, Ahmed M. Abdel-Azeem, E. S. H. El Ashry, Doaa A. Ghareeb, Asmaa Nabil-Adam
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.33009
Abstract:

Marine derived fungi are considered as a promising source of novel drugs due to their biodiversity and consequent chemo-diversity. Although marine microorganisms especially fungi are not well defined taxonomically, making this a promising frontier for the discovery of new medicines. This study focused on marine derived fungi as a model for bioactive exploration for new entities with anti-inflammatory and antioxidant capacity. Three in-vitro assays were used to investigate the bioactive antioxidant potentiality of fungal extracts. Thiobarbituric acid (TBARS),α,α-Diphenyl-β- picrylhydrazyl (DPPH) and NO assay are based on their total phenolic and flavonoid content of each extract group. Ch. globosum recorded the highest antioxidant activity (92.82%) in TBARS assay, while G. dankaliensis came first by recording 59.28% in DPPH assay in comparison with ascorbic acid (61.83%). In NO inhibition assay, N. oryzae showed 49.3% comparing with ascorbic acid (73.12%). From the preliminary result of our extracts, we can consider the marine derived fungi extracts as

Marine natural products: chemical and biological potential of seaweeds and their endophytic fungi
Oliveira, Ana Lígia Leandrini de;Felício, Rafael de;Debonsi, Hosana Maria;
Revista Brasileira de Farmacognosia , 2012, DOI: 10.1590/S0102-695X2012005000083
Abstract: marine natural products have currently been recognized as the most promising source of bioactive substances for drug discovery research. in this review, extraordinary metabolites from marine algae species are illustrated, as well as approaches for their isolation and determination of their biological properties and pharmaceutical potential. furthermore, marine endophytic microorganisms (from marine algae) are presented as a new subject for extensive investigation to find novel natural products, which make them a potentially rich and innovative source for new drug candidates.
Marine natural products: chemical and biological potential of seaweeds and their endophytic fungi
Ana Lígia Leandrini de Oliveira,Rafael de Felício,Hosana Maria Debonsi
Revista Brasileira de Farmacognosia , 2012,
Abstract: Marine natural products have currently been recognized as the most promising source of bioactive substances for drug discovery research. In this review, extraordinary metabolites from marine algae species are illustrated, as well as approaches for their isolation and determination of their biological properties and pharmaceutical potential. Furthermore, marine endophytic microorganisms (from marine algae) are presented as a new subject for extensive investigation to find novel natural products, which make them a potentially rich and innovative source for new drug candidates.
Filamentous fungi isolated from sand and water of "Bairro Novo" and "Casa Caiada" beaches, Olinda, Pernambuco, Brazil
Gomes, DNF.;Cavalcanti, MAQ.;Fernandes, MJS.;Lima, DMM.;Passavante, JZO.;
Brazilian Journal of Biology , 2008, DOI: 10.1590/S1519-69842008000300016
Abstract: fungi comprehend a heterogeneous group of heterotrophic microorganisms that act as saprobes or parasites or, less frequently, as symbionts living in association with other organisms. they are cosmopolitan and important components of ecosystems. considering the small number of brazilian papers on the filamentous mycota in marine environments, and the need to improve knowledge of the diversity of these microfungi in "casa caiada" and "bairro novo" beaches, olinda, pe, the aim of this work was to isolate and identify the fungi from sand and water samples of these ecosystems. thirty two samplings of sand (surface and 20 cm deep) and water (surface and 1 m deep) were carried out during the dry and rainy seasons, in low and high tide. from each sand sample, a suspension was made with 50 g of sand diluted in 90 ml of sterilized distilled water. from each sand suspension and water sample, 0.5 ml was spread, in triplicate, onto petri dishes containing sabouraud agar added of chloramphenicol. the plates were incubated at 28 °c (±2 °c). fifty seven species were isolated, identified, and classified in 20 genera. aspergillus and penicillium were the most frequent genera in both sand and water, with a total of 11 and 19 species, respectively.
Diversity and physiology of marine lignicolous fungi in Arctic waters: a preliminary account
Ka-Lai Pang,Raymond K.K. Chow,Chi-Wong Chan,Lilian L.P. Vrijmoed
Polar Research , 2011, DOI: 10.3402/polar.v30i0.5859
Abstract: Information on the diversity of marine fungi in polar environments is lacking, especially marine fungi colonizing wood. During visits to Troms and Longyearbyen, Norway, drift and trapped wood was collected to provide a preliminary account of lignicolous marine fungi in Arctic waters. Six marine fungi were recorded from 24 and 27 samples of wood from Troms and Longyearbyen, respectively. Among these, four marine fungi new to science were identified from wood collected at Longyearbyen. To shed light on the ecological role of this group of fungi in the Arctic, a physiological study of one of the collected fungi, Havispora longyearbyenensis, was conducted. H. longyearbyenensis grew at 4 °C, 10 °C, 15 °C and 20 °C in all salinities tested (0 0/00, 17 0/00, 34 0/00). However, growth was significantly reduced at 4 °C and 0 0/00 salinity. The optimal condition for growth of H. longyearbyenensis was at 20 °C in all salinities tested.
Immense Essence of Excellence: Marine Microbial Bioactive Compounds
Ira Bhatnagar,Se-Kwon Kim
Marine Drugs , 2010, DOI: 10.3390/md8102673
Abstract: Oceans have borne most of the biological activities on our planet. A number of biologically active compounds with varying degrees of action, such as anti-tumor, anti-cancer, anti-microtubule, anti-proliferative, cytotoxic, photo protective, as well as antibiotic and antifouling properties, have been isolated to date from marine sources. The marine environment also represents a largely unexplored source for isolation of new microbes (bacteria, fungi, actinomycetes, microalgae-cyanobacteria and diatoms) that are potent producers of bioactive secondary metabolites. Extensive research has been done to unveil the bioactive potential of marine microbes (free living and symbiotic) and the results are amazingly diverse and productive. Some of these bioactive secondary metabolites of microbial origin with strong antibacterial and antifungal activities are being intensely used as antibiotics and may be effective against infectious diseases such as HIV, conditions of multiple bacterial infections (penicillin, cephalosporines, streptomycin, and vancomycin) or neuropsychiatric sequelae. Research is also being conducted on the general aspects of biophysical and biochemical properties, chemical structures and biotechnological applications of the bioactive substances derived from marine microorganisms, and their potential use as cosmeceuticals and nutraceuticals. This review is an attempt to consolidate the latest studies and critical research in this field, and to showcase the immense competence of marine microbial flora as bioactive metabolite producers. In addition, the present review addresses some effective and novel approaches of procuring marine microbial compounds utilizing the latest screening strategies of drug discovery.
Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats
Kustiariyah Tarman,Ulrike Lindequist,Kristian Wende,Andrea Porzel,Norbert Arnold,Ludger A. Wessjohann
Marine Drugs , 2011, DOI: 10.3390/md9030294
Abstract: In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC 50 value of 1.5?μg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 μg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol ( 1) could be isolated as a new natural product.
Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin
Muftah A. M. Shushni,Rajinder Singh,Renate Mentel,Ulrike Lindequist
Marine Drugs , 2011, DOI: 10.3390/md9050844
Abstract: A new 12-membered macrolide, balticolid ( 1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3 R,11 R), (4 E,8 E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid ( 1) displayed anti-HSV-1 activity with an IC 50 value of 0.45 μM.
A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
Vita-Marques, Aline Maria de;Lira, Simone P.;Berlinck, Roberto G. S.;Seleghim, Mirna H. R.;Sponchiado, Sandra R. P.;Tauk-Tornisielo, Samia M.;Barata, Margarida;Pessoa, Claudia;Moraes, Manoel O. de;Cavalcanti, Bruno Coêlho;Nascimento, Gislene G. F.;Souza, Ana O. de;Galetti, Fabio C. S.;Silva, Célio L.;Silva, Marcio;Pimenta, Eli F.;Thiemann, Otavio;Passarini, Michel R. Z.;Sette, Lara D.;
Química Nova , 2008, DOI: 10.1590/S0100-40422008000500030
Abstract: extracts obtained from 57 marine-derived fungal strains were analyzed by hplc-pda, tlc and 1h nmr. the analyses showed that the growth conditions affected the chemical profile of crude extracts. furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. the chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus beauveria felina have yielded cyclodepsipeptides related to destruxins. the present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.
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