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Search Results: 1 - 10 of 8017 matches for " lateral hypothalamic area "
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Influences of cerebellar interpositus nucleus and fastigial nucleus on neuronal activity of lateral hypothalamic area
Jianjun Wang,Yongmei Pu,Tao Wang
Science China Life Sciences , 1997, DOI: 10.1007/BF02882046
Abstract: Stimulation of cerebellar interpositus nucleus and fastigial nucleus could influence the neuronal activity of lateral hypothalamic area in the cat, and some of the neurons which respond to the cerebellar stimulations are glucose-sensitive neurons. These results suggest that the cerebellum is involved not only in motor control, but also in the regulation of non-somatic functions through the cerebello-hypothalamic pathways.
Effects of cerebellar interpositus nucleus on neuronal activity of lateral hypothalamic area

科学通报(英文版) , 1996,
Abstract:
Effects of Baobaole oral liquid on neuron excitability of feeding center in anorectic rats
Yong-ping DU
Zhong Xi Yi Jie He Xue Bao , 2007,
Abstract: Objective: To investigate the changes of neuropeptides content in a rat model of spleen-deficiency syndrome.Methods: Rats were randomly divided into three groups: normal group, untreated group and treatment group. There were ten rats in each group. Spleen-deficiency syndrome was induced by intragastrically administration of rhubarb concentrate in rats of the untreated and treatment group. The rats in the treatment group were intragastrically administered with Sijunzi decoction, a traditional Chinese compound herbal medicine for strengthening spleen and supporting qi. Normal saline was intragastrically administered to the rats in the normal and untreated groups. The somatostatin (SS) and cholecystokinin-8 (CCK-8) content in hypothalamus and colons was detected by the method of radioimmunoassay and the D-xylose content in urine was also detected.Results: The CCK-8 content in hypothalamus of the untreated group was higher than that of the normal group (P<0.05). SS and CCK-8 content in colons of the untreated group was higher than that of the normal group (P<0.05). The CCK-8 content in colons of the untreated group was lower than that of the treatment group (P<0.05). The excretion rate of D-xylose in the untreated group was lower than that of the normal group (P<0.05).Conclusion: The disorder of neuroendocrine regulation in rats with spleen-deficiency syndrome may be chiefly responsible for "spleen-deficency and dysfunction of spleen" in traditional Chinese medicine.
Influences of cerebellar interpositus nucleus and fastigial nucleus on neuronal activity of lateral hypothalamic area
WANG Jianjun,PU Yongmei,WANG Tao,
王建军
,蒲咏梅,王韬

中国科学C辑(英文版) , 1997,
Abstract: Stimulation of cerebellar interpositus nucleus and (astigial nucleus could influence the neuronal activi-ty of lateral hypothalamic area in the cat, and some of the neurons which respond to the cerebellar stimulations are glucose-sensitive neurons. These results suggest that the cerebellum is involved not only in motor control, but also in the regulation of non-somatic functions through the cerebello-hypothalamic pathways.
Gastric vagal afferent inputs reach the glycemia-sensitive neurons of lateral hypothalamic area in the rat
Yueping Zhang,Jingning Zhu,Jianming Jiang,Jianjun Wang
Chinese Science Bulletin , 2003, DOI: 10.1360/03tb9123
Abstract: The glycemia-sensitive neuron in lateral hypothalamic area (LHA) is one of the important central neural events involved in the feeding control. Electrophysiological studies have demonstrated that gastrointestinal vagal afferent inputs could convey the meal-related information of gastrointestinal tract to the hypothalamus. In this study, we examined whether the gastric vagal afferent inputs could reach the glycemia-sensitive neurons of the LHA by using in vivo extracellular recording technique in the rat. The results showed that stimulation of gastric vagal nerves elicited two types of the LHA neurons responses: the phasic response (93/116, 80.2%) and the change in cell’s firing pattern (23/116, 19.8%). Within the 93 cells that responded to the gastric vagal stimulation with a phasic response, 67 (72.0%) showed an inhibition in the cell’s firing rate, 26 (27.4%) were excited. Of the 23 cells that showed a change in the firing pattern, 13 responded to the gastric vagal stimulation with a long-lasting increase or decrease in firing rate, the remaining 10 cells turned their discrete spiking to the burst discharging. In addition, of 101 LHA neurons including the two types of responsive neurons, 73 (72.3%) were identified to be glycemia-sensitive neurons. These results demonstrated that the gastric vagal afferent inputs could reach the LHA and predominantly reach those glycemia-sensitive neurons in the LHA. Presumably, the modulation of glycemia-sensitive neurons of LHA by the gastric vagal afferent inputs may play an important role in the short-term regulation of feeding behavior.
小脑顶核通过小脑-下丘脑通路参与卒中后抑郁的实验观察
Fastigial cerebellar nucleus may be involved in the pathogenesis of post-stroke depression through the cerebellum-hypothalamic pathways in rats

,,隋汝波,,,林宇涵
- , 2015, DOI: 10.7652/jdyxb201502004
Abstract: 摘要:目的 探讨小脑顶核是否参与了卒中后抑郁的发病,并初步研究介导这种作用的途径。方法 选用健康SD大鼠,随机分为假手术组、卒中组、卒中后抑郁组、小脑顶核损毁组和小脑上脚交叉损毁组,进行行为学观察并应用高效液相色谱法检测各组大鼠下丘脑外侧区Glu、GABA的含量。结果 与假手术组相比,卒中组大鼠下丘脑外侧区Glu、GABA的含量无统计学差异(P>0.05);而与卒中组相比,卒中后抑郁组、小脑顶核损毁组和小脑上脚交叉损毁组下丘脑外侧区Glu、GABA含量都有不同程度的降低(P<0.01)。结论 本实验初步提示小脑顶核可能参与了卒中后抑郁的发病,其途径可能通过小脑-下丘脑通路介导。
ABSTRACT: Objective To investigate whether medial cerebellar nucleus may be involved in the pathogenesis of post-stroke depression (PSD) and explore the pathway that mediates this effect. Methods Healthy SD rats were randomly divided into five groups: control group, stroke group, PSD group, medial cerebellar nucleus (Med) lesion group, and superior cerebellar peduncle (xscp) lesion group. The ethological score of depression was evaluated. The neurotransmitters of Glu and GABA in the lateral hypothalamic area were detected by high performance liquid chromatography. Results Compared with those in control group, the levels of GABA and Glu expressions did not significantly differ in the lateral hypothalamic area in stroke group (P >0.05). In contrast, the levels in PSD group, Med lesion group and xscp lesion group were lower than those in stroke group to different extent (P<0.01). Conclusion These results preliminarily show that medial cerebellar nucleus may participate in the pathogenesis of post-stroke depression, which may be mediated by the cerebellum-hypothalamic pathway
Gastric vagal afferent inputs reach the glycemia-sensitive neurons of lateral hypothalamic area in the rat
Gastric vagal afferent imputs reach the glycemia-sensitive neurons of lateral hypothalamic area in the rat

Yueping Zhang,Jingning Zhu,Jianming Jiang,Jianjun Wang,
ZHANGYueping
,ZHUJingning等

科学通报(英文版) , 2003,
Abstract: The glycemia-sensitive neuron in lateral hypothalamic area (LHA) is one of the important central neural events involved in the feeding control. Electrophysiological studies have demonstrated that gastrointestinal vagal afferent inputs could convey the meal-related information of gastrointestinal tract to the hypothalamus. In this study, we examined whether the gastric vagal afferent inputs could reach the glycemia-sensitive neurons of the LHA by using in vivo extracellular recording technique in the rat. The results showed that stimulation of gastric vagal nerves elicited two types of the LHA neurons responses: the phasic response (93/116, 80.2%) and the change in cell’s firing pattern (23/116, 19.8%). Within the 93 cells that responded to the gastric vagal stimulation with a phasic response, 67 (72.0%) showed an inhibition in the cell’s firing rate, 26 (27.4%) were excited. Of the 23 cells that showed a change in the firing pattern, 13 responded to the gastric vagal stimulation with a long-lasting increase or decrease in firing rate, the remaining 10 cells turned their discrete spiking to the burst discharging. In addition, of 101 LHA neurons including the two types of responsive neurons, 73 (72.3%) were identified to be glycemia-sensitive neurons. These results demonstrated that the gastric vagal afferent inputs could reach the LHA and predominantly reach those glycemia-sensitive neurons in the LHA. Presumably, the modulation of glycemia-sensitive neurons of LHA by the gastric vagal afferent inputs may play an important role in the short-term regulation of feeding behavior. These two authors made equal contributions to this work.
高频电刺激卒中后抑郁大鼠小脑顶核对下丘脑外侧区 神经元放电及氨基酸类递质的影响
Effect of High -Frequency Stimulation in the Medial Cerebellar Nucleus on Neuronal Activity and Neurotransmitters in the Lateral Hypothalamic Area of Rats

李 岩,隋汝波,李 媛,张 敏,张 欣
LI Yan1
, SUI Ru -bo, LI Yuan, ZHANG Min, ZHANG Xin

- , 2016,
Abstract:
Angiotensin and Arginine Vasopressin Receptor Subtypes of the Lateral Preoptic Area Effect on the Sodium Balance
Wilson Abr?o Saad,Luiz Antonio de Arruda Camargo,Jos? Antunes-Rodrigues,William Abr?o Saad
Journal of Biological Sciences , 2005,
Abstract: It was speculated whether the influence of lateral pvasopressin (AVP) and angiotensin (ANG II). The present study investigated the effects of central administration of specific AVP and ANG II antagonists (d(CH2)5-Tyr (Me)-AVP (AAVP) and [Adamanteanacetyl , 0-ET-D-Tyr , Val4, Aminobutyryl6, Arg8,9]-AVP (ATAVP) antagonists of V1 and V2 receptors of AVP. Also the effects of losartan and CGP42112A (selective ligands of the AT1 and AT2 angiotensin receptors, respectively), was investigated on Na+ uptake and renal fluid and electrolyte excretion. After an acclimatization period of 7 days, the animals were maintained under tribromoethanol (200 mg kg 1 body weight, intraperitoneal) anesthesia and placed in a Kopf stereotaxic instrument. Stainless guide cannula was implanted into the LPO. AAVP and ATAVP injected into the LPO prior to AVP produced a reduction in the sodium intake responses. Both the AT1 and AT2 ligands administered into the LPO elicited a decrease in the sodium intake induced by AVP injected into the LPO, but losartan was more effective than CGP 42112A. AVP injection into LPO increased sodium renal excretion, but this was reduced by prior AAVP administration. The ATAVP produced a decreased in the natriuretic effect of AVP. The losartan injected into LPO previous to AVP decreased the sodium excretion and the CGP 421122A also decreased the natriuretic effect of AVP with a high intensity. The AVP produced an antidiuresis effect that was inhibited by prior administration into LPO of the ATAVP. The AAVP produced no change in the antidiuretic effect of AVP. These results suggest that LPO are implicated in sodium balance that is mediated by V1, V2, AT1 and AT2 receptors.
Primary amenorrhea with transverse vaginal septum and scant hematocolpos: A case report  [PDF]
Lori Homa, Semara Thomas, Joseph Sanfilippo
Open Journal of Pediatrics (OJPed) , 2012, DOI: 10.4236/ojped.2012.21015
Abstract: Background: A genital outflow tract obstruction is an uncommon cause of primary amenorrhea. If ovulation occurs, menstrual bleeding is prevented. Patients typically present with abdominal/pelvic pain due to hematocolpos. Absence of significant hematocolpos could indicate a secondary source of primary amenorrhea and be challenging to the clinical diagnosis. Case: 17 year-old patient with primary amenorrhea, appropriate Tanner staging secondary sex characteristics, and transverse vaginal septum presents with virtual absence of hematocolpos. After vaginal septum resection, the patient began menstruating, although only evidenced by two cycles of vaginal spotting. Conclusion: Significant hematocolpos is an expected sequella of distal outlet obstruction when collated with secondary sexual characteristics. Absence of such along with suboptimal return of menstruation reflects pathophysiology which may be attributed to a coexistent disorder of the hypothalamus or higher central nervous system function.
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