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Search Results: 1 - 10 of 2023 matches for " for the FCC-ee study team "
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Search for Heavy Right Handed Neutrinos at the FCC-ee
Alain Blondel,E. Graverini,N. Serra,M. Shaposhnikov,for the FCC-ee study team
Physics , 2014,
Abstract: The Standard Model of particle physics is still lacking an understanding of the generation and nature of neutrino masses. A favorite theoretical scenario (the see-saw mechanism) is that both Dirac and Majorana mass terms are present, leading to the existence of heavy partners of the light neutrinos, presumably massive and nearly sterile. These heavy neutrinos can be searched for at high energy lepton colliders of very high luminosity, such as the Future electron-positron e+e- Circular Collider, FCC-ee (TLEP), presently studied within the Future Circular Collider design study at CERN, as a possible first step. A first look at sensitivities, both from neutrino counting and from direct search for heavy neutrino decay, are presented. The number of neutrinos should be measurable with a precision between 0.001 - 0.0004, while the direct search appears very promising due to the long lifetime of heavy neutrinos for small mixing angles. A sensitivity down to a heavy-light mixing of 10^{-12} is obtained, covering a large phase-space for heavy neutrino masses between 10 and 80 GeV/c2.
SPICA Assessment Study Report for ESA Cosmic Vision 2015-2025 Plan
SPICA Study Team Collaboration
Physics , 2010,
Abstract: SPICA (Space Infrared Telescope for Cosmology and Astrophysics) is a JAXA led observatory that will operate in the mid and far infrared wavelength range (5-210 micron) with unprecedented sensitivity, thanks to the 3.5 m (current baseline) cold telescope (< 6 K) and advanced instruments. SPICA will carry a mid infrared camera, mid infrared spectrometers and a mid infrared coronagraph (built by JAXA institutes), a far infrared imaging spectrometer (SAFARI, provided by a European/Canadian consortium), and a far infrared/sub-millimetre spectrometer (proposed by U.S.). The contribution from ESA consists of the telescope assembly, a collaboration in the ground segment and the interface management to JAXA of the European instrument SAFARI. The SPICA observatory will be open to the worldwide community and will provide unique and ground-breaking answers to fundamental questions in planetary formation and formation and evolution of galaxies through cosmic history. The target launch year of SPICA is 2018. SPICA was selected in October 2007 as a candidate M-class mission for the ESA Cosmic Vision 2015-2025 Plan, with the character of "mission of opportunity". This report presents the science case of SPICA, describes the mission and summarises the outcome of the ESA Assessment Study.
C-Reactive Protein Concentration Predicts Change in Body Mass Index during Childhood
Barbara H. Louren?o, Marly A. Cardoso, for the ACTION Study Team
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090357
Abstract: Objective Inflammation may constitute an underlying mechanism for increased risk of developing chronic diseases in later years, but few prospective studies have assessed the influence of low-grade inflammation on body weight gain, particularly among children in low- to middle-income settings with lower prevalence of overweight and obesity. We aimed to investigate whether C-reactive protein (CRP), as a biomarker of low-grade inflammation, predicts changes in body mass index-for-age z scores (BAZ) during childhood. Methods A population-based longitudinal study was conducted in the Brazilian Amazon among children aged ≤10 years in 2007, with follow-up visits in 2009 and 2012. Outcome was annual change in BAZ. As the main exposure of interest, CRP concentrations were divided into four categories, with values <1 mg/L divided in tertiles plus a fourth category with values ranging from 1 to 10 mg/L. Children were simultaneously screened for iron and vitamin A deficiencies, diarrhea, and wheezing. We used mixed-effect linear regression models to measure the effect of CRP concentrations on annual BAZ change and linear regression models to explore CRP predictors at baseline. Results At baseline, 1007 children had CRP and anthropometric data [mean (SD) age: 5.3 (2.9) years; 50.9% male, 84.5% mulatto/mixed-race, 14.0% at risk for overweight or obesity, 4.8% stunted]; 737 were successfully followed up. Morbidities and nutritional deficiencies were widespread. Among participants aged >5 years, children in the highest tertile of CRP <1 mg/L at baseline, regarded as an indicator of low-grade inflammation, had a 0.04 z/y higher gain in BAZ (95% CI: 0.01, 0.09 z/y) during follow-up. CRP was positively associated with household poverty and worse nutritional indicators. Conclusions We found evidence of a role for low-grade inflammation in predicting annual BAZ gain among children aged >5 years.
Childhood brain tumours and use of mobile phones: comparison of a case–control study with incidence data
Denis Aydin, Maria Feychting, Joachim Schüz, Martin R??sli, CEFALO study team
Environmental Health , 2012, DOI: 10.1186/1476-069x-11-35
Abstract: In a recent commentary [1], S?derqvist et al. discussed the findings of our international case–control study on mobile phone use and brain tumour risk in children and adolescents (CEFALO study) [2]. This is a response to their commentary.S?derqvist et al. see “several indications of increased risk, despite low exposure, [and] short latency, …” [1] Nevertheless, they do not provide any explanation of how such an increased risk from use of wireless phones would correspond to relatively stable incidence time trends for brain tumours among children and adolescents in the Nordic countries over the last 20?years [Figure?1, and similarly stable incidence time trends in other countries [3-5]. As shown in Figure?1 the proportion of regular mobile phone users among children and adolescents has steeply increased over the last ten years. These data are even more incompatible if one considers their arguments that the risk estimates observed in CEFALO are underestimations of the true risk because of exposure misclassification due to cordless phone use and because of more widespread use of wireless phones among adolescents today compared to the time period when CEFALO was carried out (2004–2008). Regarding the inconsistency between results from analytical studies such as CEFALO and incidence time trends, the authors repeatedly imply that central nervous system tumours are underreported to the Swedish Cancer registry [1,6]. However, each time they fail to mention that the observed underreporting was mainly confined to patients 70?years or older [7], which has little relevance for incidence trends in children and adolescents, or other age-groups with high prevalence of mobile phone users.As argued above, assuming a short latency of a few years, an increased brain tumour risk should be detectable in the incidence data that are already available today because of the steep increase in wireless phone use among adolescents during the last two decades (unless the risk is restricted to a v
The Women's international study of long-duration oestrogen after menopause (WISDOM): a randomised controlled trial
Madge R Vickers, Jeannett Martin, Tom W Meade, the WISDOM study team
BMC Women's Health , 2007, DOI: 10.1186/1472-6874-7-2
Abstract: Randomised, placebo, controlled, trial.The trial was set in general practices in the UK (384), Australia (94), and New Zealand (24). In these practices 284175 women aged 50–69 years were registered with 226282 potentially eligible. We sought to randomise 22300 postmenopausal women aged 50 – 69 and treat for ten years. The interventions were: conjugated equine estrogens, 0.625 mg orally daily; conjugated equine estrogens plus medroxyprogesterone acetate 2.5/5.0 mg orally daily; matched placebo. Primary outcome measures were: major cardiovascular disease, osteoporotic fractures, breast cancer and dementia. Secondary outcomes were: other cancers, all cause death, venous thromboembolism and cerebro-vascular disease.The trial was prematurely closed during recruitment following publication of early results from the Women's Health Initiative. At the time of closure, 56583 had been screened, 8980 entered run-in, and 5694 (26% of target of 22,300) randomised. Those women randomised had received a mean of one year of therapy, mean age was 62.8 years and total follow-up time was 6491 person years.The WISDOM experience leads to some simple messages. The larger a trial is the more simple it needs to be to ensure cost effective and timely delivery. When a trial is very costly and beyond the resources of one country, funders and investigators should make every effort to develop international collaboration with joint funding.The Women's International Study of long Duration Oestrogen after Menopause (WISDOM) developed from a joint initiative of the UK Medical Research Council (MRC) and the UK Departments of Health. At the start of the WISDOM trial observational studies had suggested that long term use of estrogen was likely to be associated with a reduced risk of osteoporosis [1] and ischaemic heart disease (IHD) [2] and an increased risk of breast cancer [3] and endometrial cancer [4]. While concomitant use of progestogens could protect against endometrial cancer [4], it was not cl
Oral Health-Related Quality of Life among a large national cohort of 87,134 Thai adults
Vasoontara Yiengprugsawan, Tewarit Somkotra, Sam-ang Seubsman, Adrian C Sleigh, The Thai Cohort Study Team
Health and Quality of Life Outcomes , 2011, DOI: 10.1186/1477-7525-9-42
Abstract: In 2005, a comprehensive health questionnaire was returned by distance learning cohort members recruited through Sukhothai Thammathirat Open University. OHRQoL dimensions included were discomfort speaking, swallowing, chewing, social interaction and pain. We calculated multivariate (adjusted) associations between OHRQoL outcomes, and sociodemographic, health behaviour and dental status.Overall, discomfort chewing (15.8%), social interaction (12.5%), and pain (10.6%) were the most commonly reported problems. Females were worse off for chewing, social interaction and pain. Smokers had worse OHRQoL in all dimensions with Odds Ratios (OR) ranging from 1.32 to 1.51. Having less than 20 teeth was strongly associated with difficulty speaking (OR = 6.43), difficulty swallowing (OR = 6.27), and difficulty chewing (OR = 3.26).Self-reported adverse oral health correlates with individual function and quality of life. Outcomes are generally worse among females, the poor, smokers, drinkers and those who have less than 20 teeth. Further longitudinal study of the cohort analysed here will permit assessment of causal determinants of poor oral health and the efficacy of preventive programs in Thailand.Oral health is an important component of both overall health and quality of life. Oral disease creates a major public health burden worldwide and receives inadequate attention in many low and middle income countries [1]. Recently, particular attention is given to increasing the global awareness of the significance and inequity of oral health and the importance of its social determinants [2]. Oral diseases including oral cancers, periodontal disease, dental caries, and tooth loss are linked to emerging chronic non-communicable diseases primarily because of common risk factors such as poor dietary habits, poor oral hygiene, and use of tobacco and alcohol [3]. The joint effects of poor oral health and chronic diseases are major impediments to overall population health and quality of life,
Weighted Road Density and Allergic Disease in Children at High Risk of Developing Asthma
Anna L. Hansell, Nectarios Rose, Christine T. Cowie, Elena G. Belousova, Ioannis Bakolis, Kitty Ng, Brett G. Toelle, Guy B. Marks, for the Childhood Asthma Prevention Study Team , Childhood Asthma Prevention Study Team
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098978
Abstract: Background Evidence for an association between traffic-related air pollution and allergic disease is inconsistent, possibly because the adverse effects may be limited to susceptible subgroups and these have not been identified. This study examined children in the Childhood Asthma Prevention Study (CAPS), potentially susceptible to air pollution effects because of a family history of asthma. Methods We examined cross-sectional associations at age eight years between road density within 75 m and 50 m of home address weighted by road type (traffic density), as a proxy for traffic-related air pollution, on the following allergic and respiratory outcomes: skin prick tests (SPTs), total and specific serum IgE, pre- and post-bronchodilator lung function, airway hyperresponsiveness, exhaled NO, and reported asthma and rhinitis. Results Weighted road density was positively associated with allergic sensitisation and allergic rhinitis. Adjusted relative risk (RR) for house dust mite (HDM) positive SPT was 1.25 (95% CI: 1.06–1.48), for detectable house dust mite-specific IgE was 1.19 (95% CI: 1.01–1.41) and for allergic rhinitis was 1.30 (95% CI: 1.03–1.63) per 100 m local road or 33.3 m motorway within 50 m of home. Associations were also seen with small decrements of peak and mid-expiratory flows and increased risk of asthma, current wheeze and rhinitis in atopic children. Conclusion Associations between road density and allergic disease were found in a potentially susceptible subgroup of children at high risk of developing atopy and asthma.
The Long-Term Effects of a Peer-Led Sex Education Programme (RIPPLE): A Cluster Randomised Trial in Schools in England
Judith Stephenson ,Vicki Strange,Elizabeth Allen,Andrew Copas,Anne Johnson,Chris Bonell,Abdel Babiker,Ann Oakley,the RIPPLE Study Team
PLOS Medicine , 2008, DOI: 10.1371/journal.pmed.0050224
Abstract: Background Peer-led sex education is widely believed to be an effective approach to reducing unsafe sex among young people, but reliable evidence from long-term studies is lacking. To assess the effectiveness of one form of school-based peer-led sex education in reducing unintended teenage pregnancy, we did a cluster (school) randomised trial with 7 y of follow-up. Methods and Findings Twenty-seven representative schools in England, with over 9,000 pupils aged 13–14 y at baseline, took part in the trial. Schools were randomised to either peer-led sex education (intervention) or to continue their usual teacher-led sex education (control). Peer educators, aged 16–17 y, were trained to deliver three 1-h classroom sessions of sex education to 13- to 14-y-old pupils from the same schools. The sessions used participatory learning methods designed to improve the younger pupils' skills in sexual communication and condom use and their knowledge about pregnancy, sexually transmitted infections (STIs), contraception, and local sexual health services. Main outcome measures were abortion and live births by age 20 y, determined by anonymised linkage of girls to routine (statutory) data. Assessment of these outcomes was blind to sex education allocation. The proportion of girls who had one or more abortions before age 20 y was the same in each arm (intervention, 5.0% [95% confidence interval (CI) 4.0%–6.3%]; control, 5.0% [95% CI 4.0%–6.4%]). The odds ratio (OR) adjusted for randomisation strata was 1.07 (95% CI 0.80–1.42, p = 0.64, intervention versus control). The proportion of girls with one or more live births by 20.5 y was 7.5% (95% CI 5.9%–9.6%) in the intervention arm and 10.6% (95% CI 6.8%–16.1%) in the control arm, adjusted OR 0.77 (0.51–1.15). Fewer girls in the peer-led arm self-reported a pregnancy by age 18 y (7.2% intervention versus 11.2% control, adjusted OR 0.62 [95% CI 0.42–0.91], weighted for non-response; response rate 61% intervention, 45% control). There were no significant differences for girls or boys in self-reported unprotected first sex, regretted or pressured sex, quality of current sexual relationship, diagnosed sexually transmitted diseases, or ability to identify local sexual health services. Conclusion Compared with conventional school sex education at age 13–14 y, this form of peer-led sex education was not associated with change in teenage abortions, but may have led to fewer teenage births and was popular with pupils. It merits consideration within broader teenage pregnancy prevention strategies. Trial registration: ISRCTN
The perspectives of clinical staff and bereaved informal care-givers on the use of continuous sedation until death for cancer patients: The study protocol of the UNBIASED study
Jane Seymour, Judith Rietjens, Jayne Brown, Agnes van der Heide, Sigrid Sterckx, Luc Deliens, the UNBIASED study team
BMC Palliative Care , 2011, DOI: 10.1186/1472-684x-10-5
Abstract: To realize the study aims, a two-phase study has been designed. The study settings include: the domestic home, hospital and expert palliative care sites. Phase 1 consists of: a) focus groups with health care staff and bereaved informal care-givers; and b) a preliminary case notes review to study the range of sedation therapy provided at the end of life to cancer patients who died within a 12 week period. Phase 2 employs qualitative methods to develop 30 patient-centred case studies in each country. These involve interviews with staff and informal care-givers closely involved in the care of cancer patients who received continuous sedation until death.To our knowledge, this is one of the few studies which seek to take a qualitative perspective on clinical decision making surrounding the use of continuous sedation until death and the only one which includes the perspectives of nurses, physicians, as well as bereaved informal care-givers. It has several potential strengths, weaknesses, opportunities and threats associated with the specific design of the study, as well as with the sensitive nature of the topic and the different frameworks for ethical review in the participating countries.A significant minority (cancer research indicates between one tenth and one quarter) of dying people experience refractory symptoms (such as agitated delirium) or extreme distress which is unresponsive to conventional therapies [1,2]. In such circumstances, sedation may be used to decrease or remove consciousness. Internationally, prevalence studies to ascertain the percentage of patients receiving sedation for refractory symptoms at the end of life report variation in use of between 15% to 60% [3-5]. The wide variation in reported prevalence is likely to be due in part to differences in the care setting, patient populations, methods and the definitions applied. These definitions include: 'palliative sedation', 'terminal sedation', 'continuous deep sedation until death', 'proportionate s
Self-reported asthma and allergies in top athletes compared to the general population - results of the German part of the GA2LEN-Olympic study 2008
Silke Thomas, Bernd Wolfarth, Caroline Wittmer, Dennis Nowak, Katja Radon, GA2LEN-Olympic study-Team
Allergy, Asthma & Clinical Immunology , 2010, DOI: 10.1186/1710-1492-6-31
Abstract: Prior to the 2008 Summer Olympic Games, 291 German candidates for participation (65%) completed a questionnaire on respiratory and allergic symptoms. Results were compared to those of a general population study in Germany (n = 2425, response 68%). Furthermore, associations between types of sports and the self-reported outcomes were calculated. All models were adjusted for age, sex, level of education and smoking.Athletes reported significantly more doctors' diagnosed asthma (17% vs. 7%), more current use of asthma medication (10% vs. 4%) and allergic rhinitis (25% vs. 17%) compared to the general population. After adjustment, top athletes only had an increased Odds Ratio for doctor's diagnosed asthma (OR: 1.6; 95% CI 1.1-2.5). Compared to the general population, athletes in endurance sports had an increased OR for doctor's diagnosed asthma (2.4; 1.5-3.8) and current use of asthma medication (1.8; 1.0-3.4). In this group, current wheeze was increased when use of asthma medication was taken into account (1.8; 1.1-2.8). For other groups of athletes, no significantly increased ORs were observed.Compared to the general population, an increased risk of asthma diagnosis and treatment was shown for athletes involved in endurance sports. This might be due to a better medical surveillance and treatment of these athletes.Allergies and asthma are frequent in elite athletes. Previous studies have shown that the prevalence of allergic rhinitis in elite athletes is between 15% and 29% [1-5] and that wheezing is reported by 6% to 15% of athletes [2,3,6]. The prevalence of asthma in athletes was reported to be different, based on the methods used and the athletes included in the study. E.g., in the US, the prevalence differed from 12% among athletes (football players) in 1984 to 15% among athletes participating in the 1996 Olympic Summer Games and up to 22% among athletes who participated in the 1998 Olympic Winter Games [2,7,8]. In Australia the prevalence of diagnosed asthma in Ol
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