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Search Results: 1 - 10 of 643 matches for " fastigial nucleus "
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Dr. G. Gajalakshmi et al
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: The aim of the present study was to investigate the role of cerebellum in immunomodulation as cerebellum was thought traditionally to play an important role in voluntary motor activities. Rats weighing about 200-220 gm were subjected to bilateral electrolytic lesion of fastigial nucleus and following immune parameters were assessed- leucocyte migration inhibition test, foot pad thickness, antibody titre and estimation of cytokines – IL-2, IL-4 and IFN-γ respectively in immunized animals. Rats were divided in to three groups, namely control immunized, sham immunized and lesioned immunized groups. The sham group was strictly considered for evaluation of lesion effect as superficial structures during surgical procedure gets damaged and could also influence on immunomodulation. The significance was fixed at P<0.05. There was significant increase in migration index with concomitant decrease in foot pad thickness in bilateral lesion immunized groups. Significant alterations in cytokine levels were observed in lesion immunized groups when compared with its respective control groups.
Excitatory effect of histamine on neuronal activity of rat cerebellar fastigial nucleus in vitro
Biao Tang,Jun Zhang,HongZhao Li,JingNing Zhu,JianJun Wang
Chinese Science Bulletin , 2007, DOI: 10.1007/s11434-007-0101-8
Abstract: The cerebellar fastigial nucleus (FN) holds an important role in motor control and body balance. Previous studies have revealed that the nucleus is innervated by direct hypothalamocerebellar histaminergic fibers. However, the functional role of histaminergic projection in cerebellar FN has never been established. In this study, we investigated the effect of histamine on neuronal firing of cerebellar FN by using slice preparations. Sixty-five FN cells were recorded from 47 cerebellar slices, and a vast majority of the cells responded to histamine stimulation with an excitatory response (58/65, 89.2%). Perfusing slices with low-Ca2+/high-Mg2+ medium did not block the histamine-induced excitation (n=10), supporting a direct postsynaptic action of histamine on the cells. Furthermore, the excitatory effect of histamine on FN neurons was not blocked by selective histamine H1 receptor antagonist triprolidine (n=15) or chlorpheniramine (n=10), but was effectively suppressed by ranitidine (n=15), a highly selective histamine H2 receptor antagonist. On the other hand, highly selective histamine H2 receptor agonist dimaprit (n=20) instead of histamine H1 receptor agonist 2-pyridylethylamine (n=16) mimicked the excitatory effect of histamine on FN neurons. The dimaprit-induced FN neuronal excitation was effectively antagonized by selective histamine H2 receptor antagonist ranitidine (n=13) but not influenced by selective histamine H1 receptor antagonist triprolidine (n=15). These results demonstrate that histamine excites cerebellar FN cells via the histamine H2 receptor mechanism and suggest that the hypothalamocerebellar histaminergic fibers may modulate cerebellar FN-mediated sensorimotor integration through their excitatory innervations on FN neurons.
Influences of cerebellar interpositus nucleus and fastigial nucleus on neuronal activity of lateral hypothalamic area
Jianjun Wang,Yongmei Pu,Tao Wang
Science China Life Sciences , 1997, DOI: 10.1007/BF02882046
Abstract: Stimulation of cerebellar interpositus nucleus and fastigial nucleus could influence the neuronal activity of lateral hypothalamic area in the cat, and some of the neurons which respond to the cerebellar stimulations are glucose-sensitive neurons. These results suggest that the cerebellum is involved not only in motor control, but also in the regulation of non-somatic functions through the cerebello-hypothalamic pathways.
Modulation of neuronal activity of cerebellar fastigial nucleus by locus coeruleus stimulation in the rat
Wang Tao,Wang Jianjun,Cheng Hong,Li Hongzhao,Yu Qixiang
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02884618
Abstract: The effects of stimulating locus coeruleus (LC) on neuronal activity of cerebellar fastigii nucleus (FN) was investigated. Stimulation of LC elicited inhibitory, excitatory and biphasic (inhibition-excitation) responses from FN cells. The majority of responsive cells showed an inhibitory response with a latency of less than 10 ms. Injection of a adrenoreceptor antagonists phentolamine (iV) could block the inhibitory response of FN cells to the LC stimulation, but propranolol (IV), a β adrenoreceptor antagonist, could not. These results suggest that LC-cerebellar noradrenergic afferent fibers may be involved in the cerebellar sensorimotor integration process by exerting their modulatory action on the cerebellar nuclear cells’ activities.
Influences of cerebellar interpositus nucleus and fastigial nucleus on neuronal activity of lateral hypothalamic area
WANG Jianjun,PU Yongmei,WANG Tao,

中国科学C辑(英文版) , 1997,
Abstract: Stimulation of cerebellar interpositus nucleus and (astigial nucleus could influence the neuronal activi-ty of lateral hypothalamic area in the cat, and some of the neurons which respond to the cerebellar stimulations are glucose-sensitive neurons. These results suggest that the cerebellum is involved not only in motor control, but also in the regulation of non-somatic functions through the cerebello-hypothalamic pathways.
Cerebellum and Ocular Motor Control
Amir Kheradmand,David S. Zee
Frontiers in Neurology , 2011, DOI: 10.3389/fneur.2011.00053
Abstract: An intact cerebellum is a prerequisite for optimal ocular motor performance. The cerebellum fine-tunes each of the subtypes of eye movements so they work together to bring and maintain images of objects of interest on the fovea. Here we review the major aspects of the contribution of the cerebellum to ocular motor control. The approach will be based on structural–functional correlation, combining the effects of lesions and the results from physiologic studies, with the emphasis on the cerebellar regions known to be most closely related to ocular motor function: (1) the flocculus/paraflocculus for high-frequency (brief) vestibular responses, sustained pursuit eye movements, and gaze holding, (2) the nodulus/ventral uvula for low-frequency (sustained) vestibular responses, and (3) the dorsal oculomotor vermis and its target in the posterior portion of the fastigial nucleus (the fastigial oculomotor region) for saccades and pursuit initiation.
A Study of Multifractal Spectra and Renyi Dimensions in 14.5A GeV/c 28Si-Nucleus Collisions  [PDF]
N. Ahmad, A. Kamal, M. M. Khan,   Hushnud, A. Tufail
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.514129

A systematic analysis of the data on 14.5A GeV/c 28Si-nucleus collisions is carried out to investigate the behaviours of Renyi dimensions, Dq and Multifractal Spectral Function, f(αq). The Renyi dimensions, Dq are observed to decrease with increasing order of the moments, q. However, the Multifractal Spectra are concave downwards with their maxima occurring around αq =1.21±0.01. A continuous curve representing Multifractal Spectral Function, f(αq), characterizes manifestation of fluctuations in the rapidity space.

Central Nervous System Control of Glucose Homeostasis  [PDF]
Poondy Gopalratnam Raman
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2017, DOI: 10.4236/ojemd.2017.712020
Abstract: Hypothalamus and brain stem play important roles in Glucose Homeostasis. There are two types of cells in the hypothalamus: Glucose excited (GE) and Glucose inhibited (GI). GE increases glucose concentration and GI decreases glucose concentration. They are located in ventromedial (VMH), arcuate, lateral, dorsomedial and paraventricular areas of hypothalamus. Nucleus of solitary tract, area postrema, dorsomedial nucleus of vagus and basolateral medulla are also related to glucose homeostasis. VMH contains sympathetic nucleus and upregulates plasma glucose and decreases hepatic glycogen, while lateral hypothalamus contains parasympathetic and down regulates plasma glucose. Through Glut-1, dependent transport glucose enters neurons and astrocytes. Glucose is metabolized and provides energy for GE and GI neurons. Their activity is guided by blood sugar level. Blood sugar level sends numerous signals through vagal pathway from periphery. Neuron astrocyte establishes via autonomic system connections with liver, pancreas, adrenal gland and maintains glucose homeostasis. Post prandial glucose levels are regulated by CNS.
Localization of BRUNOL2 in Rat Spermatogenic Cells as Revealed by Immunofluorescence and Immunoelectron Microscopic Techniques  [PDF]
Hiroka Yonetamari, Yuko Onohara, Sadaki Yokota
Open Journal of Cell Biology (OJCB) , 2012, DOI: 10.4236/ojcb.2012.22002
Abstract: Distribution and localization of a RNA-binding protein, BRUNOL2 in rat spermatogenic cells were studied by dot blotting of cell fractions, immunofluorescence (IF), and immunoelectron microscopy (IEM). BRUNOL2 distributed in nuclear (23%), mitochondrial (19%), microsomal (15%), and cytosol fractions (43%). BRUNOL2 was detected in all spermatogenic cells. In the cytoplasm and nucleoplasm of the spermatogonia, spermatocytes and spermatids, both diffuse and granular staining patterns were observed. Many cytoplasmic granules were stained also for DDX4 and DDX25. Large granules in the cytoplasm of elongated spermatids were stained for BRUNOL2 but not for the nuage proteins. IEM showed that gold signals for BRUNOL2 were concentrated in nuage components including loose aggregates of small particles, chromatoid body (CB), intermitochondrial cement (IMC), and satellite body (SB). In addition, many non-nuage structures such as ER-attached small granules, less dense material surrounding connecting piece of flagellum, reticulated body, mitochondria-associated granules (MAG), granulated body, ribosome aggregate, and manchette, were stained for BRUNOL2 with different staining intensities. In the nucleus, gold signals were concentrated in heterochromatin area and nucleolus. The results suggest that BRUNOL2 is one of the nuage proteins and also associated with the other non-nuage structures, suggesting multiple functions of this protein.
Changes in the Nuclei of Infected Cells at Early Stages of Infection with EMCV  [PDF]
Zaven A. Karalyan, Hranush R. Avagyan, Hovakim S. Zakaryan, Liana O. Abroyan, Lina H. Hakobyan, Aida S. Avetisyan, Elena M. Karalova
CellBio (CellBio) , 2013, DOI: 10.4236/cellbio.2013.23014

By the methods of quantitative cytophotometry, we have identified the changes in the nucleus and of some intranuclear compartments in the early stages of infection with encephalomyocarditis virus (EMCV). They can be characterized as early 1 - 2 hours post infection (hpi) and temporary increase (duration about 1 hour) in the content of the acidic proteins of the nucleolus, changing their decline to the control values. Then (after 1 - 2 hours) follows an increase in RNA content of nucleoli to 4 hours post infection (the process takes about 2 hours). The increase in RNA content in nucleoli is in approximately the same time (slightly behind) with the activation of PML bodies (2 - 4 hpi). Then, the RNA content in nucleoli decreased to the control values, while simultaneously decreasing activity of PML bodies (ranging from 5 - 6 hpi). The early stages of infection EMCV are also characterized by the tendency to increase in the size of the nuclei of infected cells, and preserve at a later time. Then there is an increase in RNA content in the nucleus, roughly coinciding with the increased content of RNA in the nucleoli.

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