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Eosinophilic gastroenteritis in basset hound dog  [PDF]
Carlos E. Fonseca-Alves, Aline G. Corrêa, Fabiana Elias
Open Journal of Animal Sciences (OJAS) , 2012, DOI: 10.4236/ojas.2012.22015
Abstract: An 1-year-old male Basset Hound dog was evaluated for chronic intermittent vomiting, hematemesis, and melena which had been ongoing for several months. The histopathologic examination revealed that all layers of the small intestine were thicker than normal. The lamina propria of the mucosa, including the villi, exhibited a prominent cellular infiltrate which consisted of numerous eosinophils and an increased numbers of plasma cells in addition to the normal lymphocytic component. The muscularis mucosa was invaded, and in some places disrupted, by eosinophils, which also infiltrated into the submucosa and muscularis propria. This report describes the pathological findings of a case of eosinophilic gastroenteritis (EG) in a dog.
Eosinophilic Gastroenteritis Involving the Distal Small Intestine and Proximal Colon
Guan-Yeow Ong,Chia-Chang Hsu,Chi-Sin Changchien,Sheng-Nan Lu
Chang Gung Medical Journal , 2002,
Abstract: Eosinophilic gastroenteritis (EG) is an unusual disorder. It is characterized byeosinophil infiltration of the gut wall histologically and is manifested by gastrointestinal(GI) symptoms clinically. This disease entity preferentially affects the stomach and proximalsmall intestine. Mucosal layer disease is the most common form of this uncommon disease.We present a case of EG with transmural distal small intestinal and proximal colonicinvolvement whose clinical symptoms included watery diarrhea, abdominal pain, and bodyweight loss. Colonoscopy showed non-specific colitis in the proximal colon. Small bowelseries showed diffuse jejunal dilatation with wall thickening and rigidity. Abdominal computedtomography also showed a thickened bowel wall with partial ileus and ascites.Diagnosis was established through endoscopic biopsy and ascites paracentesis, while at thesame time excluding the possibility of parasite infection. Treatment with prednisolone produceda dramatic response. A high index of suspicion in cases of peripheral eosinophiliawith concomitant GI symptoms is needed for the early diagnosis of this uncommon disease.
A rare cause of diarrhea: Eosinophilic gastroenteritis
Abdullah ?zgür Yeniova,Ya?ar Nazl?gül,Feride ?a?lar,Ay?e Kefeli
Dicle Medical Journal , 2011,
Abstract: Eosinophilic gastroenteritis (EG) is a rare disease that is characterized by an eosinophil-driven inflammation of the digestive tract, presenting with gastrointestinal symptoms. In this report, a case of EG in an elderly man who presented with diarrhea was presented.A 68-year-old man admitted to hospital due to diarrhea, nausea, abdominal pain, and weight loss started two weeks ago. Hypereosinophilia were determined. Serum immunoglobulin E level was high. Stool examinations for intestinal parasites were negative. Biopsies were taken from esophagus, stomach, duodenum during upper and lower gastrointestinal endoscopies. Histopathological assessement showed an intense edema, eosinophilic and increased lymphoplasmasitic infiltration in lamina propria. Increased eosinophil count seen in bone-marrow biopsy, atypical cell was not seen. Eosinophilic gastroenteritis was considered and, ketotifen 2 mg/day and methylprednisolone 1 mg/kg/day were started. His symptoms were improved.Gastrointestinal symptoms of EG are nonspecific. The increase of eosinophilic cells in the circulating blood can suggest the possibility of EG. Definite diagnosis is made by histopathological assessment. Glucucorticoid therapy is the mainstay and is effective in the treatment of EG. However, the antihistamines are also used solely or combined with glucocorticoids.
- , 2018,
Abstract: 摘要: 摘要:目的??探讨嗜酸粒细胞性胃肠炎(EGE)的临床表现,观察其多样性,减少误诊漏诊,提高临床诊治率。方法?回顾性分析该院2008年-2016年消化内科住院诊治的EGE患者临床资料,对其临床表现、诊断经过及方法、确诊依据及治疗进行分析、总结。结果?最终确诊21例患者临床表现无特异性,分别以腹痛、腹泻,腹胀、伴恶心和呕吐等就诊入院;多数有哮喘病史、皮肤或药物食物过敏史。临床分型以黏膜型为主16例,浆膜型3例,混合型2例。外周血中性粒细胞百分比及嗜酸性粒细胞比例增高;部分骨髓增生活跃,嗜酸性粒细胞比例增高;腹水化验嗜酸性粒细胞比例增高;胃肠镜见黏膜充血、糜烂和溃疡等表现;腹部CT亦可见肠壁增厚、可见腹水;19例患者激素治疗有效治愈。结论?EGE是可以治愈的疾病,因其临床表现多样性,需得到更多临床医生及病理科医师的认识及关注,以尽早诊断及治疗,避免误诊及漏诊。
Abstract: Abstract: Objective?To explore the clinical manifestation of eosinophilic gastroenteritis, reduce the misdiagnosis rate, then improve the clinical diagnosis and treatment rate.?Methods?The clinical data of patients with eosinophilic gastroenteritis diagnosed and treated by digestive medicine from 2008 to 2016 were analyzed and summarized retrospectively.?Results?The final diagnosis of 21 patients with no specific clinical manifestations were manifested as abdominal pain, diarrhea, abdominal distension, with nausea, vomiting, etc, respectively. Most of them have the history of asthma, skin and drug or food allergy history. The clinical type was mainly mucosa type, 16 cases, 3 case were serosa and 2 cases were mixed type. Peripheral blood neutrophil percentage and eosinophil proportion increased; Some patients with bone marrow results suggested the bone marrow hyperplasia was active, increased proportion of eosinophils. Eosinophils increased in ascites test. Abdominal CT can also be seen thickening of the intestinal wall, showing ascites. Hormone therapy to 19 patients was effective.?Conclusion?Eosinophilic gastroenteritis is a cureable disease. Because of its clinical manifestation, it is necessary to get more knowledge and attention from clinicians and pathologists to diagnosis and treatment as soon as possible to avoid misdiagnosis.
Adult eosinophilic gastroenteritis and hypereosinophilic syndromes
Hugh James Freeman
World Journal of Gastroenterology , 2008,
Abstract: Eosinophilic gastroenteritis (EGE) in the adult is a distinctive pathologically-based disorder characterized by an eosinophil-predominant mucosal inflammatory process. Most often, the disorder is detected during endoscopic investigation for abdominal pain or diarrhea. Other causes of gastric and intestinal mucosal eosinophilia require exclusion, including parasitic infections and drug-induced causes. Occasionally, the muscle wall or serosal surface may be involved. EGE appears to be more readily recognized, in large part, due to an evolution in the imaging methods used to evaluate abdominal pain and diarrhea, in particular, endoscopic imaging and mucosal biopsies. Definition of EGE, however, may be difficult, as the normal ranges of eosinophil numbers in normal and abnormal gastric and intestinal mucosa are not well standardized. Also, the eosinophilic inflammatory process may be either patchy or diffuse and the detection of the eosinophilic infiltrates may vary depending on the method of biopsy fixation. Treatment has traditionally focused on resolution of symptoms, and, in some instances, eosinophil quantification in pre-treatment and post-treatment biopsies. Future evaluation and treatment of EGE may depend on precise serological biomarkers to aid in definition of the long-term natural history of the disorder and its response to pharmacological or biological forms of therapy.
Gastroenteritis eosinofílica: espectro clínico de una misma entidad
Serna Higuera,C. de la; Rodríguez Gómez,S. J.; Martín Arribas,M. I.; Martínez Moreno,J.; Pérez Villoria,A.;
Anales de Medicina Interna , 2002, DOI: 10.4321/S0212-71992002000700007
Abstract: eosinophilic gastroenteritis is a condition of unknown etiopathogenesis and unusual description. clinical symptoms are widely diverse ranging from mild episodes of abdominal discomfort to acute intestinal obstruction which leads occasionally to urgent surgical approach. this wide range of clinical posisibilities seems to be secondary to the rate of eosinophilic infiltration of the bowel wall and the number of layers involved. we report two cases showing that anatomo-clinical variety and their therapeutic outcomes.
Unusual presentations of eosinophilic gastroenteritis: Case series and review of literature
Rafiq A Sheikh, Thomas P Prindiville, R Erick Pecha, Boris H Ruebner
World Journal of Gastroenterology , 2009,
Abstract: Eosinophilic gastroenteritis (EG) is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, and is usually associated with dyspepsia, diarrhea and peripheral eosinophilia. Diffuse gastrointestinal tract and colonic involvement are uncommon. The endoscopic appearance may vary from normal to mucosal nodularity and ulceration. Gastrointestinal obstruction is unusual and is associated with predominantly muscular disease. We present five unusual cases of EG associated with gastric outlet and duodenal obstruction. Two cases presented with acute pancreatitis and one had a history of pancreatitis. Four cases responded well to medical therapy and one had recurrent gastric outlet obstruction that required surgery. Four out of the five cases had endoscopic and histological evidence of esophagitis and two had colitis. Two patients had ascites. These cases reaffirm that EG is a disorder with protean manifestations and may involve the entire gastrointestinal tract. Gastric outlet and/or small bowel obstruction is an important though uncommon presentation of EG. It may also present as esophagitis, gastritis with polypoid lesions, ulcers or erosions, colitis and pancreatitis and may mimic malignancy.
Gastroenteritis eosinofílica: a propósito de dos casos
álvarez García,J. F.; Sánchez Sánchez,M. T.; Chiquero Palomo,M.; Costo Campoamor,A.; Saponi Cortés,J. M.; Pérez Reyes,F.; Luengo álvarez,J.;
Anales de Medicina Interna , 2004, DOI: 10.4321/S0212-71992004000900007
Abstract: eosinophilic gastroenteritis is a rare condition characterized by eosinophilic infiltration or the different layers of the intestinal wall. clinical symptoms depend of the site of eosinophilic infiltration and the layers involved. usually characterized by peripheral eosinophilia. definitive diagnosis is based on histopathological findings. we report two cases with excellent response to steroid therapy.
A Rare Case of Spontaneous Resolution of Eosinophilic Ascites in A Patient with Primary Eosinophilic Gastroenteritis
Wei-Hsuan Liao,Kuo-Liang Wei,Po-Yen-Lin,Cheng-Shyong Wu
Chang Gung Medical Journal , 2012,
Abstract: Eosinophilic gastroenteritis is a rare gastrointestinal disorder characterized by nonspecific gastrointestinal symptoms, peripheral eosinophilia, and eosinophilic infiltration of the intestinal wall. The disorder is classified into mucosal, muscular, and subserosal types, depending on the depth of eosinophilic infiltration within the gastrointestinal wall, and the clinical picture varies accordingly. Subserosal disease, which is complicated by ascites, usually results in the most severe clinical form of eosinophilic gastroenteritis and mandates early corticosteroid therapy. In such cases, a favorable outcome can be achieved after a short course of corticosteroids. We present a rare case in a 43 year-old man in whom eosinophilic gastroenteritis spontaneously resolved without any medical treatment. After reviewing the literature and excluding secondary causes of eosinophilic gastroenteritis, we concluded that this may be the first reported case of spontaneous resolution of primary subserosal eosinophilic gastroenteritis.
Strongyloides stercoralis en el sur de Galicia
Martínez-Vázquez,C.; González Mediero,G.; Nú?ez,M.; Pérez,S.; García-Fernández,J.M.; Gimena,B.;
Anales de Medicina Interna , 2003, DOI: 10.4321/S0212-71992003000900008
Abstract: strongyloides stercoralis is the only parasite which can produce a chronic illness in humans, being through autoinfection. this nematode can also provoke death when patient?s immunologic state deteriorates producing a massive hyper infection. the first patient with strongyloidiasis who has always lived in the galician south area is described. the clinical picture consisted of unspecific cutaneous lesions and abdominal pain with severe peripheral eosinophilia (>20.000/ml. the diagnosis was carried out observing the larvae in the fecal examination and was confirmed with a culture. treatment with albendazole failed and the healing was reached with ivermectin. we must consider the possibility of strongyloidiasis because misdiagnosing these patients as eosinophilic gastroenteritis there would be a higher risk of hyperinfection if they are treated with corticosteroids.
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