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Search Results: 1 - 10 of 7503 matches for " acute lymphocytic leukemia "
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Leucemia linfoide aguda común: Estudio del inmunofenotipo y las características clínicas y morfológicas
Marsán Suárez,Vianed; Sánchez Segura,Miriam; Socarrás Ferrer,Bertha Beatriz; Martínez Machado,Mercedes; Cos Padrón,Yanelkis; del Valle Pérez,Lázaro; Torres Leyva,Isabel; Nú?ez Quintana,Aramís; Macías Abraham,Consuelo;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2004,
Abstract: biological, clinical, lab and phenotypical characteristics of 87 children diagnosed with common lymphoblastic leukemia (c-all)in a period of 17 years were studied. cell immunophenotyping was performed by immunocytochemical methods (umiciq) and alkalyne phosphatase/anti-alkalyne phosphatase. higher incidence was observed in 2-5 years-old group. the most affected were caucasian boys. 98,8% of patients had l1 variety. leukocyte rates were under 20 x 109 in 79,3% of cases and no mediatinal adenopathy6 was shown at the onset of disease. 4.6% of patients presented with central nervous system infiltration at onset. hepatomegaly, spleenomegaly and adenopathies were found in 47,1%, 24,1% and 31% of cases respectively. antigen cd 10, cd 19 and tdt were observed in all the patients; cd22 in 98,8%; hla-dr in 96,5% and cd 20 in 6,9% of the total amount of children. fourteen cases (16,1%) of c-all mi+ were diagnosed of which 6 (42,8%) had leukocyte values over 20 x 109. these results proved that all is a phenotypically heterogeneous clinical disease that represents clonal expansions of lymphoblasts at different maturation stages
Avalia??o da sobrevida de crian?as com leucemia linfocítica aguda tratadas com o protocolo Berlim-Frankfurt-Munique
Laks, Dani;Longhi, Fernanda;Wagner, Mário Bernardes;Garcia, Pedro Celiny Ramos;
Jornal de Pediatria , 2003, DOI: 10.1590/S0021-75572003000200010
Abstract: objective: to determine the survival rate of children with acute lymphoblastic leukemia treated in hospital s?o lucas - pontifícia universidade católica - rio grande do sul during the past 10 years. to evaluate well known prognostic factors and to compare results of bfm 90 and 95 trials. methods: mixed cohort study of 0 to 15-years-old children treated with bfm 90 and 95 trials during the past 10 years at hospital s?o lucas - pontifícia universidade católica - rio grande do sul. data were obtained from medical records. the occurrence of death was described by kaplan-meier survival curves. the overall effect of the prognostic factors was evaluated using the cox's multivariate model. results: sixty three patients, whose mean age ( standard-deviation) was 6.3 4.2 years, were included. thirty five patients (55.6%) were female. the estimated probability of relapse free survival at 5 years ( standard-error) was 50.8 7.2% for all patients, with 77.7 9.9% in the standard risk group, 41.3 15.4% in the intermediate risk group, and 39.3 13.7% in high risk group. conclusions: the estimated probability of relapse free survival was below the results in developed countries. however the standard risk group obtained better prognostic but the small number of the cases doesn't allow permanent conclusions.
From Diagnosis to Remission: A Five-Year Case Study of a Female Collegiate Athlete’s Battle with Leukemia
International Journal of Tumor Therapy , 2012, DOI: 10.5923/j.ijtt.20120103.01
Abstract: This case follows a female collegiate basketball player who was diagnosed with Acute Lymphocytic Leukemia (ALL). This five-year study explores the unique aspects of this subject’s case by examining each characteristic of her journey from initial diagnosis as an undergraduate freshman through treatment and into remission by her senior year. Participation in collegiate athletics was identified for its positive influence in serving as a modality to overcome this oncologic condition that affected the mental, physical and emotional state of the athlete. The first part of this study examines the subject’s battle with cancer uniquely occurring over her five years of undergraduate study. Following the case report, the physical effects of cancer on the body are discussed as well as the benefits of exercise for cancer patients. To conclude the discussion, the psychological implications of cancer and tools used to combat the negative consequences on the mind are reviewed. This study concludes that physical activity in conjunction with the integration of support from her collegiate basketball team contributed to the positive outcomes of the subject’s psychological and physical well-being.
Oral Ciprofloxacin Compared with Intravenous Ceftazidim on Low Risk Febrile Neutropenia in Acute Lymphocytic Leukemia
Hashemi A,Najafi N,Behnaz F,Zare A
Iranian Journal of Pediatric Hematology Oncology , 2013,
Abstract: ObjectiveFever and neutropenia are a common complication of chemotherapy in cancer. It is usually managed by hospitalization and empiric administration of antibiotics. Use of Fluroquinolones is limited because of joint/cartilage toxicity. This study attempted to compare the efficacy of oral ciprofloxacin with intravenous ceftazidim in low risk febrile neutropenic lymphocytic leukemia.MethodsNinety two episodes of febrile neutropenia in 72 patients under 14 years old were studied prospectively for two years. All the patients received G-CSF plus intravenous ceftazidim 100 mg/kg/d and amikacin 15 mg/kg/d for 24 hours. These episodes randomly allocated into two groups. Group A received IV ceftazidim and amikacin for at least 3 days. After discharge they got oral cefixim 8 mg/kg daily. Group B discharged and received oral ciprofloxacin (20 mg/kg.day) for seven days. Failure was defined as temperature higher than 38 °C for more than 72 hours or major complication.ResultsFailure of intravenous ceftazidim plus amikasin for at least 4 days in hospital, in low risk febrile neutropenic children, was 6.5%, but failure of oral ciprofloxacin for 7 days after 24h intravenous ceftazidim plus amikasin was 4.3%. There was no arthrotoxicity in patients received ciprofloxacin.ConclusionEmpirical therapy with oral ciprofloxacin is safe and effective in children with leukemia and low risk FN.
A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia?
Campos, Mireille Guimar?es Vaz de;Chauffaille, Maria de Lourdes L. Ferrari;Rodrigues, Celso Arrais;Krum, Everson A.;Yamamoto, Mihoko;
Genetics and Molecular Biology , 2003, DOI: 10.1590/S1415-47572003000300006
Abstract: the philadelphia chromosome is observed in 5% of pediatric acute lymphocytic leukemia (all) and in 25% to 50% of adult all cases, and is associated with poor prognosis. double ph in a hyperdiploid karyotype is common in chronic myeloid leukemia (cml), but rarely found in all. we report here the case of a girl diagnosed with all at 7 years of age. after treatment with the pediatric protocol bfm 83 for all, she stayed in continuous complete remission for nine years. at age 19, she was re-admitted with a white blood cell count of 6.8 x 109/l with 3% blasts, and a platelet count of 65 x 109/l. bone marrow aspirate showed 92.6% lymphoid blast cells, and chromosome analysis after g-banding revealed the karyotype 51,xx,+?5,t(9;22)(q34.1;q11.2),+16,+20,+21,+der(22)t(9;22)(q34.1;q11.2) [10]/46,xx[1]. fish analysis for the bcr/abl fusion showed 56% of interphase cells with two fusion signals, 30% with one, and 6% with three. double ph is rare in relapsed leukemia, and the possibility of secondary leukemia cannot be ruled out.
Relevancia biológica y clínica del inmunofenotipaje celular en la leucemia linfoide aguda del ni?o
Marsán Suárez,Vianed; Cos Padrón,Yanelkys; Sánchez Segura,Miriam; Socarrás Ferrer,Bertha B.; Macías Abraham,Consuelo; del Valle Pérez,Lázaro O.; Nú?ez Quintana,Aramís; González Otero,Alejandro; Svarch Guerchicoff,Eva; Lam Díaz,Rosa M.;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2008,
Abstract: the biological and clinical characteristics of 238 children with acute lymphocytic leukemia (all) were studied for 13 years. the cellular immunophenotyping of samples from the bone marrow was performed by an immunocytochemical ultramicromethod. of the total of studied all, 81.4 % were phenotype b and 18.5 % phenotype t. 48.4 % of the children with b-all were 2-5 years old, whereas 65.9 % with t-all were 6 or over. no statistically significant differences were found when sex and colour of the skin were analyzed in relation to the cellular leukemic phenotype. on diagnosing the disease, 59.3 % of the patients with b-all showed figures of leukocytes in peripheral blood < 20x109/l, whereas in 61.4 % with t-all, the figures were higher than 50x109/l. it was observed a greater incidence of organomegaly, mediastinal adenopathies, hemorrhagic manifestations and initial infiltration of the central nervous system in patients with t-all compared with those suffering b-all. the differences were highly significant. these results proved that the leukemic phenotype in all in children could be considered as a positive or negative prognostic factor of the disease.
Caracterización biológica y clínica de pacientes pediátricos con leucemia linfoide aguda pro-B
Marsán Suárez,Vianed; Cos Padrón,Yanelkys; Socarrás Ferrer,Bertha Beatriz; Sánchez Segura,Miriam; Macías Abraham,Consuelo; del Valle Pérez,Lázaro O; Torres Leyva,Isabel; Nú?ez Quintana,Aramís; González Otero,Alejandro;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2006,
Abstract: the biological and clinical characteristics of 19 children with pro-b acute lymphocytic leukemia were studied during 14 years. the cellular immunophenotyping was performed by the immunocytochemical ultramicrornethod. a higher incidence was observed in a group aged 2-5 years old. the distribution by race was the same as in the normal population. the white boys were the most affected. 73.7 % of the patients presented leukocytes < 20x10 9 /l at the onset of the disease, and 57.9 % had hepatomegaly and splenomegaly. adenopathies and hemorrhagic manifestations were observed in 47.4 % and in 2 %, respectively. the cd19 antigen was expressed in 100 % of the patients, the cd22 plasmatic antigen in 89.5 %, the tdt enzyme in 68.4 % and hla-dr in 57.9 %. of the total of studied patients, 4 (21 %) expressed myeloid antigens and were classified as pro-b lla-mi+. the expressed myeloid antigens were cd13 and cd33 (5.3 %) in a patient, and cd15 in 2 patients (10.5 %). these results show that lla is a heterogenous disease with different biological and clinical subtypes
A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia?
Campos Mireille Guimar?es Vaz de,Chauffaille Maria de Lourdes L. Ferrari,Rodrigues Celso Arrais,Krum Everson A.
Genetics and Molecular Biology , 2003,
Abstract: The Philadelphia chromosome is observed in 5% of pediatric acute lymphocytic leukemia (ALL) and in 25% to 50% of adult ALL cases, and is associated with poor prognosis. Double Ph in a hyperdiploid karyotype is common in chronic myeloid leukemia (CML), but rarely found in ALL. We report here the case of a girl diagnosed with ALL at 7 years of age. After treatment with the pediatric protocol BFM 83 for ALL, she stayed in continuous complete remission for nine years. At age 19, she was re-admitted with a white blood cell count of 6.8 x 10(9)/L with 3% blasts, and a platelet count of 65 x 109/L. Bone marrow aspirate showed 92.6% lymphoid blast cells, and chromosome analysis after G-banding revealed the karyotype 51,XX,+?5,t(9;22)(q34.1;q11.2),+16,+20,+21,+der(22)t(9;22)(q34.1;q11.2) [10]/46,XX[1]. FISH analysis for the BCR/ABL fusion showed 56% of interphase cells with two fusion signals, 30% with one, and 6% with three. Double Ph is rare in relapsed leukemia, and the possibility of secondary leukemia cannot be ruled out.
Leucemias agudas en pacientes mayores de 60 a?os
Suárez Beyríes,Lidia; Carnot Uría,José; de Castro Arenas,Raúl; Mu?ío Perurena,Jorge; Martínez Hernández,Carlos; Suárez González,Lisbett; Pérez Román,Guillermo;
Revista Cubana de Medicina , 2003,
Abstract: a descriptive study was carried out in 50 patients with acute leukemia aged 66 years as an average at the time of diagnosis. it was proved that non-lymphoblastic leukemia affected 80% of cases whereas 22,5% of them had a history of myelodisplastic syndrome or of other hematological disorders. anemia was detected in 88% of patients and high serum lactic dehydrogenase levels in 60% of cases. visceromegalia was more frequent in acute lymphoblastic leukemia. patients with acute lymmphoblastic leukemia did not show complete remission, with an average survival rate of less than 2 months. on the contrary, complete remission was attained in 22,5% of cases with acute lymphoblastic leukemia and the average survival rate was 8 months approximately. unfavourable prognosis and high mortality rate among elderly with this disease were confirmed.
Hallazgo de células clonales B en leucemia mielomonocítica aguda
Novoa,Viviana; Nu?ez,Neri; Cervellini,Mirta; Starosta,Aida; Carballo,Orlando G.;
Medicina (Buenos Aires) , 2010,
Abstract: the coexistence of acute myeloid leukemia and chronic lymphocytic leukemia in the same patient is rare. the majority of the cases correspond to patients that developed acute leukemia during the evolutionary course of a chronic lymphatic leukemia following treatment with chemotherapy drugs. we report a case of acute myelomonocytic leukemia concurrent with untreated b-cell chronic lymphocytic leukemia in which the use of flow cytometry analysis with a large panel of monoclonal antibodies, allowed the demonstration of different pathological populations and determine immunophenotyping patterns. published cases of simultaneous chronic lymphocytic leukemia and acute leukemia are reviewed. the use of multiparametric flow cytometry to differentiate the populations demonstrates the utility of this technology in the diagnosis of these hematological malignancies.
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