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OALib Journal期刊

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Modeling Wind Energy Using Copula  [PDF]
Zuhair Bahraoui, Fatima Bahraoui, M. Amin Bahraoui
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104984
Abstract:
In most studies related to wind energy, the quantity of the air density is consid-ered constant, but actually, we know that it is variable and depending on others natural factors. We present a new procedure to estimate the wind density power energy by simulating the components of the air density. The procedure uses the copula theory and demonstrates that the estimated power energy is higher if the air density is not constant.
Analyses of π± - 12C Elastic Scattering and Reaction Cross-Section Data Below, Atop and Above the Δ-Resonance  [PDF]
Zuhair F. Shehadeh
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.56044
Abstract:

The pion-nucleus elastic scattering and reaction cross-section data at incident energies below, atop and above the Δ-resonance are analyzed using the full Klein-Gordon equation using an optical potential. Analytic forms of the potential are determined using the inverse scattering theory in those cases where phase shift analyses were available. The Coulomb effect is incorporated using Stricker’s prescription. Both elastic scattering data and the reaction cross sections between 120 and 400 MeV are well reproduced. Both real and imaginary parts of the potential are local. The potential points determined by the inverse scattering theory in the interior region at 230 MeV clearly establish that the real part is repulsive. This remains the case at higher incident energies. The real part turns repulsive above the resonance, whereas the imaginary part reflects the dominance of surface absorption, which is maximum near atop the Δ-resonance and then falling off at higher energies.

Analyses of Low-Energy π--12C Elastic Scattering Data  [PDF]
Zuhair F. Shehadeh
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.516165
Abstract: A new updated simple local optical potential is proposed for analyzing low-energy π--12C elastic scattering data at 80 MeV and below. This potential is composed of two real terms and an imaginary term. The nature of the real part of the potential is repulsive at smaller radii and attractive at larger ones. In fact, the height of the repulsive term is found to change linearly with the incident pion kinetic energy. On the other hand, the imaginary part of the potential is attractive, shallow and non-monotonic with a dip at about 1.6 fm. Such a nature of the potential makes it feasible to predict π--12C cross sections at other energies in the energy region considered herein. Coulomb effects are incorporated by following Stricker’s prescription. This study will serve positively in studying both pionic atoms and the role of negative pions in radiotherapy.
HIV-1 Tat Protein Induces the Production of IDO in Human Monocyte Derived-Dendritic Cells through a Direct Mechanism: Effect on T Cells Proliferation
Rémi Planès, Elmostafa Bahraoui
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074551
Abstract: During HIV-1 infection, an increase of indoleamine 2,3 dioxygenase (IDO) expression, and dendritic cells (DC) dysfunction were often associated with AIDS disease progression. In this work, we investigated the effect of HIV-1 Tat protein on the expression of IDO, in MoDCs. We show that Tat induces IDO protein expression and activity in a dose dependent manner by acting at the cell membrane. Using Tat-mutants, we show that the N-Terminal domain, Tat 1–45, but not the central region, Tat 30–72, is sufficient to induce the expression of active IDO. Tat protein is also able to induce several cytokines in MoDCs, including IFN-γ, a strong inducer of IDO. In order to understand whether IDO is induced directly by Tat protein or indirectly following IFN-γ production, complementary experiments were performed and showed that: i) at the kinetic level, Tat induced IDO expression before the production of IFN-γ ii) treatment of MoDCs with Tat-conditioned medium was unable to stimulate IDO expression, iii) coculture of MoDCs in a transwell cell system did not allow IDO expression in MoDCs not previously treated by Tat, iv) direct contact between Tat-treated and untreated MoDCs was not sufficient to induce IDO expression in a Tat-independent manner, and v) treatment of MoDCs in the presence of IFN-γ pathway inhibitors, Jak I and Ly294002, inhibited IFN-γ-induced IDO but had no effect on Tat-induced IDO. At the functional level, our data showed that treatment of MoDCs with Tat led to the inhibition of their capacity to stimulate T cell proliferation. This impairement was totally abolished when the stimulation was performed in the presence of 1MT, an inhibitor of IDO activity, arguing for the implication of the kynurenine pathway. By inducing IDO, Tat protein may be considered, as a viral pathogenic factor, in the dysregulation of the DC functions during HIV-1 infection.
The role of vitamin C in alteration of enzymes responsible of energy metabolism induced by administration of tamoxifen to mouse  [PDF]
Zaina Zuhair, Hasan AL-amri
Advances in Biological Chemistry (ABC) , 2011, DOI: 10.4236/abc.2011.12003
Abstract: Tamoxifen is a synthetic non-steroidal ant estrogen. It was suggested to study the role of vitamin C in alte- ration of enzymes responsible of energy metabolism induced by administration of tamoxifen to mouse. The effect of tamoxifen and tamoxifen with vitamin C on some activity of enzymes in the mice representing gly- colytic, gluconeogenic and glycogenolytic pathway and also, liver function enzymes represented by aspartate aminotransferase (AST), alanine amino-transferase (ALT), acid phosphatase (ACP) and alkaline phos- phatase (ALP) were studied. The present results showed that a significant (p < 0.001) increase in glycolytic enzymes (HK, PK, GPI and PFK), glu- coneogenic enzymes, G-6-Pase, acid phosphatase (ACP), alkaline phosphatase (ALP) and glucose, were observed in treated groups, while LDH, glycogen phos- phorylase, AST and ALT enzymes activities showed significant (p < 0.01) reduction. The present results also, showed that significant reduction in glycogen, total protein, total cholesterol, uric acid, urea, and creatinine in treated mice as compared to the normal healthy control group. However, normal control mice treated with tamoxifen and vitamin C showed no side effects of most parameters compared to the normal healthy control group. It was concluded that vitamin C may prevent tamoxifen-induced testes toxicity in mice.
Toxicity of Sumithion in Albino Rats: Hematological and Biochemical Studies
Zuhair Y. Al. Sahhaf
Journal of Applied Sciences , 2006,
Abstract: This study was carried out to investigate the hematological and biochemical effects of the organophosphate insecticide, sumithion, in albino rats. Animals were treated with sumathion at a dose level of 60 mg kg-1 body weight (1/4 LD50 ) daily for 12 days. It was found that erythrocytes (RBCs) count, haemoglobin contents, Mean Corpuscle Volume (MCV) and Mean Corpuscle Haemoglobin Concentration (MCHC) were almost similar in control and treated animals. On the other hand, the results showed that the haemotocrite value, number of leucocytes (WBCs) as well as the lymphocytes percentage were significantly increased in treated animals The platelets were significantly decreased. The results also showed that serum total protein was decreased while triglycerides showed insignificant increase in comparison with control. Cholesterol and creatinine significantly increased after 12 days of treatment. Histological examination of kidney of treated rats revealed impairment of the renal tissues.
Evaluation of natural killer cell activity in pre and post treated breast cancer patients
Piroozmand Ahmad,Hassan Zuhair
Journal of Cancer Research and Therapeutics , 2010,
Abstract: Aim: To evaluate natural killer (NK) cells activity in breast cancer patients and its comparison with normal individuals. Settings and Design: Breast cancer is the most prevalent type of spontaneous tumor in humans, and NK cells are the first line defense against such tumors. There is a reverse correlation between NK activity and metastasis and reducing the tumor mass by surgery may be monitoring the NK activity. In this study, we evaluate NK activity in pre and post mastectomy patients. Materials and Methods: Eighteen patients with invasive ductal carcinoma attended to cancer research institute were included in this study. NK cells were evaluated in pre and post mastectomy patients. PBMCs were isolated by ficoll hypaque. NK cell activity (% lysis of K562) was evaluated by flowcytometer. Statistical Analysis Used: One way analysis of variation (ANOVA) and KruskalWallis nonparametric test were employed using SPSS software. Results: While NK cell activity was greatly impaired in breast cancer patients (average lysis of K562 target cells: 24.4% vs. 62.5% in healthy controls, n = 18), it was found to be significantly increased after mastectomy (37.7%). Conclusions: Mastectomy may lead to increased activity of NK cells among patients suffering from breast cancer and their increased activity may produce positive therapeutic effect.
KINETICS OF HYDROLYSIS OF TRIBUTYRIN BY LIPASE
SULAIMAN AL-ZUHAIR
Journal of Engineering Science and Technology , 2006,
Abstract: Kinetics of the enzymatic hydrolysis of tributyrin using lipase has been investigated. The initial rate of reaction was determined experimentally at different substrate concentration by measuring the rate of butyric acid produced. Michaels-Menten kinetic model has been proposed to predict the initial rate of hydrolysis of tributyrin in micro-emulsion system. The kinetic parameters were estimated by fitting the data to the model using three methods, namely, the Lineweaver-Burk, Edie-Hofstee and Hanes methods. The Michaels-Menten model with the constant predicted by Edie-Hofstee and Hanes methods predicted the initial rate of reaction at various substrate concentrations better than the model with the constant predicted Lineweaver-Burk method, especially at high substrate concentrations.
Tsunami Impacts on Nuclear Power Plants along Western Coast of India Due to a Great Makran Earthquake: A Numerical Simulation Approach  [PDF]
Mohd Zuhair, Shahnawaz Alam
International Journal of Geosciences (IJG) , 2017, DOI: 10.4236/ijg.2017.812083
Abstract:
The major seismicity source in the northern Arabian Sea is the Makran Subduction Zone (MSZ) that defines the tectonic boundary between the Arabian plate and the Eurasian plate, located offshore Iran and Pakistan over which an instrumentally registered earthquake (Mw 8.1) generated a tsunami on 27 November, 1945. It has caused severe cataclysm to a vulnerable population along the surrounding coastlines, including India. It has been on a long seismic quiescence since this last event. The population and industrialization have exponentially increased along the coastal areas in last half decade. The highly exposed coastal locations to the tsunamis are the areas where the nuclear power plants are located. In the present work, a numerical simulation of a great tsunamigenic earthquake (M 9) is presented that predicts the generation, propagation, run-up and travel time using TUNAMI N2 for estimating tsunami impacts along the nuclear power plants of the western coast of India. TUNAMI N2 code was designed for shallow water wave equations, which uses the finite-difference method based on staggered-leap frog scheme. Thus, it has potential to simulate a far-field tsunami with much more accuracy than other methods. It is observed that the tsunami will strike along the coast of Jaitapur Nuclear Power Plant (Maharashtra), Tarapur Nuclear Power Plant (Maharashtra), Kaiga Nuclear Power Plant (Karnataka) and Mithi-Virdi Nuclear Power Plant (Gujarat) after 210, 215, 225 and 230 minutes, respectively. Results show that the tsunami run-up is highest for Jaitapur coast (2.32 m). The Mithi-Virdi coast is the least effected (0.93 m) while Kaiga (2.15 m) and Tarapur coast (2.12 m) might have faced quite intense tsunami consequences. The arrival times and run-ups of the tsunami along the coast of different power plants have been calculated since these parameters are of vital importance in mitigation of the coastal hazard, evacuation planning and installation of early warning system in order to save the inhabited communities from the disaster.
An Evaluation of FaHRAS Computer Programmes’ Utility in Family History Triage of Breast Cancer  [PDF]
áine Gorman, Michael Sugrue, Zuhair Ahmed, Alison Johnston
Advances in Breast Cancer Research (ABCR) , 2014, DOI: 10.4236/abcr.2014.32004
Abstract:

Introduction: Rapid and appropriate family risk assessment and triage of patients are essential for patients presenting to a symptomatic breast unit and international criteria for review are well established. Family History Risk Assessment Software (FaHRAS) is a computerized program, involving different modalities of risk assessment, which is available but has not been widely assessed. Aims: This study evaluated the FaHRAS software scoring of family history risk. Its analysis was compared to multi-tool family history risk assessment models in a cohort of 353 patients on a historic family history waiting list. Methods: A recent published pilot study assessed and categorized family history risk in 353 patients on a historic family history waiting list, according to international guidelines including NICE criteria, Gail and IBIS risk estimates. The current study involved a reassessment of all 353 patients using the FaHRAS software program to determine its accuracy and ease of use. Patient demographics and time required to perform the analysis were documented. Results: FaHRAS identified 73 (20.7%) patients had an IBIS family history score of 17% or greater and 89 (25.2%) patients met the NICE guidelines criteria for management beyond primary care. In the previous study, this was 79 (22.4%) and 112 (31.7%) respectively. Using the largest denominator (NICE guidelines), 264/353 (74.8%) patients could be discharged to primary care using FaHRAS. Using this largest denominator, FaHRAS also identified a total of 28 (7.9%) patients requiring referral to tertiary care while the previous study identified 3 (0.8%). Conclusion: This is one of the first studies to validate FaHRAS, which is accurate and easy to use. FaHRAS system can enable clinicians to become more efficient gatekeepers to genetic services.

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