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Search Results: 1 - 10 of 2991 matches for " Zu?iga Dedorite "
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Dise o de una formulación de fenilefrina 10 % y tropicamida 1 % colirio: eyedrops Design of a 10 % Phenylephrine and 1 % Tropicamide formula
Georgy Armando Zuiga Dedorite,Caridad Margarita García Pe?a,Martha Botet García,Yenilen Troche Concepción
Revista Cubana de Farmacia , 2010,
Abstract: El colirio de fenilefrina 10 % y tropicamida 1 % se emplea en la práctica médica como antihistamínico, analgésico, midriáticos y ciclopléjico. El objetivo del presente trabajo consistió en desarrollar una formulación de fenilefrina 10 % y tropicamida 1 % que cumpliera con las especificaciones de calidad establecidas por el fabricante, que fuera estable física, química y microbiológicamente, para lo cual se realizó un dise o y los estudios de preformulación. Se estudió además, las especificaciones de calidad de la formulación seleccionada, la estabilidad del producto y el tiempo de vigencia de este. Se desarrolló y validó un método analítico para el control de la calidad y el estudio de estabilidad del producto terminado por cromatografía líquida de alta resolución. Se realizaron los resultados analíticos del estudio de estabilidad acelerado y por vida de estante, para lo cual se emplearon 3 lotes del producto a escala piloto. El colirio resultó estable física, química y microbiológicamente envasado en frascos de polietileno de baja densidad, por un tiempo de 12 meses almacenados a temperatura ambiente. The 10 % Phenylephrine and 1 % Tropicamide eyedrops is used in medical practice as antihistaminic, analgesic, mydiatric and cycloplegic. The aim of present paper was to develop a 10% Phenylephrine and 1 % Tropicamide formula fulfilling the quality specifications established by manufacturer physically, chemically and microbiologically stable with the performing of a design and pre-formula studies. Also, we studied the quality specifications of selected formula, the product stability and its expiry time. An analytical method was developed and validated to quality control and stability study of the finished product by high-performance liquid chromatography. Analytical results of accelerated stability study and by shelf life using 3 batches of product at pilot scale. Eyedrops was physically, chemically and microbiologically stable when it was bottling in low density polyethylene flasks during 12 months of storage at room temperature.
Dise?o de una formulación de fenilefrina 10 % y tropicamida 1 % colirio: eyedrops
Zuiga Dedorite,Georgy Armando; García Pe?a,Caridad Margarita; Botet García,Martha; Troche Concepción,Yenilen; Montes de Oca Porto,Yanet; Baró Román,Gerardo;
Revista Cubana de Farmacia , 2010,
Abstract: the 10 % phenylephrine and 1 % tropicamide eyedrops is used in medical practice as antihistaminic, analgesic, mydiatric and cycloplegic. the aim of present paper was to develop a 10% phenylephrine and 1 % tropicamide formula fulfilling the quality specifications established by manufacturer physically, chemically and microbiologically stable with the performing of a design and pre-formula studies. also, we studied the quality specifications of selected formula, the product stability and its expiry time. an analytical method was developed and validated to quality control and stability study of the finished product by high-performance liquid chromatography. analytical results of accelerated stability study and by shelf life using 3 batches of product at pilot scale. eyedrops was physically, chemically and microbiologically stable when it was bottling in low density polyethylene flasks during 12 months of storage at room temperature.
El cálculo en carreras de ingeniería: un estudio cognitivo
Zuiga, Leopoldo;
Revista latinoamericana de investigación en matemática educativa , 2007,
Abstract: this paper reports a cognitive study of a qualitative character in relation to the learning of the two variable functions and partial derivative concepts in the engineering context. it defends the fact that didactic settings in context can be conducive to a logical meaningful learning for the student with sense in the future professional area. this motivated us to research what happened at cognitive levels for students in this type of didactic environment. the theoretical framework is described by the study of cognitive functioning in a mental act of learning (the process of resolving problem). the analysis reports the experience which results in the implementation of didactic setting designs with one group of engineering students.
Estimando un Modelo de 2 Factores del Tipo
Sergio Zu?±iga
Revista de Análisis Económico (RAE) , 1999,
Abstract: In this article we estimate a two-factor model for the risk-free term structure yield in Chile. These factors are the short rate and the central tendency that are not directly estimable. Both factors follow an Ito stochastic process. In the solution of the model we follow the Balduzzi et al. (1996) specification, which provides an estimation procedure that do not depend on the parametric specification of the second factor and an "exponential affine" solution type that allows to estimate the model by mean of only one equation. The data used in this study is the average weekly yields of the bonds "Bonos de Reconocimiento" (BR) of the Chilean stock exchange during May 1993 and December 1997. The results show that when we use a stochastic level for the long term rates the yields adjust better than the case when this level is constant. Also, the speed of the reversion process increases due to the better performance of the short term rate. In addition, using an ARCH specification for the rate volatility we found additional evidence that the variance of the rates. In this article we estimate a two-factor model for the risk-free term structure yield in Chile. These factors are the short rate and the central tendency that are not directly estimable. Both factors follow an Ito stochastic process. In the solution of the model we follow the Balduzzi et al. (1996) specification, which provides an estimation procedure that do not depend on the parametric specification of the second factor and an "exponential affine" solution type that allows to estimate the model by mean of only one equation. The data used in this study is the average weekly yields of the bonds "Bonos de Reconocimiento" (BR) of the Chilean stock exchange during May 1993 and December 1997. The results show that when we use a stochastic level for the long term rates the yields adjust better than the case when this level is constant. Also, the speed of the reversion process increases due to the better performance of the short term rate. In addition, using an ARCH specification for the rate volatility we found additional evidence that the variance of the rates.
El síndrome judicial
Francisco Ciofalo Zuiga
Medicina Legal de Costa Rica , 2000,
Abstract:
JUVENTUD, CRIMEN Y MUERTE: EL NAUFRAGIO DE LOS JOVENES OLVIDADOS
Enrique Zuiga
Archivos de Criminología, Criminalística y Seguridad Privada , 2011,
Abstract:
Conductance in diffusive quasi-one-dimensional periodic waveguides: a semiclassical and random matrix study
Jaime Zuiga Vukusich
Physics , 2012,
Abstract: We study quantum transport properties of finite periodic quasi-one-dimensional waveguides whose classical dynamics is diffusive. The system we consider is a scattering configuration, composed of a finite periodic chain of $L$ identical (classically chaotic and finite-horizon) unit cells, which is connected to semi-infinite plane leads at its extremes. Particles inside the cavity are free and only interact with the boundaries through elastic collisions; this means waves are described by the Helmholtz equation with Dirichlet boundary conditions on the waveguide walls. The equivalent to the disorder ensemble is an energy ensemble, defined over a classically small range but many mean level spacings wide. The number of propagative channels in the leads is $N$. We have studied the (adimensional) Landauer conductance $g$ as a function of $L$ and $N$ in the cosine-shaped waveguide and by means of our RMT periodic chain model. We have found that $$ exhibit two regimes. First, for chains of length $L\lesssim\sqrt{N}$ the dynamics is diffusive just like in the disordered wire in the metallic regime, where the typic ohmic scaling is observed with $ = N/(L+1)$. In this regime, the conductance distribution is a Gaussian with small variance but which grows linearly with $L$. Then, in longer systems with $L\gg\sqrt{N}$, the periodic nature becomes relevant and the conductance reaches a constant asymptotic value $ \sim $. The variance approaches a constant value $\sim\sqrt{N}$ as $L\to\infty$. Comparing the conductance using the unitary and orthogonal circular ensembles we observed that a weak localization effect is present in the two regimes.
Epidemiological changes and financial consequences of hypertension in Latin America: implications for the health system and patients in Mexico
Arredondo, Armando;Zuiga, Alexis;
Cadernos de Saúde Pública , 2012, DOI: 10.1590/S0102-311X2012000300010
Abstract: the aim of this study was to assess the costs and financial consequences of epidemiological changes in hypertension in méxico. the cost evaluation method to estimate costs was based on instrumentation techniques. to estimate the epidemiological changes and expected cases of hypertension in 2010-2012, three probabilistic models were constructed according to the box-jenkins technique. comparing the economic impact, from 2010 to 2012 there will be a 24% increase in financial requirements (p < 0.05). the total cost of hypertension in 2011 will be us$ 5,733,350,291, including us$ 2,718,280,941 in direct costs and us$ 3,015,069,350 in indirect costs. if the risk factors and various healthcare models remain unaltered in the institutions analyzed here, the financial consequences will have a major impact on users' pockets, followed by social security providers and public healthcare providers. the authors suggest a revision in the planning, organization, and allocation of resources, particularly programs for health promotion and prevention of hypertension.
LAS CONCEPCIONES DE LA NATURALEZA DE DARWIN Y GOETHE, DISCUTIDAS POR TRES FILóSOFOS ALEMANES (NIETZSCHE, CASSIRER Y SIMMEL)
Zuiga Rengifo Nestor Javier
Acta Biológica Colombiana , 2009,
Abstract: RESUMEN En este artículo se presentan las semejanzas y diferencias entre las concepciones de la naturaleza de Darwin y Goethe, discutidas por tres filósofos Alemanes: Friedrich Nietzsche, Ernst Cassirer y Georg Simmel. La discusión se centra principalmente en reconocer el método histórico del cambio caprichoso funcional por parte de los tres filósofos como un principio estructuralista de la metodología histórica y las diferencias sobre los enfoques explicativos, El goethiano morfológico y el darwiniano funcionalista. Nietzsche y Cassirer integran en sus filosofías aspectos de la teoría morfológica goethiana, y aunque reconocen en la teoría de Darwin la importancia de la explicación histórica, rechazan lo que ellos consideran la permanencia de la explicación teleológica en la teoría de Darwin. Simmel establece una relación entre las concepciones de Goethe y Darwin por medio del concepto de acción. Palabras clave: Descendencia con modificación, Metamorfosis, Cambio caprichoso funcional, Filosofía alemana, Acción ABSTRACT The conceptions of the nature of Darwin and Goethe, discussed by three German philosophers (Nietzsche, Simmel and Cassirer)
Desarrollo y validación de un método analítico para el control de calidad y estabilidad de fenilefrina 10 % colirio y tropicamida 1 % Development and validation of an analytical method for quality control and the stability of the eyedrops 10 % Phenylephrine and the 1 % Tropicamide
Caridad Margarita García Pe?a,Martha Botet García,Yenilen Troche Concepción,Georgy Zú?iga Dedorite
Revista Cubana de Farmacia , 2011,
Abstract: Se desarrolló y validó un método analítico por cromatografía líquida de alta resolución, aplicable al control de la calidad y el estudio de estabilidad de fenilefrina 10 % más tropicamida 1 %, colirio. Para cuantificar simultáneamente los 2 principios activos en el producto terminado, la separación se realizó a través de una columna cromatográfica Lichrosorb RP-18 (5 μm) (250 x 4 mm), con detección ultravioleta a 253 nm, empleando una fase móvil compuesta por metanol:agua destilada (1:1), con 1,1 g de 1-octanosulfonato de sodio por litro ajustado pH a 3,0 con ácido fosfórico y la cuantificación de este frente a una muestra de referencia con el método del estándar externo. El método analítico desarrollado resultó lineal, preciso, específico y exacto en el rango de concentraciones estudiadas, el cual se estableció para el control de la calidad y el estudio de estabilidad del producto terminado ya que no existían métodos analíticos reportados para estos fines. An analytical high-performance liquid chromatography method was developed and validated applicable to quality control and to stability study of 10 % phenylephrine plus eyedrops 1 % tropicamide. To quantify simultaneously both active principles in the finished product, separation was carried out through a Lichrosorb RP-18 (15 μm) (260 x 4 mm) column chromatography, with ultraviolet detection at 253 nm using the mobile phase composed of methanol: distilled water (1:1), with 1.1 g of sodium 1-octasulfanate by litre and pH fitted to 3.0 with phosphoric acid and the quantification of this front to a reference sample using the external standard method. The analytical method developed was linear, precise, specific and accurate in the rank of study concentrations, established for the quality control and stability study of the finished product since there were not analytical methods designed for these aims.
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