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Search Results: 1 - 10 of 2924 matches for " Zong Yijia "
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Research on Supply Side Structural Reform in China from the Perspective of Multiple Streams Theory  [PDF]
Yijia Guo, Tianxue Li
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.612010
Abstract: From the perspective of multi-source flow theory, this paper explores the process of setting up the policy agenda for China’s supply-side structural reform. It began discussions by combining social issues such as the decline in economic indicators and the decline of the energy industry with changes in the political environment jumping out of the traditional perspective of a single economic analysis. At the same time, this article focuses on the role of the supply school in policy advice. From the three aspects of issues, policies, and politics, it explores the opening of the policy window.
Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells
Chuang Dennis Y,Chan Ming-Huan,Zong Yijia,Sheng Wenwen
Journal of Neuroinflammation , 2013, DOI: 10.1186/1742-2094-10-15
Abstract: Background The bark of magnolia has been used in Oriental medicine to treat a variety of remedies, including some neurological disorders. Magnolol (Mag) and honokiol (Hon) are isomers of polyphenolic compounds from the bark of Magnolia officinalis, and have been identified as major active components exhibiting anti-oxidative, anti-inflammatory, and neuroprotective effects. In this study, we investigate the ability of these isomers to suppress oxidative stress in neurons stimulated by the ionotropic glutamate receptor agonist N-methyl-D-aspartate (NMDA) and oxidative and inflammatory responses in microglial cells activated by interferon-γ (IFNγ) and lipopolysaccharide (LPS). We also attempt to elucidate the mechanism and signaling pathways involved in cytokine-induced production of reactive oxygen species (ROS) in microglial cells. Methods Dihydroethidium (DHE) was used to assay superoxide production in neurons, while CM-H2DCF-DA was used to test for ROS production in murine (BV-2) and rat (HAPI) immortalized microglial cells. NADPH oxidase inhibitors (for example, diphenyleneiodonium (DPI), AEBSF, and apocynin) and immunocytochemistry targeting p47phox and gp91phox were used to assess the involvement of NADPH oxidase. Western blotting was used to assess iNOS and ERK1/2 expression, and the Griess reaction protocol was employed to determine nitric oxide (NO) concentration. Results Exposure of Hon and Mag (1–10 μM) to neurons for 24 h did not alter neuronal viability, but both compounds (10 μM) inhibited NMDA-stimulated superoxide production, a pathway known to involve NADPH oxidase. In microglial cells, Hon and Mag inhibited IFNγ±LPS-induced iNOS expression, NO, and ROS production. Studies with inhibitors and immunocytochemical assay further demonstrated the important role of IFNγ activating the NADPH oxidase through the p-ERK-dependent pathway. Hon and, to a lesser extent, Mag inhibited IFNγ-induced p-ERK1/2 and its downstream pathway for ROS and NO production. Conclusion This study highlights the important role of NADPH oxidase in mediating oxidative stress in neurons and microglial cells and has unveiled the role of IFNγ in stimulating the MAPK/ERK1/2 signaling pathway for activation of NADPH oxidase in microglial cells. Hon and Mag offer anti-oxidative or anti-inflammatory effects, at least in part, through suppressing IFNγ-induced p-ERK1/2 and its downstream pathway.
An Alternative Explanation of Supernova Ia Data
Yijia Zheng
Physics , 2013,
Abstract: Before 1998 the universe expansion was thought to be slowing down. After 1998 the universe expansion is thought to be accelerating up. This change of the belief is motivated by the observed brightness of the high redshift supernova Ia fainter than expected. In this paper it is argued that this change of the belief is not necessary. There is a more reasonable explanation for the observed brightness of the supernovae Ia fainter than expected. That is: the universe space filled with the tenuous ionized gas; the Thomson Effect of free electron in the ionized gas caused the observed brightness of the high redshift supernova Ia fainter than expected. The observations of Warm-Hot Intergalactic Medium (WHIM) support this explanation. The universe space filled with tenuous ionized gas explanation will lead to the puzzle of the dark matter and dark energy disappeared simultaneously
The Propagation of Photons in the Dilute Ionized Gas
Yijia Zheng
Physics , 2013,
Abstract: The dilute ionized gas is very popular in the Universe. Usually only the Compton interactions, the "Sunyaev-Zel'dovich" effect, were considered while photons propagated in this medium. In this paper the "soft-photon process" is considered. Due to the soft photons emitted during the propagation of a photon in the dilute ionized gas, the main photon (propagating in the original direction) will be redshifted. The formula to calculate this redshift is derived.
Research on Rural Land Right Confirmation from the Perspective of Campaign-Style Governance  [PDF]
Yijia Guo
Open Journal of Business and Management (OJBM) , 2019, DOI: 10.4236/ojbm.2019.73101
Abstract: This paper focuses on the implementation effect of the rural land right confirmation work carried out in China since 2013. It discusses the imbalance and good governance in the rural land right confirmation work through the review of this policy agenda. The author adopts the grounded theory research method based on interviews and literature research to find out the unbalanced points and interest conflicts of each subject in the policy agenda, focusing on Shanxi Province, which has a high proportion of traditional agriculture. This land right verification work has significant movement type governance characteristics, driven by the central, within five years to complete a nationwide land management work. Behind its high timeliness and predetermined target is a series of games from policy entrusting parties, intermediate contractors and grass-roots agents. The three forces interact and reconstruct. Task transmission becomes the main line of activities and task objectives are constantly overhead. The implementation of policy objectives is challenged. Based on this, this study proposes to improve the top-level design to avoid imbalance in sports governance. To achieve good governance through long-term planning. It provides reference for understanding the deficiency of the implementation of the policy agenda and the defect of the movement governance.
The Constant Inapproximability of the Parameterized Dominating Set Problem
Yijia Chen,Bingkai Lin
Computer Science , 2015,
Abstract: We prove that there is no fpt-algorithm that can approximate the dominating set problem with any constant ratio, unless FPT= W[1]. Our hardness reduction is built on the second author's recent W[1]-hardness proof of the biclique problem. This yields, among other things, a proof without the PCP machinery that the classical dominating set problem has no polynomial time constant approximation under the exponential time hypothesis.
The parameterized complexity of k-edge induced subgraphs
Bingkai Lin,Yijia Chen
Computer Science , 2011,
Abstract: We prove that finding a $k$-edge induced subgraph is fixed-parameter tractable, thereby answering an open problem of Leizhen Cai. Our algorithm is based on several combinatorial observations, Gauss' famous \emph{Eureka} theorem [Andrews, 86], and a generalization of the well-known fpt-algorithm for the model-checking problem for first-order logic on graphs with locally bounded tree-width due to Frick and Grohe [Frick and Grohe, 01]. On the other hand, we show that two natural counting versions of the problem are hard. Hence, the $k$-edge induced subgraph problem is one of the rare known examples in parameterized complexity that are easy for decision while hard for counting.
Analysis of Logistics Service Attributes Based on Quantitative Kano Model: A Case Study of Express Delivering Industries in China  [PDF]
Qingliang Meng, Nongji Zhou, Jian Tian, Yijia Chen, Fen Zhou
Journal of Service Science and Management (JSSM) , 2011, DOI: 10.4236/jssm.2011.41007
Abstract: Considering the non-linear relationship between product attributes and customer satisfaction, Kano’s model is widely used in the area of quality management and product innovation. In order to address the deficiencies of traditional Kano method in qualitative analysis and subjective classification criteria, a quantitative Kano model is set up. By the building of Kano Quantitative satisfaction index and importance index, an objective classification method and the decision- making rule to improve service quality are proposed. Then a well-established logistics service attributes analysis model based on quantitative Kano model has come up. The model is illustrated through a case study of express delivering in- dustries in China.
Research on Irradiation Electric Field for Charged Particles Beam with High Energy  [PDF]
Jianping Shi, Yijia Tang, Lingli Zhan, Hongjian Liu, Xunan Chen
Engineering (ENG) , 2011, DOI: 10.4236/eng.2011.31002
Abstract: Irradiation protection of the nonlinear optical devices used in the spacecraft and next generation active laser system must be solved. The first problem was to find the irradiation damage mechanism of the nonlinear materials. In this paper the irradiation electronic field originating from high speed charged particle beams was discussed. The calculating model of the electronic field, based on the relativistic mechanics and electro-magnetic theory, was founded. The common characters of the irradiation electronic field were predicted and the fields of α ray and β ray were calculated by means of our model. The simulating results showed that the intensity of the electric field increased with the energy or the intensity of the beam. The results also showed that the field change trend of α ray and β ray was similar, but the field value was quite different. When the beam intensity I = 100 μA and the beam energy εm = 500 Mev, the electronic field values were about 3.5 × 107 v/m for α ray and 2.4 × 1011 v/m for β ray.
Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in astrocytes and microglia
Wenwen Sheng, Yijia Zong, Arwa Mohammad, Deepa Ajit, Jiankun Cui, Dongdong Han, Jennifer L Hamilton, Agnes Simonyi, Albert Y Sun, Zezong Gu, Jau-Shyong Hong, Gary A Weisman, Grace Y Sun
Journal of Neuroinflammation , 2011, DOI: 10.1186/1742-2094-8-121
Abstract: Cytokines (TNF-alpha, IL-1beta, and IFN-gamma) and LPS + IFN-gamma induced a time-dependent increase in fine processes (filopodia) in microglial cells but not in astrocytes. Filopodia production was attributed to IFN-gamma and was dependent on ERK1/2 activation. Cytokines induced an early (15 min) and a delayed phase (1 ~ 4 h) increase in p-ERK1/2 expression in microglial cells, and the delayed phase increase corresponded to the increase in filopodia production. In general, microglial cells are more active in responding to cytokines and LPS than astrocytes in the induction of NO. Although IFN-gamma and LPS could individually induce NO, additive production was observed when IFN-gamma was added together with LPS. On the other hand, while TNF-alpha, IL-1beta, and LPS could individually induce sPLA2-IIA mRNA and protein expression, this induction process does not require IFN-gamma. Interestingly, neither rat immortalized nor primary microglial cells were capable of responding to cytokines and LPS in the induction of sPLA2-IIA expression.These results demonstrated the utility of BV-2 and HAPI cells as models for investigation on cytokine and LPS induction of iNOS, and DITNC astrocytes for induction of sPLA2-IIA. In addition, results further demonstrated that cytokine-induced sPLA2-IIA is attributed mainly to astrocytes and not microglial cells.Activation of glial cells, including astrocytes and microglial cells, has been implicated in the inflammatory responses in brain injury and in neurological diseases such as Alzheimer's disease, Parkinson's disease and stroke [1-5]. Astrocytes and microglia are two distinct types of glial cells in the central nervous system. Despite obvious differences in morphology and functional properties, they are regarded as immune active cells and in some instances, they share common innate immune responses. For example, both astrocytes and microglial cells have been shown to respond to pro-inflammatory cytokines and lipopolysaccharide (LPS) i
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