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Search Results: 1 - 10 of 320973 matches for " Zoltán Bálint Geocze "
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Níveis diferenciados de governan a corporativa e o efeito sobre o risco de suas a es
Zoltán Bálint Geocze
Revista de Finan?as Aplicadas , 2010,
Abstract: O artigo responde se a ado o de níveis diferenciados de corporativa por parte das empresas brasileiras é um fator que as torna op es de investimento de menor risco. Para tal, s o comparadas as volatilidades do IGC e de outros índices de a es no Brasil, entre janeiro de 2005 e agosto de 2008. Conclui-se que a volatilidade média diária do IGC foi inferior se comparada com os outros índices estudados.
HAGYMáSSY Zoltán,SüLE Bálint Péter
Debreceni M?szaki K?zlemények , 2011,
Abstract: Fotovoltaic energy as an alternative source, usually appears against grid connected systems. However solar pumps could service in irrigated rural areas too, where hard to find grid plugs, thus farmers have to use gas or diesel powered pumps which is more expensive than grid energy.Use of solar pumps in sunny coutryes is increasing. This areas could use the pumps all the year, hence they could achieve 2 year payback. for example: USA – California, Chile, African States, India. In Hungary we could use solar pumps only half of the year, but its payback time could be thought-provoking. Int he view of environment the apply of the solar pumps could decrease the harmful emissions. In this article we have calculated payback times under various conditios. As well as the yearly solar panel work for the year 2010.
Comparative In Vivo Analysis of Recombinant Type II Feline Coronaviruses with Truncated and Completed ORF3 Region
ádám Bálint, Attila Farsang, Zoltán Zádori, Sándor Belák
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088758
Abstract: Our previous in vitro comparative study on a feline coronavirus (FCoV) pair, differing only in the intactness of their ORF3abc regions, showed that the truncated ORF3abc plays an important role in the efficient macrophage/monocyte tropism of type II feline infectious peritonitis virus (FIPV). In the present study, we describe a challenge experiment with the same recombinant FCoVs in order to gain data on the in vivo characteristics on these viruses. While parent virus FIPV DF-2 developed feline infectious peritonitis in all the infected cats, its recombinant virus PBFIPV-DF-2, differing only in seven nucleotides, proved to be surprisingly low virulent, although caused an acute febrile episode similarly to the original FIPV DF-2. PBFIPV-DF-2 infection induced significantly lower virus neutralization titers than its parent virus, and lacked the second phase of viremia and development of fatal course of the disease. The recombinant PBFIPV-DF-2-R3i with completed ORF3abc gained biological properties that differentiate between the feline enteric coronavirus (FECV) and FIPV biotypes such as intensive replication in the gut, absence of viremia and weak or no serological response. Using reverse genetic approaches our study is the first experimental proof that ORF3abc is indeed responsible for the restriction of FECV replication to the intestine in vivo.
What Is the Personal Experience of IBD Patients about Their Anti-TNF-Alpha Therapy?  [PDF]
ágnes Milassin, Mariann Rutka, ágnes Anna Csontos, Pál Miheller, Károly Palatka, Mónika Sz?cs, Zoltán Szepes, Anita Bálint, Renáta Bor, Anna Fábián, Klaudia Farkas, Ferenc Nagy, Tamás Molnár
Health (Health) , 2017, DOI: 10.4236/health.2017.97073
AIM: To evaluate and compare the patients opinion on the two types of anti- TNF-α therapies in a Hungarian cohort of IBD patients. METHODS: This was a prospective, multicentre, questionnaire-based observational study carried out in three Hungarian tertiary centres. From April to September 2014, an anonymous questionnaire was distributed to patients diagnosed with ulcerative colitis (UC) or Crohn’s disease (CD), who have received infliximab (IFX) and/or adalimumab (ADA). The survey focused on the preferences of the two anti-TNF-α therapies on the basis of the efficacy, the administration routes and the side effects. RESULTS: 292 IBD patients, 216 CD, 75 UC and 1 indeterminate colitis patient completed the questionnaire. The mean duration of biological therapy was 1.7 (1 - 7) years. IFX treated patients noticed improvement of symptoms at 4 - 5 weeks while ADA treated patients noticed at 5 - 6 weeks. There was no difference between the patients’ satisfaction regarding the types of anti-TNF-α therapy if they received both. However, subcutaneous administration was preferred by ADA-treated patients previously receiving IFX (p = 0.007) compared to intravenous route and they did not intend to change the mode of therapy (p = 0.040). 90% of the patients, receiving only IFX or ADA were satisfied with their present therapy. The majority of patients (186/292, 63.7%) would not switch therapy. 63 of 291, 22% of the patients reported to have some concern with biological therapy—the majority (32/63, 50.8%) due to fear from side effects. CONCLUSION: Generally, patients preferred and would not change the present anti-TNF-α therapy, however, subcutaneous administration was preferred among those patients who had have experience with both.
Cystic Dilation of the Aqueductus Sylvii in Case of Trisomy 17p11.2—pter with the Deletion of the Terminal Portion of the Chromosome 6
Emese Horváth,János Sikovanyecz,Attila Pál,László Kaiser,Bálint L. Bálint,Póliska Szilárd,Zoltán Kozinszky,János Szabó
Case Reports in Medicine , 2010, DOI: 10.1155/2010/354170
Abstract: Since the 1970s, about 30 cases of partial or complete trisomy 17p have been presented in the literature. Partial trisomies of the short arm of chromosome 17 are somewhat more common, but complete trisomy is quite rare. Most of these cases were described in infants and newborns; and to our knowledge only 3 cases of trisomy 17p have been detected intrauterine. Phenotypic features of trisomy 17p in fetuses are intrauterine growth retardation, ventriculomegaly, cleft lip and cleft palate, micrognathia, horseshoe kidneys, single umbilical artery, and congenital heart defects. The sonographic and foetopathologic findings of a pregnancy trisomy 17p11.2—pter with the deletion of the terminal portion of the chromosome 6 due to paternal balanced translocation are described in this case report.
Quantification of Tortuosity and Fractal Dimension of the Lung Vessels in Pulmonary Hypertension Patients
Michael Helmberger, Michael Pienn, Martin Urschler, Peter Kullnig, Rudolf Stollberger, Gabor Kovacs, Andrea Olschewski, Horst Olschewski, Zoltán Bálint
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087515
Abstract: Pulmonary hypertension (PH) can result in vascular pruning and increased tortuosity of the blood vessels. In this study we examined whether automatic extraction of lung vessels from contrast-enhanced thoracic computed tomography (CT) scans and calculation of tortuosity as well as 3D fractal dimension of the segmented lung vessels results in measures associated with PH. In this pilot study, 24 patients (18 with and 6 without PH) were examined with thorax CT following their diagnostic or follow-up right-sided heart catheterisation (RHC). Images of the whole thorax were acquired with a 128-slice dual-energy CT scanner. After lung identification, a vessel enhancement filter was used to estimate the lung vessel centerlines. From these, the vascular trees were generated. For each vessel segment the tortuosity was calculated using distance metric. Fractal dimension was computed using 3D box counting. Hemodynamic data from RHC was used for correlation analysis. Distance metric, the readout of vessel tortuosity, correlated with mean pulmonary arterial pressure (Spearman correlation coefficient: ρ = 0.60) and other relevant parameters, like pulmonary vascular resistance (ρ = 0.59), arterio-venous difference in oxygen (ρ = 0.54), arterial (ρ = ?0.54) and venous oxygen saturation (ρ = ?0.68). Moreover, distance metric increased with increase of WHO functional class. In contrast, 3D fractal dimension was only significantly correlated with arterial oxygen saturation (ρ = 0.47). Automatic detection of the lung vascular tree can provide clinically relevant measures of blood vessel morphology. Non-invasive quantification of pulmonary vessel tortuosity may provide a tool to evaluate the severity of pulmonary hypertension. Trial Registration ClinicalTrials.gov NCT01607489
Parallel Evolution under Chemotherapy Pressure in 29 Breast Cancer Cell Lines Results in Dissimilar Mechanisms of Resistance
Bálint Tegze, Zoltán Szállási, Irén Haltrich, Zsófia Pénzváltó, Zsuzsa Tóth, István Likó, Balázs Gy?rffy
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030804
Abstract: Background Developing chemotherapy resistant cell lines can help to identify markers of resistance. Instead of using a panel of highly heterogeneous cell lines, we assumed that truly robust and convergent pattern of resistance can be identified in multiple parallel engineered derivatives of only a few parental cell lines. Methods Parallel cell populations were initiated for two breast cancer cell lines (MDA-MB-231 and MCF-7) and these were treated independently for 18 months with doxorubicin or paclitaxel. IC50 values against 4 chemotherapy agents were determined to measure cross-resistance. Chromosomal instability and karyotypic changes were determined by cytogenetics. TaqMan RT-PCR measurements were performed for resistance-candidate genes. Pgp activity was measured by FACS. Results All together 16 doxorubicin- and 13 paclitaxel-treated cell lines were developed showing 2–46 fold and 3–28 fold increase in resistance, respectively. The RT-PCR and FACS analyses confirmed changes in tubulin isofom composition, TOP2A and MVP expression and activity of transport pumps (ABCB1, ABCG2). Cytogenetics showed less chromosomes but more structural aberrations in the resistant cells. Conclusion We surpassed previous studies by parallel developing a massive number of cell lines to investigate chemoresistance. While the heterogeneity caused evolution of multiple resistant clones with different resistance characteristics, the activation of only a few mechanisms were sufficient in one cell line to achieve resistance.
Relationship of circulating cell-free DNA levels to cell-free fetal DNA levels, clinical characteristics and laboratory parameters in preeclampsia
Levente Lazar, János Rigó, Bálint Nagy, Krisztián Balogh, Veronika Makó, László Cervenak, Miklós Mézes, Zoltán Prohászka, Attila Molvarec
BMC Medical Genetics , 2009, DOI: 10.1186/1471-2350-10-120
Abstract: Circulating total cell-free DNA was measured by real-time quantitative PCR in plasma samples obtained from 67 preeclamptic and 70 normotensive pregnant women. Standard laboratory parameters, C-reactive protein, plasma von Willebrand factor antigen, plasma fibronectin, plasma malondialdehyde and cell-free fetal DNA levels were also determined.Circulating total cell-free and fetal deoxyribonucleic acid levels were significantly elevated in pregnancies complicated by preeclampsia (median: 11.395 vs. 32.460 and 0.001 vs. 0.086 pg/μl; P < .001). The quantity of plasma total cell-free DNA did not correlate with most of the laboratory parameters, except for serum aspartate aminotransferase and alanine aminotransferase activities (correlation coefficient: 0.31; P = 0.012 and 0.46; P < .001). There was no correlation with clinical characteristics, including body mass index. The releases of both free fetal and total cell-free deoxyribonucleic acid were found to be affected in preeclampsia. Hepatocellular necrosis seems to be responsible - at least partly - for increased circulating total DNA levels in preeclampsia, as suggested by the significant correlation with liver enzyme activities.Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality in the developed world [1,2]. It is characterized by hypertension and proteinuria developing after midgestation in previously normotensive pregnant women. Although the exact etiology of preeclampsia remains elusive [2], there appears to be a defect in trophoblast invasion with diminished infiltration and modification of the spiral arteries leading to impaired placentation and subsequent uteroplacental insufficiency [3]. The ischemic and oxidatively stressed placenta releases proinflammatory (Th1) cytokines, lipid peroxidation products and trophoblast debris (syntitiotrophoblast microfragments, cytokeratin, soluble DNA and RNA of fetal origin and even trophoblast cells) into the maternal circulation, whi
CpG Distribution and Methylation Pattern in Porcine Parvovirus
Renáta Tóth, István Mészáros, Rajmund Stefancsik, Dániel Bartha, ádám Bálint, Zoltán Zádori
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0085986
Abstract: Based on GC content and the observed/expected CpG ratio (oCpGr), we found three major groups among the members of subfamily Parvovirinae: Group I parvoviruses with low GC content and low oCpGr values, Group II with low GC content and high oCpGr values and Group III with high GC content and high oCpGr values. Porcine parvovirus belongs to Group I and it features an ascendant CpG distribution by position in its coding regions similarly to the majority of the parvoviruses. The entire PPV genome remains hypomethylated during the viral lifecycle independently from the tissue of origin. In vitro CpG methylation of the genome has a modest inhibitory effect on PPV replication. The in vitro hypermethylation disappears from the replicating PPV genome suggesting that beside the maintenance DNMT1 the de novo DNMT3a and DNMT3b DNA methyltransferases can’t methylate replicating PPV DNA effectively either, despite that the PPV infection does not seem to influence the expression, translation or localization of the DNA methylases. SNP analysis revealed high mutability of the CpG sites in the PPV genome, while introduction of 29 extra CpG sites into the genome has no significant biological effects on PPV replication in vitro. These experiments raise the possibility that beyond natural selection mutational pressure may also significantly contribute to the low level of the CpG sites in the PPV genome.
Effect of Antimicrobial Peptide-Amide: Indolicidin on Biological Membranes
Attila Gergely Végh,Krisztina Nagy,Zoltán Bálint,ádám Kerényi,Gábor Rákhely,Gy rgy Váró,Zsolt Szegletes
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/670589
Abstract: Indolicidin, a cationic antimicrobial tridecapeptide amide, is rich in proline and tryptophan residues. Its biological activity is intensively studied, but the details how indolicidin interacts with membranes are not fully understood yet. We report here an in situ atomic force microscopic study describing the effect of indolicidin on an artificial supported planar bilayer membrane of dipalmitoyl phosphatidylcholine (DPPC) and on purple membrane of Halobacterium salinarum. Concentration dependent interaction of the peptide and membranes was found in case of DPPC resulting the destruction of the membrane. Purple membrane was much more resistant against indolicidin, probably due to its high protein content. Indolicidin preferred the border of membrane disks, where the lipids are more accessible. These data suggest that the atomic force microscope is a powerful tool in the study of indolicidin-membrane interaction.
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