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Search Results: 1 - 9 of 9 matches for " Zolinda Stoneman "
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Correlates of Family Routines in Head Start Families
Susan L. Churchill,Zolinda Stoneman
Early Childhood Research & Practice , 2004,
Abstract: The popular parenting literature places great importance on the role of routines in children's lives. Empirical research on family routines, however, is limited. This study examined correlates of family routines in a Head Start population in order to better understand their significance in the lives of families. Weak correlations were found between family demographic characteristics and the number of established routines in the home. No correlations were found between family routines and teacher and observer ratings of child outcomes and standardized test scores for the full sample. Mothers' reports of their depression levels and their children's behavior problems were correlated with the number of routines in the home. Interesting sex differences emerged, in that teachers' and observers' ratings of girls' outcomes and mothers' ratings of girls' behavior were related to the number of family routines, but boys' behavior was not.
The industrialisation of Zimbabwe: past, present and future
C. Stoneman
Afrika Focus , 1990,
Abstract: In this paper I look at Zimbabwe's moderately successful industrialisation experience, past, present and future. The lessons that can be drawn from this experience in comparison with what has happened in other countries, both more and less succesful, are: that there is a need for an intelligent state role; that both import substitution and export substitution are necessary; that emphasis on industry need not and must not be mean neglect of agriculture; and that the key problem is how to avoid enclave industrialisation which services urban elites but neglects the rest of the country and the region.
Jane Eyre between the Wars Jane Eyre entre les deux guerres
Patsy Stoneman
Revue LISA / LISA e-journal , 2009, DOI: 10.4000/lisa.843
Abstract: L’un des héritages que Charlotte Bront laissa derrière elle avec son roman Jane Eyre, c’est une trame qui fut indéfiniment recyclée dans le roman féminin. Une femme jeune, isolée et désargentée rencontre un homme plus riche et plus agé qu’elle, au tempérament morose et au passé mystérieux dans lequel se trouve une épouse démente et mauvaise. Dans le monde de Charlotte Bront , la société offre peu d’alternatives au mariage pour une femme qui ne peut compter que sur elle-même pour subvenir à ses besoins, et même le dénouement tranché de Jane Eyre n’est qu’une version plus égalitaire du mariage traditionnel. Sa structure triangulaire, toutefois, s’est avérée fertile pour les écrivains qui examinèrent les relations hommes/femmes dans des époques sociales ultérieures. Dans l’Angleterre d’entre-deux-guerres, les femmes de la classe moyenne étaient, comme le formule Virginia Woolf, on the bridge entre la maison privée et le monde professionnel. La plupart des obstacles légaux qui leur barraient l’accès à l’instruction et à l’emploi disparaissaient, mais l’éthos de la domesticité imprimait encore sa marque sur les attentes émotionnelles des femmes. Dans cet article, j’examine quatre romans qui utilisent l’intrigue de Jane Eyre afin de tracer les contours des possibilités qui s’offraient aux femmes à cette époque. Il s’agit de Vera d’Elizabeth von Arnim (1921), The Weather in the Streets de Rosamond Lehmann (1936), South Riding de Winifred Holtby (1936) et Rebecca de Daphne du Maurier (1938). La distinction que Tania Modleski dresse entre la romance (‘romance’) – dans laquelle la peur ou le dégo t initial de l’héro ne pour le héros se transforme en amour – et le gothique (‘gothic’) – où le processus est inverse – souligne que ces romans modernes ne peuvent envisager autre chose qu’un dénouement gothique à une situation à l’origine romantique. Le seul de ces quatre romans à se terminer sur une note d’espoir est South Riding, dont la réponse passe par le sacrifice radical de l’amour.
Patient assessment of an electronic device for subcutaneous self-injection of interferon -1a for multiple sclerosis: an observational study in the UK and Ireland
D'Arcy C, Thomas D, Stoneman D, Parkes L
Patient Preference and Adherence , 2012, DOI: http://dx.doi.org/10.2147/PPA.S26250
Abstract: tient assessment of an electronic device for subcutaneous self-injection of interferon -1a for multiple sclerosis: an observational study in the UK and Ireland Original Research (2727) Total Article Views Authors: D'Arcy C, Thomas D, Stoneman D, Parkes L Published Date January 2012 Volume 2012:6 Pages 55 - 61 DOI: http://dx.doi.org/10.2147/PPA.S26250 Received: 17 September 2011 Accepted: 08 November 2011 Published: 18 January 2012 Caroline D’Arcy1, Del Thomas2, Dee Stoneman3, Laura Parkes3 1West London Neuroscience Centre, Charing Cross Hospital, London, UK; 2Wye Valley NHS Trust, Hereford, UK; 3Merck Serono Ltd, Feltham, Middlesex, UK Background: Injectable disease-modifying drugs (DMDs) reduce the number of relapses and delay disability progression in patients with relapsing–remitting multiple sclerosis (RRMS). Regular self-injection can be stressful and impeded by MS symptoms. Auto-injection devices can simplify self-injection, overcome injection-related issues, and increase treatment satisfaction. This study investigated patient responses to an electronic auto-injection device. Methods: Patients with RRMS (n = 63), aged 18–65 years, na ve to subcutaneous (sc) interferon (IFN) -1a therapy, were recruited to a Phase IV, observational, open-label, multicenter study (NCT01195870). Patients self-injected sc IFN -1a using the RebiSmart (Merck Serono S.A. – Geneva, Switzerland) electronic auto-injector for 12 weeks, including an initial titration period if recommended by the prescribing physician. In week 12, patients completed a questionnaire comprising of a visual analog scale (VAS) to rate how much they liked using the device, a four-point response question on ease of use (‘very difficult’, ‘difficult’, ‘easy’, or ‘very easy’), and a list of ten device functions to rank, based upon their experiences. Results: Six patients (9.5%) discontinued the study: one switched to manual injection; two discontinued all treatment; three changed therapy. In total, 59 out of 63 patients (93.7%) completed the VAS; 54 out of 59 (91.5%; 95% confidence interval: 81.3%–97.2%) ‘liked’ using the electronic auto-injector (score ≥6), whereas 57 out of 59 (96.6%) rated the device overall as ‘easy’ or ‘very easy’ to use. Device features rated as most useful were the hidden needle (mean [standard deviation] score: 3.3 [3.01]; n = 56), confirmation sound (3.9 [2.45]), and multidose cartridge (4.6 [2.32]). The least useful functions were the dose history list (8.0 [2.57]) and dose history calendar (7.5 [2.30]). Conclusions: These findings suggest that the electronic auto-injector may be suitable for patients who are new to injectable DMD therapy. Devices that simplify the injection process may help to ensure that patients receive the full benefits of treatment.
Patient assessment of an electronic device for subcutaneous self-injection of interferon ß-1a for multiple sclerosis: an observational study in the UK and Ireland
D'Arcy C,Thomas D,Stoneman D,Parkes L
Patient Preference and Adherence , 2012,
Abstract: Caroline D’Arcy1, Del Thomas2, Dee Stoneman3, Laura Parkes31West London Neuroscience Centre, Charing Cross Hospital, London, UK; 2Wye Valley NHS Trust, Hereford, UK; 3Merck Serono Ltd, Feltham, Middlesex, UKBackground: Injectable disease-modifying drugs (DMDs) reduce the number of relapses and delay disability progression in patients with relapsing–remitting multiple sclerosis (RRMS). Regular self-injection can be stressful and impeded by MS symptoms. Auto-injection devices can simplify self-injection, overcome injection-related issues, and increase treatment satisfaction. This study investigated patient responses to an electronic auto-injection device.Methods: Patients with RRMS (n = 63), aged 18–65 years, na ve to subcutaneous (sc) interferon (IFN) -1a therapy, were recruited to a Phase IV, observational, open-label, multicenter study (NCT01195870). Patients self-injected sc IFN -1a using the RebiSmart (Merck Serono S.A. – Geneva, Switzerland) electronic auto-injector for 12 weeks, including an initial titration period if recommended by the prescribing physician. In week 12, patients completed a questionnaire comprising of a visual analog scale (VAS) to rate how much they liked using the device, a four-point response question on ease of use (‘very difficult’, ‘difficult’, ‘easy’, or ‘very easy’), and a list of ten device functions to rank, based upon their experiences.Results: Six patients (9.5%) discontinued the study: one switched to manual injection; two discontinued all treatment; three changed therapy. In total, 59 out of 63 patients (93.7%) completed the VAS; 54 out of 59 (91.5%; 95% confidence interval: 81.3%–97.2%) ‘liked’ using the electronic auto-injector (score ≥6), whereas 57 out of 59 (96.6%) rated the device overall as ‘easy’ or ‘very easy’ to use. Device features rated as most useful were the hidden needle (mean [standard deviation] score: 3.3 [3.01]; n = 56), confirmation sound (3.9 [2.45]), and multidose cartridge (4.6 [2.32]). The least useful functions were the dose history list (8.0 [2.57]) and dose history calendar (7.5 [2.30]).Conclusions: These findings suggest that the electronic auto-injector may be suitable for patients who are new to injectable DMD therapy. Devices that simplify the injection process may help to ensure that patients receive the full benefits of treatment.Keywords: multiple sclerosis, interferon beta-1a, injection device, training, drug delivery
Incommensurable Worldviews? Is Public Use of Complementary and Alternative Medicines Incompatible with Support for Science and Conventional Medicine?
Paul Stoneman, Patrick Sturgis, Nick Allum, Elissa Sibley
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053174
Abstract: Proponents of controversial Complementary and Alternative Medicines, such as homeopathy, argue that these treatments can be used with great effect in addition to, and sometimes instead of, ‘conventional’ medicine. In doing so, they accept the idea that the scientific approach to the evaluation of treatment does not undermine use of and support for some of the more controversial CAM treatments. For those adhering to the scientific canon, however, such efficacy claims lack the requisite evidential basis from randomised controlled trials. It is not clear, however, whether such opposition characterises the views of the general public. In this paper we use data from the 2009 Wellcome Monitor survey to investigate public use of and beliefs about the efficacy of a prominent and controversial CAM within the United Kingdom, homeopathy. We proceed by using Latent Class Analysis to assess whether it is possible to identify a sub-group of the population who are at ease in combining support for science and conventional medicine with use of CAM treatments, and belief in the efficacy of homeopathy. Our results suggest that over 40% of the British public maintain positive evaluations of both homeopathy and conventional medicine simultaneously. Explanatory analyses reveal that simultaneous support for a controversial CAM treatment and conventional medicine is, in part, explained by a lack of scientific knowledge as well as concerns about the regulation of medical research.
Opportunities for Cost-Sharing in Conservation: Variation in Volunteering Effort across Protected Areas
Paul R. Armsworth, Lisette Cantú-Salazar, Mark Parnell, Josephine E. Booth, Rob Stoneman, Zoe G. Davies
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055395
Abstract: Efforts to expand protected area networks are limited by the costs of managing protected sites. Volunteers who donate labor to help manage protected areas can help defray these costs. However, volunteers may be willing to donate more labor to some protected areas than others. Understanding variation in volunteering effort would enable conservation organizations to account for volunteer labor in their strategic planning. We examined variation in volunteering effort across 59 small protected areas managed by Yorkshire Wildlife Trust, a regional conservation nonprofit in the United Kingdom. Three surveys of volunteering effort reveal consistent patterns of variation across protected areas. Using the most detailed of these sources, a survey of site managers, we estimate that volunteers provided 3200 days of labor per year across the 59 sites with a total value exceeding that of paid staff time spent managing the sites. The median percentage by which volunteer labor supplements management costs on the sites was 36%. Volunteering effort and paid management costs are positively correlated, after controlling for the effect of site area. We examined how well a range of characteristics of the protected areas and surrounding communities explain variation in volunteering effort. Protected areas that are larger have been protected for longer and that are located near to denser conurbations experience greater volunteering effort. Together these factors explain 38% of the observed variation in volunteering effort across protected areas.
Development and Experimental Testing of an Optical Micro-Spectroscopic Technique Incorporating True Line-Scan Excitation
Gabriel Biener,Michael R. Stoneman,Gheorghe Acbas,Jessica D. Holz,Marianna Orlova,Liudmila Komarova,Sergei Kuchin,Valeric? Raicu
International Journal of Molecular Sciences , 2014, DOI: 10.3390/ijms15010261
Abstract: Multiphoton micro-spectroscopy, employing diffraction optics and electron-multiplying CCD (EMCCD) cameras, is a suitable method for determining protein complex stoichiometry, quaternary structure, and spatial distribution in living cells using F?rster resonance energy transfer (FRET) imaging. The method provides highly resolved spectra of molecules or molecular complexes at each image pixel, and it does so on a timescale shorter than that of molecular diffusion, which scrambles the spectral information. Acquisition of an entire spectrally resolved image, however, is slower than that of broad-bandwidth microscopes because it takes longer times to collect the same number of photons at each emission wavelength as in a broad bandwidth. Here, we demonstrate an optical micro-spectroscopic scheme that employs a laser beam shaped into a line to excite in parallel multiple sample voxels. The method presents dramatically increased sensitivity and/or acquisition speed and, at the same time, has excellent spatial and spectral resolution, similar to point-scan configurations. When applied to FRET imaging using an oligomeric FRET construct expressed in living cells and consisting of a FRET acceptor linked to three donors, the technique based on line-shaped excitation provides higher accuracy compared to the point-scan approach, and it reduces artifacts caused by photobleaching and other undesired photophysical effects.
Imaging protein interactions in vivo with sub-cellular resolution
Valerica Raicu,Michael R. Stoneman,Russell Fung,Mike Melnichuk,David B. Jansma,Luca Pisterzi,Michael Fox,James W. Wells,Dilano K. Saldin
Physics , 2008,
Abstract: Resonant Energy Transfer (RET) from an optically excited donor molecule (D) to a non-excited acceptor molecule (A) residing nearby is widely used to detect molecular interactions in living cells. Stoichiometric information, such as the number of proteins forming a complex, has been obtained so far for a handful of proteins, but only after exposing the sample sequentially to at least two different excitation wavelengths. During this lengthy process of measurement, the molecular makeup of a cellular region may change, and this has so far limited the applicability of RET to determination of cellular averages. Here we demonstrate a method for imaging protein complex distribution in living cells with sub-cellular spatial resolution, which relies on a spectrally-resolved two-photon microscope, a simple but competent theory, and a keen selection of fluorescent tags. This technology may eventually lead to tracking dynamics of macromolecular complex formation and dissociation with spatial resolution inside living cells.
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