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Search Results: 1 - 10 of 126282 matches for " Zhuanjian Li "
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Identification and profiling of conserved and novel microRNAs from Chinese Qinchuan bovine longissimus thoracis
Sun Jiajie,Li Mijie,Li Zhuanjian,Xue Jing
BMC Genomics , 2013, DOI: 10.1186/1471-2164-14-42
Abstract: Background MicroRNAs (miRNAs) are a family of ~22 nucleotide small RNA molecules that regulate gene expression by fully or partially binding to their complementary sequences. Recently, a large number of miRNAs and their expression patterns have been identified in various species. However, to date no miRNAs have been reported to modulate muscle development in beef cattle. Results Total RNAs from the Chinese Qinchuan bovine longissimus thoracis at fetal and adult stages were used to construct small RNA libraries for Solexa SBS technology sequencing. A total of 15,454,182 clean reads were obtained from the fetal bovine library and 13,558,164 clean reads from the adult bovine library. In total, 521 miRNAs including 104 novel miRNA candidates were identified. Furthermore, the nucleotide bias, base edit and family of the known miRNAs were also analyzed. Based on stem-loop qPCR, 25 high-read miRNAs were detected, and the results showed that bta-miRNA-206, miRNA-1, miRNA-133, miRNAn12, and miRNAn17 were highly expressed in muscle-related tissue or organs, suggesting that these miRNAs may play a role in the development of bovine muscle tissues. Conclusions This study confirmed the authenticity of 417 known miRNAs, discovered 104 novel miRNAs in bos taurus, and identified five muscle-specific miRNAs. The identification of novel miRNAs significantly expanded the repertoire of bovine miRNAs and could contribute to further studies on the muscle development of cattle.
MEF2A Gene Polymorphisms are Associated with Growth Traits in Chinese Indigenous Cattle Breeds
Fuying Chen,Hong Chen,Juqiang Wang,Hui Niu,Xianyong Lan,Liushuai Hua,Zhuanjian Li,Chuzhao Lei,Xingtang Fang
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2010.814.819
Abstract: Myocyte enhancer factor 2A (MEF2A) gene encodes a member of the myocyte enhancer factor 2 (MEF2) protein family, which involves in vertebrate skeletal muscle development and differentiation. The important function of MEF2A implies this gene is a potential candidate gene for considering association analysis between polymorphism and growth trait. Sequencing and forced-PCR-RFLP were used to analyze the polymorphisms of the MEF2A gene in 1009 cattle from three Chinese indigenous breeds. Three SNPs (C1598T, G1641A and C1734T) were detected in the cattle MEF2A gene, leading to a missense (P420L) and two silent mutations (E434 E, P465P). The frequencies of 1598CC genotype and the frequencies of allele 1598C varied from 0.884-1.000 in the analyzed population (NY, QC and JX). The genotypic and allelic frequencies of G1641A and C1734T in three populations were 0.034-1.000. The C1598T was associated with body length at 6 and 12 months of cattle. The G1641A was associated with average daily gain at 12 months of cattle. And the C1734T affected the average daily gain and body weight at 6 months of cattle. Those three mutations affected the early growth and development of cattle, which could be potential molecular makers in assistant selection of cattle breeding.
Beneficial Experience from Teaching and Education to Research and Development  [PDF]
Li Li
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B039

Teaching and Education (T&E) constitute the most important activity in knowledge transfer from generation to generation. This can explain why government organizations consider the training of highly qualified personnel as one of the most important criteria in the selection of research and development (R&D) grant applications. A university professor should thus not only play the role of researcher, but also that of teacher. T&E and R&D combine to form an inseparable relationship for university professors. By shooting for excellence in T&E, we could get a new perception of a familiar field or initiate a brand new field altogether, which would in turn enhance our research. The quest for excellence in R&D leads to deeper and better understanding of materials taught, and progress in R&D enriches our T&E endeavors. Here, the author shares a beneficial experience from T&E to R&D.

A Causality Analysis of Coal Consumption and Economic Growth for China and India  [PDF]
Jinke Li, Zhongxue Li
Natural Resources (NR) , 2011, DOI: 10.4236/nr.2011.21007
Abstract: China and India are the two countries with the strongest economic growth in the world. Meanwhile they consume much of the global coal to fuel their economic development. With coal burning as a major factor contributing to global greenhouse gas emissions, China and India are confronted with a dilemma of economic growth and environment protection. Will coal consumption reduction cause economic shocks? Is there a causal relationship between coal consumption and economic growth in China and India? In this paper Granger causality tests were used to examine the relationship between coal consumption and GDP in China and India, using data for the period from 1965 to 2006. It was found that a unidirectional causality from GDP to coal consumption existed in China while a unidirectional causality from coal consumption to GDP did in India. Therefore, developing cleaner and more efficient technologies is essential to reduce their CO2 emissions to reach sustainable development.
An Investigation and Analysis of Information Overload in Manager's Work  [PDF]
Tao Li, Min Li
iBusiness (IB) , 2011, DOI: 10.4236/ib.2011.31008
Abstract: The problem of information overload in management field has been receiving increasing attention, while there are less empirical researches now. This paper proposes a conceptual model and some operational variables, in which information overload is as an intervening variable between the factors of causes and impacts. An investigation and analysis has been conducted from a selected sample of managers. This research suggests that work efficiency and work quality are both not strongly connected with information overload. We also find that the main causes of information overload are the work interruption and work time pressure but the amount of information.
Selection Advantage Pattern of International Sci-Tech Cooperation and Empirical Analysis  [PDF]
Li Li, Bin Yu
Journal of Service Science and Management (JSSM) , 2011, DOI: 10.4236/jssm.2011.41006
Abstract: Traditional international sci-tech cooperation theories mainly focus on the ability and advantage owned by cooperative parties, and according to which to guide the direction of international science and technology cooperation. Based on the integration of traditional theories of international science and technology cooperation and concrete practice, this paper proposes the selection advantage pattern and matching mechanism, which comprehensively take cooperator advantages, specification of project and change in circumstance into account and will play a guiding role in terms of determining the key country or region with which to prior carry out international science and technology cooperation. This paper also gives an analysis of the current status of industry development in Guangdong province and the research upon competitiveness evaluation of the world's related leading technology, puts forward corresponding countermeasures and suggestions on the science and technology cooperation patterns and approaches in terms of technological level and resources of Guangdong province.
Soil reinforcement by a root system and its effects on sediment yield in response to concentrated flow in the loess plateau  [PDF]
Peng Li, Zhanbin Li
Agricultural Sciences (AS) , 2011, DOI: 10.4236/as.2011.22013
Abstract: The importance of roots in soil conservation has long been underestimated due to a lack of sys-tematic studies conducted to evaluate root dis-tribution patterns and their effects on soil ero-sion. Current knowledge regarding root mor-phology and its impact on soil erosion by water is limited; therefore, detailed analysis of the role that root systems play in controlling soil ero-sion is needed. In this study, stratified runoff scouring at different soil depths in the field was conducted in a grassland area. The results in-dicated that both root biomass and soil wa-ter-stable aggregates decreased as soil depth increased at all three sites, while there was al-most no change in soil bulk density at 1.3g/cm3. Sediment yields under different runoff dis-charge at different sites showed similar trends, and the sediment yield increased as the soil depth increased at all three sites. Further analysis revealed that close relationships ex-isted between root biomass and the amount of water-stable aggregates and soil organic matter content, and that these factors greatly influ-enced soil erosion. Based on the data generated by the experiment, equations describing the relationship between sediment production at different soil depths and root biomass were determined.
Second-Order Volition and Conflict between Desires  [PDF]
Hengxi Li, Hengwei Li
Open Journal of Philosophy (OJPP) , 2012, DOI: 10.4236/ojpp.2012.21004
Abstract: In Freedom of the Will and the Concept of a Person, Harry Frankfurt put forward a theory that what is essential to be a person is second-order volition. The notion of second-order volition can be used as a key conceptual tool in understanding the conflict between desires. By means of the notion, this paper argues that the conflict between desires in our minds lies in the conflict between second-order volitions, other than the conflict between first-order desires. Based on this claim, this paper suggests that, due to the misunderstanding of the nature of the conflict between desires, the analysis of unwilling addict and wanton addict given by Frankfurt is thus wrong, and in his follow-up articles he made wrong description of the phenomenon concerning the conflict between desires.
A Fixed-Phase Quantum Search Algorithm with More Flexible Behavior  [PDF]
Xin Li, Panchi Li
Journal of Quantum Information Science (JQIS) , 2012, DOI: 10.4236/jqis.2012.22006
Abstract: When the Grover’s algorithm is applied to search an unordered database, the probability of success usually decreases with the increase of marked items. To address this phenomenon, a fixed-phase quantum search algorithm with more flexible behavior is proposed. In proposed algorithm, the phase shifts can be fixed at the different values to meet the needs of different practical problems. If research requires a relatively rapid speed, the value of the phase shifts should be appropriately increased, if search requires a higher success probability, the value of the phase shifts should be appropriately decreased. When the phase shifts are fixed at , the success probability of at least 99.38% can be obtained in iterations.
Game Analysis of Institutional Investors Participating in Corporate Governance  [PDF]
Yingzhao Li, Zhenqin Li
American Journal of Industrial and Business Management (AJIBM) , 2013, DOI: 10.4236/ajibm.2013.31008

By building a game model between the institutional investors and the management, an analysis has been conducted to uncover the influential factors that are crucial to the role switching of institutional investors when confronting tunneling behaviors of the management: supervision cost, shareholding ratio, invisible income, fines and patience. In cases of lower supervision cost, higher shareholding ratios, less invisible income, larger amount of fines, more patience and pursuing long-term gains, institutional investors will tend to play an active role in corporate governance. They will act as an active supervisor to restrain the tunneling behavior of the management.

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