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Search Results: 1 - 10 of 34438 matches for " Zhou Yingqun "
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TCMGIS-II based prediction of medicinal plant distribution for conservation planning: a case study of Rheum tanguticum
Hua Yu, Caixiang Xie, Jingyuan Song, Yingqun Zhou, Shilin Chen
Chinese Medicine , 2010, DOI: 10.1186/1749-8546-5-31
Abstract: Native habitats were determined by specimen examination. An improved version of GIS-based program for the distribution prediction of traditional Chinese medicine (TCMGIS-II) was employed to integrate national geographic, climate and soil type databases of China. Grid-based distance analysis of climate factors was based on the Mikowski distance and the analysis of soil types was based on grade division. The database of resource survey was employed to assess the reliability of prediction result.A total of 660 counties of 17 provinces in China, covering a land area of 3.63 × 106 km2, shared similar ecological factors with those of native habitats appropriate for R. tanguticum growth.TCMGIS-II modeling found the potential habitats of target medicinal plants for their conservation planning. This technology is useful in conservation planning and regional management of medicinal plant resources.More than one-tenth of plant species are used in drugs and health products [1]. The demand for herbal drugs and health products is steadily growing [2]. Thus, many medicinal herbs are threatened by overexploitation, habitat destruction and lack of proper cultivation practices. Some wild species are disappearing at alarming rates [3,4]. Rheum tanguticum Maxim. ex Balf (Dahuang) is one of those species. R. tanguticum belongs to the family Polygonaceae and is a high-altitude perennial herb sensitive to high temperature, mainly found in the alpine regions of temperate and subtropical Asia, especially in Southwest and Northwest China (e.g. Sichuan, Gansu and Qinghai) [5,6]. As a source for rhubarb according to the Chinese Pharmacopoeia and a purgative and anti-inflammatory agent [7], R. tanguticum has been overexploited, suffering from replant diseases, inadequate seed dispersal, low reproductive efficiency and narrow distribution and habitat fragmentation, leading to its declines in the wild resources [6,8].In-situ conservation, which considered as the method of conserving endangered sp
The Hippo-Yes Association Protein Pathway in Liver Cancer
Lu Jie,Wang Fan,Dai Weiqi,Zhou Yingqun,Xu Ling,Shen Miao,Cheng Ping,Guo Chuanyong
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/187070
Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and the third leading cause of cancer mortality. Despite continuing development of new therapies, prognosis for patients with HCC remains extremely poor. In recent years, control of organ size becomes a hot topic in HCC development. The Hippo signaling pathway has been delineated and shown to be critical in controlling organ size in both Drosophila and mammals. The Hippo kinase cascade, a singling pathway that antagonizes the transcriptional coactivator Yes-associated protein (YAP), plays an important role in animal organ size control by regulating cell proliferation and apoptosis rates. During HCC development, this pathway is likely inactivated in tumor initiated cells that escape suppressive constrain exerted by the surrounding normal tissue, thus allowing clonal expansion and tumor development. We have reviewed evolutionary changes in YAP as well as other components of the Hippo pathway and described the relationships between YAP genes and HCC. We also discuss regulation of transcription factors that are up- and downstream of YAP in liver cancer development. 1. Introduction Human hepatocellular carcinoma (HCC) is one of the most common cancers, with nearly 600,000 deaths each year worldwide. In addition, its incidence increases every year. HCC usually develops in patients with chronic inflammatory liver disease such as viral infection and/or exposure to chemical carcinogens. Surgical reaction and liver transplantation are currently the best curative options to treat HCC. However, recurrence or metastasis is quite common in patients who have had a resection [1]. Hepatocarcinogenesis is a complex process associated with accumulation of genetic and epigenetic changes that occur during initiation, promotion, and progression of the disease. The role of hepatitis B virus (HBV) infection in causing HCC is well established. The risk of developing HCC was 200 times higher among employees who had chronic HBV as compared to employees without chronic HBV. Hepatitis B virus X protein (HBx) plays critical roles in the development of HCC. Zhang et al. found that the expression of YAP was dramatically elevated in clinical HCC samples, HBV infected hepatic cell line, and liver cancer tissues of HBx transgenic mice. Overexpression of HBx resulted in the upregulation of YAP, while HBx-RNA interference reduced YAP expression. YAP short interfering RNA was able to remarkably block the HBx-enhanced growth of hepatoma cells in vivo and in vitro. Hepatitis C virus (HCV) infection is also
Study on methods of traditional Chinese medicinal resources survey

Zhou Yingqun,Chen Shilin,Zhang Bengang,Huang Linfang,Lu Jianwei,Yang Zhi,

世界科学技术-中医药现代化 , 2005,
Abstract: 中药资源可持续利用及生物多样性保护已成为当前中药领域的研究热点,选择合适的资源调查方法是其要解决的关键问题之一。作者提出在改进传统中药资源调查方法的基础上,引进现代技术,形成适应时代发展的科学调查方法,推动中药资源可持续利用及生物多样性保护。
Comparison of Copper Scavenging Capacity between Two Different Red Mud Types
Yingqun Ma,Chunhua Si,Chuxia Lin
Materials , 2012, DOI: 10.3390/ma5091708
Abstract: A batch experiment was conducted to compare the Cu scavenging capacity between two different red mud types: the first one was a highly basic red mud derived from a combined sintering and Bayer process, and the second one was a seawater-neutralized red mud derived from the Bayer process. The first red mud contained substantial amounts of CaCO 3, which, in combination with the high OH ? activity, favored the immobilization of water-borne Cu through massive formation of atacamite. In comparison, the seawater-neutralized red mud had a lower pH and was dominated by boehmite, which was likely to play a significant role in Cu adsorption. Overall, it appears that Cu was more tightly retained by the CaCO 3-dominated red mud than the boehmite-dominated red mud. It is concluded that the heterogeneity of red mud has marked influences on its capacity to immobilize water-borne Cu and maintain the long-term stability of the immobilized Cu species. The research findings obtained from this study have implications for the development of Cu immobilization technology by using appropriate waste materials generated from the aluminium industry.

Wen Yingqun,

植物科学学报 , 1997,
Abstract: Callus was induced in the modified MS hasal medium with high concentration of NAA and 2,4-D from young inflorescence of coconut (Cocos nucifera L. ). During the callus subculture with gradually reduced concentration of NAA and 2,4-D,it developed into compact nodular tissue. There were conducting tissue,meristematic cell clumps,root primordia and embryoids at different developing stage in the nodular tissue. The normal roots and green buds were developed subsequently from some of the nodular tissue. At the same time,some green buds grew out directly from the base of the young flower branches, and finally became the plantlets with normal roots and leaves,but without apical meristem and leaf primordia. Moreover,some of the stem apex developed into flower branches and even showed several small abnormal flowers.
Genome-Wide Screening Reveals an EMT Molecular Network Mediated by Sonic Hedgehog-Gli1 Signaling in Pancreatic Cancer Cells
Xuanfu Xu, Yingqun Zhou, Chuangao Xie, Shu-mei Wei, Huizhong Gan, Shengli He, Fan Wang, Ling Xu, Jie Lu, Weiqi Dai, Lei He, Ping Chen, Xingpeng Wang, Chuanyong Guo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043119
Abstract: Aims The role of sonic hedgehog (SHH) in epithelial mesenchymal transition (EMT) of pancreatic cancer (PC) is known, however, its mechanism is unclear. Because SHH promotes tumor development predominantly through Gli1, we sought to understand its mechanism by identifying Gli1 targets in pancreatic cancer cells. Methods First, we investigated invasion, migration, and EMT in PC cells transfected with lentiviral Gli1 interference vectors or SHH over-expression vectors in vitro and in vivo. Next, we determined the target gene profiles of Gli1 in PC cells using cDNA microarray assays. Finally, the primary regulatory networks downstream of SHH-Gli1 signaling in PC cells were studied through functional analyses of these targets. Results Our results indicate there is decreased E-cadherin expression upon increased expression of SHH/Gli1. Migration of PC cells increased significantly in a dose-dependent manner within 24 hours of Gli1 expression (P<0.05). The ratio of liver metastasis and intrasplenic miniature metastasis increased markedly upon activation of SHH-Gli1 signals in nude mice. Using cDNA microarray, we identified 278 upregulated and 59 downregulated genes upon Gli1 expression in AsPC-1 cells. The data indicate that SHH-Gli1 signals promote EMT by mediating a complex signaling network including TGFβ, Ras, Wnt, growth factors, PI3K/AKT, integrins, transmembrane 4 superfamily (TM4SF), and S100A4. Conclusion Our results suggest that targeting the molecular connections established between SHH-Gli1 signaling and EMT could provide effective therapies for PC.
Study of Method for Application of Remote - sensing Technology to Investigation of Reserves of Ginseng Resources

Chen Shilin,Zhang Bengang,Zhang Jinsheng,Zhou Yingqun,Su Gangqiang,Xiao Shiying,Yang Zhi,Xiao Peigen,

世界科学技术-中医药现代化 , 2005,
Abstract: 利用遥感技术对人参种植区域的人参种植面积进行调查,建立了人参资源遥感调查的技术路线弄口方法,并通过抽样调查对人参进行了产区面积测算和估产。野外验证点与图象判读结果对比分析表明,人参调查样区的人工判读精度,Landsat7ETM图像(15米)达90%,ETM与Spot融合图像(5米)达97%,Quick Brid图像(0.61米)达100%,本研究为遥感技术在中药资源调查中的应用摸索了方法。
Design and Realization of traditional Chinese Medicine Adaptability Analyzing System Based on GIS

Sun Chengzhong,Liu Zhaoqin,Chen Shilin,Wei Jianhe,Zhao Runhuai,Wang Jiyong,Zhou Yingqun,

世界科学技术-中医药现代化 , 2006,
Abstract: 根据物种引种原则气候相似性,设计了基于数据库的GIS中药材产地适宜性分析系统,国家基础地理信息数据库、气候因子数据库、土壤数据库和第三次全国中药普查数据库为分析的数据基础。初步研究结果表明,将GIS的空间聚类分析与空间分析应用于中药材产地适宜性分析中,能够科学、快速、准确地分析出与药材道地产区最为相近的地区,结束了依靠传统经验和单个药材、单个气候因子、单个产地分析的低效、准确性差的做法。
TCMAE based Adaptability Evaluation for Drynaria roosii Nakaike

Li Guiying,Zhang Bengang,Sun Chengzhong,Xie Caixiang,Zhang Zhao,Chen Shilin,Zhao RunHuai,Zhou Yingqun,
,张本刚,孙成忠,谢彩香,张 昭,陈士林,赵润怀,周应群

世界科学技术-中医药现代化 , 2009,
Abstract: We analyzed the appropriate growing area for Drynaria roosii Nakaike using a geographic information based TCM adaptability evaluation system (TCMAE). In the study, TCMAE was used to analyze the desirable growing area for D. roosii based on the optimized ecological factors, including averaged annual temperature, altitude, soil type, precipitation, sunlight, and relative humidity. Weight value of each key factor was also evaluated based on the data collected in the field survey. Analysis result showed that the potential areas desirable for growing D. roosii sit in the subtropical monsoon region in the country, mostly on the Yunnan-Guizhou Plateau, covering the most part of Guizhou, the east part of Yunnan, the west part of Guangxi, the west of Hubei, and border areas of Hunan, though Guangdong, Fujian, Sichuan, and Zhejiang have limited areas desirable for growing the herb. It is important to sort out the appropriate growing area for D. roosii through TCMAE. The system provides scientific evidences for transplanting and cultivation of D. roosii in China.
The Synergistic In Vitro and In Vivo Antitumor Effect of Combination Therapy with Salinomycin and 5-Fluorouracil against Hepatocellular Carcinoma
Fan Wang, Weiqi Dai, Yugang Wang, Miao Shen, Kan Chen, Ping Cheng, Yan Zhang, Chengfen Wang, Jingjing Li, Yuanyuan Zheng, Jie Lu, Jing Yang, Rong Zhu, Huawei Zhang, Yingqun Zhou, Ling Xu, Chuanyong Guo
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097414
Abstract: Hepatocellular carcinoma (HCC) is one of the few cancers in which a continuous increase in incidence has been observed over several years. Drug resistance is a major problem in the treatment of HCC. In the present study, we used salinomycin (Sal) and 5-fluorouracil (5-FU) combination therapy on HCC cell lines Huh7, LM3 and SMMC-7721 and nude mice subcutaneously tumor model to study whether Sal could increase the sensitivity of hepatoma cells to the traditional chemotherapeutic agent such as 5-FU. The combination of Sal and 5-FU resulted in a synergistic antitumor effect against liver tumors both in vitro and in vivo. Sal reversed the 5-FU-induced increase in CD133(+) EPCAM(+) cells, epithelial–mesenchymal transition and activation of the Wnt/β-catenin signaling pathway. The combination of Sal and 5-FU may provide us with a new approach to reverse drug resistant for the treatment of patients with HCC.
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