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Search Results: 1 - 10 of 11327 matches for " Zhongzan Cao "
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Proteomics analysis of differentially expressed proteins in chicken trachea and kidney after infection with the highly virulent and attenuated coronavirus infectious bronchitis virus in vivo
Zhongzan Cao, Zongxi Han, Yuhao Shao, Xiaoli Liu, Junfeng Sun, Demin Yu, Xiangang Kong, Shengwang Liu
Proteome Science , 2012, DOI: 10.1186/1477-5956-10-24
Abstract: Fifty-eight differentially expressed proteins were identified. Results demonstrated that some proteins which had functions in cytoskeleton organization, anti-oxidative stress, and stress response, showed different change patterns in abundance from chicken infected with the highly virulent ck/CH/LDL/97I P5 strain and those given the embryo-passaged, attenuated P115 stain. In addition, the dynamic transcriptional alterations of 12 selected proteins were analyzed by the real-time RT-PCR, and western blot analysis confirmed the change in abundance of heat shock proteins (HSP) beta-1, annexin A2, and annexin A5.The proteomic alterations described here may suggest that these changes to protein expression correlate with IBV virus' virulence in chicken, hence provides valuable insights into the interactions of IBV with its host and may also assist with investigations of the pathogenesis of IBV and other coronavirus infections.Coronaviruses (CoVs) are enveloped single-stranded positive sense RNA viruses that belong to the family Coronaviridae in the order Nidovirales. They are able to infect humans as well as other animals, including cows, pigs, mice, and chickens, they generally cause respiratory infection, gastrointestinal, and neurological disorders of varying severity. Infectious bronchitis virus (IBV) was the first coronavirus to be discovered, and is classed among the Gamma coronaviruses on the basis of antigenic and genetic relatedness [1]. It is a major poultry pathogen and is probably endemic in all chicken-raising regions; it has a severe impact on poultry production, causing heavy economic losses. All strains of IBV are capable of infecting a large range of epithelial surfaces of chickens, such as those of the trachea, kidney, oviduct and proventriculus [2].Coronavirus infection has dramatic effects on host cell morphology, transcription and translation patterns, the cell cycle, cytoskeleton, suppression of interferon, and apoptosis pathways. Coronavirus infection
Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus
Zhongzan Cao, Zongxi Han, Yuhao Shao, Heyuan Geng, Xiangang Kong, Shengwang Liu
Proteome Science , 2011, DOI: 10.1186/1477-5956-9-11
Abstract: 17 differentially expressed proteins from tracheal tissues and 19 differentially expressed proteins from kidney tissues were identified. These proteins mostly related to the cytoskeleton, binding of calcium ions, the stress response, anti-oxidative, and macromolecular metabolism. Some of these altered proteins were confirmed further at the mRNA level using real-time RT-PCR. Moreover, western blotting analysis further confirmed the changes of annexin A5 and HSPB1 during IBV infection.To the best of our knowledge, we have performed the first analysis of the proteomic changes in chicken embryonic trachea and kidney tissues during IBV infection in ovo. The data obtained should facilitate a better understanding of the pathogenesis of IBV infection.Avian infectious bronchitis (IB) is one of the most serious diseases of chickens. It is of economic importance in the poultry industry worldwide and is associated with respiratory disease, reduction in weight gain, poor egg production and quality, and decreased feed conversion efficiency. Its etiologic agent is the avian infectious bronchitis coronavirus (IBV), which is a Gamma coronavirus of the coronavirus genus and replicates primarily in the upper respiratory tract, kidney, and oviduct of chickens [1-3].Knowledge of the interactions between virus and host is critical in order to understand the pathogenesis of viral infection. On the one hand, the virus usurps the biological processes of the host to evade the innate immune response of the host; on the other hand, the host mounts a variety of defensive responses against the viral infection. These virus-host interactions can cause changes in the level of expression of host genes. Alteration of gene expression in the host after infection with coronavirus (CoV) has been investigated mainly with regard to infection with mouse hepatitis virus (MHV) and severe acute respiratory syndrome coronavirus (SARS-CoV) [4]. Limited studies have been performed to analyze host gene expression
Hilbert Boundary Value Problem with an Unknown Function on Arbitrary Infinite Straight Line  [PDF]
Lixia Cao
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.32033

We consider a Hilbert boundary value problem with an unknown parametric function on arbitrary infinite straight line passing through the origin. We propose to transform the Hilbert boundary value problem to Riemann boundary value problem, and address it by defining symmetric extension for holomorphic functions about an arbitrary straight line passing through the origin. Finally, we develop the general solution and the solvable conditions for the Hilbert boundary value problem.

Some Properties of a Kind of Singular Integral Operator with Weierstrass Function Kernel  [PDF]
Lixia Cao
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.48166

We considered a kind of singular integral operator with Weierstrass function kernel on a simple closed smooth curve in a fundamental period parallelogram. Using the method of complex functions, we established the Bertrand Poincaré formula for changing order of the corresponding integration, and some important properties for this kind of singular integral operator.

Riemann Boundary Value Problem of Non-Normal Type on the Infinite Straight Line  [PDF]
Lixia Cao
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.48165

Various kinds of Riemann boundary value problems (BVPs) for analytic functions on closed curves or on open arc, doubly periodic Riemann BVPs, doubly quasi-periodic Riemann BVPs, and BVPs for polyanalytic functions have been widely investigated in [1-8]. The main ap- proach is to use the decomposition of polyanalytic functions and their generalization to transform the boundary value problems to their corresponding boundary value problems for analytic functions. Recently, inverse Riemann BVPs for generalized analytic functions or bianalytic functions have been investigated in [9-12].
In this paper, we consider a kind of Riemann BVP of non-normal type on the infinite straight line and discuss the solvable conditions and the general solution for it.

The Asymmetry of Chinese/English Action-Result Events Encoding: A Cognitive Approach  [PDF]
Duxin Cao
Open Journal of Modern Linguistics (OJML) , 2013, DOI: 10.4236/ojml.2013.32017
Abstract: The present paper attempts to look at Chinese resultative verb compounds form the perspective of cognitive relativism, namely through the contrastive study of Chinese and English verb-resultatives. Based on the comparison, the present thesis tries to explore the underlying conceptual approaches to structuring events consisting of both action and result by Chinese native speakers and English native speakers and show the discrepancies between them in cognition or more specifically, conceptualization of reality. Resultative verb compounds in Chinese are analyzed in terms of Talmy’s conceptual structure and are shown to present a problem for Talmy’s well-known typological dichotomy between \"verb-framed\" and \"satellite-framed\" languages. It is also argued that the so-called \"resultative complement\" in Chinese resultative verb compounds can be treated as the center of predication, even as the main verb. Pending further psycholinguistic evidence, it appears that Chinese speakers place relatively more emphasis on the result of an event, whereas English speakers more on the process of an event.
A Numerical Approach to a Nonlinear and Degenerate Parabolic Problem by Regularization Scheme  [PDF]
Haitao Cao
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.25012
Abstract: In this work we propose a numerical scheme for a nonlinear and degenerate parabolic problem having application in petroleum reservoir and groundwater aquifer simulation. The degeneracy of the equation includes both locally fast and slow diffusion (i.e. the diffusion coefficients may explode or vanish in some point). The main difficulty is that the true solution is typically lacking in regularity. Our numerical approach includes a regularization step and a standard discretization procedure by means of C0-piecewise linear finite elements in space and backward-differences in time. Within this frame work, we analyze the accuracy of the scheme by using an integral test function and obtain several error estimates in suitable norms.
Memory Suggestibility under Social Pressure and Inhibitory Control in Preschoolers  [PDF]
Xiaojun Cao
Journal of Behavioral and Brain Science (JBBS) , 2015, DOI: 10.4236/jbbs.2015.54012
Abstract: The current study examined the interaction of inhibitory control and social pressure on young children’s memory suggestibility. Children were administered the Video Memory Suggestibility Scale for Children (VMSSC) and batteries of inhibitory control tasks, and were exposed to different levels of situational social pressures during interviews for memory suggestibility. The findings indicated that inhibitory control played a significantly moderating role in the relationship between social pressure and memory suggestibility. The greater the inhibitory control, the lower the effects of social pressure on the memory suggestibility of children. For the children with lower levels of inhibitory control, the social pressure positively predicted memory suggestibility; but for the children with higher levels of inhibitory control, the social pressure didn’t significantly predict memory suggestibility. So, to a certain extent, memory suggestibility may be a dynamic integration of stable trait and fluctuating state elements. The implications for the essence of memory suggestibility were discussed.
Robot Global Path Planning Based on an Improved Ant Colony Algorithm  [PDF]
Jingang Cao
Journal of Computer and Communications (JCC) , 2016, DOI: 10.4236/jcc.2016.42002
Abstract: Aiming at the disadvantages of the basic ant colony algorithm, this paper proposes an improved ant colony algorithm for robot global path planning. First, adjust the pheromone evaporation rate dynamically to enhance the global search ability and convergence speed, and then modify the heuristic function to improve the state transition probabilities in order to find the optimal solution as quickly as possible; and finally change the pheromone update strategy to avoid premature by strengthening pheromone on the optimal path and limiting pheromone level. Simulation results verify the effectiveness of the improved algorithm.
Dynamic Time-Dependent Strategy Model for Predicting Human’s Offer in E-Commerce Negotiation  [PDF]
Mukun Cao
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.47010

Human-computer negotiation plays an important role in B2C e-commerce. There is a paucity of further scientific investigation and a pressing need on designing the software agent that can deal with the human’s random and dynamic offer, which is crucially useful in human-computer negotiation to achieve better online negotiation outcomes. The lack of such studies has decelerated the process of applying automated negotiation to real world applications. To address the critical issue, this paper develops a dynamic time-dependent strategy concession model, that can predict the human’s negotiation behavior during the process of the negotiation. To demonstrate the effectiveness of this model, we implement a prototype and conduct human-computer negotiations over 121 subjects. The experimental analysis not only confirms our model’s effect but also reveals some insights into future work about human-computer negotiation systems.

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