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Search Results: 1 - 10 of 13585 matches for " Zhongchun Fan "
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DKLFRS: A default knowledge logical framework representation system
DKLFRS:A Default Knowledge Logical Framework Representation System

Zhongchun Fan,Hancheng Xing,
Fan Zhongchun
,Xing Hancheng

计算机科学技术学报 , 1992,
Abstract: The traditional reasoning system based on first order predicate logic can’t represent and handle default knowledge. This paper presents a logical framework representation approach for default reasoning. Based on Mixed SLDNF-resolution, a nonmonotonic reasoning system has been constructed.
Soil Nitrate Monitoring for Turfgrass Sod Farms and Other Turf Areas
W. Michael Sullivan,Zhongchun Jiang
The Scientific World Journal , 2001, DOI: 10.1100/tsw.2001.303
Abstract:
Effects of Sputtering Power on Structural,ElectricalandOpticalPropertiesof Indium -tin-oxide Thin Film s
Wang Zhongchun,Chen Jiefeng,Hu Xingfang
半导体学报 , 1999,
Abstract: Indiumtinoxide,commonlyreferredtoasITO,isawidebandgap,degeneraten-typesemiconductor.Intheformofthinfilm,ithaswi...
Experimental Research on C_2H_2 Detonation by Decomposition
C_2H_2分解爆轰的实验研究

Mi Zhongchun,
糜仲春
,朱奎元

实验力学 , 1987,
Abstract: 在长30m,公称直径(Dg)分别为50、65、80和100mm的管道内,进行了C_2H_2分解爆轰实验。用O_2—C_2H_2爆轰波引爆C_2H_2,测量了管道内的爆轰压力,及在管道端面上的反射压力。与以前认为在管径500mm管道内不会出现自持的C_2H_2分解爆轰的意见相反,在这样的管道内也发生了C_2H_2分解炸轰。在管端测到了1700kg/cm~2的异常高压,并对数次异常高压的破坏威力作了记录。
Development of Viral Vectors for Gene Therapy for Chronic Pain
Yu Huang,Xin Liu,Lanlan Dong,Zhongchun Liu,Xiaohua He,Wanhong Liu
Pain Research and Treatment , 2011, DOI: 10.1155/2011/968218
Abstract: Chronic pain is a major health concern that affects millions of people. There are no adequate long-term therapies for chronic pain sufferers, leading to significant cost for both society and the individual. The most commonly used therapy for chronic pain is the application of opioid analgesics and nonsteroidal anti-inflammatory drugs, but these drugs can lead to addiction and may cause side effects. Further studies of the mechanisms of chronic pain have opened the way for development of new treatment strategies, one of which is gene therapy. The key to gene therapy is selecting safe and highly efficient gene delivery systems that can deliver therapeutic genes to overexpress or suppress relevant targets in specific cell types. Here we review several promising viral vectors that could be applied in gene transfer for the treatment of chronic pain and further discuss the possible mechanisms of genes of interest that could be delivered with viral vectors for the treatment of chronic pain. 1. Introduction Chronic pain is defined by the U.S. Food and Drug Administration as pain that persists for more than 3 months [1]. This leads to great suffering for patients and results in a heavy burden for society. Chronic pain is not simply related to anatomical reorganization; other changes in neurotransmission and electrophysiological activity are also involved in the pain pathway [2]. Conventional drug treatment has many limitations, such as drug dependence, tolerance, respiratory depression, and other systemic side effects. The development of gene therapy has opened the possibility of using either nonviral or viral vectors to transduce genes encoding antinociceptive substances to treat chronic pain. Compared with nonviral systems, viral vectors are much more efficient in delivering exogenous genes to target cells and inducing long-term gene expression [3]. However, not all viruses are suitable for gene delivery. For instance, murine leukemia virus and lentivirus are both retroviruses, but lentivirus can infect nondividing cells, while murine leukemia virus cannot. This is the reason murine leukemia virus is usually not used as a gene carrier in neurological disease treatments [4]. It was reported that 2 of 11 children receiving gene therapy using a retroviral vector caused leukemia. A possible reason is the integration of viral gene may activate oncogenes. So the safety of retroviral vectors has been paid more and more attention [5, 6]. The ideal gene therapy vector should not be able to replicate its own DNA and be conducive to long-term gene expression. In
RESEARCH ON OPTICAL METHOD OF MONITORING PHOTOCATHODE PROCESSES
光学法检测光阴极的研究

Gao Lushan,Liu Libin,Wang Zhongchun,
高鲁山
,刘力滨,王仲春

电子与信息学报 , 1989,
Abstract: Principle of optical method of photocathode process control, which is one of pho-tocathode process monitoring techniques, is discussed. A monitoring apparatus is described and had applied to investigate the optical parameters of multialkali photoemiiter during process. Some actual schemes using the method to monitor the preparation of photocathodes are suggested.
Effects of Intracanal Irrigant MTAD Combined with Nisin at Sub-Minimum Inhibitory Concentration Levels on Enterococcus faecalis Growth and the Expression of Pathogenic Genes
Zhongchun Tong, Lijia Huang, Junqi Ling, Xueli Mao, Yang Ning, Dongmei Deng
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090235
Abstract: Exposure to antibiotics is considered to be the major driver in the selection of antibiotic-resistant bacteria and may induce diverse biological responses in bacteria. MTAD is a common intracanal irrigant, but its bactericidal activity remains to be improved. Previous studies have indicated that the antimicrobial peptide nisin can significantly improve the bactericidal activity of MTAD against Enterococcus faecalis. However, the effects of MTAD and its modification at sub-minimum inhibitory concentration (sub-MIC) levels on Enterococcus faecalis growth and the expression of pathogenic genes still need to be explored. In this study, the results of post-antibiotic effects (PAE) and post-antibiotic sub-MIC effects (PASME) showed that MTADN (nisin in combination with MTAD) had the best post-antibiotic effect. E. faecalis after challenge with MTAD was less sensitive to alkaline solutions compared with MTAN (nisin in place of doxycycline in MTAD) and MTADN. E. faecalis induced with sub-MIC of MTAD generated resistance to the higher concentration, but induction of E. faecalis with MTAN did not cause resistance to higher concentrations. Furthermore, real-time polymerase chain reaction (RT-PCR) showed that the stress caused by sub-MIC exposure to MTAD, MTAN, or MTADN resulted in up- or down-regulation of nine stress genes and four virulence-associated genes in E. faecalis and resulted in different stress states. These findings suggested that nisin improved the post-antibacterial effect of MTAD at sub-MIC levels and has considerable potential for use as a modification of MTAD.
An In Vitro Study on the Effects of Nisin on the Antibacterial Activities of 18 Antibiotics against Enterococcus faecalis
Zhongchun Tong, Yuejiao Zhang, Junqi Ling, Jinglei Ma, Lijia Huang, Luodan Zhang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089209
Abstract: Enterococcus faecalis rank among the leading causes of nosocomial infections worldwide and possesses both intrinsic and acquired resistance to a variety of antibiotics. Development of new antibiotics is limited, and pathogens continually generate new antibiotic resistance. Many researchers aim to identify strategies to effectively kill this drug-resistant pathogen. Here, we evaluated the effect of the antimicrobial peptide nisin on the antibacterial activities of 18 antibiotics against E. faecalis. The MIC and MBC results showed that the antibacterial activities of 18 antibiotics against E. faecalis OG1RF, ATCC 29212, and strain E were significantly improved in the presence of 200 U/ml nisin. Statistically significant differences were observed between the results with and without 200 U/ml nisin at the same concentrations of penicillin or chloramphenicol (p<0.05). The checkerboard assay showed that the combination of nisin and penicillin or chloramphenicol had a synergetic effect against the three tested E. faecalis strains. The transmission electron microscope images showed that E. faecalis was not obviously destroyed by penicillin or chloramphenicol alone but was severely disrupted by either antibiotic in combination with nisin. Furthermore, assessing biofilms by a confocal laser scanning microscope showed that penicillin, ciprofloxacin, and chloramphenicol all showed stronger antibiofilm actions in combination with nisin than when these antibiotics were administered alone. Therefore, nisin can significantly improve the antibacterial and antibiofilm activities of many antibiotics, and certain antibiotics in combination with nisin have considerable potential for use as inhibitors of this drug-resistant pathogen.
An In Vitro Study on the Effect of Free Amino Acids Alone or in Combination with Nisin on Biofilms as well as on Planktonic Bacteria of Streptococcus mutans
Zhongchun Tong, Luodan Zhang, Junqi Ling, Yutao Jian, Lijia Huang, Dongmei Deng
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099513
Abstract: Free D-amino acids (D-AAs) are one of the most striking features of the peptidoglycan composition in bacteria and play a key role in regulating and disassembling bacterial biofilms. Previous studies have indicated that the antimicrobial peptide nisin can inhibit the growth of the cariogenic bacteria Streptococcus mutans. The present study investigated the effect of free amino acids either alone or in combination with nisin on biofilm and on planktonic S. mutans bacteria. The results of the MIC and MBC analyses showed that D-cysteine (Cys), D- or L-aspartic acid (Asp), and D- or L-glutamic acid (Glu) significantly improve the antibacterial activity of nisin against S. mutans and that the mixture of D-Cys, D-Asp, and D-Glu (3D-AAs) and the mixture of L-Cys, L-Asp, and L-Glu (3L-AAs) at a concentration of 40 mM can prevent S. mutans growth. Crystal violet staining showed that the D- or L-enantiomers of Cys, Asp, and Glu at a concentration of 40 mM can inhibit the formation of S. mutans biofilms, and their mixture generated a stronger inhibition than the components alone. Furthermore, the mixture of the three D-AAs or L-AAs may improve the antibacterial activity of nisin against S. mutans biofilms. This study underscores the potential of free amino acids for the enhancement of the antibacterial activity of nisin and the inhibition of the cariogenic bacteria S. mutans and biofilms.
Research on Plane 2-D Sediment Model of a Watercourse on Yangtze River  [PDF]
Yong FAN
Journal of Water Resource and Protection (JWARP) , 2009, DOI: 10.4236/jwarp.2009.14032
Abstract: To provide basis for sand excavation of hydraulic fill and land forming in Daohukou region in a watercourse (Wuhan reach) on Yangtze River, a 2-D water-sand mathematic model of this river reach is established. The variation of water levels of this reach and the back silting of watercourse after sand excavation are calculated. The rationality of the results calculated by this model and the measured data are validated and analyzed. The results show that, this model is reasonable and reliable.
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