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Search Results: 1 - 10 of 24264 matches for " Zhiqiang Shi "
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Communication Complexities of XOR functions
Yaoyun Shi,Zhiqiang Zhang
Computer Science , 2008,
Abstract: We call $F:\{0, 1\}^n\times \{0, 1\}^n\to\{0, 1\}$ a symmetric XOR function if for a function $S:\{0, 1, ..., n\}\to\{0, 1\}$, $F(x, y)=S(|x\oplus y|)$, for any $x, y\in\{0, 1\}^n$, where $|x\oplus y|$ is the Hamming weight of the bit-wise XOR of $x$ and $y$. We show that for any such function, (a) the deterministic communication complexity is always $\Theta(n)$ except for four simple functions that have a constant complexity, and (b) up to a polylog factor, the error-bounded randomized and quantum communication complexities are $\Theta(r_0+r_1)$, where $r_0$ and $r_1$ are the minimum integers such that $r_0, r_1\leq n/2$ and $S(k)=S(k+2)$ for all $k\in[r_0, n-r_1)$.
On the parity complexity measures of Boolean functions
Zhiqiang Zhang,Yaoyun Shi
Computer Science , 2010, DOI: 10.1016/j.tcs.2010.03.027
Abstract: The parity decision tree model extends the decision tree model by allowing the computation of a parity function in one step. We prove that the deterministic parity decision tree complexity of any Boolean function is polynomially related to the non-deterministic complexity of the function or its complement. We also show that they are polynomially related to an analogue of the block sensitivity. We further study parity decision trees in their relations with an intermediate variant of the decision trees, as well as with communication complexity.
Trastuzumab-Doxorubicin Conjugate Provides Enhanced Anti-Cancer Potency and Reduced Cardiotoxicity  [PDF]
Ningyan Zhang, Melvin E. Klegerman, Hui Deng, Yun Shi, Eva Golunski, Zhiqiang An
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41038

Since trastuzumab monotherapy for treatment of breast cancer with HER2/ErbB2 over-expression has been shown to have limited efficacy, combined treatment of trastuzumab with chemotherapy is widely practiced in clinic. However, certain combination treatments of trastuzumab and chemotherapy (i.e. doxorubicin) are not recommended due to high risk of cardiotoxicity. Antibody-drug conjugates (ADCs) offer selective delivery of cytotoxic agents into targeted cancer cells, thereby allowing for reduced general cellular cytotoxicity caused by chemotherapeutic agents through antibody mediated specific recognition of tumor antigens. In this study, we constructed a trastuzumab-doxorubicin conjugate (T-Dox) using a thioether linkage and characterized both biophysical stability and anti-cancer potency of the T-Dox using a panel of HER2 expressing cancer cell lines. The T-Dox conjugate showed significantly improved anti-cancer potency in comparison with trastuzumab. The results demonstrated for the first time that there were significant differences in the uptake of T-Dox among high HER2 expression cancer cells and higher T-Dox uptake also showed stronger anti-cancer potency. Similar to trastuzumab, T-Dox selectively bound to HER2 overexpressing cancer cells and low HER2 expression cells had no detectable uptake of T-Dox. Consistent to the uptake data, human cardiomyocyte cells had no detectable HER2 expression and T-Dox showed minimal cytotoxic effects. On the contrary, a treatment with combination of trastuzumab and doxorubicin showed severe cytotoxicity to human cardiomyocytes (>90% cell death after 3 day exposure). This study demonstrated that trastuzumab conjugated with doxorubicin (T-Dox) can provide valuable alternative to the combination treatment with doxorubicin and trastuzumab for high HER2 expressing cancer patients.

北京密云地区放马峪条带状铁建造的形成与变质时代:锆石SHRIMP UPb定年
Formation and Metamorphic Ages of the Banded Iron Formation in Fangmayu of Miyun, Beijing: Zircon SHRIMP UPb Dating

SHI Zhiqiang
, SHI Yuruo

- , 2017,
Abstract: 摘要: 通过对北京密云地区放马峪条带状铁矿矿石围岩中含磁铁矿石榴子石斜长片麻岩进行SHRIMP 锆石UPb测年研究,主要获得3组锆石207Pb/206Pb年龄,分别为(1 817±13) Ma、(2 456±6) Ma和(2 529±8) Ma。结合其岩相学、阴极发光图像分析,其中具有变质成因的锆石年龄分别为(1 817±13) Ma和(2 456±6) Ma,代表了该区条带状铁建造的两期变质时代;而另外1组年龄为(2 529±8) Ma的锆石,具岩浆锆石韵律环带特征,代表了该含磁铁矿石榴子石斜长片麻岩中碎屑锆石的年龄,从而间接限定了该区条带状铁建造的形成时代为(2 456±6) Ma到(2 529±8) Ma之间。结合前人研究资料,认为其可能形成于新太古代晚期。这些成果为该区乃至整个华北地区前寒武纪BIF型铁矿以及晚太古代至古元古代的构造演化提供了进一步详实的年代学资料。
Abstract: This paper reports zircon SHRIMP UPb ages for magnetitegarnetplagioclase gneiss from host rocks in the Fangmayu iron deposit, Miyun of Beijing. Zircon 207Pb/206Pb ages of the gneiss we mainly obtained are (1 817±13) Ma and (2 456±6) Ma, respectively. Based on the cathodoluminescence images of zircons, together with the petrography of rocks, the ages represent two stages of metamorphism of the banded magnetic quartzite, corresponding to similar ages of two largescale metamorphic events (namely ca. 244 Ga and ca. 182 Ga) reported from the eastern block of North China Craton. Then, we also found some owning oscillatory zoning zircons with 207Pb/206Pb age of (2 529±8) Ma, which represent the age of the detrital zircon from the magnetitegarnetplagioclase gneiss. It also indirectly constrains that the banded iron formation was formed between (2 456±6) to (2 529±8) Ma, most likely at the end of Neoarchean by combining previous research data. The results also provide further detailed information for research of early tectonic evolution of North China Craton and iron deposits (BIF) in China
Research on Industry Leaders’ External Auditing Demand in China—Based on the Signal Transfer Theory  [PDF]
Zhiqiang Wen
Open Journal of Business and Management (OJBM) , 2016, DOI: 10.4236/ojbm.2016.41013
Abstract: This paper validates the demand for audit’s signal transfer theory by China’s A-share listed company data. As having a significant influence on the region and the industries where they locate in, industry leaders will catch more attention. In this case, compared to other companies, industry leaders have stronger demands for high-quality audit services, because it can transmit a signal to the market that they are under a good company supervision. However, high growth industry leaders don’t have a stronger demand for high quality audit services than other ones as we refer in the hypothesis. The reason is that even industry leaders do not have external financing needed, they will still choose high-quality audit services, as it can transfer a good signal to the outside world.
An Open Conformance Test System towards the Standardization of Wireless Sensor Networks
Zhonghua Zhao,Wei Huangfu,Linmin Sun,Zhiqiang Shi,Wei Gan
International Journal of Distributed Sensor Networks , 2012, DOI: 10.1155/2012/931869
Abstract: The conformance testing on the wireless sensor networks (WSNs) is fundamental for the functional large-scale deployment and interconnection with the global Internet. The WSN protocols based on the Internet Protocol version 6 (IPv6) are the major trends of the future applications, which include IEEE 802.15.4, 6LoWPAN, and RPL. These protocols are not only diverse for various applications, but also volatile in the future. Moreover, sensor nodes are resource constrained, application related and lack the standardized test interface. Hence the corresponding conformance testing is seriously insufficient and needs urgently research. In this paper, the IPv6-based WSN protocols are analyzed and the conformance testing techniques and methods for IPv6-based WSNs are investigated towards the standardization of WSNs. A novel conformance test system for IPv6-based WSNs is designed and implemented, which is open, flexible, full featured, and practical. The conformance test system is suitable for the protocol evolution and the various hardware interfaces for the sensor nodes. The related outcomes will promote the standardization and commercialization of WSNs. 1. Introduction Wireless sensor networks (WSNs) are the emerging research areas in the current international academia and industry, which can be widely used in many fields, such as intelligent transportation, environmental monitoring, and industrial automation. WSNs have received widespread attention, with a great prospect for economic and social value. It is fundamental to consider the interconnection between WSNs and Internet for the large-scale application of WSNs. As the core of next-generation Internet protocols, IPv6 has many advantages which include the richness in address resource, the autoconfiguration of address, supporting real-time business, higher security, and better mobility. With the combination of IPv6 and WSNs, IPv6-based WSNs can meet the demands of the current WSNs in the address, security, mobility, and the integration with the existing networks, which will greatly promote the development of WSNs and has become a hot research field of WSNs. Some lightweight IPv6 protocol standards and draft for WSNs have successively been developed in industry, such as IEEE 802.15.4 in MAC (Media Access Control) layer, 6LoWPANs (IPv6 over Low-power Wireless Personal Area Networks) in the adaptation layer, and routing protocol RPL (IPv6 Routing Protocol for Low-power and Lossy Networks) in the network layer. The IETF is accelerating the standardization process of the above-mentioned protocols. IEEE 802.15.4 is
A TD-DFT Study on the Photo-Physicochemical Properties of Chrysophanol from Rheum
Xue Zhao,Zebao Zheng,Shuai Feng,Zhiqiang Shi,Dezhan Chen
International Journal of Molecular Sciences , 2009, DOI: 10.3390/ijms10073186
Abstract: As a naturally occurring anthraquinone pigment, chrysophanol (MHAQ) has attracted considerable attention in recent years owing to its efficient photosensitivity under the solar spectrum. Considering the successful use of time-dependent density functional theory (TD-DFT) in investigating the photo-physicochemical behaviors of dyes and pigments, we performed a study by means of TD-DFT calculations, which provided us with various excited state properties of chrysophanol, including absorption spectrum, lowest triplet excited-state energy, vertical electron affinity and vertical ionization potential. On the basis of the calculated results, the photosensitive mechanisms of chrysophanol were discussed and some deeper insights were gained. First, we indicated that the experimentally observed chrysophanol’s photo-damage to DNA in oxygen-free media is more likely to arise from MHAQ ?+ rather than from T1 state chrysophanol. Second, we revealed that it is the MHAQ ?? that is responsible for the O2?? generation in solvents. Based on the photosensitive activities, chrysophanol may be potentially used as the photodynamic medicine for clinical therapy of the diseases occurring on the shallow surface and vascular capillary diseases.
Phase boundary sliding model controlled by diffusionsolution zone in superplastic deformation
Zhiqiang Shi,Yifu Ye,Shichun Li,Xinying Teng,Huanrong Wang
Chinese Science Bulletin , 2002, DOI: 10.1007/BF02907615
Abstract: With scanning electron microscope (SEM), the surface morphology of phase boundary sliding (PBS) in superplastic deformation (SPD) of Zn-Al alloy and the diffusion behavior of Zn, Al interfaces in their powers’ sintering have been investigated. The results show that Zn-Al eutectoid microstructure can be achieved through their powders’ sintering, and the diffusion characteristic between Zn and Al is just a demonstration of Kirkendall effect, in which Zn can dissolve into Al whereas A1 can hardly dissolve into Zn. During sintering, a diffusion-solution zone α′ has formed and subsequently transformed into a eutectoid microstructure in the cooling process. The superplastic deformation mechanism of Zn-Al eutectic alloy is phase boundary sliding which is controlled by the diffusion-solution zone α′. If the diffusion-solution zone α′ is unsaturated, it will have much more crystal defects and the combination between α′ and phase β is weak, thus the process of phase boundary sliding becomes easily; on the contrary, if the diffusion-solution zone α′ becomes thick and saturated, the sliding will be difficult.
Electrochemical performance of MCMB/(AC+LiFePO4) lithium-ion capacitors
LiNa Ping,JiaMing Zheng,ZhiQiang Shi,Jie Qi,ChengYang Wang
Chinese Science Bulletin , 2013, DOI: 10.1007/s11434-012-5456-9
Abstract: Lithium-ion capacitors (LICs) were fabricated using mesocarbon microbeads (MCMB) as a negative electrode and a mixture of activated carbon (AC) and LiFePO4 as a positive electrode (abbreviated as LAC). The phase structure and morphology of LAC samples were characterized by X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM). The electrochemical performance of the LICs was studied using cyclic voltammetry, charge-discharge rate measurements, and cycle performance testing. A LIC with 30 wt% LiFePO4 was found to have the best electrochemical performance with a specific energy density of 69.02 W h kg 1 remaining at 4 C rate after 100 cycles. Compared with an AC-only positive electrode system, the ratio of practical capacity to theoretical calculated capacity of the LICs was enhanced from 42.22% to 56.59%. It was proved that adding LiFePO4 to AC electrodes not only increased the capacity of the positive electrode, but also improved the electrochemical performances of the whole LICs via Li+ pre-doping.
Synthesis and antioxidative properties of polyphenol-fullerenes
Zhiqiang Shi,Yuliang Li,Shu Wang,Hongjuan Fang,Daoben Zhu
Chinese Science Bulletin , 2001, DOI: 10.1007/BF02900551
Abstract: Fullerene derivatives have exhibited fascinating properties in biological systems. Several antioxidative hindered phenol units were connected to C60 called radical sponge, resulting in its excellent solubility in polar solvents. The stable radical scavenging experiments were performed with electron spin resonance spectroscopy. The results indicate that both samples show desirable efficiency in eliminating free radicals.
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