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Search Results: 1 - 10 of 20632 matches for " ZhiZhong Jing "
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ABA-Mediated ROS in Mitochondria Regulate Root Meristem Activity by Controlling PLETHORA Expression in Arabidopsis
Li Yang,Jing Zhang,Junna He,Yingying Qin,Deping Hua,Ying Duan,Zhizhong Chen,Zhizhong Gong
PLOS Genetics , 2014, DOI: doi/10.1371/journal.pgen.1004791
Abstract: Although research has determined that reactive oxygen species (ROS) function as signaling molecules in plant development, the molecular mechanism by which ROS regulate plant growth is not well known. An aba overly sensitive mutant, abo8-1, which is defective in a pentatricopeptide repeat (PPR) protein responsible for the splicing of NAD4 intron 3 in mitochondrial complex I, accumulates more ROS in root tips than the wild type, and the ROS accumulation is further enhanced by ABA treatment. The ABO8 mutation reduces root meristem activity, which can be enhanced by ABA treatment and reversibly recovered by addition of certain concentrations of the reducing agent GSH. As indicated by low ProDR5:GUS expression, auxin accumulation/signaling was reduced in abo8-1. We also found that ABA inhibits the expression of PLETHORA1 (PLT1) and PLT2, and that root growth is more sensitive to ABA in the plt1 and plt2 mutants than in the wild type. The expression of PLT1 and PLT2 is significantly reduced in the abo8-1 mutant. Overexpression of PLT2 in an inducible system can largely rescue root apical meristem (RAM)-defective phenotype of abo8-1 with and without ABA treatment. These results suggest that ABA-promoted ROS in the mitochondria of root tips are important retrograde signals that regulate root meristem activity by controlling auxin accumulation/signaling and PLT expression in Arabidopsis.
Study on Bifurcation and Chaos in Boost Converter Based on Energy Balance Model  [PDF]
Quanmin NIU, Zhizhong JU
Energy and Power Engineering (EPE) , 2009, DOI: 10.4236/epe.2009.11006
Abstract: Based on boost converter operating in discontinuous mode, this paper proposes an energy balance model (EBM) for analyzing bifurcation and chaos phenomena of capacitor energy and output voltage when the converter parameter is varying. It is found that the capacitor energy and output voltage dynamic behaviors exhibit the typical period-doubling route to chaos by increasing the feedback gain constant K of proportional controller. The accurate position of the first bifurcation point and the iterative diagram of the capacitor energy with every K can be derived from EBM. Finally, the underlying causes for bifurcations and chaos of a general class of nonlinear systems such as power converters are analyzed from the energy balance viewpoint. Com-paring with the discrete iterative model, EBM is simple and high accuracy. This model can be easily devel-oped on the nonlinear study of the other converters.
FPGA Design and Implementation of a Convolutional Encoder and a Viterbi Decoder Based on 802.11a for OFDM  [PDF]
Yan Sun, Zhizhong Ding
Wireless Engineering and Technology (WET) , 2012, DOI: 10.4236/wet.2012.33019
Abstract: In this paper, a modified FPGA scheme for the convolutional encoder and Viterbi decoder based on the IEEE 802.11a standards of WLAN is presented in OFDM baseband processing systems. The proposed design supports a generic, robust and configurable Viterbi decoder with constraint length of 7, code rate of 1/2 and decoding depth of 36 symbols. The Viterbi decoder uses full-parallel structure to improve computational speed for the add-compare-select (ACS) modules, adopts optimal data storage mechanism to avoid overflow and employs three distributed RAM blocks to complete cyclic trace-back. It includes the core parts, for example, the state path measure computation, the preservation and transfer of the survivor path and trace-back decoding, etc. Compared to the general Viterbi decoder, this design can effectively decrease the 10% of chip logic elements, reduce 5% of power consumption, and increase the encoder and decoder working performance in the hardware implementation. Lastly, relevant simulation results using Verilog HDL language are verified based on a Xinlinx Virtex-II FPGA by ISE 7.1i. It is shown that the Viterbi decoder is capable of decoding (2, 1, 7) convolutional codes accurately with a throughput of 80 Mbps.
Aeroelastic Analysis of a Transonic Fan Blade with Low Hub-to-Tip Ratio including Mistuning Effects  [PDF]
Zhizhong Fu, Yanrong Wang
Journal of Power and Energy Engineering (JPEE) , 2015, DOI: 10.4236/jpee.2015.34049
Abstract:

This paper presents a comprehensive investigation of aeroelastic stability for a high aft-swept transonic fan blade with low hub-to-tip ratio. The evolution of the blade’s aeroelastic stability in the first bending modes is studied. A 3D flutter computation representing today’s industry standard is performed. Steady state flow field and motion-induced unsteady pressures acting on the blade have been determined by a 3D Reynolds-Averaged Navier-Stokes (RANS) equations with a standard k-ε turbulence model. A weakly coupled (one-way) method has been employed to describe the interaction between fluid and structure. The results of aerodynamic damping indicate a significant shock-driven risk. To increase the flutter margin by a viable method, a statistical mistuned aeroelastic stability investigation has been performed. It has been found that alternately intentional mistuning with a small blade frequency offset stabilizes the system effectively. However, as the standard deviation of random mistuning reaches some critical values, the introduction of alternately intentional mistuning does not provide any additional stabilizing effects.

p53 codon 72 polymorphism and Hematological Cancer Risk: An Update Meta-Analysis
Yu Weng, Liqin Lu, Guorong Yuan, Jing Guo, Zhizhong Zhang, Xinyou Xie, Guangdi Chen, Jun Zhang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045820
Abstract: Background Previous studies on the association of p53 codon 72 (Arg72Pro) polymorphism with hematological malignancies risk have produced conflicting results. The purpose of this meta-analysis is to define the effect of p53 Arg72Pro polymorphism on hematological malignancies risk. Methodology/Principal Findings Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH terms and keywords: “p53”, “codon 72” “polymorphism” and “leukemia”, or “lymphoma”, or “myeloma”, thirteen were identified as eligible articles in this meta-analysis for p53 Arg72Pro polymorphism (2,731 cases and 7, 356 controls), including nine studies on leukemia (1,266 cases and 4, 474 controls), three studies on lymphoma (1,359 cases and 2,652 controls), and one study on myeloma. The overall results suggested that p53 Arg72Pro polymorphism was not associated with hematological malignancies risk. In stratified analyses, significantly increased non-Hodgkin lymphomas risk was found in p53 Arg72Pro polymorphism heterozygote model (Arg/Pro vs. Arg/Arg: OR = 1.18, 95%CI: 1.02–1.35) and dominant model (Arg/Pro+Pro/Pro vs. Arg/Arg: OR = 1.18, 95%CI: 1.03–1.34), but no significant association was found between leukemia risk and p53 Arg72Pro polymorphism. Further studies showed no association between leukemia risk and p53 Arg72Pro polymorphism when stratified in subtypes of leukemias, ethnicities and sources of controls. Conclusions/Significance This meta-analysis indicates that the p53 Arg72Pro polymorphism may contribute to susceptibility to non-Hodgkin lymphomas.
The Histological Structure and Location of Substance P in the Digestive Tract of the Siberian Tiger (Panthera tigris altaica)
Yunhai Zhang,Yunsheng Li,Zhizhong Zhang,Zubing Cao,Shudong Jiang,Jing Yang,Xiaorong Zhang,Fugui Fang
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2012.735.741
Abstract: Substance P (SP) belongs to the tachykinin family and plays important roles in many physiological processes. The distribution of SP has not been investigated in the digestive tract of the tiger. The present study was performed to describe the histological structure and location of SP in the digestive tract which included the esophagus, stomach, small intestine and large intestine of the Siberian tiger at 8 days of age. The tissues of the digestive tract were collected from three 8 days old Siberian tigers that died of cold weather. The weight was recorded and the histological sections were made and stained with HE. The localization of SP in tissue was detected by immunohistochemical two-step PV-9000. The results show that the length of the digestive tract was approximately 215.6 cm with an average weight of 48.95 g. The wall of the digestive tract consisted of mucosa, submucosa, unica muscularis and tunica adventitia. The epithelium of the esophagus was a stratified squamous type without beginning surface cornification and the unica muscularis consisted of skeletal muscle. The lamina propria of the stomach was located by many glands but did not reach the muscularis mucosa. SP-immunoreactive cells were identified primarily in the epithelium and the cardiac gland of the stomach. SP- immunoreactive cells were also found in the intestinal gland of the lamina propria of the cecum and the colon. The current study preliminarily revealed the histological features and the distribution of SP in the digestive tract of an 8 days old Siberian tiger which requires further investigation.
Characterization of Interferon-α1 of Yak
GuoHua Chen,HuaiJie Jia,YaDong Zhen,Shuang Zeng,YongXiang Fang,XiaoBing He,ZhiZhong Jing,XuePeng Cai
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2012.3978.3983
Abstract: The yak (Bos grunniens) is an important grazing livestock in Western of China. In this study, the full length of yIFN-a1 gene was cloned then the recombinant yIFN-a1 was expressed in yeast expression system. In vitro bioactivity of IFN-α1 was determined by inhabition infection BHK cell against Vesicular Stomatitis Virus (VSV). The results showed that cDNA contains an Open Reading Frame (ORF) of 570 base pairs encoding a protein of 189 amino acid (aa) precursor with a signal peptide of 23 aa. The homology of the yIFN-a1 was up to 65.3~94.4% with other species at the amino acid levels. The recombinant yIFN-a1 was recognized in Western blot by mAb against human IFN-α1. The activity unit of the purified recombinant yIFN- a1 protein was 1.16×105 IU mg-1 by against Vesicular Stomatitis Virus (VSV) antiviral assay in vitro. This made a basis for the development of anti-virus medicine of yak in the future.
Innate immune recognition of the pathogenic parasites by Toll-like receptors
Toll样受体对病原寄生虫的天然免疫识别

Xiaobing He,Huaijie Jia,Zhizhong Jing,
何小兵
,贾怀杰,景志忠

生物工程学报 , 2012,
Abstract: Toll-like receptors (TLRs) have emerged as major receptor components of pattern-recognition receptors (PRRs), which are responsible for the recognition of pathogen-associated molecular patterns (PAMPs)-derived pathogenic parasites. This recognition triggers the secretion of a large amount of type I interferons (IFNs), inflammatory cytokines, and chemokines and maturation of immune cells, for effective host defense by eradicating infectious parasites. Both the myeloid differentiation factor 88 (MyD88) and the TIR domain containing the adaptor molecule (TRIF) are involved in these signaling pathways. Here, we review the latest ?ndings on the recognition of the pathogenic parasites and activation of corresponding signaling pathways through TLRs, with special emphasis on the recognition of pathogenic protozoan and helminthes. By highlighting recent progress in these areas, we hope to provide references in future studies not only for the complexity of host-parasite interactions but also for the prevention of the pathogenic parasite infections.
Organizational Innovation and Learning in the Biotechnological Industry
Zhizhong Chen
International Journal of Business and Management , 2009,
Abstract: The biotechnological industry is a comparative new technology-intensive industry, which is facing a fast-changing environment. Therefore, the firms in the biotechnological industry have been more and more depending on the ability of innovation. In the other words, learning ability is the key abilities in the biotechnological industry. What is the relationship between the organizational innovation and the learning? The paper puts forward the opinion that the learning causes the organization to innovate. And while the firm structure becomes more flexible, the organization learning would have more chance to be achieved.
Phylogenetic analysis of Chinese sheeppox and goatpox virus isolates
Tao Zhou, Huaijie Jia, Guohua Chen, Xiaobing He, Yongxiang Fang, Xiaoxia Wang, Qisai Guan, Shuang Zeng, Qing Cui, Zhizhong Jing
Virology Journal , 2012, DOI: 10.1186/1743-422x-9-25
Abstract: Sequence and phylogenetic analysis showed that there was a close relationship among SPPV/GanS/2/2011/China, SPPV/GanS/1/2011/China and SPPV/NingX/2009/China. They were clustered on the same SPPV clade. GTPV/HuB/2009/China and GS-V1 belonged to the GTPV lineage. GS-V1 was closely related to other GTPV vaccine strains. GTPV/HuB/2009/China and GS-V1 were clustered with GTPVs from China and some southern Asian countries.This study may expand the datum for spread trend research of Chinese SPPVs and GTPVs, meanwhile provide theoretical references to improve the preventive and control strategy.Sheeppox virus (SPPV), goatpox virus (GTPV) and lumpy skin disease virus (LSDV) comprising Genus Capripoxvirus of the Family Poxviridae are important aetiological agents to ruminants. They cause sheep pox, goat pox and lumpy skin disease of cattle respectively, which are well-known economically significant animal diseases. Sheep pox and goat pox, classified as notifiable animal diseases by the World Organisation for Animal Health (OIE), are mainly endemic in central and northern Africa, the Middle East, Indian sub-continent, central Asia and parts of P. R. China [1]. In contrast, the endemic geographic range of lumpy skin disease is currently limited to Africa, with sporadic outbreaks occurring in the Middle East [2,3].Sheep pox and goat pox are characterized by pyrexia, rhinitis, conjunctivitis, excessive salivation and generalized pock lesions in the skin. They may cause the significant damage to wool and hides (can affect as much as 50% of the skin surface) and the production loss of mutton and milk [2]. Furthermore, sheep pox and goat pox may be associated with very high morbidity and mortality rate except indigenous animals. The mortality rate in young animals can exceed 50%. However, in na?ve animals, morbidity and mortality can even approach to 100% [4]. As for host preference, it was once a common belief that SPPV only infected sheep while GTPV only infected goats. But now, m
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