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Search Results: 1 - 10 of 36972 matches for " ZhenLin Yan "
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The ninth-mode sectorial oscillation of acoustically levitated drops
ZhenLin Yan,WenJun Xie,DeLu Geng,BingBo Wei
Chinese Science Bulletin , 2011, DOI: 10.1007/s11434-011-4698-2
Abstract: We report on the ninth-mode sectorial oscillation of acoustically levitated drops excited by actively modulating sound pressure. A numerical computation based on the level set method was performed to model drop shape evolution by solving an incompressible two-phase flow problem. The calculated shapes of the oscillating drop are in good agreement with experimental observations. The relationship between the oscillation frequency and parameters describing the flattened drops is studied both experimentally and numerically. The frequency of the ninth-mode sectorial oscillation decreases with increasing equatorial radius and can be well-described by a modified Rayleigh equation.
Baicalin Induced Dendritic Cell Apoptosis in Vitro
Huahua Zhang,Qingqing Jiao,Yan Zhang,Weidong Zhang,Zhenlin Hu
Frontiers in Pharmacology , 2011, DOI: 10.3389/fphar.2011.00015
Abstract: This study was aimed to investigate the effects of baicalin (BA), a major flavonoid constituent found in the herb Baikal skullcap, on dendritic cells (DCs). DCs were generated by culturing murine bone marrow (BM) cells for 6 days with granulocyte–macrophage colony-stimulating factor and interleukin (IL)-4, and lipopolysaccharide (LPS) was added on day 5 to stimulate DCs maturation. The expression levels of DC maturity markers (CD80/CD86) were assessed by flow cytometry using direct immunofluorescence method. IL-12 levels in the culture supernatants were assayed by ELISA. Apoptosis of DCs was analyzed by flow cytometry after annexin V/propidium iodide staining. The mitochondrial membrane potential (Δψm) changes were measured by using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Exposure of DCs to BA (2–50 μM) during BM cell differentiation showed no effects on the up-regulation of CD80/CD86 expression on DCs in response to LPS stimulation, but reduced DCs recovery by inducing apoptosis, and significantly inhibited the release of IL-12 to culture supernatants. BA-induced DC apoptosis in a time- and dose-dependent way, and immature DCs were more sensitive for BA-induced apoptosis than mature DC. BA also induced Δψm changes in DCs. These results demonstrate that BA induces selective apoptosis in immature DCs possibly through mitochondria-mediated pathway.
Comparison of grain protein components and processing quality in responses to dim light during grain filling between strong and weak gluten wheat cultivars

LI Wenyang,YAN Suhui,WANG Zhenlin,

生态学报 , 2012,
Abstract: Low light intensity as a result of cloudy or rainy days often occurs during the grain filling of winter wheat (Triticum aestivum L.) in Huanghuai region of China, largely affecting grain yield and quality. Many investigators have demonstrated the effects of shading on photosynthesis, dry matter accumulation, grain yield and its components of winter wheat. However, there are few reports on the effects of shading on protein compositions and processing quality in wheat grain. The strong gluten wheat cultivars are remarkably different from the weak gluten cultivars in many grain quality parameters. This study attempted to determine the processing quality and protein compositions of wheat cultivars differing in quality type wheat grown under low light intensity at different grain filling stages. Two wheat cultivars, Jimai 20 (strong gluten wheat cultivars) and Shannong 1391 (weak gluten wheat cultivars), were used to investigate the effect of dim light on grain yield, protein compositions and processing quality. The field was shaded by the black nets with 90% shading over the plants in early (6-9 d after anthesis, S1 treatment), middle (16-19 d after anthesis, S2 treatment) and late (26-29 d after anthesis, S3 treatment) grain filling. The treatments were arranged in a randomized complete design with three replications. The results showed that dim light after anthesis remarkably reduced grain yield, especially in S2 treatment for Jimai 20 and S3 treatment for Shannong 1391. Shading stress after anthesis significantly decreased the kernel weight. The kernel number per spike had great difference in treatments. The low light stress of S1 treatment reduced the kernel number per spike, in fact, it reduced the upper kernel number per spike, and the decrease extent of kernel weight of S1 treatment was lower than S2 and S3 treatments. Under shading condition, grain nitrogen accumulation and nitrogen harvest index decreased sharply in both cultivars. Dim light after anthesis significantly increased the grain protein content in both cultivars, especially at the middle grain filling stage, and the trend as following: S2>S3>S1>Control. Combined grain protein content with kernel weight, we suggested that it was less kernel weight that increased protein content of shading treatments. Under shading stress, especially at middle and late grain filling stages, the insoluble glutenin content enhanced significantly, but the soluble glutenin content was no significant difference with the control, then, the glutenin polymerization index in grain increased sharply. Compared with the control, The dry and wet gluten contents and sedimentation values were all significantly increased at three shading stress. And dim light after anthesis significantly increased the dough development time and stability time, especially at middle and late grain filling stages. After it was analyzed that the relationship between the farinograph parameters and insoluble glutenin content and glutenin
Baicalein Selectively Induces Apoptosis in Activated Lymphocytes and Ameliorates Concanavalin A-Induced Hepatitis in Mice
Yan Zhang, Lei Shan, Yaping Hua, Dan Wang, Huawu Zeng, Runhui Liu, Weidong Zhang, Zhenlin Hu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069592
Abstract: Background Insufficient apoptosis in activated lymphocytes contributes to the development of autoimmune hepatitis (AIH). Baicalein (BE), a flavonoid originally isolated from the root of Scutellaria baicalensis Georgi, possesses anti-inflammatory properties. However, whether BE can selectively induce apoptosis in activated lymphocytes and exert therapeutic effect on AIH has not been studied. Methodology/Principal Findings The pro-apoptotic properties of BE were evaluated in vitro on different types of immune cells, and in vivo effects of BE were examined in a murine model of Concanavalin A (Con A)-induced hepatitis. In vitro treatment with BE resulted in a higher increase in the level of apoptosis in Con A-stimulated murine splenocytes, Con A-stimulated CD3+ splenocytes, lipopolysaccharide (LPS)-stimulated CD19+ splenocytes, and phorbol 12-myristate 13-acetate/ionomycin-stimulated Jurkat T cells, compared with that in unstimulated na?ve ones. Murine bone marrow-derived dentritic cells, peritoneal macrophages, and RAW264.7 cells, either stimulated with LPS or unstimulated, were all insensitive to the BE-induced apoptosis. BE treatment also led to a loss of mitochondrial membrane potential, an increase of cytochrome c release from mitochondria to the cytosol, a decrease in the ratio of Bcl-2/Bax, and activation of caspase-9,-3 in Con A-stimulated CD3+ splenocytes and LPS-stimulated CD19+ splenocytes, while showing no impact on Fas/FasL expressions and caspase-8 activation. In vivo administration of BE alleviated Con A-induced liver injury, suppressed serum level of TNF-α and IFN-γ, and reduced liver infiltration of mononuclear cells (MNCs). Furthermore, BE treatment increased the incidences of apoptosis in liver-infiltrating MNCs and splenocytes, as well as in CD3+ and CD19+ splenocytes. When liver MNCs and splenocytes from BE-treated mice were cultured in vitro for 24 h, they exhibited marked increase in apoptosis compared to vehicle-treated control. Conclusions/Significance The present study demonstrates the ability of BE to promote apoptosis in activated lymphocytes through mitochondrial pathway and its potential use in the treatment of AIH.
A thermodynamically consistent phase-field model for two-phase flows with thermocapillary effects
Zhenlin Guo,Ping Lin
Physics , 2014, DOI: 10.1017/jfm.2014.696
Abstract: In this paper, we develop a phase-field model for binary incompressible (quasi-incompressible) fluid with thermocapillary effects, which allows for the different properties (densities, viscosities and heat conductivities) of each component while maintaining thermodynamic consistency. The governing equations of the model including the Navier-Stokes equations with additional stress term, Cahn-Hilliard equations and energy balance equation are derived within a thermodynamic framework based on entropy generation, which guarantees thermodynamic consistency. A sharp-interface limit analysis is carried out to show that the interfacial conditions of the classical sharp-interface models can be recovered from our phase-field model. Moreover, some numerical examples including thermocapillary convections in a two-layer fluid system and thermocapillary migration of a drop are computed using a continuous finite element method. The results are compared to the corresponding analytical solutions and the existing numerical results as validations for our model.
Analysis on Mistakes which Occur Often in Writing English Notes of Figures and Tables

ZHANG ZhenLin,

中国科技期刊研究 , 2007,
Abstract: 分析了科技期刊图表英文注释中的常见差错,认为这些差错的主要表现有省略错误、动词词义和语法功能误用、主谓语搭配不当、标点符号使用混乱等。同时,探讨了图表英文注释差错处理办法。

WANG Zhenlin,

心理学报 , 2000,
Abstract: One of the most prominent characteristics of children's human figure drawing is disproportion. Over 300 children aged from 4.5 to 6.5 panicipated in this research. The results showed that the trunk/head ratios of all participants, averaged 1.3, increased from 4.5 to 5.5, then decreased until 6 and increased again on free drawing condition. Due to the relatively stable size of the head, the variation of the ratio was mostly caused by the variation of the size of the trunk, which is deemed pertinent to the cognitive development of body structure. On model drawing condition, the trunk/head ratio was significantly greater than that of free drawing, although the direction of variation was the same except ages of 4.5 to 5. Changing the order of drawing and exaggerating the function of body parts can also affect the ratio.
A numerical method for the quasi-incompressible Cahn-Hilliard-Navier-Stokes equations for variable density flows with a discrete energy law
Zhenlin Guo,Ping Lin,John S. Lowengrub
Physics , 2014, DOI: 10.1016/j.jcp.2014.07.038
Abstract: In this paper, we investigate numerically a diffuse interface model for the Navier-Stokes equation with fluid-fluid interface when the fluids have different densities \cite{Lowengrub1998}. Under minor reformulation of the system, we show that there is a continuous energy law underlying the system, assuming that all variables have reasonable regularities. It is shown in the literature that an energy law preserving method will perform better for multiphase problems. Thus for the reformulated system, we design a $C^0$ finite element method and a special temporal scheme where the energy law is preserved at the discrete level. Such a discrete energy law (almost the same as the continuous energy law) for this variable density two-phase flow model has never been established before with $C^0$ finite element. A Newton's method is introduced to linearise the highly non-linear system of our discretization scheme. Some numerical experiments are carried out using the adaptive mesh to investigate the scenario of coalescing and rising drops with differing density ratio. The snapshots for the evolution of the interface together with the adaptive mesh at different times are presented to show that the evolution, including the break-up/pinch-off of the drop, can be handled smoothly by our numerical scheme. The discrete energy functional for the system is examined to show that the energy law at the discrete level is preserved by our scheme.
A three dimensional field formulation, and isogeometric solutions to point and line defects using Toupin's theory of gradient elasticity at finite strains
Zhenlin Wang,Shiva Rudraraju,Krishna Garikipati
Physics , 2015,
Abstract: We present a field formulation for defects that draws from the classical representation of the cores as force dipoles. We write these dipoles as singular distributions. Exploiting the key insight that the variational setting is the only appropriate one for the theory of distributions, we arrive at universally applicable weak forms for defects in nonlinear elasticity. Remarkably, the standard, Galerkin finite element method yields numerical solutions for the elastic fields of defects, that when parameterized suitably, match very well with classical, linearized elasticity solutions. The true potential of our approach, however, lies in its easy extension to generate solutions to elastic fields of defects in the regime of nonlinear elasticity, and even more notably for Toupin's theory of gradient elasticity at finite strains (Arch. Rat. Mech. Anal., 11, 385, 1962). In computing these solutions we adopt recent numerical work on an isogeometric analytic framework that allowed the first three-dimensional solutions to general boundary value problems of Toupin's theory (Rudraraju et al. Comp. Meth. App. Mech. Engr., 278, 705, 2014). We present exhaustive solutions to point defects, edge and screw dislocations, as well as a study on the energetics of interacting dislocations.
Stage II/III Rectal Cancer Patients Benefit from Extremely Early Initiation of Postoperative Adjuvant Chemotherapy: A Retrospective Study  [PDF]
Liuniu Xiao, Li Zhu, Yingming Chen, Zhenlin Hou, Lingwei Jia, Junbo Hu, Yongdong Feng
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.101004
Abstract: Background: For Stage II/III rectal cancer patients, curative resection is the primary treatment, prescribing of postoperative adjuvant chemotherapy (PAC) is regarded as a standard therapy. The interval between surgery and the initiation of PAC is usually within 8 weeks. However, the optimal cut-off is still controversial. This study aimed to explore the impact of extremely early initiation of PAC for II/III rectal cancer. Methods: Patients with Stage II/III rectal cancer treated from January 2013 to December 2015 were retrospectively collected at the Department of Tongji Hospital. According to the starting point of PAC, patients were categorized into two groups: extremely early group (The interval of PAC ≤ 2 weeks) and normal group (The interval of PAC within 3 - 5 weeks). For the sake of evaluating the effectiveness of different intervals, Overall Survival rate (OS), Progress-Free Survival rate (PFS) and Recurrence or Metastasis Rate (RMR) were analyzed, as well as the Quality of Life Score. To estimate the safety of the extremely early PAC, we evaluated the first post chemotherapy adverse reactions and defecation ability, and analyzed the variance laboratory indexes around the first postoperative adjuvant chemotherapy. Results: A total of 267 patients were included in this study. Compared to normal group (192 cases), extremely early group (75 cases) of patients attained a better tendency of OS and PFS, although there were no significant statistical differences (OS: P = 0.0930; PFS: P = 0.1058). However, the RMR was significant lower (P = 0.0452) and the Quality of Life Score was significantly higher (P = 0.0090) in extremely early group. Multivariate analysis also showed that extremely early group had better defecation ability (P = 0.0149) and less side reactions of post
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