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Search Results: 1 - 10 of 15504 matches for " ZhenHua Ren "
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Cells therapy for Parkinson’s disease—so close and so far away
ZhenHua Ren,Yu Zhang
Science China Life Sciences , 2009, DOI: 10.1007/s11427-009-0090-8
Abstract: One of the strategies of treating Parkinson’s disease (PD) is the replacement of lost neurons in the substantia nigra with healthy dapamingergic cells. Potential sources for cells range from autologous grafts of dopamine secreting cells, fetal ventral mesencephalon tissue, to various stem cell types. Over the past quarter century, many experimental replacement therapies have been tried on PD animal models as well as human patients, yet none resulted in satisfactory outcomes that warrant wide applications. Recent progress in stem cell biology has shown that nuclear transfer embryonic stem cells (ntES) or induced pluripotent stem cells (iPS) derived cells can be used to successfully treat rodent PD models, thus solving the problem of immunorejection and paving the way for future autologous transplantations for treating PD. Meanwhile, however, post mortem analysis of patients who received fetal brain cell transplantation revealed that implanted cells are prone to degeneration just like endogenous neurons in the same pathological area, indicating long-term efficacy of cell therapy of PD needs to overcome the degenerating environment in the brain. A better understanding of neurodegeneration in the midbrain appeared to be a necessary step in developing new cell therapies in Parkinson’s disease. It is likely that future cell replacement will focus on not only ameliorating symptoms of the disease but also trying to slow the progression of the disease by either neuroprotection or restoring the micro-environment in the midbrain.
Cells therapy for Parkinson’s disease so close and so far away

REN ZhenHua &,ZHANG Yu,

中国科学C辑(英文版) , 2009,
Abstract: One of the strategies of treating Parkinson’s disease (PD) is the replacement of lost neurons in the substantia nigra with healthy dapamingergic cells. Potential sources for cells range from autologous grafts of dopamine secreting cells, fetal ventral mesencephalon tissue, to various stem cell types. Over the past quarter century, many experimental replacement therapies have been tried on PD animal models as well as human patients, yet none resulted in satisfactory outcomes that warrant wide applications. Recent progress in stem cell biology has shown that nuclear transfer embryonic stem cells (ntES) or induced pluripotent stem cells (iPS) derived cells can be used to successfully treat rodent PD models, thus solving the problem of immunorejection and paving the way for future autologous transplantations for treating PD. Meanwhile, however, post mortem analysis of patients who received fetal brain cell transplantation revealed that implanted cells are prone to degeneration just like endogenous neurons in the same pathological area, indicating long-term efficacy of cell therapy of PD needs to overcome the degenerating environment in the brain. A better understanding of neurodegeneration in the midbrain appeared to be a necessary step in developing new cell therapies in Parkinson’s disease. It is likely that future cell replacement will focus on not only ameliorating symptoms of the disease but also trying to slow the progression of the disease by either neuroprotection or restoring the micro-environment in the midbrain. Support by the National Key Basic Research and Development Program of China (Grant No. 2006CB0F0603) and Science and Technology Plan, Beijing Municipal Science & Technology Commission (Grant No. H020220010290)
Topological Phases in Two-Dimensional Materials: A Brief Review
Yafei Ren,Zhenhua Qiao,Qian Niu
Physics , 2015,
Abstract: Topological phases with insulating bulk and gapless surface or edge modes have attracted much attention because of their fundamental physics implications and potential applications in dissipationless electronics and spintronics. In this review, we mainly focus on the recent progress in the engineering of topologically nontrivial phases (such as $\mathbb{Z}_2$ topological insulators, quantum anomalous Hall effects, quantum valley Hall effects \textit{etc.}) in two-dimensional material systems, including quantum wells, atomic crystal layers of elements from group III to group VII, and the transition metal compounds.
Research on the Impact of Entity’s “Non-Professional Business” on Audit Quality  [PDF]
Zhenhua Cui
American Journal of Industrial and Business Management (AJIBM) , 2018, DOI: 10.4236/ajibm.2018.84057
Abstract: Driven by the excess return rate, the entity financial trends are becoming more and more intense, which the entity enterprise carrying out financial and real estate business are often advertised as work outside. In order to explore whether entitys Non-professional Business can influence the audit quality or not, this paper takes A shares in the two stock markets of Shanghai and Shenzhen between 2007 and 2016 as a sample to find out their relationship. Entitys Non-professional Business can be divided into direct and indirect entry way. Direct entry way means the entity carries out related financial and real estate businesses independently, while indirect entry means the entity buys existing financial assets through the secondary market and other channels. The results show that the direct entry of enterprises into the financial and real estate business will reduce the audit quality. And enterprises in the way of indirect entry into the financial and real estate business will improve the quality of the audit.
Low field phase diagram of spin-Hall effect in the mesoscopic regime
Zhenhua Qiao,Wei Ren,Jian Wang,Hong Guo
Physics , 2006, DOI: 10.1103/PhysRevLett.98.196402
Abstract: When a mesoscopic two dimensional four-terminal Hall cross-bar with Rashba and/or Dresselhaus spin-orbit interaction (SOI) is subjected to a perpendicular uniform magnetic field $B$, both integer quantum Hall effect (IQHE) and mesoscopic spin-Hall effect (MSHE) may exist when disorder strength $W$ in the sample is weak. We have calculated the low field "phase diagram" of MSHE in the $(B,W)$ plane for disordered samples in the IQHE regime. For weak disorder, MSHE conductance $G_{sH}$ and its fluctuations $rms(G_{SH})$ vanish identically on even numbered IQHE plateaus, they have finite values on those odd numbered plateaus induced by SOI, and they have values $G_{SH}=1/2$ and $rms(G_{SH})=0$ on those odd numbered plateaus induced by Zeeman energy. For moderate disorder, the system crosses over into a regime where both $G_{sH}$ and $rms(G_{SH})$ are finite. A larger disorder drives the system into a chaotic regime where $G_{sH}=0$ while $rms(G_{SH})$ is finite. Finally at large disorder both $G_{sH}$ and $rms(G_{SH})$ vanish. We present the physics behind this ``phase diagram".
Universal spin-Hall conductance fluctuations in two dimensions
Wei Ren,Zhenhua Qiao,Jian Wang,Qingfeng Sun,Hong Guo
Physics , 2006, DOI: 10.1103/PhysRevLett.97.066603
Abstract: We report a theoretical investigation on spin-Hall conductance fluctuation of disordered four terminal devices in the presence of Rashba or/and Dresselhaus spin-orbital interactions in two dimensions. As a function of disorder, the spin-Hall conductance $G_{sH}$ shows ballistic, diffusive and insulating transport regimes. For given spin-orbit interactions, a universal spin-Hall conductance fluctuation (USCF) is found in the diffusive regime. The value of the USCF depends on the spin-orbit coupling $t_{so}$, but is independent of other system parameters. It is also independent of whether Rashba or Dresselhaus or both spin-orbital interactions are present. When $t_{so}$ is comparable to the hopping energy $t$, the USCF is a universal number $\sim 0.18 e/4\pi$. The distribution of $G_{sH}$ crosses over from a Gaussian distribution in the metallic regime to a non-Gaussian distribution in the insulating regime as the disorder strength is increased.
A Guess Model of Black Holes and the Evolution of Universe  [PDF]
Zhenhua Mei, Shuyu Mei
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.329154
Abstract: Based on the gravitational theory, fundamental data, and comprehensible suppositions, an evolution model of the universe was proposed. The universe exists in explosion and constringency mobile equilibrium state. The critical sizes of celestial bodies were calculated in their evolution process.
Mass the Confined Movement of Energy  [PDF]
Zhenhua Mei, Shuyu Mei
Journal of Modern Physics (JMP) , 2017, DOI: 10.4236/jmp.2017.86058
Abstract: According to Einstein’s mass-energy relation (E=mc2), and the discovery of neutrino oscillation fact, a new view of mass nature is proposed: The rest mass of a particle is not else something but just the confined movement of energy.
Comparative characterization of mesenchymal stem cells from different age groups of cynomolgus monkeys
ZhenHua Ren,JiaYin Wang,ChunLin Zou,YunQian Guan,Y. Alex Zhang
Science China Life Sciences , 2010, DOI: 10.1007/s11427-010-0083-7
Abstract: Bone marrow mesenchymal stem cells (BM-MSCs) are a potential tool for cell therapy and tissue engineering. In this study, we carried on a comparative study of the characteristics of MSCs from different age cynomolgus monkeys. A variety of factors, including donor age, must be considered before further applications, and various tests should be used to properly assess MSCs before the clinical application, especially when a prolonged culture and ex vivo expansion is necessary.
Characterizing the induction of diabetes in juvenile cynomolgus monkeys with different doses of streptozotocin
ChunLin Zou,JiaYin Wang,ShuYan Wang,Fen Huang,ZhenHua Ren,ZhiGuo Chen,Yu Zhang
Science China Life Sciences , 2012, DOI: 10.1007/s11427-012-4288-9
Abstract: Juvenile (2–23 years old) cynomolgus monkeys are frequently used as recipients in non-human primate islet transplantation studies. The aim of this study was to examine the effects of different doses of streptozotocin (STZ), and find the optimal dose for inducing diabetes in these monkeys. Fifteen juvenile (2–3 years old) cynomolgus monkeys were separated into three groups and administered with different doses of STZ (100, 68 or 60 mg kg 1). Basal and glucose-stimulated blood glucose, insulin, and C-peptide levels, as well as body weights were monitored. Hepatic and renal function tests and pancreatic immunohistochemistry were performed before and after STZ treatment. Monkeys treated with both 100 and 68 mg kg 1 of STZ exhibited continuous hyperglycemia, which coincided with a nearly complete loss of islet β-cells. Two monkeys received 60 mg kg 1 of STZ, but only one became completely diabetic. During the first week following STZ treatment, hepatic and renal function slightly increased in these three groups. However, 24 hours post-STZ, serum total bile acid levels were significantly increased in monkeys treated with 100 mg kg 1 than those treated with 68 mg kg 1 of STZ (P<0.05). These data suggest that 100 mg kg 1 and 68 mg kg 1 of STZ can safely induce diabetes in cynomolgus monkeys aged 2–3 years, but 68 mg kg 1 of STZ, rather than 100 mg kg 1 of STZ, may be more appropriate for inducing diabetes in these monkeys. Furthermore, body surface area, rather than body weight, was a more reliable determinant of dosage, where 700 mg m 2 of STZ should be the lower limit for inducing diabetes in juvenile monkeys.
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