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Search Results: 1 - 10 of 80885 matches for " ZhaoQian Liu "
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Characterization of Nanoporous Ceramic Granules Made with Coal Fly Ash and Their Utilization in Phenol Removal from Water
Zhaoqian Jing
Journal of Nanomaterials , 2013, DOI: 10.1155/2013/606940
40Ar/39Ar geochronology constraints on hydrocarbon accumulation and destruction periods in the Bankeng paleo-reservoir in the southern margin of the middle Yangtze block
ZhaoQian Liu,LianFu Mei,HuaNing Qiu,ChuanBo Shen,JiGuang Tang,JianBing Yun
Chinese Science Bulletin , 2011, DOI: 10.1007/s11434-011-4625-6
Abstract: The exact determination of isotopic ages of hydrocarbon accumulation, reconstruction and destruction periods using traditional isotopic dating methods is complex because of the small numbers of minerals that correlate with hydrocarbons. The quantitative and direct study of hydrocarbon geochronology is therefore an important scientific problem for isotope geochronology and petroleum geology. This study obtains two isotopic ages from a quartz vein sample associated with bitumen in a reverse fault located in the Bankeng paleo-reservoir on the southern margin of the middle Yangtze block (the northern margin of the Jiangnan-Xuefeng uplift) by inclusion 40Ar/39Ar stepwise crushing in a vacuum. Two different and good linear inverse isochrons that correspond to two age plateaus were determined. The two ages correspond to primary inclusions of about 228 Ma and secondary inclusions of about 149 Ma. These inclusion groups represent two distinct kinds of fluids. Quartz veins associated with bitumen in faulted paleo-reservoirs, which have a strict response relationship with tectonization and hydrocarbon accumulation, are the unified products of tectonic processes, hydrocarbon accumulation and reconstruction. Therefore, they can be used to constrain the hydrocarbon accumulation, reconstruction and destruction periods that are controlled by multiphase and complicated tectonic actions. The evolutionary processes of hydrocarbon accumulation can be divided into two periods consisting of a primary oil and gas reservoir formation period in the late Indosinian epoch (about 228 Ma) and a period of oil and gas reservoir reconstruction in the early Yanshan epoch (about 149 Ma). This study quantitatively reconstructs the hydrocarbon accumulation and destruction chronological framework of a giant hydrocarbon accumulation belt along the southern margin of the middle Yangtze block (the northern margin of the Jiangnan-Xuefeng uplift) controlled by multiphase and complicated tectonism. The two ages associated with hydrocarbons here correspond to the special controlling actions of continental tectonics in the Jiangnan-Xuefeng uplift that affected the timeline of reconstruction and destruction in this giant marine hydrocarbon accumulation. This study shows the feasibility and usefulness of dating inclusions with the 40Ar/39Ar technique for hydrocarbon geochronology, especially in the marine hydrocarbon accumulation region of southern China within a geological setting of old strata, high thermal evolution hydrocarbons, and complex, multiphase and multicycle tectonization.

Chen Zhaoqian,Zhou Rong,Liu Hong,Chen Shifu,

软件学报 , 1996,
Abstract: This paper proposes a neural network learning algorithm FTART(field theory-based adaptive resonance theory)that combines many neural network theories.It is based on the main idea of ART(adaptive resonance theory) and makes use of many merits of Field Theory and ARTMAP,etc.,and corrects the classification regarding the supposed possibility of examples in the instance space.FTART gains some goodness by employing a special conflict resolution process and dynamically expanding the classification area. Some benchmark test results are also given.
Combined Application of UV Photolysis and Ozonation with Biological Aerating Filter in Tertiary Wastewater Treatment
Zhaoqian Jing,Shiwei Cao
International Journal of Photoenergy , 2012, DOI: 10.1155/2012/140605
Abstract: To enhance the biodegradability of residual organic pollutants in secondary effluent of wastewater treatment plants, UV photolysis and ozonation were used in combination as pretreatment before a biological aerating filter (BAF). The results indicated that UV photolysis could not remove much COD (chemical oxygen demand), and the performance of ozonation was better than the former. With UV photolysis combined with ozonation (UV/O3), COD removal was much higher than the sum of that with UV photolysis and ozonation alone, which indicated that UV photolysis could efficiently promote COD removal during ozonation. This pretreatment also improved molecular weight distribution (MWD) and biodegradability greatly. Proportion of organic compounds with molecular weight (MW) <3 kDalton was increased from 51.9% to 85.9%. COD removal rates with BAF and O3/BAF were only about 25% and 38%, respectively. When UV/O3 oxidation was combined with BAF, the average COD removal rate reached above 61%, which was about 2.5 times of that with BAF alone. With influent COD ranging from 65 to 84?mg/L, the effluent COD was stably in the scope of 23–31?mg/L. The combination of UV/O3 oxidation with BAF was quite efficient in organic pollutants removal for tertiary wastewater treatment. 1. Introduction In recent years, contamination of surface and subsurface water by organic pollutants has received much attention. Wastewater treatment plants (WWTPs) play important roles in such pollutants removal. In China, more and more WWTPs have been built not only in large cities, but also in small towns and counties. To meet the national discharge standard for municipal WWTPs, most of them have been built with secondary treatment processes, which usually comprise physical interception, precipitation, and biological treatment. Although the secondary treatment processes are efficient in bulk and soluble pollutants removal, there are still some residual organic compounds, nitrogen, phosphorus, and pathogenic bacteria in the effluent. Some researchers have found that there are more than 200 organic micropollutants in the secondary effluent of municipal WWTPs [1, 2]. Most of these organic pollutants are refractory and difficult to be further degraded, and therefore their discharge in water may cause long-term environmental effects to aquatic and terrestrial organisms [3, 4]. In late May, 2007, a drinking water crisis took place in Wuxi, Jiangsu Province, China, owing to the large scale growth of algae bloom in Wuxi’s drinking water source—Taihu Lake. This crisis has made nearly 170 WWTPs being required to
Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate
Lichen Gao, Yijing He, Jie Tang, Jiye Yin, Zhengyu Huang, Fangqun Liu, Dongsheng Ouyang, Xiaoping Chen, Wei Zhang, Zhaoqian Liu, Honghao Zhou
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062489
Abstract: This study investigated the effects of pregnane X receptor (PXR/NR1I2) and CYP2B6 genetic variants on sodium ferulate (SF)-mediated induction of bupropion hydroxylation. The pharmacokinetics of bupropion and hydroxybupropion were evaluated after an oral dose of bupropion (150 mg) administered with and without SF pretreatment for 14 days in 33 healthy subjects. The area under the time-concentration curve (AUC) ratio of AUC_hyd (AUC(0-∞) of hydroxybupropion)/AUC_bup (AUC(0-∞) of bupropion) represents the CYP2B6 hydroxylation activity, which was significantly lower in CYP2B6*6 carriers (NR1I2 TGT noncarriers or carriers) than in noncarriers in both the basal and SF-induced states (p-value<0.05). AUC ratio and AUC_hyd of NR1I2 -24113AA variant were markedly lower than GA and GG genotypes (7.5±2.1 versus 14.5±3.3 and 20.6±1.1, and 8873±1431 versus 14,504±2218 and 17,586±1046) in the induced states. However, -24020(-)/(-) variant didn't show significant difference in the induction of CYP2B6 hydroxylation activity by SF compared with other -24020[GAGAAG]/(-) genotypes. NR1I2 TGT haplotype (-25385T+g.7635G+g.8055T) carriers exhibited a significantly decreased AUC ratio, compared with TGT noncarriers, in the basal states (7.6±1.0 versus 9.7±1.0), while this result wasn't observed in CYP2B6*6 noncarriers. Moreover, individuals with complete mutation-type [CYP2B6*6/*6+NR1I2 TGT+ -24113AA+ -24020 (-)/(-)] showed even lower percent difference of AUC ratio (8.7±1.2 versus 39.5±8.2) than those with complete wild-type. In conclusion, it is suggested that NR1I2 variants decrease the bupropion hydroxylation induced by SF treatment, particularly in CYP2B6*6 carriers. Trial Registration ChiCTR.org ChiCTR-TRC-11001285
Ethnopharmacokinetic- and Activity-Guided Isolation of a New Antidepressive Compound from Fructus Aurantii Found in the Traditional Chinese Medicine Chaihu-Shugan-San: A New Approach and Its Application
Rong Fan,Xi Huang,Yang Wang,Xiao Chen,Ping Ren,Hui Ji,Ying Xie,Yingjin Zhang,Wei Huang,Xinjian Qiu,Zhaoqian Liu,Honghao Zhou,Lan Fan,Lichen Gao
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/607584
Abstract: Aims. We aimed to identify an antidepressive compound found in traditional Chinese medicine (TCM) by a new approach called ethnopharmacokinetic- and activity-guided isolation (EAGI). Methods. The new approach targets an unknown chromatographic peak produced by an absorbed compound found in oral Chaihu-Shugan-San (CSS) taken by patients with depression. Once the compound was isolated from Fructus Aurantii (FA), spectral data was employed to identify the compound. The effects of this compound, FA, and CSS on depressive behaviors were investigated. Results. The identified compound was merazin hydrate (MH) according to the new approach. MH, FA, and CSS significantly reduced immobility time and increased locomotor activity. The effects of MH, FA and CSS were similar to Fluoxetine at high doses. Conclusion. MH, a compound whose antidepressive effect is similar to FA and CSS, was isolated for the first time from FA via targeting its corresponding unknown chromatographic peak, and its antidepressive effect was compared with FA or CSS. These findings highlight the potential for drug R&D and pharmacological research of ∼100,000 TCMs.
蛇床子素通过激活 PI3K/Akt 通路减轻谷氨酸诱导的海马神经元损伤
Osthole ameliorates glutamate-induced toxicity in HT22 cells via activating PI3K/Akt signaling pathway

MAO Xiaoyuan
, WANG Zhibin, ZHOU Honghao, LIU Zhaoqian, ZHOU Yong

- , 2015, DOI: 10.11817/j.issn.1672-7347.2015.09.002
Abstract: 目的:研究蛇床子素(osthole,OST)减轻谷氨酸诱导的HT22细胞损伤的机制。方法:建立谷氨酸诱导的 HT22细胞损伤模型;HT22损伤细胞经OST处理,MTS法检测细胞活力;乳酸脱氢酶(lactate dehydrogenase,LDH)释放 实验检测HT22细胞LDH漏出率;caspase-3活性检测试剂盒测定各组caspase-3活性;Western印迹法测定细胞内磷脂酰肌 醇(-3)激酶(phosphatidylinositol-3-kinase,PI3K),蛋白激酶B(protein kinase B,Akt),磷酸化PI3K(p-PI3K)和磷酸化Akt(p- Akt)蛋白表达情况。结果:OST在0~10 mmol/L范围内呈剂量依赖性提高谷氨酸诱导的HT22细胞活力,降低LDH漏出 率,改善HT22细胞损伤。此外,OST显著上调谷氨酸损伤细胞p-PI3K和p-Akt蛋白表达,而PI3K抑制剂LY294002明显 抑制OST谷氨酸损伤细胞p-Akt蛋白表达的上调作用。结论:OST对谷氨酸损伤的HT22细胞具有保护作用,其保护作 用机制可能是通过激活PI3K/Akt信号通路来实现的
Multiple lncRNAs affect the incidence and#br# development of melanoma

颜晗, ,谭丹, ,谢攀, ,刘昭前, ,李曦,
, , TAN Dan, , XIE Pan, , LIU Zhaoqian, , LI Xi

- , 2017, DOI: 10.11817/j.issn.1672-7347.2017.02.003
Abstract: 目的:通过生物大数据挖掘,探讨长链非编码RNA(long noncoding RNA,lncRNA)与黑色素瘤发生发展的 关系。方法:从基因表达综合数据库中的黑色素瘤mRNA表达谱数据集GSE15605中提取出一些lncRNA的表达信息, 并分析这些lncRNA与黑色素瘤的关联关系。结果:LINC01213,PGM5-AS1,LINC01133和LOC284578共4个lncRNA 与黑色素瘤的发生和转移显著相关,其中LINC01213,LINC01133和LOC284578的表达可被BRAF基因突变影响,而 PGM5-AS1的表达能被NRA S基因突变影响。利用这4个lncRNA的表达值构建的预测模型可较好地区分正常样本、初发 黑色素瘤样本和转移性黑色素瘤样本。结论:LncRNA可能在黑色素瘤的发生和转移中起重要作用
Effect of Sisal Fiber Surface Treatment on Properties of Sisal Fiber Reinforced Polylactide Composites
Zhaoqian Li,Xiaodong Zhou,Chonghua Pei
International Journal of Polymer Science , 2011, DOI: 10.1155/2011/803428
Abstract: Mechanical properties of composites are strongly influenced by the quality of the fiber/matrix interface. The objective of this study was to evaluate the mechanical properties of polylactide (PLA) composites as a function of modification of sisal fiber with two different macromolecular coupling agents. Sisal fiber reinforced polylactide composites were prepared by injection molding, and the properties of composites were studied by static/dynamic mechanical analysis (DMA). The results from mechanical testing revealed that surface-treated sisal fiber reinforced composite offered superior mechanical properties compared to untreated fiber reinforced polylactide composite, which indicated that better adhesion between sisal fiber and PLA matrix was achieved. Scanning electron microscopy (SEM) investigations also showed that surface modifications improved the adhesion of the sisal fiber/polylactide matrix. 1. Introduction With the increasing of environmental protection consciousness, natural fibers as a group of environmental friendly reinforcements are in considerable demand in composites [1, 2]. Natural fibers such as flax, hemp, sisal, nettle and jute were the most common reinforced elements [2, 3]. Of course, natural fiber reinforced degradable polymers composite is likely more ecofriendly because that the reinforcement and the matrix (e.g., polylactide (PLA)) are readily biodegradable and such biocomposites are sometimes termed “green composites” [4, 5]. Natural fibers as reinforcement are familiar. However, there is also a major drawback associated with its application for reinforcement of polymeric matrices. The presence of hydroxyl and other polar groups in natural fibers constituents makes them exhibit high hydrophilic nature, which leads to incompatibility and poor wettability in a hydrophobic polymer matrix, and weak bonding in the fiber/matrix interface [6]. Herewith, there are many problems in dealing with the interface of natural fiber and polylactide. Several approaches have been studied, such as surface modification of cellulose (e.g., esterification of cellulose and graft copolymerization onto cellulose substrates) and the use of some compatibilizers (e.g., maleated polylactide and isocyanate [7–11]). Nevertheless, only a limited number of studies had achieved good results. And there is no commercial sale of such interfacial compatibilizers in the market. Among the various natural fibers, sisal fiber is fairly coarse and inflexible. It possesses moderately high specific strength and stiffness, durability, ability to stretch, and resistance to
Computed tomography imaging of an ectopic thyroid on the ascending aorta  [PDF]
Chongfu Jia, Zhiqiang Yang, Xiaoming Bian, Fei Zheng, Xixia Sun, Zhaoqian Wang
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.32032
Abstract: Ectopic thyroid on the ascending aorta is extremely rare, and its radiologic characteristics have not been reported in the radiologic literature. A case of ectopic thyroid on the ascending aorta is reported, and its imaging characteristics on computed tomography are discussed.
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