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Search Results: 1 - 10 of 103980 matches for " Zhang Ruolin "
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Semi-Quantitative Analysis of Brain MR Imaging in 76 Cases of Neonatal Indirect Hyperbilirubinemia  [PDF]
Ruolin Zhang, Tao Bo, Li Shen, Senlin Luo, Jian Li
Open Journal of Pediatrics (OJPed) , 2016, DOI: 10.4236/ojped.2016.64039
Abstract: Background: Neonatal hyperbilirubinemia is indeed common. However, severe nerve injuries and bilirubin encephalopathy are rare and only occur in the unusual cases of extreme hyperbilirubinemia. Objectives: To investigate brain magnetic resonance imaging (MRI) changes and their correlations with perinatal predisposing factors in neonates with indirect hyperbilirubinemia, via regions of interest (ROIs) analysis. Methods: Seventy-six neonates with a gestational age of ≥35 weeks diagnosed with neonatal indirect hyperbilirubinemia or bilirubin encephalopathy all underwent brain MRI during hospitalization. Depending on peak total serum bilirubin (TSB), they were assigned to group A (<221 μmol/L), B (≥221 μmol/L <342 μmol/L), C (≥42 μmol/L <428 μmol/L), or D (≥428 μmol/L). The globus pallidus and the white matter around the anterior horn of the lateral ventricle and posterior horn of the lateral ventricle were selected as the ROIs. Average optical densities (AODs) of the ROIs and the cerebrospinal fluid region were measured. The ratio between the AODs was designated as the relative optical density (ROD), and used to determine relative signal intensity. Results: RODs of the globus pallidus were significantly lower in group D than in all other groups. TSB and the ratio of TSB to serum albumin concentration (B/A) was significantly negatively correlated with ROD in theglobus pallidus. Corrected age was significantly negatively correlated with the ROD of the ROIs. Conclusions: Semi-quantitative image analysis is a feasible method to assess conventional brain MRI for neonatal indirect hyperbilirubinemia. The signal intensity of the globus pallidus in T1-weighted images was significantly correlated with TSB level and B/A.
Bronchopulmonary Dysplasia in Premature Infants with Very Low Birth Weight: A Single Centre Retrospective Study in China  [PDF]
Li Shen, Tao Bo, Senlin Luo, Ruolin Zhang, Jian Li
Open Journal of Pediatrics (OJPed) , 2016, DOI: 10.4236/ojped.2016.64041
Abstract: To investigate bronchopulmonary dysplasia (BPD) and its treatment with dexamethasone (DEX) in premature infants with birth weight (BW) < 1500 g. We retrospectively reviewed the records of preterm infants admitted to the Division of Neonatology, the Second Xiangya Hospital, Central South University between September 2011 and December 2014. Patients were excluded if they needed oxygen therapy but were lost to follow-up at ≤36 weeks post-menstrual age (PMA) or <56 days after birth, or they had severe congenital anomalies. The incidence of BPD was 18% (37/212). Gestational age (GA) was <32 weeks in all BPD patients. GA, BW, and Apgar scores were lower and hospitalization duration and pulmonary surfactant (PS) use were higher in the BPD group than in the non-BPD group (P < 0.05). Risk factors for BPD included neonatal respiratory distress syndrome, neonatal pneumonia, positive sputum culture, pulmonary hemorrhage, respiratory failure. Multivariate logistic regression revealed that GA (odds ratio [OR]: 0.479, P = 0.004) and neonatal respiratory distress syndrome (OR: 6.146, P = 0.043) were independent risk factors for BPD. DEX was administered to 26 patients after the diagnosis of BPD. After one and two weeks of DEX treatment, the oxygen requirement had significantly reduced compared to the week prior to treatment (P < 0.05), while during treatment, the weight gain rate and weight gain efficiency slower significantly than that during either of the two preceding weeks (P < 0.001). These results suggest that low GA was the most important risk factor for BPD, DEX reduced oxygen dependency but decreased weight gain.
Abrupt Change in Sahara Precipitation and the Associated Circulation Patterns  [PDF]
Celestin Sindikubwabo, Ruolin Li, Chenghai Wang
Atmospheric and Climate Sciences (ACS) , 2018, DOI: 10.4236/acs.2018.82017
Abstract: This study investigates the changes in inter-annual summer precipitation and the relationship with the atmospheric general circulation in the Sahara Desert occurred in the last 40 years (1971-2010). The results show that the summer precipitation undergone in drought recovery with a strong abrupt change at the end of 20th century. This change in Sahara precipitation is subsequently accompanied with the changes in the atmospheric circulation. The Sahara drought recovery is associated with a significant warming in the tropical and extratropical sea surface temperature, which led to the increase in moisture budget of the tropical African monsoon. The remarkable features such as the strengthening in Arctic high and mid-latitude upper level westerly wind, weakening in subpolar low and upper tropospheric zonal wind over North Africa have shown a distinct relationship with the Sahara precipitation changes.
TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood
Qian Zhang, Ruolin Guo, Edward M Schwarz, Brendan F Boyce, Lianping Xing
Arthritis Research & Therapy , 2008, DOI: 10.1186/ar2391
Abstract: OCPs were generated from bone marrow cells of TNF-transgenic mice or wild-type mice treated with TNF or PBS. The percentage of CD11b+/Gr-1-/lo OCPs was assessed by fluorescence-activated cell sorting. OCP migration to the SDF-1 gradient and the osteoclast forming potency were assessed in chemotaxis/osteoclastogenic assays. SDF-1 expression was assessed by real-time RT-PCR, ELISA and immunostaining in primary bone marrow stromal cells, in the ST2 bone marrow stromal cell line, and in bones from TNF-injected mice.OCPs generated in vitro from wild-type mice migrated to SDF-1 gradients and subsequently gave rise to osteoclasts in response to RANKL and macrophage colony-stimulating factor. TNF reduced SDF-1 expression by ST2 cells. Bone marrow stromal cells from TNF-transgenic mice produced low levels of SDF-1. TNF treatment of wild-type mice decreased the SDF-1 concentration in bone marrow extracts and decreased the SDF-1 immunostaining of bone marrow stromal cells, and it also increased the circulating OCP numbers. The percentage of bone marrow CXCR4+ OCPs was similar in TNF-transgenic mice and wild-type littermates and in TNF-treated and PBS-treated wild-type mice.Systemically elevated TNF levels inhibit bone marrow stromal cell production of SDF-1 and increase the release of bone marrow OCPs to the peripheral blood. Disruption of the SDF-1/CXCR4 axis by TNF may play an important role in mediating OCP mobilization from the bone marrow cavity in chronic inflammatory arthritis.TNF is a clinically validated etiological factor in inflammatory-erosive arthritis and is known to synergize with RANKL and macrophage colony-stimulating factor (M-CSF) to enhance the differentiation of osteoclast precursors (OCPs) into bone-resorbing osteoclasts in inflamed joints [1,2]. Patients with psoriatic arthritis [3] and mice with TNF-induced arthritis [4,5] have increased numbers of circulating OCPs, which correlate with systemically increased TNF concentrations and are reduced by anti-T


红外与毫米波学报 , 1991,
Abstract: 通过对α-Fe_2O_3球状和园柱状超细微粒的红外透射光谱测量,发现形状不同导致表面声子吸收的明显差异,并对实验结果进行了讨论和分析。
Characterization and Comparison of the Tissue-Related Modules in Human and Mouse
Ruolin Yang,Bing Su
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011730
Abstract: Due to the advances of high throughput technology and data-collection approaches, we are now in an unprecedented position to understand the evolution of organisms. Great efforts have characterized many individual genes responsible for the interspecies divergence, yet little is known about the genome-wide divergence at a higher level. Modules, serving as the building blocks and operational units of biological systems, provide more information than individual genes. Hence, the comparative analysis between species at the module level would shed more light on the mechanisms underlying the evolution of organisms than the traditional comparative genomics approaches.
Increased lymphangiogenesis in joints of mice with inflammatory arthritis
Qian Zhang, Yan Lu, Steven T Proulx, Ruolin Guo, Zhenqiang Yao, Edward M Schwarz, Brendan F Boyce, Lianping Xing
Arthritis Research & Therapy , 2007, DOI: 10.1186/ar2326
Abstract: Joint disease in rheumatoid arthritis (RA) is characterized by inflamed hyperplastic synovial tissue or 'pannus' formation [1]. Pannus is composed of various cell types that produce a vast array of inflammatory mediators, including cytokines and chemokines that destroy the extracellular matrix in the joint by direct and indirect mechanisms. Pannus is extremely vascular, providing portals of entry for effector cells to enter the joint from the circulation and mediate joint destruction via autocrine and paracrine mechanisms. As a result of neovascularization, inflammatory cell infiltration, and concomitant synovial cell hyperplasia, the volumes of the synovium and synovial fluid increase, resulting in joint swelling and pain [2]. Thus, inhibition of new blood vessel formation has been proposed as an important therapeutic approach for patients with inflammatory-erosive arthritis [3].The lymphatic circulation has been known for many years to be an important secondary vascular system to remove fluid, macromolecules, and cells from the interstitial spaces, and it functions as a 'compensatory' system for blood circulation. However, studies of the lymphatic system have been hampered until recently by the lack of markers that definitively distinguish blood from lymphatic vessels and a paucity of knowledge about growth factors specific to lymphatic endothelial cells. Gene array analysis comparing lymphatic endothelial cells and blood vascular endothelial cells has recently identified numerous previously unknown lineage-specific markers for blood and lymphatic vascular endothelium. Newly identified lymphatic endothelium-specific markers include [4] lymphatic endothelial hyaluronan receptor 1 (LYVE-1), prospero-related homeobox 1, vascular endothelial growth factor receptor 3 (VEGFR-3), and the mucin-type transmembrane glycoprotein, podoplanin [5-8].In studies using these lymphatic markers, several factors, such as VEGF-A, platelet-derived growth factor (PDGF)-BB, and fibroblas
The Design and Implementation of Smart Library

Dong Xiaoxia,Gong Xiangyang,Zhang Ruolin,Yan Chaobin,

现代图书情报技术 , 2011,
Abstract: The paper first provides a definition of smart library. Then it describes the system architecture and key technologies of the BUPT-SLDS developed by Beijing University of the Post and Telecommunications. Finally, the paper addresses the functions of smart library demonstration system. It is to make the smart library’s definition clear and provide the advising to the future practical smart library.
MicroRNA-mediated gene regulation plays a minor role in the transcriptomic plasticity of cold-acclimated Zebrafish brain tissue
Ruolin Yang, Zhonghua Dai, Shue Chen, Liangbiao Chen
BMC Genomics , 2011, DOI: 10.1186/1471-2164-12-605
Abstract: Among the total 214 unique, mature zebrafish miRNAs deposited on the miRBase website (release 16), 175 were recovered in this study. In addition, we identified 399 novel, mature miRNAs using multiple miRNA prediction methods. We defined a set of 25 miRNAs differentially expressed under the cold and normal conditions and predicted the molecular functions and biological processes that they involve through Gene Ontology (GO) annotation of their target genes. On the other hand, microarray analysis showed that genes related to mRNA processing and response to stress were overrepresented among the up-regulated genes in cold-stress, but are not directly corresponding to any of the GO molecular functions and biological processes predicted from the differential miRNAs. Using several statistical models including a novel, network-based approach, we found that miRNAs identified in this study, either individually or together, and either directly or indirectly (i.e., mediated by transcription factors), only make minor contribution to the change in gene expression patterns under the low-temperature condition.Our results suggest that the cold-stress response of mRNA expression may be governed mainly through regulatory modes other than miRNA-mediated regulation. MiRNAs in animal brains might act more as developmental regulators than thermal adaptability regulators.MicroRNAs (miRNAs) are a class of ~22 nt, non-coding RNAs present in plants and animals that play important roles in regulating gene expression by directing translational repression and/or mRNA destabilization [1-3]. Recognition and interaction between miRNA and mRNA take effect only if the 5' end seed (6-8 nt) of the miRNA is complementary to the 3' UTR site of the mRNA. A miRNA typically targets multiple, even hundreds of, genes [4], which makes miRNAs potentially global regulators responsible for spatio-temporal gene expression patterns.Like let-7 [5,6], some miRNAs are highly conserved throughout evolution and participa
The New Mathematical Model of Motion Compensation for Stepped-Frequency Radar Signal
Yun Lin,Xiaochun Xu,Jinfeng Pang,Bin Li,Ruolin Zhou
Mathematical Problems in Engineering , 2014, DOI: 10.1155/2014/142482
Abstract: When a stepped-frequency radar is used to obtain the high-resolution range profile (HRRP) of high-speed target, accurate speed estimation and motion compensation must be considered. Therefore, in this paper, a novel mathematical method is presented for estimating the target speed. Firstly, the pulse Doppler method is used to calculate the initial estimation value. Secondly, based on the initial estimation value, the minimum entropy method is used to calculate the coarse estimation value. Finally, based on the coarse estimation value, the minimum -Norms method is used to calculate the accurate estimation value. The numeric simulation results confirm that this new method is effective and predominant, which has a much higher estimation accuracy in a low SNR and a much larger estimation range of target speed. The final estimation value can be used to well compensate for the influence of target speed on HRRP. 1. Introduction Stepped-frequency (SF) signal is widely used in the high-resolution radar systems [1–3], because it can be used to get the high-resolution range profile (HRRP) of target. ?However, SF signal is highly sensitive to targets motion. The radial speed between target and radar contributes influence on phase term, which will lead to severe range-speed coupling [4, 5]. As it is well known, the impact of range-speed coupling is well mitigated through motion compensation. Thus, for noncooperative targets, speed estimation method is very important and necessary. In the literature [6, 7], based on time domain and waveform entropy, two speed estimation methods are presented. However, they have low estimation accuracy and are only effective in a high signal-to-noise ratio (SNR) and low-speed moving targets. In the literature [8], based on SF and pulse Doppler radar signal, an effective algorithm of speed estimation is presented. Simulation results show that this method has a higher estimation accuracy and better antinoise performance. However, it will increase the complexity of radar system. So far, besides these methods mentioned above, many other effective speed estimation methods have been presented, such as in the literature [9–11]. These methods have gotten much better estimation accuracy. Nevertheless, in common, they have much higher computation complexity and need larger calculation burden; therefore, they are not applicable to use in engineering application. Furthermore, the speed estimation of super-speed moving targets in extremely low SNR is still a key problem for SF signal. And much easier implementation in engineering application also
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