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Situación de alojamiento en Brasil y utilización de sistemas de auto-ayuda y ayuda mutua en la producción del ambiente construido
Zenha Kaupatez, Ros Mari
Informes de la Construccion , 1987,
Abstract: No disponible
Egressos como fonte de informa??o à gest?o dos cursos de Ciências Contábeis
Lousada, Ana Cristina Zenha;Martins, Gilberto de Andadre;
Revista Contabilidade & Finan?as , 2005, DOI: 10.1590/S1519-70772005000100006
Abstract: this study aims to show the importance of planning and developing alumni follow-up systems as a tool to allow for the continuous improvement of the whole planning and operation of higher education institutions - ies, particularly of the teachinglearning process. as one of the aims of iess is to provide society with graduates who are ready for the professional market, they should receive feedback from their former students through quality indicators, particularly concerning the qualification to work. the perceptions and motivations of iess managers, particularly those of accountancy programs, were subject to empirical examination, in order to gather elements from reality with a view to the description and understanding of the phenomenon under study. the results revealed that the iess recognize the need to institutionalize and practice alumni follow-up to improve the quality of the educational services they deliver.
Embedding Instruments & Modules into an IEEE1451-FPGA-based Weblab Infrastructure
Ricardo JGSN Costa,Gustavo Ribeiro Alves,M Zenha Rela
International Journal of Online Engineering (iJOE) , 2012, DOI: 10.3991/ijoe.v8i3.2064
Abstract: Adopting standard-based weblab infrastructures can be an added value for spreading their influence and acceptance in education. This paper suggests a solution based on the IEEE1451.0 Std. and FPGA technology for creating reconfigurable weblab infrastructures using Instruments and Modules (I&Ms) described through standard Hardware Description Language (HDL) files. It describes a methodology for creating and binding I&Ms into an IEEE1451-module embedded in a FPGA-based board able to be remotely controlled/accessed using IEEE1451-HTTP commands. At the end, an example of a step-motor controller module bond to that IEEE1451-module is described.
Reconfigurable Weblabs Based on the IEEE1451 Std.
Ricardo JGSN Costa,Gustavo RC Alves,Mário Zenha Rela
International Journal of Online Engineering (iJOE) , 2010, DOI: 10.3991/ijoe.v6i3.1277
Abstract: Technology plays a double role in Education: it can act as a facilitator in the teaching/learning process and it can be the very subject of that process in Science & Engineering courses. This is especially true when students perform laboratory activities where they interact with equipment and objects under experimentation. In this context, technology can also play a facilitator role if it allows students to perform experiments in a remote fashion, through the Internet, in a so-called weblab or remote laboratory. No doubt, the Internet has been revolutionizing the educational process in many aspects, and it can be stated that remote laboratories are just an angle of that on-going revolution. As any other educational tool or resource, the i) pedagogical approach and the ii) technology used in the development of a remote laboratory can dictate its general success or its ephemeral existence. By pedagogical approach we consider the way remote experiments address the process by which students acquire experimental skills and link experimental results to theoretical concepts. In respect to technology, we discuss different specification and implementation alternatives, to show the case where the adoption of a family of standards would positively contribute to a larger acceptance and utilization of remote laboratories, and also to a wider collaboration in their development.
Clinical and immunological evaluation after BCG-id vaccine in leprosy patients in a 5-year follow-up study
Zenha EM,Wambier CG,Novelino AL,Andrade TA
Journal of Inflammation Research , 2012,
Abstract: Erika Muller Ramalho Zenha, Carlos Gustavo Wambier, Ana Lúcia Novelino, Thiago Ant nio Moretti de Andrade, Maria Aparecida Nunes Ferreira, Marco Andrey Cipriani Frade, Norma Tiraboschi FossDivision of Dermatology, Ribeir o Preto Medical School, S o Paulo University, S o Paulo, BrazilIntroduction: The use of bacillus Calmette–Guérin (BCG) has long been considered a stimulus for immune reactivity in leprosy household contacts. Probably, the combination of multidrug therapy with BCG could facilitate the clearance of leprosy bacilli in the host, reduce relapse rates, and shorten the duration of skin-smear positivity.Methods: To investigate the mechanism of action of BCG, a study involving 19 leprosy patients, eleven multibacillary (MB) and eight paucibacillary, was performed to assess the in vitro production of interleukin (IL)-10, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, IL-6, and IL-17 in the supernatant of peripheral blood mononuclear cells, before and 30 days after inoculation with BCG intradermally (BCG-id). Peripheral blood mononuclear cells isolated by Ficoll–Hypaque gradient were cultivated with Concanavalin-A (Con-A), lipopolysccharides (LPS), or BCG. The supernatant was collected for ELISA quantification of cytokines. The immunohistochemistry of IFN-γ, IL-1, IL-10, IL-12, transforming growth factor (TGF)-β, and TNF-α was carried out in biopsies of skin lesions of leprosy patients before and 30 days after inoculation of BCG-id. These patients were followed up for 5 years to assess the therapeutic response to multidrug therapy, the occurrence of leprosy reactions, and the results of bacterial index and anti-PGL-1 serology after the end of treatment. Results: The results showed increased production of cytokines after BCG-id administration in MB and paucibacillary leprosy patients. There was statistically higher levels of TNF-α (P = 0.017) in MB patients and of IL-17 (P = 0.008) and IFN-γ (P = 0.037) in paucibacillary patients. Immunohistochemical staining, especially for TNF-α, was more intense in biopsies of MB leprosy patients taken after BCG-id administration, probably for induction of innate human immunity. The clinical evaluation suggests that BCG-id is able to induce a more effective therapeutic response, with reduction of the number and the intensity of leprosy reactions. Conclusion: These results suggest that BCG-id induces activation of the initial phase of immunocellular activity: innate human immunity (increase in TNF-α, IL-12 and macrophage activation). Therefore, we conclude that the use of BCG-id could be indicated as an adjuv
Osteonecrose da Mandíbula Associada ao Uso de Bifosfonatos: Uma Patologia Secundária Grave
Lopes,Isabel; Zenha,Horácio; Costa,Horácio; Barroso,Jo?o;
Arquivos de Medicina , 2009,
Abstract: bisphosphonates have been introduced in the medical community as a possible therapy in diseases with high rate of resorption. a few years later became ?rst-line treatment in osteoporosis. osteonecrosis of the jaw associated with the use of bisphosphonates is a relatively new clinical entity. this severe secondary pathology affects the quality of life, producing signi?cant morbidity. the authors present a case of osteonecrosis of the jaw associated with the use of bisphosphonates, developed after dental extraction due to tooth infection in a 64 year-old male patient with metastatic prostate cancer, submitted to chemotherapy and bisphosphonate intravenous treatment. the diagnosis was con?rmed by the complementary diagnostic tests carried out. the therapeutic orientation was towards the conservative treatment using antibiotics and limited curettage, with good clinical outcome. they also review the aetiology, diagnosis and treatment options. osteonecrosis of the jaw associated with the use of bisphosphonates is a severe disease, previously unknown and dif?cult to treat, which should be prevented in patients receiving bisphosphonates. the use of bisphosphonates is increasing and therefore the detailed knowledge of all potential serious side effects is imperative.
Use of anti-PGL-1 antibodies to monitor therapy regimes in leprosy patients
Zenha, E.M.R.;Ferreira, M.A.N.;Foss, N.T.;
Brazilian Journal of Medical and Biological Research , 2009, DOI: 10.1590/S0100-879X2009001000016
Abstract: the suitability of igm antibodies to pgl-1 for monitoring the response to multidrug therapy (mdt) was sequentially tested by elisa in 105 leprosy patients, and bacterial indexes (bi) were also determined. patients were divided into 3 groups: group 1, 34 multibacillary (mb) patients treated for 12 months with mdt-mb; group 2, 33 mb patients treated for 24 months with mdt-mb, and group 3, 38 paucibacillary (pb) patients treated for 6 months with mdt-pb. untreated mb patients exhibited higher antibody levels (mean ± sem): group 1 (6.95 ± 1.35) and group 2 (12.53 ± 2.02) than untreated pb patients (1.28 ± 0.35). there was a significant difference (p < 0.01) in anti-pgl-1 levels in group 1 patients: untreated (6.95 ± 1.35) and treated for 12 months (2.78 ± 0.69) and in group 2 patients: untreated (12.53 ± 2.02) and treated for 24 months (2.62 ± 0.79). there was no significant difference between untreated (1.28 ± 0.35) and treated (0.62 ± 0.12) pb patients. antibody levels correlated with bi. the correlation coefficient (pearson’s r) was 0.72 before and 0.23 (p < 0.05) after treatment in group 1 and 0.67 before and 0.96 (p < 0.05) after treatment in group 2. bi was significantly reduced (p < 0.01) after 12 and 24 months on mdt (group 1: 1.26-0.26; group 2: 1.66-0.36). our data indicate that monitoring anti-pgl-1 levels during mdt may be a sensitive tool for evaluating treatment efficacy. these data also indicate that the control of leprosy infection can be obtained with 12 months of mdt in mb patients.
Clinical and immunological evaluation after BCG-id vaccine in leprosy patients in a 5-year follow-up study
Zenha EM, Wambier CG, Novelino AL, Andrade TA, Ferreira MA, Frade MA, Foss NT
Journal of Inflammation Research , 2012, DOI: http://dx.doi.org/10.2147/JIR.S33854
Abstract: ical and immunological evaluation after BCG-id vaccine in leprosy patients in a 5-year follow-up study Original Research (1038) Total Article Views Authors: Zenha EM, Wambier CG, Novelino AL, Andrade TA, Ferreira MA, Frade MA, Foss NT Published Date December 2012 Volume 2012:5 Pages 125 - 135 DOI: http://dx.doi.org/10.2147/JIR.S33854 Received: 14 May 2012 Accepted: 25 September 2012 Published: 18 December 2012 Erika Muller Ramalho Zenha, Carlos Gustavo Wambier, Ana Lúcia Novelino, Thiago Ant nio Moretti de Andrade, Maria Aparecida Nunes Ferreira, Marco Andrey Cipriani Frade, Norma Tiraboschi Foss Division of Dermatology, Ribeir o Preto Medical School, S o Paulo University, S o Paulo, Brazil Introduction: The use of bacillus Calmette–Guérin (BCG) has long been considered a stimulus for immune reactivity in leprosy household contacts. Probably, the combination of multidrug therapy with BCG could facilitate the clearance of leprosy bacilli in the host, reduce relapse rates, and shorten the duration of skin-smear positivity. Methods: To investigate the mechanism of action of BCG, a study involving 19 leprosy patients, eleven multibacillary (MB) and eight paucibacillary, was performed to assess the in vitro production of interleukin (IL)-10, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, IL-6, and IL-17 in the supernatant of peripheral blood mononuclear cells, before and 30 days after inoculation with BCG intradermally (BCG-id). Peripheral blood mononuclear cells isolated by Ficoll–Hypaque gradient were cultivated with Concanavalin-A (Con-A), lipopolysccharides (LPS), or BCG. The supernatant was collected for ELISA quantification of cytokines. The immunohistochemistry of IFN-γ, IL-1, IL-10, IL-12, transforming growth factor (TGF)-β, and TNF-α was carried out in biopsies of skin lesions of leprosy patients before and 30 days after inoculation of BCG-id. These patients were followed up for 5 years to assess the therapeutic response to multidrug therapy, the occurrence of leprosy reactions, and the results of bacterial index and anti-PGL-1 serology after the end of treatment. Results: The results showed increased production of cytokines after BCG-id administration in MB and paucibacillary leprosy patients. There was statistically higher levels of TNF-α (P = 0.017) in MB patients and of IL-17 (P = 0.008) and IFN-γ (P = 0.037) in paucibacillary patients. Immunohistochemical staining, especially for TNF-α, was more intense in biopsies of MB leprosy patients taken after BCG-id administration, probably for induction of innate human immunity. The clinical evaluation suggests that BCG-id is able to induce a more effective therapeutic response, with reduction of the number and the intensity of leprosy reactions. Conclusion: These results suggest that BCG-id induces activation of the initial phase of immunocellular activity: innate human immunity (increase in TNF-α, IL-12 and macrophage activation). Therefore, we conclude that the use of BCG-id could be indic
Work-in-Progress on a Thin IEEE1451.0-Architecture to Implement Reconfigurable Weblab Infrastructures
Ricardo Jorge Guedes Silva Nunes Costa,Gustavo Ribeiro Costa Alves,Mário Zenha Rela
International Journal of Online Engineering (iJOE) , 2011, DOI: 10.3991/ijoe.v7is2.1810
Abstract: Institutions have been creating their own specific weblab infrastructures. Usually, they use distinct software and hardware architectures comprehending instruments and modules (I&M) able to be parameterized but difficult to be shared. These aspects are impairing their widespread in education, since collaboration between institutions, in developing and sharing resources, is still low. To handle both aspects, this paper proposes the adoption of the IEEE1451.0 Std. with FPGA technology for creating reconfigurable weblab infrastructures. It is suggested the adoption of an IEEE1451.0 infrastructure with compatible instruments, described in Hardware Description Languages (HDL), to be reconfigured in FPGA-based boards. Besides an overview of the IEEE1451.0 Std., this paper presents a solution currently under development which seeks to enable the reconfiguration and the remote control of weblab infrastructures using a set of IEEE1451.0 HTTP commands.
HLA class I haplotypes and progression of primary open-angle glaucoma
Zenha, Fábio;Castadelli, Rosistele Maria Oliveira Bezerra;Deghaide, Neifi Hassam Saloum;Donadi, Eduardo Antonio;Rodrigues, Maria de Lourdes Veronese;
Arquivos Brasileiros de Oftalmologia , 2011, DOI: 10.1590/S0004-27492011000200003
Abstract: purpose: to verify if patients with primary open-angle glaucoma with hla class i haplotypes (a9-b12, a2-b40, a1-b8) associated with this disease may have a greater rate of progression than patients who do not present these haplotypes. methods: anatomical and functional glaucoma evaluation (cup-to-disc ratio and visual field) of 25 patients (six of them with one of the haplotypes associated with glaucoma) followed at the glaucoma outpatient clinic of the university hospital, ribeir?o preto school of medicine, s?o paulo university (hcfmrp-usp) for ten years after typing of their hla antigens in order to compare with their previous condition. results: a greater increase of the cup-to-disc ratio was observed in patients with hla haplotypes associated with primary open-angle glaucoma predisposition. however, no significant differences in functional damage progression or in retinal nerve fibers loss were detected between them and other patients with glaucoma. conclusion: the present results indicate an association of class i hla haplotypes with progression of anatomic alterations of the optic nerve head in glaucomatous patients.
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