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Search Results: 1 - 10 of 173637 matches for " Zecchin de Fasano "
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Temor y compasión en los Poemas Homéricos
Zecchin de Fasano,Graciela Cristina;
Synthesis (La Plata) , 2002,
Abstract: from aristotle′s poetics, fear and compassion have been understood as emotions or tragic "pleasures". however, the homeric poems attest the presence of both emotions, and included a special definition of fear, not only as concepts that limits the heroic action or carries a conduct code also as expression of the vulnerability shared among the characters and the potential audience. the present article analizes the epic definition about such concepts and her importance in order to interpret the iliad and the odyssey.
Fronteras sociales de Odisea: Pretendientes, nobles y servidores
Zecchin de Fasano,Graciela Cristina;
Synthesis (La Plata) , 2004,
Abstract: the relation between suitors, noblemen and servant results very complex in the odyssey . inside of the expanded domestic world that the poem offers, we do not find a clear response to the presence of the suitors, neither to the social roll playing by the servants, whose definitory characteristic is to have being noblemen and express at that time an authentic proof of variations of the fortune. that is the case of eurykleia and eumaios. this work proposes the discussion of the elaboration of the limits between one social class and another, as the constitution of the boundary between them, to interpret the form in which is joined in the poem the social situation by the minor characters with the relationship about the protagonist hero.
Espacio privado, espacio social y distancia en Odisea
Zecchin De Fasano,Graciela Cristina;
Synthesis (La Plata) , 2006,
Abstract: a special feature characterised by the value of identification and by the categories of "centre" and "periphery" is observed in the treatment of space in the odyssey. this paper analyzes space related to three different situations: the telemachus', polyphemus' -odysseus's and the suitors' situation, in order to demonstrate that the odysseus itinerary basically consist of a correction of
Deixis social: los valores absolutos y relativos de la Deixis en la relación Odiseo/Pretendientes
Zecchin de Fasano,Graciela Cristina;
Synthesis (La Plata) , 2008,
Abstract: on 22 book of the odyssey , the social deixis is composed through a signifier net of deictic elements applied to the relationship between odysseus and the suitors. this important net incorporates specific determinations of the heroic society proposed like unique features of the characters in the execution of their speeches. this article studies the absolute and relational value of deictic expressions, the distinction of the pronominal uses and the selected words attributed to the characters to set new conclusions about the interpretation and narrative movement of the 22 book, and of the odyssey in general.
El concepto de Eunomía: ?Odisea en Solón?
Zecchin de Fasano,Graciela C.;
Synthesis (La Plata) , 2010,
Abstract: the ionic ideological context has been considered a basic support of solonian elegy. this article explores the intertextual relationship between fr.3 d eunomía by solon and odyssey. from the language shared by both texts, the absorption of epic formulas and again defined concepts it intends explain the admonitory role solon acquires as expression of a heroic action on a political dimension.
Tracking the genomic evolution of breast cancer metastasis
Davide Zecchin, Alberto Bardelli
Breast Cancer Research , 2010, DOI: 10.1186/bcr2469
Abstract: During the metastatic process, breast cancer cells leave the original (primary) tumor site and migrate to other parts of the body, often bones or lungs, via the bloodstream or the lymphatic system. Breast cancer metastases are primarily responsible for morbidity associated with this tumor type [1]. The biological events involved in invasion and metastasis of breast cancer cells are fairly well understood, but very little is known about the genomic changes that occur during this process. Assessing whether the primary tumor and its corresponding metastasis share the same genetic alterations would be of utmost relevance to predict whether therapeutic strategies targeting oncogenic events found in primary lesions can also be effective on metastatic sites.In a recent paper, Shah and colleagues [2] used whole-genome high-throughput sequencing to compare the genetic drift of an estrogen receptor-α-positive metastatic lobular breast tumor with that of the corresponding primary tumor from which it originated and that was surgically removed 9 years earlier.Massive parallel paired-end sequencing of the genome and transcriptome of the metastatic lesion led to the identification of multiple genetic aberrations, including single-nucleotide variants (SNVs), insertions/deletions, gene fusions, translocations, inversions, and copy number alterations. Alternative splicing, biased biallelic expression, and RNA editing changes were also assessed. Comparison of the sequence of tumor and normal DNA samples led to the identification of somatic changes. The prevalent genetic alterations were SNVs (32 non-synonymous coding point mutations), whereas a handful were gene copy number gains. Interestingly, somatic genomic rearrangements, such as translocations, inversions, or fusions, were not identified. This is somewhat surprising if we consider that in other cancer types, such as prostate cancer [3] and lung cancer [4], gene fusions have been detected by the use of the same technology, and th
Critical current and topology of the supercooled vortex state in NbSe2
M. Menghini,Yanina Fasano,F. de la Cruz
Physics , 2001, DOI: 10.1103/PhysRevB.65.064510
Abstract: We study the behavior of the critical current, Ic(H,T), of pure and Fe doped NbSe2 crystals in the denominated disordered vortex region, limited by the critical field Hc2(T) and the field Hp(T) at which the peak effect in Ic(H,T) is detected. The critical current follows an individual pinning response as demonstrated by its field independent universal function of the superfluid density. Transport measurements combined with Bitter decorations show no evidence of the existence of an amorphous phase in the high temperature region.
Novel Therapeutic/Integrative Approaches for Celiac Disease and Dermatitis Herpetiformis
Alessio Fasano
Clinical and Developmental Immunology , 2012, DOI: 10.1155/2012/959061
Abstract: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gluten is a protein component in wheat and other cereals like rye and barley. At present, the only available treatment is a strict gluten-free diet. Recent advances have increased our understanding of the molecular basis for this disorder. Last decade has seen new scientific developments in this disease and led to the formulation of new concepts of pathophysiology that offer possible targets for new treatments or interventions integrative to the gluten-free diet.
Novel Therapeutic/Integrative Approaches for Celiac Disease and Dermatitis Herpetiformis
Alessio Fasano
Journal of Immunology Research , 2012, DOI: 10.1155/2012/959061
Abstract: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gluten is a protein component in wheat and other cereals like rye and barley. At present, the only available treatment is a strict gluten-free diet. Recent advances have increased our understanding of the molecular basis for this disorder. Last decade has seen new scientific developments in this disease and led to the formulation of new concepts of pathophysiology that offer possible targets for new treatments or interventions integrative to the gluten-free diet. 1. Introduction Celiac disease (CD) is an immune-mediated chronic enteropathy with a wide range of presenting manifestations of variable severity. It is triggered by the ingestion of gliadin fraction of wheat gluten and similar alcohol-soluble proteins (prolamins) of barley and rye in genetically susceptible subjects with subsequent immune reaction leading to small bowel inflammation and normalization of the villous architecture in response to a gluten-free diet (GFD). CD not only affects the gut, but it is a systemic disease that may cause injury to the skin (dermatitis herpetiformis, the topic of this special issue), liver, joints, brain, heart, and other organs. It is a complex genetic disorder, and human leukocyte antigen (HLA) status appears to be the strongest genetic determinant of risk for celiac autoimmunity. There is a propensity for individuals with CD to carry specific HLA class II alleles, which has been estimated to account for up to 40% of the genetic load [1]. In affected individuals, 95% have either DQ2 (HLA-DQA1*05-DQB1*02) or DQ8 (HLADQA1*03-DQB1*0302), in comparison with the general population in which 39.5% have either DQ2 or DQ8 [2]. It is the interplay between genes (both HLA and non-HLA associated) and environment (i.e., gluten) that leads to the intestinal damage typical of the disease [3]. Under physiological circumstances, this interplay is prevented by competent intercellular tight junctions (TJs), structures that limit the passage of macromolecules (including gluten) across the intestinal epithelial barrier. Recent evidence suggests that the gluten-induced upregulation of zonulin, a recently described intestinal peptide involved in TJ regulation, is responsible, at least in part, for the aberrant increase in gut permeability characteristic of the early phase of CD [4] and the subsequent abnormal passage of gluten into the lamina propria. Here, the protein is deamidated by tissue transglutaminase and is then recognized by HLA-DQ2/DQ8
A Framework of Conjugate Direction Methods for Symmetric Linear Systems in Optimization
Giovanni Fasano
Mathematics , 2014, DOI: 10.1007/s10957-014-0600-0
Abstract: In this paper we introduce a parameter dependent class of Krylov-based methods, namely CD, for the solution of symmetric linear systems. We give evidence that in our proposal we generate sequences of conjugate directions, extending some properties of the standard Conjugate Gradient (CG) method, in order to preserve the conjugacy. For specific values of the parameters in our framework we obtain schemes equivalent to both the CG and the scaled-CG. We also prove the finite convergence of the algorithms in CD, and we provide some error analysis. Finally, preconditioning is introduced for CD, and we show that standard error bounds for the preconditioned CG also hold for the preconditioned CD.
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