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Search Results: 1 - 10 of 3669 matches for " Zafreen Rahman "
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Successful treatment with eltrombopag in avoiding splenectomy for patients with chronic refractory immune thrombocytopenia
Alhossain A. Khalafallah,Zafreen Rahman,Kath Ogden,Terry Hannan
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: Background: Chronic immune thrombocytopenia (ITP) is a condition associated with significant morbidity; however the management options are often unsatisfactory with a portion of patients exhibiting a refractory-relapsing disease path despite various lines of treatment including splenectomy. As a Thrombopoietin receptor agonist, eltrombopag (GlaxoSmithKline, Australia) provides a novel treatment option for patients with refractory disease. We describe the outcomes of four patients with chronic ITP, who were treated with eltrombopag as a single agent. Methods: Four Caucasian patients with chronic refractory ITP (2 males; 2 females) were enrolled in this study with a mean age of 48 years (range, 39–59). All patients were non-splenectomised and were refractory to several lines of treatment including steroids, intravenous immunogobulin, vincristine, and azathioprine, one patient has also received rituximab (a monoclonal antibody that binds the CD20 antigen expressed by B-lymphocytes). All patients were treated with oral eltrombopag (50-75 mg) for a median period of 12 months (range, 9-16). Results: After a median follow up of 20 months (range, 11-34), platelet counts recovered to normal levels in two patients. One recovered a normal platelet count after 13 months, the other 34 months of completion of treatment with eltrombopag. No additional immune suppressive therapy was required. The other two patients also discontinued Eltromboapag at 27 and 11 months after achievement of satisfactory platelet counts above 30/nL without any bleeding complications. Other forms of immune therapy were also ceased in these two cases. None of the four patients required splenectomy. Conclusion: The clinical outcomes in this small cohort of patients suggests that Eltrombapag may have a role to play in the long term control of chronic ITP with avoiding splenectomy and long term immunosuppressive therapy. The beneficial outcomes in our patients led to a sustained elevation in platelets with no adverse effects noted when used for relatively longer periods than previously reported. It is worth noting that spontaneous remission does occur with ITP and is the most likely cause for the favourable outcome with eltrombopag therapy. However, if Eltrombapag is able to reduce the need for splenectomy in patients with chronic ITP then a distinct quality of care outcome can be achieved by avoiding the recognised short- and long-term complications of splenectomy. Randomised controlled trials with long-term follow up are warranted.
Comparison of tolerability between quetiapine and haloperidol in schizophrenia
Naba Raj Koirala,Manisha Chapagain,Pratikchya Tulachan,Siquafa Zafreen
Journal of Nobel Medical College , 2011, DOI: 10.3126/jonmc.v1i1.7289
Abstract: Schizophrenia is a serious, disabling, often lifetime condition, which can produce severe functional impairment in patients. The life time morbidity risk for schizophrenia is estimated to be 1% and account for 2.8% of the total global YLDs. The World Health Organization Assessment Instrument for Mental Health Systems report of 2006 done in Nepal states in Nepal states that 12% of the patients are diagnosed as schizophrenia in out-patient mental facilities, 14% in community based psychiatry inpatient units and 34% in mental hospital. Atypical antipsychotics are the first line agents recommended for the treatment of schizophrenia considering better efficacy at least in the negative symptoms and better side-effect profile compared with typical antipsychotic. Haloperidol has been used as a standard comparator in numerous trials and new drugs have been compared to it to establish their efficacy, and safety profile. As the authors could not find out any such study which had compared the safety profile of quetipine against conventional antipsychotic, hence this present study is purposed to carry as an attempt to address this issue among Nepalese population. DOI: http://dx.doi.org/10.3126/jonmc.v1i1.7289 Journal of Nobel Medical College Vol.1(1) 2011 59-64
Computational Modeling of Government Policy to Attain Long-Term Higher Voter Turnout for Sustainable Democracy  [PDF]
Mizan Rahman
American Journal of Computational Mathematics (AJCM) , 2013, DOI: 10.4236/ajcm.2013.32016

People power is the fundamental concept of democracy and power of the people is exercised though voting. People decide who should be elected to make decisions for them. However, if people do not properly participate in the voting process and only two-thirds of all eligible voters participate in an election, the democratic institution loses its credibility and becomes vulnerable. This paper investigates various changes in voting institutions throughout the USAwith a simulation model that analyzes the efficacy of such methods to attain higher voter turnout.

Introducing “Arithmetic Calculus” with Some Applications: New Terms, Definitions, Notations and Operators  [PDF]
Rahman Khatibi
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.519277
Abstract: New operators are presented to introduce “arithmetic calculus”, where 1) the operators are just obvious mathematical facts, and 2) arithmetic calculus refers to summing and subtracting operations without solving equations. The sole aim of this paper is to make a case for arithmetic calculus, which is lurking in conventional mathematics and science but has no identity of its own. The underlying thinking is: 1) to shift the focus from the whole sequence to any of its single elements; and 2) to factorise each element to building blocks and rules. One outcome of this emerging calculus is to understand the interconnectivity in a family of sequences, without which they are seen as discrete entities with no interconnectivity. Arithmetic calculus is a step closer towards deriving a “Tree of Numbers” reminiscent of the Tree of Life. Another windfall outcome is to show that the deconvolution problem is explicitly well-posed but at the same time implicitly ill-conditioned; and this challenges a misconception that this problem is ill-posed. If the thinking in this paper is not new, this paper forges it through a mathematical spin by presenting new terms, definitions, notations and operators. The return for these out of the blue new aspects is far reaching.
Symptomatic Trigeminal Neuralgia Pain Treatment Options—A Case Report  [PDF]
Abed Rahman
Open Journal of Anesthesiology (OJAnes) , 2015, DOI: 10.4236/ojanes.2015.59038
Abstract: Background: Severe pain is present in trigeminal neuralgia and may be devastating and debilitating. There are multiple modalities of nonsurgical techniques to help with pain and functionality. Patient: 47 year old male with 6 year history of facial pain due to trigeminal neuralgia. Treated at outside institution with medical management. Intervention: Left gasserian ganglion pulsed radiofrequency with acupuncture and biofeedback by pain psychologist. Results: >50% pain relief for greater than 12 months with improved quality of life. Conclusions: Trigeminal neuralgia may be one of the most challenging disorders to treat in the field of pain management due to the refractory and prolonged course of pain. The purpose of this article is to report the difficult treatment requiring true multidisciplinary treat to treat the severity of the patients pain. Due to his young age we opted for the pulsed radiofrequency as opposed to the thermal radiofrequency.
Heuristic Contextualisation of Arithmetic Calculus by a New Network Based on the Difference Table  [PDF]
Rahman Khatibi
Applied Mathematics (AM) , 2017, DOI: 10.4236/am.2017.810102
“Arithmetic Calculus” (AC), introduced recently by the author, is explored further in this paper by giving a new lease of life to the age-old differences table by transforming it into a new kind of network. Any sequence that can be laid out in this network can be classified into one of five types of sequences, which can be expressed by algebraic polynomial or exponential functions but AC can reveal information concealed by algebra. The paper defines these sequences and refers to each family member as the parent sequence. These sequences make up their own universe as: (i) the population of the terms in each parent sequence is infinite; (ii) each parent sequence forms a hierarchy, in which their number of levels can extend into infinity; and (ii) there are infinitely diverse parent sequences. A glimpse of AC is illustrated through examples but their analytical capability is applicable in their universe. The paper shows that small sets of building blocks are operated by the convolution theorem or its variations, which is embedded “all-pervasively” in each and every member of the universe. Sufficient details are presented to ensure the emergence of the mosaic image of AC through problems including: (i) differentiation (reducement), (ii) integration (conducement), (iii) diagonal operations (reminiscent of gradient methods), and (iv) structure of hierarchies. These operations reveal that the new network can parallel Cartesian coordinates and that for problems with no noise, the deconvolution problem is well-posed against common myth of it being ill-posed.
Determination of the Metastable Zone Width, Nucleation Kinetics, Structural and Optical Properties of KCl Doped KAP Crystal  [PDF]
M. A. Rahman, M. M. Rahman
Journal of Crystallization Process and Technology (JCPT) , 2015, DOI: 10.4236/jcpt.2015.52005
Abstract: Slow evaporation method was used to grow pure and KCl (10 mol%) doped KAP single crystal. The solubility and metastable zone width of aqueous solutions of pure and KCl (10 mol%) doped KAP crystal were evaluated to analyze the crystallization process. Measuring the induction period τ, the critical nucleation parameters like interfacial energy (σ), energy of formation of the critical nucleus (ΔG*) were determined using the classical theory of nucleation. The structural properties and optical constants of the grown crystals have been put to test and observed that the addition of KCl results in an enhancement of properties of the crystal. Grown crystals were characterized by powder X-ray diffraction. FTIR spectra confirmed the presence of KCl in pure KAP crystal. UV- Visible spectroscopic studies revealed that addition of KCl in pure KAP crystal increased transparency from 75% to 80%. The analysis of the optical absorption data revealed the presence of both indirect and direct transitions and both of these band gaps increased with the addition of KCl. The transmittance data was analyzed to calculate the refractive index, oscillator energy, dispersion energy, electric susceptibility, zero-frequency dielectric constant and both the real and imaginary parts of the dielectric permittivity as a function of photon energy. The moments of ε(E) were also determined. The dispersion i.e. spectral dependence of the refractive index was discussed according to the single-effective oscillator model proposed by Wemple and DiDomenico.
Infection of Toxoplasma gondii in Humans and Livestock Animals: An Emerging Silent Threat for Bangladesh  [PDF]
Taibur Rahman, Atiqur Rahman, Sajib Chakraborty
Open Journal of Medical Microbiology (OJMM) , 2018, DOI: 10.4236/ojmm.2018.84010
Abstract: Toxoplasma gondii is an intracellular, zoonotic protozoan parasite that causes toxoplasmosis. It can potentially infect almost all mammalian and avian hosts including one-third of the human population world-wide. The major target group of the parasite includes immunocompromised patients (e.g. AIDS, cancer, organ transplantation) and fetus bearing pregnant women where it develops toxoplasmic encephalitis, myocarditis, chorioretinitis and abnormal fetal brain development or stillbirths respectively. In this review, we have presented the current status of T. gondii infection in livestock animals and human population in Bangladesh to assess the country-wide relative risk. Although exact prevalence is difficult to predict due to the scarcity of data, nevertheless existing literature suggests that 16% - 39% humans and 8% - 70% domestic animals are infected with T. gondii, which implies Bangladeshi population is at high risk of toxoplasmosis. Furthermore, we have proposed a potential area of research to decipher the genetic diversity and transmission routes of T. gondii infection into Bangladeshi population.
Fabrication of self-assembled monolayer using carbon nanotubes conjugated 1-aminoundecanethiol on gold substrates  [PDF]
Mohammed M. Rahman
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.33027
Abstract: The carbon nanotube (fundamentally Single- walled carbon nanotube, SWCNT) based on 1-Amino-undecanethiol (AUT) were extremely controlled (nano-level) organizing a vertical self-assembled monolayer (SAM) on gold single crystal surfaces. The produced nano-surfaces were explored particularly by Fourier Transform Infra-red Spectroscopy (FT-IR), Cyclic Voltammetry (CV), Raman spectroscopy, Electrochemi- cal quartz crystal microbalance (EQCM), and Atomic force microscopy (AFM) techniques. The SWCNTs were initially cut (chemically) into short pipes and thiol-derivatized at the open ends. The vertical aggregation of SWCNT-AUTs on chemically refined Au(111) substrates was made-up by their spontaneous chemical bonding among carboxyl derivatized SWCNT-COOH and AUT SAM on Au(111), via peptide bonds, or directly by synthesized SWCNT-AUT composites. Raman spectroscopy and AFM surface images obviously disclosed that the SWCNT- AUT (dia. 20~40 nm) has been vertically categorized d on gold (111) substrates, shaping a SAM with a perpendicular direction.
Effects of zinc and nitrogen fertilizer and their application method on yield and yield components of Phaseolus vulgaris L.  [PDF]
Faizus Salehin, Shahedur Rahman
Agricultural Sciences (AS) , 2012, DOI: 10.4236/as.2012.31003
Abstract: An experiment in factorial format based on randomized complete block design with 3 replications was conducted to study the effects of zinc spray (0 and 1 g/L) and nitrogen fertilizer (0, 25, 50 and 75 kg/ha pure nitrogen) on yield and yield components of Phaseolus vulgaris. In maturity time, seed yield, 100 seed weight, number of pods per plant, number of seeds per pod and plant height were measured. Results showed that, use of zinc spray had a significant effect in 1% probability level on all measured traits. Also, the effect of nitrogen on all studied traits was significant in 1% probability level. Interaction effect of zinc spray and nitrogen fertilizer on number of seed per pod in 1% and on seed yield and plant height in 5% was significant and on other traits was non significant. The highest seed yield was obtained by zinc spray application with 1996 kg/ha. Among nitrogen fertilizer levels, use of 90 kg/ha pure nitrogen showed highest seed yield.
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