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Search Results: 1 - 10 of 28247 matches for " ZHU Kailin "
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Discrimination of approved drugs from experimental drugs by learning methods
Kailin Tang, Ruixin Zhu, Yixue Li, Zhiwei Cao
BMC Bioinformatics , 2011, DOI: 10.1186/1471-2105-12-157
Abstract: Four methodologies were compared by their performance to classify approved drugs from experimental ones. The best results were obtained by SVM, in which the accuracy is 0.7911, the sensitivity is 0.5929, and the specificity is 0.8743. Based on the results, consensus model was developed to effectively discriminate drugs, which further pushed the correct classification rate up to 0.8517, sensitivity up to 0.7242, specificity up to 0.9352. The applications on the Traditional Chinese Medicine Ingredients Database (TCM-ID) tested the methods. Therefore this model has been proven to be a potent tool for identifying drug molecules.The studies would have potential applications in the research of combinatorial library design and virtual high throughput screening for drug discovery.In the early 1990s, the advent of high-throughput screening (HTS) and combinational chemistry methodologies was widely seen as having great potential to revolutionize modern drug discovery. However, the quality of the output from these technologies was limited than expected. Despite advances in technology and understanding of biological systems, drug discovery is still a "lengthy, expensive, difficult, and inefficient process" with low rate of new therapeutic discovery [1]. Drugs as well as drug-like compounds are distributed extremely meagerly through chemical space, which is estimated to contain ~1040 to ~10100 molecules. Among the whole chemical space, the majority is nondrug molecules, the minority is druglike molecules. To assess whether a compound is druglike or not as early as possible in drug discovery process will be extremely meritorious. Druglike compounds generally indicates molecules that contain functional groups and/or have physical properties consistent with the majority of known drugs, and hence can be inferred as compounds which might be biologically active or show therapeutic potential [2]. For a drug, properties like synthetic ease, stability, oral availability, good pharmacokin
新型橡胶铜复合多孔材料的制造方法及其吸声特性
Preparation of the novel rubber-copper porous composite and its acoustic absorption property

朱远志,朱凯麟,曲振林,刘 冉,彭 欢,隋之敏
ZHU Yuanzhi
,ZHU Kailin,QU Zhenlin,LIU Ran,PENG Huan,SUI Zhimin

- , 2018,
Abstract: 对200目橡胶粉和500目高纯无氧铜在高能行星式球磨机内进行20 min混料,混料后在模具中,在50℃温度下,在20 MPa压力下,压制成Φ 100 mm×5 mm的圆片,再通过选择性腐蚀方法,把其中的铜腐蚀掉,得到多孔橡胶材料.发现,多孔橡胶中存在大量20 μm以下的小孔以及少量尺寸大于100 μm的大孔.吸声系数试验表明,多孔橡胶对于不同频率的声波均有较好的吸收效果.
Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
Haitao Yang,Weiqing Xie,Xiaoyu Xue,Kailin Yang,Jing Ma,Wenxue Liang,Qi Zhao,Zhe Zhou,Duanqing Pei,John Ziebuhr,Rolf Hilgenfeld,Kwok Yung Yuen,Luet Wong,Guangxia Gao,Saijuan Chen,Zhu Chen,Dawei Ma,Mark Bartlam,Zihe Rao
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0030428
Abstract:
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
Haitao Yang,Weiqing Xie,Xiaoyu Xue,Kailin Yang,Jing Ma,Wenxue Liang,Qi Zhao,Zhe Zhou,Duanqing Pei,John Ziebuhr,Rolf Hilgenfeld,Kwok Yung Yuen,Luet Wong,Guangxia Gao,Saijuan Chen,Zhu Chen,Dawei Ma,Mark Bartlam,Zihe Rao
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0030324
Abstract: The genus Coronavirus contains about 25 species of coronaviruses (CoVs), which are important pathogens causing highly prevalent diseases and often severe or fatal in humans and animals. No licensed specific drugs are available to prevent their infection. Different host receptors for cellular entry, poorly conserved structural proteins (antigens), and the high mutation and recombination rates of CoVs pose a significant problem in the development of wide-spectrum anti-CoV drugs and vaccines. CoV main proteases (Mpros), which are key enzymes in viral gene expression and replication, were revealed to share a highly conservative substrate-recognition pocket by comparison of four crystal structures and a homology model representing all three genetic clusters of the genus Coronavirus. This conclusion was further supported by enzyme activity assays. Mechanism-based irreversible inhibitors were designed, based on this conserved structural region, and a uniform inhibition mechanism was elucidated from the structures of Mpro-inhibitor complexes from severe acute respiratory syndrome-CoV and porcine transmissible gastroenteritis virus. A structure-assisted optimization program has yielded compounds with fast in vitro inactivation of multiple CoV Mpros, potent antiviral activity, and extremely low cellular toxicity in cell-based assays. Further modification could rapidly lead to the discovery of a single agent with clinical potential against existing and possible future emerging CoV-related diseases.
Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
Haitao Yang,Weiqing Xie,Xiaoyu Xue,Kailin Yang,Jing Ma,Wenxue Liang,Qi Zhao,Zhe Zhou,Duanqing Pei,John Ziebuhr,Rolf Hilgenfeld,Kwok Yung Yuen,Luet Wong,Guangxia Gao,Saijuan Chen,Zhu Chen,Dawei Ma,Mark Bartlam,Zihe Rao
PLOS Biology , 2005, DOI: 10.1371/journal.pbio.0030428
Abstract:
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
Haitao Yang,Weiqing Xie,Xiaoyu Xue,Kailin Yang,Jing Ma,Wenxue Liang,Qi Zhao,Zhe Zhou,Duanqing Pei,John Ziebuhr,Rolf Hilgenfeld,Kwok Yung Yuen,Luet Wong,Guangxia Gao,Saijuan Chen,Zhu Chen,Dawei Ma ,Mark Bartlam,Zihe Rao
PLOS Biology , 2005, DOI: 10.1371/journal.pbio.0030324
Abstract: The genus Coronavirus contains about 25 species of coronaviruses (CoVs), which are important pathogens causing highly prevalent diseases and often severe or fatal in humans and animals. No licensed specific drugs are available to prevent their infection. Different host receptors for cellular entry, poorly conserved structural proteins (antigens), and the high mutation and recombination rates of CoVs pose a significant problem in the development of wide-spectrum anti-CoV drugs and vaccines. CoV main proteases (Mpros), which are key enzymes in viral gene expression and replication, were revealed to share a highly conservative substrate-recognition pocket by comparison of four crystal structures and a homology model representing all three genetic clusters of the genus Coronavirus. This conclusion was further supported by enzyme activity assays. Mechanism-based irreversible inhibitors were designed, based on this conserved structural region, and a uniform inhibition mechanism was elucidated from the structures of Mpro-inhibitor complexes from severe acute respiratory syndrome-CoV and porcine transmissible gastroenteritis virus. A structure-assisted optimization program has yielded compounds with fast in vitro inactivation of multiple CoV Mpros, potent antiviral activity, and extremely low cellular toxicity in cell-based assays. Further modification could rapidly lead to the discovery of a single agent with clinical potential against existing and possible future emerging CoV-related diseases.
Cylindrical Magnetorheological Fluid Variable Transmission Controlled by Shape-Memory Alloy
Song Chen,Kailin Jian,Xianghe Peng
Science and Technology of Nuclear Installations , 2012, DOI: 10.1155/2012/856082
Abstract: Centrifugal fan is an important component of a ventilation system in a nuclear power plant. In this paper, we proposed a magnetorheological speed-adjustment system controlled by shape-memory alloy for centrifugal fan. A theoretical analysis of the effect of the applied magnetic field on the viscoplastic flow between two cylinders in the speed-adjustment system is presented. The expressions for the velocity in viscoplastic flow and the torque transmitted by MR fluids are derived. A sliding mode SMA switch is proposed to modify the magnetic field acting on working gap under thermal effect. The results indicate that with the increases of applied magnetic field, the torque transmitted by MR fluid goes up rapidly. 1. Introduction Centrifugal fans are widely used for transporting air in a ventilation system in a nuclear power plant. For different operation conditions of ventilating system, the rotational velocity of centrifugal fan needs to be adjusted to improve the operating efficiency of a ventilating system. In this paper, we propose a speed-adjustment system based on magnetorheological (MR) fluid and shape-memory alloy (SMA) for centrifugal fan. MR fluids are the suspension of micron-sized, magnetizable particles in a carrier fluid. When exposed to a magnetic field, the rheological characteristics of MR fluids reversibly and instantaneously change from a free-flowing liquid to a semisolid with controllable yield strength. Altering the strength of the applied magnetic field precisely and proportionally controls the consistency or yield strength of the fluids [1, 2]. Based on the mechanical characteristics, the fluids can be used in the controllable, energy-dissipating applications such as dampers [3, 4], valves [5, 6], and variable transmission devices [7–9]. An MR variable transmission device transmits torque by the shear stress of the MR fluids from the driving shaft to driven shell. The MR variable transmission device has the property that its transmitting torque changes quickly in response to an external magnetic field. A literature review indicates that the variable transmission devices that use MR fluids can be classified as having either disc type or cylindrical type [10]. In the disc type, the MR fluid within the activation region between two parallel circular plates is a circular plate. In the cylindrical type, the activated MR fluid between two concentric cylinders is an annular cylinder. In order to rationally design the MR variable transmission devices, a designer should analyze the torque transmission ability. In this paper, Bingham model is
A pathway profile-based method for drug repositioning
Hao Ye,LinLin Yang,ZhiWei Cao,KaiLin Tang,YiXue Li
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-012-4982-9
Abstract: Finding new applications for existing pharmaceuticals, known as drug repositioning, is a validated strategy for resolving the problem of high expenditure but low productivity in drug discovery. Currently, the prevalent computational methods for drug repositioning are focused mainly on the similarity or relevance between known drugs based on their “features”, including chemical structure, side effects, gene expression profile, and/or chemical-protein interactome. However, such drug-oriented methods may constrain the newly predicted functions to the pharmacological functional space of the existing drugs. Clinically, many drugs have been found to bind “off-target” (i.e. to receptors other than their primary targets), which can lead to undesirable effects. In this study, which integrates known drug target information, we propose a disease-oriented strategy for evaluating the relationship between drugs and disease based on their pathway profile. The basic hypothesis of this method is that drugs exerting a therapeutic effect may not only directly target the disease-related proteins but also modulate the pathways involved in the pathological process. Upon testing eight of the global best-selling drugs in 2010 (each with more than three targets), the FDA (Food and Drug Administration, USA)-approved therapeutic function of each was included in the top 10 predicted indications. On average, 60% of predicted results made using our method are proved by literature. This approach could be used to complement existing methods and may provide a new perspective in drug repositioning and side effect evaluation.
Incoherent pulse Doppler lidar as the velocimeter system
Zhishen Liu,Xiaoquan Song,Jintao Liu,Kailin Zhang
Chinese Science Bulletin , 2002, DOI: 10.1360/02tb9120
Abstract: This note reports a new type of incoherent pulse laser Doppler lidar velocimeter with iodine molecular filter as a frequency discriminator. Its transmitter subsystem applies a Nd:YAG pulse laser which is injected with a single longitudinal-mode diode pumped continuous seeder laser. The field experiment proved that this velocimeter measurement results are consistent with those measured by photoelectric velocimeter. Measurements of eight different velocities show that the standard deviation is 0.56 m/s, the range resolution is 3.75 m.
Incoherent pulse Doppler lidar as the velocimeter system

LIU Zhishen,SONG Xiaoquan,LIU Jintao,ZHANG Kailin,

科学通报(英文版) , 2002,
Abstract: This note reports a new type of incoherent pulse laser Doppler lidar velocimeter with iodine molecular filter as a frequency discriminator. Its transmitter subsystem applies a Nd:YAG pulse laser which is injected with a single longitudinal-mode diode pumped continuous seeder laser.The field experiment proved that this velocimeter measurement results are consistent with those measured by photoelectric velocimeter. Measurements of eight different velocities show that the standard deviation is 0.56 m/s, the range resolution is 3.75 m.
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