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Search Results: 1 - 10 of 54794 matches for " ZHAO Ke-Qin "
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Research on Tasks Scheduling Algorithms for Dynamic and Uncertain Computing Grid Based on a+bi Connection Number of SPA
Decai Huang,Yuan Yuan,Li-jun Zhang,Ke-qin Zhao
Journal of Software , 2009, DOI: 10.4304/jsw.4.10.1102-1109
Abstract: Task scheduling algorithms are key techniques in task management system of computing grid. Because of the uncertainty nature of a grid, traditional task scheduling algorithms do not work well in an open, heterogeneous and dynamic grid environment of real world. In this paper, Set Pair Analysis (SPA), a new soft computation method is used to process the synthetic uncertainty in the task scheduling of a computing grid. After introducing SPA and its application, the paper goes on to introduce the definition of connection number to express the uncertain Expected Time to Compute of tasks, analysis operation properties and linear order relation suitable for computing grid scheduling. Three online uncertain dynamic scheduling algorithms, OUD_OLB, OUD_MET, OUD_MCT, and three batch uncertain dynamic scheduling algorithms BUD_Min-min, BUD_Min-max, BUD_Surferage, are presented for the uncertain dynamic computing grid. Theoretical analysis and experimental results illustrate that these algorithms are capable of representing the dynamics and uncertainty in a computing grid environment. These algorithms are the generalization of traditional grid scheduling algorithms, and they possess high value in theory and application in a grid environment. Certainly it will be a new method to design tasks scheduling algorithm in uncertain computing grid environment.
A Practical Approach to Management of Chronic Hepatitis B
Hu Ke-Qin
International Journal of Medical Sciences , 2005,
Abstract: Chronic hepatitis B (CHB) is one of the important public health problems worldwide. Major advances have been made in the treatment of CHB during the past several years. This article systemically reviews advances in the application of HBV DNA quantitation and three approved drugs for HBV treatment, and presents an updated and practical clinical approach to managing CHB. Highly sensitive PCR-based quantitation of HBV DNA makes it possible to precisely determine pre-treatment HBV load and monitor HBV DNA response during treatment. HBV DNA level, HBeAg status, degree of hepatic histological activity and fibrosis, and serum transaminases are the most important parameters in determining indication, regimen, and duration of HBV treatment. Although interferon alfa-2b, lamivudine, and adefovir are all approved as initial HBV treatment, understanding the advantages and advantages of each agent is important in choosing the best treatment for each individual patient with CHB.
Guest Editor's Editorial: Advances in Managing Hepatitis C Virus (HCV) Infection (A Special Issue)
Hu Ke-Qin
International Journal of Medical Sciences , 2006,
Abstract:
Identifying dysregulated pathways in cancers from pathway interaction networks
Ke-Qin Liu, Zhi-Ping Liu, Jin-Kao Hao, Luonan Chen, Xing-Ming Zhao
BMC Bioinformatics , 2012, DOI: 10.1186/1471-2105-13-126
Abstract: In this paper, we propose a novel approach to identify dysregulated pathways in cancer based on a pathway interaction network. Our contribution is three-fold. Firstly, we present a new method to construct pathway interaction network based on gene expression, protein-protein interactions and cellular pathways. Secondly, the identification of dysregulated pathways in cancer is treated as a feature selection problem, which is biologically reasonable and easy to interpret. Thirdly, the dysregulated pathways are identified as subnetworks from the pathway interaction networks, where the subnetworks characterize very well the functional dependency or crosstalk between pathways. The benchmarking results on several distinct cancer datasets demonstrate that our method can obtain more reliable and accurate results compared with existing state of the art methods. Further functional analysis and independent literature evidence also confirm that our identified potential pathogenic pathways are biologically reasonable, indicating the effectiveness of our method.Dysregulated pathways can serve as better biomarkers compared with single genes. In this work, by utilizing pathway interaction networks and gene expression data, we propose a novel approach that effectively identifies dysregulated pathways, which can not only be used as biomarkers to diagnose cancers but also serve as potential drug targets in the future.
Characterizing structural features of cuticle-degrading proteases from fungi by molecular modeling
Shu-Qun Liu, Zhao-Hui Meng, Jin-Kui Yang, Yun-Xin Fu, Ke-Qin Zhang
BMC Structural Biology , 2007, DOI: 10.1186/1472-6807-7-33
Abstract: Structural models of serine proteases PR1 from entomophagous fungus, Ver112 and VCP1 from nematophagous fungi, have been modeled using the homology modeling technique based on the crystal coordinate of the proteinase K. In combination with multiple sequence alignment, these models suggest one similar calcium-binding site and two common disulfide bridges in the three cuticle-degrading enzymes. In addition, the predicted models of the three cuticle-degrading enzymes present an essentially identical backbone topology and similar geometric properties with the exception of a limited number of sites exhibiting relatively large local conformational differences only in some surface loops and the N-, C termini. However, they differ from each other in the electrostatic surface potential, in hydrophobicity and size of the S4 substrate-binding pocket, and in the number and distribution of hydrogen bonds and salt bridges within regions that are part of or in close proximity to the S2-loop.These differences likely lead to variations in substrate specificity and catalytic efficiency among the three enzymes. Amino acid polymorphisms in cuticle-degrading enzymes were discussed with respect to functional effects and host preference. It is hoped that these structural models would provide a further basis for exploitation of these serine proteases from pathogenic fungi as effective bio-control agents.Proteases are enzymes that catalyze the hydrolysis of peptide bonds in other proteins and are often used in biotechnology, industry, and agriculture as bio-control agents against parasites. Serine proteases (EC 3.4.21.-) are present in virtually all organisms and exist as two major families, the trypsin-like (EC 3.4.21.4) and the subtilisin-like (EC 3.4.21.14) families. These two families have independently evolved with a similar catalytic mechanism which has been widely investigated [1-4]. Although the overall fold of various serine proteases may differ, they all follow the same mechanism
Static Scheduling Algorithms Based on Connective-number of Type a+bi for Uncertain Computing Grid
基于a+bi型联系数的不确定网格静态调度算法

HUANG De-Cai,ZHANG Li-Jun,ZHAO Ke-Qin,
黄德才
,张丽君,赵克勤

计算机科学 , 2007,
Abstract: Job scheduling algorithms are kernel technique in task management system of computing grid. Because the dynamic and uncertainty exist in grid environment, the traditional job scheduling algorithms cannot be applied effectively in the real open, heterogene
CMZ Reversed Chronic Ethanol-Induced Disturbance of PPAR-α Possibly by Suppressing Oxidative Stress and PGC-1α Acetylation, and Activating the MAPK and GSK3β Pathway
Tao Zeng, Cui-Li Zhang, Fu-Yong Song, Xiu-Lan Zhao, Ke-Qin Xie
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098658
Abstract: Background Cytochrome P4502E1 (CYP2E1) has been suggested to play critical roles in the pathogenesis of alcoholic fatty liver (AFL), but the underlying mechanisms remains unclear. The current study was designed to evaluate whether CYP2E1 suppression by chlormethiazole (CMZ) could suppress AFL in mice, and to explore the underlying mechanisms. Methods Mice were treated with or without CMZ (50 mg/kg bw, i.p.) and subjected to liquid diet with or without ethanol (5%, w/v) for 4 weeks. Biochemical parameters were measured using commercial kits. The protein and mRNA levels were detected by western blot and qPCR, respectively. Histopathology and immunohistochemical assay were performed with routine methods. Results CYP2E1 inhibition by CMZ completely blocked AFL in mice, shown as the decline of the hepatic and serum triglyceride levels, and the fewer fat droplets in the liver sections. Chronic ethanol exposure led to significant decrease of the mRNA and protein levels of peroxisome proliferator-activated receptor α (PPAR-α), which was blocked by CMZ co-treatment. CMZ co-treatment suppressed ethanol-induced oxidative stress, overproduction of tumor necrosis α (TNF-α), and decrease of protein levels of the PPAR-α co-activators including p300 and deacetylated PGC1-α. Furthermore, CMZ co-treatment led to the activation of AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), and PI3K/Akt/GSK3β pathway. However, chronic ethanol-induced decline of acyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) protein levels was partially restored by CMZ, while the activation of autophagy appeared to be suppressed by CMZ. Conclusion These results suggested that CMZ suppressed chronic ethanol-induced oxidative stress, TNF-α overproduction, decline of p300 protein level and deacetylation of PGC1-α, and activated AMPK, MAPK, and PI3K/Akt/GSK3β pathway, which might contribute to the activation of PPAR-α and account for the protection of CMZ against AFL.
Protective Effects of Garlic Oil on Hepatocarcinoma Induced by N-Nitrosodiethylamine in Rats
Cui-Li Zhang, Tao Zeng, Xiu-Lan Zhao, Li-Hua Yu, Zhen-Ping Zhu, Ke-Qin Xie
International Journal of Biological Sciences , 2012,
Abstract: To investigate the protective effects and the possible mechanisms of garlic oil (GO) against N-nitrosodiethylamine (NDEA)-induced hepatocarcinoma in rats, Wistar rats were gavaged with GO (20 or 40 mg/kg) for 1 week, and then were gavaged with GO and NDEA (10 mg/kg) for the next 20 weeks. The changes of morphology, histology, the biochemical indices of serum, and DNA oxidative damage of liver were examined to assess the protective effects. Lipid peroxidation (LPO), antioxidant defense system, and apoptosis-related proteins were measured to investigate potential mechanisms. At the end of the study (21 weeks), GO administration significantly inhibited the increase of the nodule incidence and average nodule number per nodule-bearing liver induced by NDEA, improved hepatocellular architecture, and dramatically inhibited NDEA-induced elevation of serum biochemical indices (alanine aminotransferase , aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase) and hepatic 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in a dose-dependent manner. The mechanistic studies demonstrated that GO counteracted NDEA-induced oxidative stress in rats illustrated by the restoration of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST) levels, and the reduction of the malondialdehyde (MDA) levels in liver. Furthermore, the mRNA and protein levels of Bcl-2, Bcl-xl, andβ-arrestin-2 were significantly decreased whereas those of Bax and caspase-3 were significantly increased. These data suggest that GO exhibited significant protection against NDEA-induced hepatocarcinogenesis, which might be related with the enhancement of the antioxidant activity and the induction of apoptosis.
Roles of Cytochrome P4502E1 Gene Polymorphisms and the Risks of Alcoholic Liver Disease: A Meta-Analysis
Tao Zeng, Fang-Fang Guo, Cui-Li Zhang, Fu-Yong Song, Xiu-Lan Zhao, Ke-Qin Xie
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054188
Abstract: Background Previous studies investigating the association between cytochrome P4502E1 (CYP2E1) polymorphisms and the risk of alcoholic liver diseases (ALD) have yielded conflicting results. Thus, a meta-analysis was performed to clarify the association between CYP2E1 polymorphisms and the risks of ALD. Methods A comprehensive literature search was conducted to identify the relevant studies. The fixed or random effect model was selected based on the heterogeneity test among studies. Publication bias was estimated using Begg’s funnel plots and Egger’s regression test. Results A total of 27 and 9 studies were finally included for the association between the CYP2E1 Pst I/Rsa I or Dra I polymorphisms and the risks of ALD, respectively. Overall, the combined results showed that homozygous genotype c2c2 was significantly associated with increase risk of ALD in worldwide populations (c2c2 vs. c1c1: OR = 3.12, 95%CI 1.91–5.11) when ALD patients were compared with alcoholics without ALD. Significant associations between CYP2E1 Pst I/Rsa I polymorphism and ALD risk were also observed in Asians (c2c2 vs. c1c1: OR = 4.11, 95%CI 2.32–7.29) and in Caucasians (c2c2/c1c2 vs. c1c1: OR = 1.58, 95%CI 1.04–2.42) when ALD patients were compared with alcoholics without ALD. However, subgroup analysis stratified by ALD types showed that CYP2E1 Pst I/Rsa I polymorphism was not significantly associated with the risks of alcoholic cirrhosis (ALC). No significant association was observed between CYP2E1 Dra I polymorphism and ALD risks. Conclusion This meta-analysis suggested that CYP2E1 Pst I/Rsa I polymorphism might be not significantly associated with advanced form of ALD (ALC), but might be significantly associated with other form of ALD such as steatosis, hepatisis, fibrosis. Furthermore, CYP2E1 Dra I polymorphism might be not significantly associated with the ALD risks. Since potential confounders could not be ruled out completely, further studies were needed to confirm these results.
The Water Use Effeciency of the Goldspur Apple Tree
金矮生苹果水分利用效率研究

WANG Ke-Qin,
王克勤

生态学报 , 2002,
Abstract: After measuring the photosynthetic rate and transpiration rate of the leaves of seven-year field and two-year potted Malus pumila CV. Goldspur under different soil water and illumination conditions, together with the calculation of water use efficiency (WUE), the result showed that because photosynthetically active radiation (PAR) and soil water content (SWC) affected the photosynthetic rate and transpiration rate of Goldspur, they thus influenced WUE. The response of WUE to different illumination condition...
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