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Search Results: 1 - 10 of 88208 matches for " ZHAO CHANG-LIN "
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Mechanism of A375 cell apoptosis induced by 2-chlorodeoxyadenosine(2-CDA)
Chang-lin WANG,Ming ZHAO,Jian MA,Qi ZHANG
Medical Journal of Chinese People's Liberation Army , 2011,
Abstract: Objective The effect of nucleoside analogue,2-chlorodeoxyadenosine(2-CDA) on human malignant melanoma has not been fully studied heretofore.The aim of present study was to investigate the mechanisms of apoptosis of human melanoma A375 cells induced by 2-chlorodeoxyadenosine(2-CDA).Methods A375 cells were treated with different doses(0,0.5,1,2,5μmol/L) of 2-CDA for different duration.The inhibitory effect on cell proliferation was measured by MTT assay.The cell apoptosis was detected by flow cytometry after annexin V-FITC/PI double staining.The expressions of p-Stat3,t-Stat3,Caspase-3,PARP and β-actin proteins were determined by Western blot.Results 2-CDA inhibited the proliferation of A375 cells in a time-and dose-dependent manner.After treatment for 48h,the IC50 of 2-CDA was 3.04μmol/L.Results of annexin V-FITC/PI double staining and flow cytometry indicated that 2-CDA effectively induced A375 apoptosis in a dose-dependent manner.The apoptotic rate of A375 cells was increased from 1.01% to 32.0% after treatment with 5μmol/L 2-CDA for 48h.The results of Western blotting showed that 2-CDA decreased the phosphorylation level of Stat3 kinase in time-and dose-dependent manner.When the cells treated with 5μmol/L 2-CDA for 36h,there was a prominent inhibitory effect on Stat3 kinase,indicated by a sharp decline of its phosphorylation level.At the same time,both the Caspase-3 and its client PARP,a hallmark of apoptosis,were all cleaved,implying that the cell apoptosis was induced in a caspase-dependent pathway.Conclusion 2-CDA may inhibit proliferation and induce apoptosis in human melanoma A375 cells by blocking the activity of Stat3 kinase and activating the Caspase-3/PARP apoptosis pathway.


物理学报 , 1993,
Abstract: The effect of electron cyclotron wave on trapped electrons and runaway electrons in mirror plasma is discussed in the context of the Lagrangian formulism of the guiding center for charged particle developed by Littlejohn. The condition for transition between trapped electrons and runaway electrons is given, their transition probabilities are evaluated as well.
Audible sound metamaterial

Ding Chang-Lin,Zhao Xiao-Peng,

物理学报 , 2009,
Abstract: 制作了一维周期排列的亥姆霍兹共振器超材料,在空气环境下测试了其在可听声频段声学透射行为.实验结果表明,在2.1—3.5 kHz附近该材料具有透射衰减的吸收峰,利用声传输线理论(ATLM)计算的透射率和实验结果一致,同时由计算的等效阻抗分析可知,实验中出现的吸收峰是由HRs共振的回波反射引起的.另外,实验测试的样品中透射信号分布进一步验证了材料的共振效应,也就是会出现与外加激励反相响应.基于前述的共振模型计算出该材料的等效弹性模量为负.
Five species of Perenniporia (Polyporales) new to China

ZHAO Chang-Lin,CUI Bao-Kai,

菌物学报 , 2013,
Abstract: 报道了多年卧孔菌属Perenniporia 5个中国新记录种。非洲多年卧孔菌Perenniporia africana采自安徽省,孔口表面浅黄色至赭色,且骨架菌丝不分枝;下延多年卧孔菌P. decurrata采自云南省,担子果盖形,具较小孔口和担孢子;椭圆孢多年卧孔菌P. ellipsospora采自云南省,担子果平伏,孔口圆形至多角形,担孢子不平截;硬多年卧孔菌P. inflexibilis 采自福建省,担子果盖形,孔口表面灰白至浅褐色,担孢子无色至浅黄色;黄多年卧孔菌P. xantha采自海南省,孔口较小,表面呈黄色,且在KOH试剂中呈深褐色。根据采集的标本材料提供了它们的详细描述和显微结构图。
Three species of Perenniporia (Polyporales) new to China

ZHAO Chang-Lin,CUI Bao-Kai,

菌物学报 , 2012,
Abstract: 报道了多年卧孔菌属Perenniporia 3个中国新记录种。竹生多年卧孔菌P. bambusicola采自云南省,孔口表面橙色且仅生长于竹子上;树状多年卧孔菌P. dendrohyphidia采自广西,具树状菌丝;灰黄多年卧孔菌P. isabellina采自云南省,担子果平伏,孔口灰黄色,具树状骨架菌丝,且担孢子较大。根据采集的标本材料提供了它们的详细描述和显微结构图。
Two species of Perenniporia from Hainan new to China

ZHAO Chang-Lin,CUI Bao-Kai,

菌物学报 , 2011,
Abstract: 在海南省发现中国多孔菌两个新记录种,分别为戈氏多年卧孔菌Perenniporia gomezii和近邻多年卧孔菌P. vicina。根据采集的标本材料提供了它们的详细描述和显微结构图,同时提供了中国多年卧孔菌属分种检索表。
Nonlinear Liouville problems in a quarter plane
Chang-Lin Xiang
Mathematics , 2015,
Abstract: We answer affirmatively the open problem proposed by Cabr\'e and Tan in their paper "Positive solutions of nonlinear problems involving the square root of the Laplacian" (see Adv. Math. {\bf 224} (2010), no. 5, 2052-2093).
Gradient Estimates for Solutions To Quasilinear Elliptic Equations with Critical Sobolev Growth and Hardy Potential
Chang-Lin Xiang
Mathematics , 2015,
Abstract: This note is a continuation of the work \cite{CaoXiangYan2014}. We study the following quasilinear elliptic equations \[ -\Delta_{p}u-\frac{\mu}{|x|^{p}}|u|^{p-2}u=Q(x)|u|^{\frac{Np}{N-p}-2}u,\quad\, x\in\mathbb{R}^{N}, \] where $1
Asymptotic Behaviors of Solutions to quasilinear elliptic Equations with critical Sobolev growth and Hardy potential
Chang-Lin Xiang
Mathematics , 2015, DOI: 10.1016/j.jde.2015.05.007
Abstract: Optimal estimates on the asymptotic behaviors of weak solutions both at the origin and at the infinity are obtained to the following quasilinear elliptic equations \[-\Delta_{p}u-\frac{\mu}{|x|^{p}}|u|^{p-2}u=Q(x)|u|^{\frac{Np}{N-p}-2}u,\quad\,x\in \mathbb{R}^{N},\] where $1
Remarks on Nondegeneracy of Ground States for Quasilinear Schr?dinger Equations
Chang-Lin Xiang
Mathematics , 2015,
Abstract: In this paper, we answer affirmatively the problem proposed by A. Selvitella in his paper "Nondegenracy of the ground state for quasilinear Schr\"odinger Equations" (see Calc. Var. Partial Differ. Equ., {\bf 53} (2015), pp 349-364): every ground state of equation \begin{eqnarray*}-\Delta u-u\Delta |u|^2+\omega u-|u|^{p-1}u=0&&\text{in }\mathbb{R}^N\end{eqnarray*} is nondegenerate for $10$ is a given constant and $N\ge1$. We also derive further properties on the linear operator associated to ground states of above equation.
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