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匹配条件: “Zülfiye KO?AK” ,找到相关结果约36140条。
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er‘iyye Sicillerine G re XVII. Yüzy lda Ayntab ve evresinde Gayrimenkul Sat lar (1600- 1650)/// The Real Estate Sales in the Vicinity of Ayntab in XVII. Century According to Ser’iyye Records (1600- 1650)
Zülfiye KOAK
History Studies : International Journal of History , 2010,
Abstract: The sales and buying of certain goods peculiar to the city should be taken into consideration when social and economic activities of a certain period of a city are studied. As the study on the real estate sales in buying and selling goods indicate the power of man to buy, it will also provide valuable information in determining the classes and the rate of localization within the city. All sorts of real estate sales in Ayntab in XVII. Century are dealt with and currency, types of sales, features determining the sales, and units of measurement are the main issues of this study.
1017 ( M.1608–1609) TAR HL AYNTAB ER’ YYE S C L N N TANITIMI VE F HR ST / INTRODUCTION AND THE LIST OF 1017 (AD 1608) ER‘IYYE RECORDS OF AYNTAB CITY
Zülfiye KOAK
Journal of the Human and Social Science Researches (itobiad) , 2012,
Abstract: Osmanl ehir tarihi al malar n n en nemli kaynaklar er’iyye sicilleridir. Ait olduklar d neme ait bir ok konuda bilgiler veren sicillerden yararlanma konusu problem te kil etmektedir. Bu problemi zmenin yollar ndan biri de bütün sicillerin fihristlerinin yap lmas d r.Bu al mada, ehir tarihi a s ndan olduk a nem ta yan er’iyye sicillerinden birinin tan t m n ve fihristini yapmak suretiyle, bu alanda yap lan al malara katk sunmak ama lanm t r.The most important sources of Ottoman town history are er’iyye records. To use the records, which reveal wide range of information on the era they belong, is still poses a problem. One of the ways of overcoming this problem is to make a list of all these records.In this study, it was aimed to contribute to current studies ongoing in this area by introducing and making a list of one of the er’iyye records, which is very important in terms of finding out on town history.
Sparsity as Cellular Objective to Infer Directed Metabolic Networks from Steady-State Metabolome Data: A Theoretical Analysis
Melik ?ksüz, Hasan Sad?ko?lu, Tunahan ?ak?r
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084505
Abstract: Since metabolome data are derived from the underlying metabolic network, reverse engineering of such data to recover the network topology is of wide interest. Lyapunov equation puts a constraint to the link between data and network by coupling the covariance of data with the strength of interactions (Jacobian matrix). This equation, when expressed as a linear set of equations at steady state, constitutes a basis to infer the network structure given the covariance matrix of data. The sparse structure of metabolic networks points to reactions which are active based on minimal enzyme production, hinting at sparsity as a cellular objective. Therefore, for a given covariance matrix, we solved Lyapunov equation to calculate Jacobian matrix by a simultaneous use of minimization of Euclidean norm of residuals and maximization of sparsity (the number of zeros in Jacobian matrix) as objective functions to infer directed small-scale networks from three kingdoms of life (bacteria, fungi, mammalian). The inference performance of the approach was found to be promising, with zero False Positive Rate, and almost one True positive Rate. The effect of missing data on results was additionally analyzed, revealing superiority over similarity-based approaches which infer undirected networks. Our findings suggest that the covariance of metabolome data implies an underlying network with sparsest pattern. The theoretical analysis forms a framework for further investigation of sparsity-based inference of metabolic networks from real metabolome data.
Radiation therapy for the solitary plasmacytoma
Esengül Koak,Giorgio Ballerini,Abderrahim Zouhair,Mahmut ?z?ahin
Turkish Journal of Hematology , 2010,
Abstract: Plasma-cell neoplasms are classically categorized into four groups as: multiple myeloma (MM), plasma-cell leukemias, solitary plasmacytomas (SP) of the bone (SPB), and extramedullary plasmacytomas (EMP). These tumors may be described as localized or diffuse in presentation. Localized plasma-cell neoplasms are rare, and include SP of the skeletal system, accounting for 2-5% of all plasma-cell neoplasms, and EMP of soft tissue, accounting for approximately 3% of all such neoplasms. SP is defined as a solitary mass of neoplastic plasma cells either in the bone marrow or in various soft tissue sites. There appears to be a continuum in which SP often progresses to MM. The main treatment modality for SP is radiation therapy (RT). However, there are no conclusive data in the literature on the optimal RT dose for SP. This review describes the interrelationship of plasma-cell neoplasms, and attempts to determine the minimal RT dose required to obtain local control.
Granulocytic sarcoma after stem cell transplantation in a child with biphenotypic leukemia
Zühre Kaya,ülker Koak,Meryem Albayrak,Türkiz Gürsel
Turkish Journal of Hematology , 2009,
Abstract: Granulocytic sarcoma is an extramedullary tumor composed of leukemic blasts. Isolated granulocytic sarcoma has rarely been reported in children with leukemia undergoing allogeneic stem cell transplantation. We report a case of isolated granulocytic sarcoma arising from the pleura in an 11-year-old girl who was previously treated for biphenotypic leukemia with allogeneic stem cell transplantation. Complete resolution of the tumor was achieved after two inductions with MRC 12 protocol; however, she died of sepsis during the neutropenic period. The unusual presentation, immunophenotypic differences at diagnosis and relapse, and the management options are discussed.
Primary intrameduller primitive neuroendocrine tumor: case report
Naciye ?Z?EKER,Kemal EK?C?,Alpaslan MAYADA?LI,Mihriban KOAK
Turkish Journal of Oncology , 2012,
Abstract: Primitive neuroendocrine tumors (PNETs) are rare neoplasms that are usually seen in children and frequently metastasis in the central nervous system. At this setting, intramedullary, extramedullary, intra-extramedullary and extradural have been described. To our knowledge, only 25 cases of purely intramedullary PNETs (IPNETs) have been previously reported. We present a case of primary intrameduller PNET. The initial treatment of the PNET is surgery and, if possible, the radical extirpation of the tumour. Administration of radiotherapy and chemotherapy appears to increase survival.
Bilateral knee and right ankle osteonecrosis in an adolescent girl with acute lymphoblastic leukemia
ülker Koak,Zühre Kaya,Meryem Albayrak,Alpaslan ?enk?ylü
Turkish Journal of Hematology , 2009,
Abstract: Although rare, avascular necrosis of bone is a serious and incapacitating complication seen in children with acute lymphoblastic leukemia receiving high dose steroids. Here we present a 16 year-old girl who developed bilateral knee and right ankle avascular osteonecrosis one year after intensive chemotherapy for medium risk acute lymphoblastic leukemia. Indirect curettage of necrotic tissue and bone grafting were performed for both knees whereas conservative measures had been sufficient for the ankle. Early recognition of this condition is important in prevention of disabling sequela in skeletal system.
Re-Irradiation of Progressive Brain Metastases After Whole Brain Radiotherapy: Outcome of Stereotactic Radiosurgery
Naciye I?IK ?Z?EKER,Mihriban KOAK,Alpaslan MAYADA?LI,Cengiz GEM?C?
Journal of Neurological Sciences , 2012,
Abstract: Purpose: In our study, rates of and factors affecting survival obtained by frameless robotic stereotactic radiosurgery are investigated retrospectively in progressive brain metastases previously treated with total cranial radiotherapy.Materials and Methods: SRS was given as salvage therapy to 60 patients with brain metastases after WBRT. CyberKnife radiosurgical system (Accuray, Sunnyvale, CA) was used for SRS. Median 1800 (800- 2400) cGy dosage of SRS was used in 44 cases (68%) in one fraction, and in 21 cases (32%) in two fractions.Result: For 12 patients, progression occurred within the SRS field, and overall local control was 80%. Survival rate was 85% at sixth months, and 52% in 12th months (median 12.5 months). Significantly better survival rates were achieved in the patients who breast carcinoma was the primary tumor site. Survival rates significantly decreased if the systemic disease showed progression. A significant change in survival was not observed in different Recursive Partitioning Analysis (RPA) groups, however for Score Index for Radiosurgery (SIR) survival, there was a significant relation. In the multivariance analysis, younger age and smaller tumor size were significantly related with better survival.Conclusion: In the progressive brain metastases, patients with relatively limited life expectancy, SRS is a preferable alternative with 12 months median survival.
The new era in therapeutic approaches: Non-coding RNAs and diseases
Zülfiye Yeliz AKKAYA,Pervin D?N?ER
Marmara Medical Journal , 2013,
Abstract: As a result of finding novel ribonucleic acid (RNA)’s and identifying their functions, it is now known that RNAs play a very important role for living organisms. Particularly, the ncRNAs (non-coding RNAs), which cover 62% of the genome, participate in the regulation of important processes such as cellular defense, development, differentiation, DNA replication, transcription and post-transcriptional silencing. Not surprisingly, therefore, their disruption has been linked to diseases such as cancers, neurodegenerative diseases, immunodeficiency, and cardiovascular diseases. ncRNAs have become the targets and tools of novel therapeutic approaches. By the help of identifying all functional ncRNAs that are encoded in the human genome, new therapeutic approaches may be developed and clinical trials using ncRNAbased molecules may be achieved. In this paper, we review the literature regarding the types of ncRNAs, their relation to diseases, and new diagnostic-therapeutic approaches.
Investigating the Visual-Motor Integration Skills of 60-72 Month Children from High and Low Socio- Economic Status As Regard Age Factor
Zülfiye Gül Ercan,Emine Ahmetoglu,Neriman Aral
International Education Studies , 2011, DOI: 10.5539/ies.v4n3p100
Abstract: This study aims to define whether age creates any differences in the visual-motor integration skills of 60- 72 months old children at low and high socio- economic status. The study was conducted on a total of 148 children consisting of 78 children representing low socio- economic status and 70 children representing high socio- economic status in the city center of Edirne. The Beery- Buktenica Developmental Test of Visual Motor Integration (VMI- 5th) which was developed by Beery- Buktenica (2004) and of which validity and reliability studies were made by Ercan and Aral (2011) after being translated into Turkish was used. It’s reported that both the age and the status of being at low and high socio-economic status create a meaningful difference in the visual-motor integration, visual perception and motor integration of 60-72 months old children at low and high socio-economic status (p<.05) while visual-motor integration mean score is higher for 66- 72 months old children at high socio- economic status.
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